The DOI matches its Crossref record.
CLINICOPATHOLOGIC CORRELATION OF DRUSEN AND RETINAL PIGMENT EPITHELIAL ABNORMALITIES IN AGE-RELATED MACULAR DEGENERATION
Abstract
Background: Clinicopathologic studies of eyes lead to a better understanding of the nature of the ophthalmoscopic and fluorescein angiographic features of drusen. A study was conducted to provide clinicopathologic correlation of drusen and present a classification of drusen based on clinical and histopathologic features. Methods: The macular areas of three eyes from two patients were serially sectioned and studied, and features were depicted in a two-dimensional map and compared with clinical findings. Results: All three tyes had large drusen (>63 µm) with soft morphologic characteristics (poorly demarcated borders) documented on fundus photographs. In both eyes from one patient, these large drusen corresponded to areas of focal retinal pigment epithelium hypopigmentation overlying Bruch's membrane, which was diffusely thickened throughout the macula. Similar findings were noted in another eye from a second patient, and additionally, where there was relatively marked fluorescein staining of large drusen on the late phase of an angiogram, the pathologic correlation demonstrated detachment of the thickened inner aspect of Bruch's membrane from the remainder of Bruch's membrane. Focal hyperpigmentation corresponded to areas of hypertrophy of the retinal pigment epithelium and to clusters of pigmented cells in the subretinal space and outer nuclear area. Conclusion: Diffuse thickening of the inner aspect of Bruch's membrane is associated with retinal pigment epithelial hypopigmentation, focal atrophy, and soft (large) drusen formation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Soft drusen are often large and are associated with the detachment of the retinal pigment epithelium and diffusely abnormal Bruch’s membrane alterations.122,124”
From Age-related macular degeneration (2008) · cites this paper as [124]
Citations
Cited by
Sorted by citations
A role for local inflammation in the formation of drusen in the aging eye
Anderson, D. H., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01624-0 · Cited by 1,087
Current concepts in the pathogenesis of age-related macular degeneration
Zarbin, M. A. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.598 · Cited by 1,006
“Soft drusen can also represent a localized accumulation of basal laminar deposit in an eye with diffuse basal laminar deposit.(174) Thus, the abnormal ECM of AMD eyes includes basal laminar deposit, basal linear deposit, and their clinically evident manifestation, soft drusen.”
BackgroundAge-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P. (2003) · Survey of Ophthalmology · doi:10.1016/s0039-6257(03)00030-4 · Cited by 959
The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
Datta, S., Cano, M., Ebrahimi, K. B., Wang, L., & Handa, J. T. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.03.002 · Cited by 843
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript different morphologic forms of the same lesion (Abdelsalam et al., 1999; Bressler et al., 1994; Curcio and Millican, 1999; Green and Enger, 1993; Spraul et al., 1996).”
BackgroundJohnson, L. V., Leitner, W. P., Staples, M. K., & Anderson, D. H. (2001) · Experimental Eye Research · doi:10.1006/exer.2001.1094 · Cited by 621
Age-related macular degeneration
Coleman, H. R., Chan, C.-C., Ferris, F. L., & Chew, E. Y. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61759-6 · Cited by 542
Mata, N. L., Weng, J., & Travis, G. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130110497 · Cited by 456
Johnson, L. V., Leitner, W. P., Rivest, A. J., Staples, M. K., Radeke, M. J., & Anderson, D. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192203399 · Cited by 447
Age-Related Macular Degeneration
Fine, S. L., Berger, J. W., Maguire, M. G., & Ho, A. C. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420707 · Cited by 424
Self-citationRecent developments in age-related macular degeneration: a review
Al-Zamil, W. M., & Yassin, S. A. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s143508 · Cited by 427
“Drusen formation signals RPE dysfunction, which promotes RPE loss with further progression that results in photoreceptor death.(18) As previously described, RPE degeneration consequently leads to dysfunction of Bruch’s membrane.”
