ESCMID guideline for the diagnosis and management of Candida diseases 2012: prevention and management of invasive infections in neonates and children caused by Candida spp.
Open accessAbstract
Invasive candidiasis (IC) is a relatively common syndrome in neonates and children and is associated with significant morbidity and mortality. These guidelines provide recommendations for the prevention and treatment of IC in neonates and children. Appropriate agents for the prevention of IC in neonates at high risk include fluconazole (A-I), nystatin (B-II) or lactoferrin ± Lactobacillus (B-II). The treatment of IC in neonates is complicated by the high likelihood of disseminated disease, including the possibility of infection within the central nervous system. Amphotericin B deoxycholate (B-II), liposomal amphotericin B (B-II), amphotericin B lipid complex (ABLC) (C-II), fluconazole (B-II), micafungin (B-II) and caspofungin (C-II) can all be potentially used. Recommendations for the prevention of IC in children are largely extrapolated from studies performed in adults with concomitant pharmacokinetic data and models in children. For allogeneic HSCT recipients, fluconazole (A-I), voriconazole (A-I), micafungin (A-I), itraconazole (B-II) and posaconazole (B-II) can all be used. Similar recommendations are made for the prevention of IC in children in other risk groups. With several exceptions, recommendations for the treatment of IC in children are extrapolated from adult studies, with concomitant pharmacokinetic studies. Amphotericin B deoxycholate (C-I), liposomal amphotericin B (A-I), ABLC (B-II), micafungin (A-I), caspofungin (A-I), anidulafungin (B-II), fluconazole (B-I) and voriconazole (B-I) can all be used.
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The echinocandins have been recommended as first-line agents for invasive candidiasis.
“They display in vitro fungicidal activity against most Candida species, attractive tolerability and pharmacokinetic profiles, and have been recommended as first line agents for invasive candidiasis (1–6).”
From Echinocandin resistance: an emerging clinical problem? (2014) · cites this paper as [4]
The echinocandins display in vitro fungicidal activity against most Candida species.
“They display in vitro fungicidal activity against most Candida species, attractive tolerability and pharmacokinetic profiles, and have been recommended as first line agents for invasive candidiasis (1–6).”
From Echinocandin resistance: an emerging clinical problem? (2014) · cites this paper as [4]
The echinocandins display in vitro fungicidal activity against most Candida species.
“They display in vitro fungicidal activity against most Candida species, attractive tolerability and pharmacokinetic profiles, and have been recommended as first line agents for invasive candidiasis (1–6).”
From Echinocandin resistance: an emerging clinical problem? (2014) · cites this paper as [3]
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Ullmann, A. J., Aguado, J. M., Arikan-Akdagli, S., Denning, D. W., Groll, A. H., Lagrou, K., Lass-Flörl, C., Lewis, R. E., Munoz, P., Verweij, P. E., et al. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.01.002 · Cited by 1,556 · see citing works
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Antifungals in Clinical Use and the Pipeline
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- Authors
- Hope, W. W., Castagnola, E., Groll, A. H., Roilides, E., Akova, M., Arendrup, M. C., Arikan-Akdagli, S., Bassetti, M., Bille, J., Cornely, O. A., Cuenca-Estrella, M., Donnelly, J. P., Garbino, J., Herbrecht, R., Jensen, H. E., Kullberg, B. J., Lass-Flörl, C., Lortholary, O., Meersseman, W., Petrikkos, G., Richardson, M. D., Verweij, P. E., Viscoli, C., & Ullmann, A. J.
- Affiliations
- University of Liverpool (GB)
- Istituto Giannina Gaslini (IT)
- University of Münster (DE)
- Aristotle University of Thessaloniki (GR)
- Hacettepe University (TR)
- Statens Serum Institut (DK)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- University of Cologne (DE)
- Radboud University Medical Center (NL)
- University Hospital of Geneva (CH)
- Hôpital d'Hautepierre (FR)
- University of Copenhagen (DK)
- Hôpital Necker-Enfants Malades (FR)
- Universitair Ziekenhuis Leuven (BE)
- National and Kapodistrian University of Athens (GR)
- Manchester Academic Health Science Centre (GB)
- University of Genoa (IT)
- University of Würzburg (DE)
- ORCID
- Venue
- Clinical Microbiology and Infection
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 18
- Pages
- 38-52
- ISSN
- 1198-743X (ISSN-L)
- OpenAlex
- W1857969962
- Cited by
- 360
- References
- 142
- Citations by year
- 2026: 16 · 2025: 17 · 2024: 32 · 2023: 24 · 2022: 25 · 2021: 35 · 2020: 25 · 2019: 27 · 2018: 29 · 2017: 26 · 2016: 23 · 2015: 25 · 2014: 32 · 2013: 22 · 2012: 2
- FWCI
- 17.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Clinical Microbiology and Infection (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- IRIS (submittedVersion)
- Hacettepe University Institutional Repository (hacettepe.edu.tr) (submittedVersion, other-oa)
- Research Explorer (The University of Manchester) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- National Institute for Health and Care Research (CS/08/08/10)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Keywords
- invasive candidiasis, candidiasis, neonates, pediatric patients, antifungal prophylaxis, antifungal therapy, amphotericin B deoxycholate, liposomal amphotericin B, amphotericin B lipid complex, fluconazole, micafungin, caspofungin, voriconazole, posaconazole, itraconazole, anidulafungin, hematopoietic stem cell transplantation, pediatric pharmacokinetics
- MeSH terms
- Adolescent, Antifungal Agents, Candida, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Pediatrics, Candidiasis, Invasive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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