Effects of ibuprofen on exercise-induced muscle soreness and indices of muscle damage.
Open accessAbstract
Thirty-two volunteers participated in a two-period crossover study in which ibuprofen was tested against an identical placebo for its effectiveness in reducing muscle soreness and damage after two bouts of downhill running. Subjective soreness, quadriceps isometric strength and isometric endurance time at 50 percent of maximum strength, serum activities of creatine kinase, lactate dehydrogenase and aspartate transaminase and serum levels of creatinine and urea were recorded at intervals up to 72 hours after exercise. Each downhill run produced muscle soreness, and a decline in muscle strength and 50 percent endurance time, although these parameters were unaffected by ibuprofen treatment. All serum parameters measured increased after both runs, but for the three enzymes this increase was smaller after the second run. Serum creatine kinase and urea levels were higher in the ibuprofen group after both runs. These results indicate that ibuprofen is not an appropriate treatment for delayed onset muscle soreness and damage.
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A number of studies have found no effect of NSAIDs on analgesia or inflammation during exercise.
“By contrast, a number of studies have found no effect of NSAIDs on analgesia or inflammation during exercise [184–188].”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [184]
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Cites
Myofibrillar damage following intense eccentric exercise in man
Fridén, J., Sjöström, M., & Ekblom, B. (1983) · International Journal of Sports Medicine · doi:10.1055/s-2008-1026030 · Cited by 1,005 · see citing works
Repeated high-force eccentric exercise: effects on muscle pain and damage
Newham, D. J., Jones, D. A., & CLARKSON, P. M. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.4.1381 · Cited by 494 · see citing works
Injury to skeletal muscle fibers of mice following lengthening contractions
McCully, K. K., & Faulkner, J. A. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.1.119 · Cited by 408 · see citing works
Delayed onset muscle soreness following repeated bouts of downhill running
Byrnes, W. C., Clarkson, P. M., White, J. S., Hsieh, S. S., Frykman, P., & Maughan, R. J. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.3.710 · Cited by 331 · see citing works
Self-citationMuscle fiber necrosis associated with human marathon runners
Hikida, R. S., Staron, R. S., Hagerman, F. C., Sherman, W. M., & Costill, D. L. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90037-0 · Cited by 276 · see citing works
Large delayed plasma creatine kinase changes after stepping exercise
Newham, D. J., Jones, D. A., & Edwards, R. H. T. (1983) · Muscle & Nerve · doi:10.1002/mus.880060507 · Cited by 270 · see citing works
Influence of a Prostaglandin-lnhibiting Drug on Muscle Soreness After Eccentric Work
Kuipers, H., KEIZER, H. A., VERSTAPPEN, F. T. J., et al. (1985) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025866 · Cited by 95 · see citing works
Characterization of muscles injured by forced lengthening. I. Cellular infiltrates
Stauber, W. T., FRITZ, V. K., VOGELBACH, D. W., & Dahlmann, B. (1988) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198808000-00004 · Cited by 82 · see citing works
Donnelly, A., McCormick, K., Maughan, R. J., Whiting, P. H., & Clarkson, P. M. (1988) · British Journal of Sports Medicine · doi:10.1136/bjsm.22.1.35 · Cited by 74 · see citing works
Self-citationCOMPARATIVE STUDY OF IBUPROFEN AND ASPIRIN IN SOFT-TISSUE INJURIES
Muckle, D. S. (1974) · Lara D. Veeken · doi:10.1093/rheumatology/13.3.141 · Cited by 57 · see citing works
Variable schedules of ibuprofen for ankle sprains.
McLatchie, G., Allister, C., MacEwen, C. J., et al. (1985) · British Journal of Sports Medicine · doi:10.1136/bjsm.19.4.203 · Cited by 27 · see citing works
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Research works printed but not linked: 6
- Hikida, R.S., Staron, R.S., Hagerman, F.C., Sherman, W.M. and Costill, D.L. Muscle fibre necrosis associ- ated with human marathon runners J Neurol Sci 1983, 59, 185-203
- Smith, L.L., McCammon, M., Smith, S., Chamness, M., Israel, R.G. and O'Brien, K.F. Leukocytosis: response to metabolic demands or a sign of acute inflammation related to delayed muscle soreness (DMS) Med Sci Sports Exerc 1988, 20(2), S74
- Headley, S.A.E., Newham, D.J. and Jones, D.A. The effect of prednisilone on exercise induced muscle soreness and damage Clin Sci 1985, 10(13), 85
- Clarkson, P.M. and Tremblay, I. Exercise-induced muscle damage, repair and adaptation in humans I Appl Physiol 1988, 65, 1-6 16
- McCulley, K.K. and Faulkner, J.A. Injury to skeletal muscie fibres of mice following lengthening contrac- tions I Apple Physiol 1985, 59, 119-126
- Pivarnik, J., Kayrouz, T., Senay, L.C. Plasma volume and protein content in progressive exercise: influence of cydooxygenase inhibitors Med Sci Sports Exerc 1985, 17, 1531-6 Br. J. Sports Med., Vol 24, No. 3 195 on July 10, 2023 by guest. Protected by copyright. http://bjsm.bmj.com/ Br J Sports Med: first published as 10.1136/bjsm.24.3.191 on 1 September 1990. Downloaded from
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- Authors
- Donnelly, A. E., Maughan, R. J., & Whiting, P. H.
- Affiliations
- University of Aberdeen (GB)
- Venue
- British Journal of Sports Medicine
- Publisher
- BMJ
- Published
- 1990-09
- Volume
- 24
- Issue
- 3
- Pages
- 191-195
- ISSN
- 0306-3674 (ISSN-L)
- 1473-0480
- PMC
- PMC1478782
- OpenAlex
- W2169051341
- Cited by
- 113
- References
- 11
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 8 · 2012: 8
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Sports Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Aberdeen
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- ibuprofen, delayed onset muscle soreness, exercise-induced muscle damage, downhill running, creatine kinase, lactate dehydrogenase, aspartate aminotransferase, serum urea, quadriceps strength, isometric endurance, NSAID analgesia
- MeSH terms
- Adolescent, Adult, Aspartate Aminotransferases, Creatine Kinase, Creatinine, Humans, Ibuprofen, L-Lactate Dehydrogenase, Male, Muscles, Pain, Physical Endurance, Running, Time Factors, Urea
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