BackgroundMullins, R. F., Johnson, M. N., Faidley, E. A., Skeie, J. M., & Huang, J. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6476 · Cited by 394
“It is possible that the observed choroidal microvascular changes are a secondary event that follows the formation of drusen and interference of trophic signaling by the RPE.”
ResultInfluentialDRUSEN CHARACTERIZATION WITH MULTIMODAL IMAGING
Spaide, R. F., & Curcio, C. A. (2010) · Retina · doi:10.1097/iae.0b013e3181ee5ce8 · Cited by 397
Drusen in Age-Related Macular Degeneration
Abdelsalam, A., Del Priore, L., & Zarbin, M. A. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(99)00072-7 · Cited by 352
Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies
Curcio, C. A. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24882 · Cited by 322
Photoreceptor degeneration and dysfunction in aging and age-related maculopathy
Jackson, G. R., Owsley, C., & Curcio, C. A. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00007-7 · Cited by 317
Infrared imaging of sub-retinal structures in the human ocular fundus
Elsner, A. E., Burns, S. A., Weiter, J. J., & Delori, F. C. (1996) · Vision Research · doi:10.1016/0042-6989(95)00100-e · Cited by 310
“Most significantly , features identified in photography as drusen have been found to be atrophic regions on examination with histology (Bressler et al., 1994).”
BackgroundKim, S., Oh, J., Kwon, S.-S., Yoo, J. H., & Huh, K. (2011) · Retina · doi:10.1097/iae.0b013e31821801c5 · Cited by 310
“Age-related maculopathy is characterized by RPE or sub-RPE changes.(17,18) Choroidal neovascular membrane (CNVM) of nAMD is associated with degeneration of Bruch membranes and localized hypoxia of the fovea in old age.”
BackgroundPhotoreceptor topography in ageing and age-related maculopathy
Curcio, C. A. (2001) · Eye · doi:10.1038/eye.2001.140 · Cited by 308
Transplantation of the RPE in AMD
Binder, S., Stanzel, B. V., Krebs, I., & Glittenberg, C. G. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.02.002 · Cited by 298
Curcio, C. A., Johnson, M., Huang, J.-D., & Rudolf, M. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.08.001 · Cited by 293
Schuman, S. G., Koreishi, A. F., Farsiu, S., Jung, S., Izatt, J. A., & Toth, C. A. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2008.10.006 · Cited by 282
Malek, G., Li, C.-M., Guidry, C., Medeiros, N. E., & Curcio, C. A. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63836-9 · Cited by 270
Swaroop, A., Chew, E. Y., Bowes Rickman, C., & Abecasis, G. R. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164350 · Cited by 270
“Drusen can present as small discrete nodules, known as hard drusen, or as large nodules with ill-defined, indistinct boundaries, known as soft drusen (19, 126).”
Spraul, C. W., Lang, G., Grossniklaus, H. E., & Lang, G. K. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(99)00086-7 · Cited by 258
Fundus autofluorescence and age-related macular degeneration
Spaide, R. F. (2003) · Ophthalmology · doi:10.1016/s0161-6420(02)01756-6 · Cited by 257
Chong, N. H. V., Keonin, J., Luthert, P. J., Frennesson, C. I., Weingeist, D. M., Wolf, R. L., Mullins, R. F., & Hageman, G. S. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62248-1 · Cited by 218
Ma, W., Zhao, L., Fontainhas, A. M., Fariss, R. N., & Wong, W. T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007945 · Cited by 222
Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy
Zhang, S. X., & Ma, J. (2006) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.09.002 · Cited by 213
Hageman, G. S., Mullins, R. F., Russell, S. R., Johnson, L. V., & Anderson, D. H. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.3.477 · Cited by 206
Sub-retinal drusenoid deposits in human retina: Organization and composition
Rudolf, M., Malek, G., Messinger, J. D., Clark, M. E., Wang, L., & Curcio, C. A. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.07.010 · Cited by 201
Associations between Lutein, Zeaxanthin, and Age-Related Macular Degeneration: An Overview
Carpentier, S., Knaus, M., & Suh, M. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390802066979 · Cited by 182
MULTIMODAL IMAGING OF PIGMENT EPITHELIAL DETACHMENT
Mrejen, S., Sarraf, D., Mukkamala, S. K., & Freund, K. B. (2013) · Retina · doi:10.1097/iae.0b013e3182993f66 · Cited by 179
Basal deposits and drusen in eyes with age-related maculopathy: Evidence for solid lipid particles
Curcio, C. A., Presley, J. B., Millican, C. L., & Medeiros, N. E. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2004.09.017 · Cited by 171
Balaratnasingam, C., Messinger, J. D., Sloan, K. R., Yannuzzi, L. A., Freund, K. B., & Curcio, C. A. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2016.12.034 · Cited by 174
Rakoczy, P. E., Zhang, D., Robertson, T., Barnett, N. L., Papadimitriou, J., Constable, I. J., & Lai, C.-M. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64427-6 · Cited by 173
Cukras, C., Agrón, E., Klein, M. L., Ferris, F. L., Chew, E. Y., Gensler, G., & Wong, W. T. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2009.12.002 · Cited by 170
Nagineni, C. N., Samuel, W., Nagineni, S., Pardhasaradhi, K., Wiggert, B. O., Detrick, B., & Hooks, J. J. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10378 · Cited by 169
Grisanti, S., & Tatar, O. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.05.002 · Cited by 163
How does the macula protect itself from oxidative stress?
Handa, J. T. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.03.006 · Cited by 154
“BlinD and large drusen constitute different morphologic forms of the same lesion (Figure 4) (Abdelsalam et al., 1999; Bressler et al., 1994; Curcio and Millican, 1999; Green and Enger, 1993).”
BackgroundTan, A. C. S., Pilgrim, M. G., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A. P., Li, M., Messinger, J. D., Dolz‐Marco, R., Lei, J., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat4544 · Cited by 157
Blatt, G. J., & Rosene, D. L. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980302)392:1 · Cited by 102
Nagineni, C. N., Kommineni, V. K., William, A., Detrick, B., & Hooks, J. J. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22708 · Cited by 158
Retinal Pigment Epithelial Detachment
Zayit‐Soudry, S., Moroz, I., & Loewenstein, A. (2007) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2007.02.008 · Cited by 166
Age-Related Macular Degeneration: Review of Pathogenesis
Zarbin, M. A. (1998) · European Journal of Ophthalmology · doi:10.1177/112067219800800401 · Cited by 162
The role of glia in retinal vascular disease
Coorey, N. J., Shen, W., Chung, S. H., Zhu, L., & Gillies, M. C. (2012) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2012.00741.x · Cited by 136
“It exists in Clinical and Experimental Optometry 95.3 May 2012 © 2012 The Authors 274 Clinical and Experimental Optometry © 2012 Optometrists Association Australia two forms: non-neovascular (‘dry’) and neovascular (‘wet’) AMD.”
BackgroundInfluentialCHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION—WHAT IS THE CAUSE?
Spaide, R. F., Armstrong, D., & Browne, R. W. (2003) · Retina · doi:10.1097/00006982-200310000-00001 · Cited by 122
Submacular Surgery Trials Research Group (2005) · Archives of Ophthalmology · doi:10.1001/archopht.123.7.914 · Cited by 119
“25-nm collagen 119/142 (84) 47/50 (94) 51/66 (77) 21/26 (81) Retinal pigment epithelium 113/137 (82) 40/47 (85) 51/63 (81) 22/27 (81) Central macrophages 114/142 (80) 41/49 (84) 50/66 (76) 23/27 (85) Extravasated erythrocytes 115/142 (81) 34/50 (68) 61/65 (94) 20/27 (74) Fibrin 111/140 (79) 41/50 (82) 52/63 (83) 18/27…”
BackgroundInfluentialLipids, oxidized lipids, oxidation-specific epitopes, and Age-related macular degeneration.
Handa, J. T., Cano, M., Wang, L., Datta, S., & Liu, T. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.07.013 · Cited by 112
Age-Related Macular Degeneration
la Cour, M., Kiilgaard, J. F., & Nissen, M. H. (2002) · Drugs & Aging · doi:10.2165/00002512-200219020-00003 · Cited by 111
“[13] The presence of small hard drusen (≤63μm) is an almost ubiquitous feature of older”
BackgroundOn the origin of proteins in human drusen: The meet, greet and stick hypothesis
Bergen, A. A., Arya, S., Koster, C., Pilgrim, M. G., Wiatrek-Moumoulidis, D., van der Spek, P. J., Hauck, S. M., Boon, C. J. F., Emri, E., Stewart, A. J., et al. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.12.003 · Cited by 101
Clinical features of drusenoid pigment epithelial detachment in age related macular degeneration
Roquet, W. (2004) · British Journal of Ophthalmology · doi:10.1136/bjo.2003.017632 · Cited by 106
Psychophysical Function in Age-related Maculopathy
Neelam, K., Nolan, J. M., Chakravarthy, U., & Beatty, S. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2008.12.003 · Cited by 108
“The characteristics of drusen, such as large number and size, confluence, softness, and associated focal hyperpigmentation of the RPE, are associated with an increased risk for progression to the neovascular stage of this disease.(42,43,45,128,269,300) However, the overall predictive value of such morphological change…”
BackgroundLaser treatment of drusen to prevent progression to advanced age-related macular degeneration
Virgili, G., Michelessi, M., Parodi, M. B., Bacherini, D., & Evans, J. R. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006537.pub3 · Cited by 95
Retinal pigment epithelial cell proliferation
Stern, J. H., & Temple, S. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215587530 · Cited by 96
The spectrum of phenotypes caused by variants in the CFH gene
Boon, C. J. F., van de Kar, N. C. A. J., Klevering, B. J., KEUNEN, J. E. E., Cremers, F. P. M., Klaver, C. C. W., Hoyng, C. B., Daha, M. R., & den Hollander, A. I. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.02.013 · Cited by 92
Ultrastructure of the human retina in aging and various pathological states
Nag, T. C., & Wadhwa, S. (2012) · Micron · doi:10.1016/j.micron.2012.01.011 · Cited by 88
Blue-light filtering intraocular lenses (IOLs) for protecting macular health
Downie, L. E., Busija, L., & Keller, P. R. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011977.pub2 · Cited by 95
Hartmann, K. I., Bartsch, D., Cheng, L., et al. (2011) · Retina · doi:10.1097/iae.0b013e31820a6850 · Cited by 82
“There is evidence that the progression of drusen in number, size, and confluence is associated with progressive atrophy–related vision loss and also with the risk of developing choroidal neovascularization.(29) The ability to measure the effect of structural changes in AMD on vision function in focal retinal areas may…”
BackgroundCrystallin distribution in Bruch's membrane–choroid complex from AMD and age-matched donor eyes
Nakata, K., Crabb, J. W., & Hollyfield, J. G. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2004.12.011 · Cited by 81
Xu, W., Grunwald, J. E., Metelitsina, T. I., DuPont, J. C., Ying, G., Martin, E. R., Dunaief, J. L., & Brucker, A. J. (2010) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2010.01.041 · Cited by 80
Hartnett, M. E., & Elsner, A. E. (1996) · Ophthalmology · doi:10.1016/s0161-6420(96)30731-8 · Cited by 79
Fernández‐Robredo, P., Sancho, A., Johnen, S., Recalde, S., Gama, N., Thumann, G., Gröll, J., & García‐Layana, A. (2014) · Journal of Ophthalmology · doi:10.1155/2014/510285 · Cited by 77
“[16] N.”
BackgroundLittle, H. L., Showman, J. M., & Brown, B. W. (1997) · Ophthalmology · doi:10.1016/s0161-6420(97)30261-9 · Cited by 74
Suzuki, M., Curcio, C. A., Mullins, R. F., & Spaide, R. F. (2015) · Retina · doi:10.1097/iae.0000000000000503 · Cited by 74
Bressler, N. M., & Bressler, S. B. (1995) · Ophthalmology · doi:10.1016/s0161-6420(95)30889-5 · Cited by 73
Self-citationCharacterization of Drusen-associated Glycoconjugates
Mullins, R. F., Johnson, L. V., Anderson, D. H., & Hageman, G. S. (1997) · Ophthalmology · doi:10.1016/s0161-6420(97)30322-4 · Cited by 72
Clinical Characteristics and Current Treatment of Age-Related Macular DegenerationPreprint
Yonekawa, Y., & Kim, I. K. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a017178 · Cited by 75
“In AMD with RPE degeneration, the patchy BLamD seen in normal aging develop an overlying layer of a diffuse, thick, amorphous, hyalinized material, which can become nodular elevations (Bressler et al. 1994).”
BackgroundDyslipidemia in age-related macular degeneration
Lin, J. B., Halawa, O. A., Husain, D., Miller, J. W., & Vavvas, D. G. (2022) · Eye · doi:10.1038/s41433-021-01780-y · Cited by 67
“BLinD and drusen are considered to be alternative forms of the same entity, and patients with AMD are orders of magnitude more likely to have BLinD and large drusen (>125 μm) compared with agematched controls [16, 18].”
BackgroundRetinal Pigment Epithelial Detachment in Age-Related Macular Degeneration
Karampelas, M. D., Malamos, P., Petrou, P., Georgalas, I., Papaconstantinou, D., & Brοuzas, D. (2020) · Ophthalmology and Therapy · doi:10.1007/s40123-020-00291-5 · Cited by 64
Blue-light filtering intraocular lenses (IOLs) for protecting macular health
Downie, L. E., Busija, L., & Keller, P. R. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011977 · Cited by 65
HMG CoA Reductase Inhibitors (Statins): Do They Have a Role in Age-related Macular Degeneration?
Guymer, R. H., Chiu, A. W.-I., Lim, L. L., & Baird, P. N. (2005) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2004.12.002 · Cited by 61
Garland, D. L., Fernández‐Godino, R., Kaur, I., Speicher, K. D., Harnly, J. M., Lambris, J. D., Speicher, D. W., & Pierce, E. A. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt395 · Cited by 54
Age‐Related Macular Degeneration
Nivison‐Smith, L., Milston, R., Madigan, M. C., & Kalloniatis, M. (2014) · Optometry and Vision Science · doi:10.1097/opx.0000000000000281 · Cited by 56
“Basal deposits may contribute to AMD pathogenesis as precursors for drusen or by promoting drusen growth as subretinal bridges.(9,34,35) Alternatively, these deposits may simply be associated with the disease AMD: Clinical Presentation and Pathology LinkVNivison-Smith et al.”
BackgroundVascular endothelial growth factors in retinal and choroidal neovascular diseases
Kinnunen, K., & Ylä‐Herttuala, S. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.532150 · Cited by 53
“Soft drusen can represent focal accentuations of basal linear deposits and a localized accumulation of basal laminar deposits (87).”
BackgroundAge-related macular degeneration: genetic and clinical findings
Kokotas, H., Grigoriadou, M., & Petersen, M. B. (2010) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.091 · Cited by 55
“‘Soft’ drusen are usually larger than the ‘hard’ forms (33, 34, 43).”
BackgroundSoubrane, G. (2001) · British Journal of Ophthalmology · doi:10.1136/bjo.85.4.483 · Cited by 51
Distribution of Cathepsin D in Human Eyes with or without Age-related Maculopathy
Rakoczy, P. E., Sarks, S. H., Daw, N., & Constable, I. J. (1999) · Experimental Eye Research · doi:10.1006/exer.1999.0700 · Cited by 46
Abnormal cone synapses in human cone-rod dystrophy
Gregory-Evans, K., Fariss, R. N., Possin, D. E., Gregory, C. Y., & Milam, A. H. (1998) · Ophthalmology · doi:10.1016/s0161-6420(98)91233-7 · Cited by 43
Age-Related Macular Degeneration: Nonneovascular Early AMD, Intermediate AMD, and Geographic Atrophy
Bressler, S. B., Bressler, N. M., Sarks, S. H., & Sarks, J. P. (2006) · Elsevier eBooks · doi:10.1016/b978-0-323-02598-0.50066-5 · Cited by 40
Self-citationLaser treatment of drusen to prevent progression to advanced age-related macular degeneration
Parodi, M. B., Virgili, G., & Evans, J. R. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006537.pub2 · Cited by 39
RETINAL PIGMENT EPITHELIUM APERTURE
Querques, G., Capuano, V., Costanzo, E., Corvi, F., Querques, L., Introini, U., Souied, E. H., & Bandello, F. M. (2016) · Retina · doi:10.1097/iae.0000000000001231 · Cited by 36
Nagineni, C. N., Kommineni, V. K., Ganjbaksh, N., Nagineni, K. K., Hooks, J. J., & Detrick, B. (2015) · Aging and Disease · doi:10.14336/ad.2015.0323 · Cited by 35
“In addition, the involvement of inflammatory molecules produced by infiltrating leukocytes has been shown to play a key role in the pathophysiological processes of CNV in AMD [9-12].”
BackgroundDrusen and lipid‐filled retinal pigment epithelium cells in a rhesus macula
Anderson, M. E., Dawson, W. W., González‐Martínez, J., & Curcio, C. A. (2006) · Veterinary Ophthalmology · doi:10.1111/j.1463-5224.2006.00463.x · Cited by 34
Chen, L., Bai, Y., Zhao, M., & Jiang, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4890 · Cited by 34
“Accumulation of drusen in the extracellular compartment between the choroid and the RPE is an early event in the course of AMD (3,4).”
Mulfaul, K., Russell, J. F., Voigt, A. P., Stone, E. M., Tucker, B. A., & Mullins, R. F. (2022) · Annual Review of Vision Science · doi:10.1146/annurev-vision-100820-085958 · Cited by 35
Querques, G., & Souied, E. H. (2015) · Retina · doi:10.1097/iae.0000000000000761 · Cited by 31
The Immunological Basis of Degenerative Diseases of the Eye
Nussenblatt, R. B., Liu, B., Wei, L., & Sen, H. N. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2012.740536 · Cited by 31
“Large drusen and the associated RPE changes are the major risk factors for the development of advanced AMD, which can be classified into two subtypes: dry and wet [2, 3].”
BackgroundBerinstein, D. M., Hassan, T., Williams, G. A., Margherio, R. R., Ruby, A. J., & Garretson, B. R. (2000) · Ophthalmology · doi:10.1016/s0161-6420(00)00417-6 · Cited by 26
Neovascular (Exudative) Age-Related Macular Degeneration
Bressler, N. M., Bressler, S. B., & Fine, S. L. (2006) · Elsevier eBooks · doi:10.1016/b978-0-323-02598-0.50067-7 · Cited by 29
Self-citationSheibani, N., Farnoodian, M., & Sorenson, C. M. (2018) · Journal of Ophthalmic and Vision Research · doi:10.4103/jovr.jovr_67_18 · Cited by 26
“[142,145] The limitations with PDT include a low rate of vision improvement in patients (only 14%) and high incidence of CNV recurrence after laser treatment.[142,145] Extensive research on the molecular and cellular mechanisms involved in AMD pathogenesis and CNV has provided a better understanding of disease develop…”
BackgroundJawad, S., Liu, B., Li, Z., Katamay, R., Campos, M. M., Wei, L., Sen, H. N., Ling, D., Martínez, F. O., Amaral, J., et al. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-11380 · Cited by 25
Polypoidal choroidal vasculopathy with drusen
Iwama, D., Tsujikawa, A., Sasahara, M., et al. (2008) · Japanese Journal of Ophthalmology · doi:10.1007/s10384-007-0503-9 · Cited by 24
“In addition, drusen often disappear beneath a longstanding detached retina because they are byproducts of rod and cone metabolism of the RPE.24 In this study, we evaluated patients with PCV who had drusen in at least one eye, because the presence of drusen is reported to often be symmetric, that is, to involve both ey…”
BackgroundInfluentialDrusen, an Old but New Frontier
Spaide, R. F., Curcio, C. A., & Zweifel, S. A. (2010) · Retina · doi:10.1097/iae.0b013e3181ed8d05 · Cited by 22
Sanie‐Jahromi, F., Ahmadieh, H., Soheili, Z., Davari, M., Ghaderi, S., Kanavi, M. R., Samiei, S., Deezagi, A., Pakravesh, J., & Bagheri, A. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-182 · Cited by 22
“A number of treatments have previously been used, some of which, in addition to not being suitable for retinal restoration, have been found to affect the adjacent healthy cells [5-8].”
BackgroundAge-Related Macular Degeneration
Hagedorn, C. L., & Adelman, R. A. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-047-8_1 · Cited by 24
Khan, K. N., Borooah, S., Landó, L., Dans, K., Mahroo, O. A., Meshi, A., Kalitzeos, A. A., Agorogiannis, G., Moghimi, S., Freeman, W. R., et al. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.6.26 · Cited by 23
SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING OF DRUSENOID PIGMENT EPITHELIAL DETACHMENTS
Filho, C. A. D. A. G., Yehoshua, Z., Gregori, G., Farah, M. E., Feuer, W. J., & Rosenfeld, P. J. (2013) · Retina · doi:10.1097/iae.0b013e318285cbd2 · Cited by 21
“nine green angiography; spectral-domain optical coherence tomography (SD-OCT); and histopathology.(2,3) Drusenoid pigment epithelial detachments carry a better prognosis when compared with vascularized”
BackgroundMcgill, T., Osborne, L., Lu, B., Stoddard, J., Huhn, S., Tsukamoto, A., & Capela, A. (2019) · Translational Vision Science & Technology · doi:10.1167/tvst.8.3.43 · Cited by 17
“AMD with GA.(41) Our data in this study suggested a role for HuCNS-SC in augmenting that putative regenerative capacity, particularly in the context of AMD with GA.”
BackgroundScanning and transmission electron microscopic findings during RPE wound healing in vivo
Oganesian, A., Bueno, E., Yan, Q., Spee, C., Black, J., Rao, N. A., & Lopez, P. F. (1997) · International Ophthalmology · doi:10.1023/a:1026402031902 · Cited by 20
“focal hyperpigmentation [63, 64] in choroidal neovascularization [26, 29, 30, 64] associated with the”
BackgroundHomeostasis and dyshomeostasis of the retina
Zhang, C.-J., & Jin, Z. (2023) · Current Medicine · doi:10.1007/s44194-023-00021-6 · Cited by 25
Metadata
- Authors
- BRESSLER, N. M., SILVA, J. C., BRESSLER, S. B., FINE, S. L., & GREEN, W. R.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- BRESSLER, NEIL M.
- BRESSLER, SUSAN B.
- FINE, STUART L.
- Venue
- Retina
- Published
- 1994
- Volume
- 14
- Issue
- 2
- Pages
- 130-142
- ISSN
- 0275-004X (ISSN-L)
- OpenAlex
- W4234378667
- Cited by
- 200
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 12 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 9 · 2017: 7 · 2016: 5 · 2015: 10 · 2014: 5 · 2013: 7 · 2012: 11
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Retina (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Retinal and Macular Surgery
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- drusen, age-related macular degeneration, retinal pigment epithelium, retinal pigment epithelium atrophy, clinicopathological correlation, outer nuclear layer
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
