Natural history of drusenoid pigment epithelial detachment in age-related macular degeneration: Age-Related Eye Disease Study Report No. 28
Open accessAbstract
Objective To describe the natural history of eyes with drusenoid pigment epithelial detachments (DPEDs) associated with age-related macular degeneration (AMD).Design Multicenter, clinic-based, prospective cohort study.Participants Among 4757 participants enrolled in the Age-Related Eye Disease Study (AREDS), 255 were identified as having DPED in at least 1 eye and having 5 or more years of follow-up after the initial detection of the DPED.Methods Baseline and annual fundus photographs were evaluated for the evolution of the fundus features and the development of advanced AMD in the forms of central geographic atrophy (CGA) or neovascular (NV) AMD. Kaplan-Meier analyses of progression to advanced AMD and of moderate vision loss (> or =15 letters compared with baseline) were performed.Main outcome measures Rate of progression to advanced AMD and change in visual acuity from baseline (in terms of mean letters lost and proportion losing > or =15 letters).Results A total of 311 eyes (from 255 participants) with DPED were followed for a median follow-up time of 8 years subsequent to the initial detection of a DPED. Of the 282 eyes that did not have advanced AMD at baseline, advanced AMD developed within 5 years in 119 eyes (42%) (19% progressing to CGA and 23% progressing to NV-AMD). In the remaining eyes that did not develop advanced AMD (n=163), progressive fundus changes, typified by the development of calcified drusen and pigmentary changes, were detected. Visual decline was prominent among study eyes, with approximately 40% of all eyes decreasing in visual acuity by > or =15 letters at 5 years follow-up. Mean visual acuity decreased from 76 letters ( approximately 20/30) at baseline to 61 letters ( approximately 20/60) at 5 years. Five-year decreases in mean visual acuity averaged 26 letters for eyes progressing to advanced AMD and 8 letters for non-progressing eyes.Conclusions The natural history of eyes containing DPED is characterized by a high rate of progression to both CGA and NV-AMD. Among eyes not progressing to advanced AMD, progressive development of pigmentary changes and calcified drusen were observed. Decline of visual acuity is a common outcome, with or without progression to advanced forms of AMD.
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A previous report showed a relatively high rate of development of choroidal neovascularization (23%) in eyes with drusenoid pigment epithelial detachment with no advanced AMD at baseline.
“A previous report showed a relatively high rate of development of CNV (23%) in eyes with drusenoid PED with no advanced AMD at baseline (Cukras et al., 2010).”
From Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: Preliminary results in Asian patients (2015) · cites this paper as Cukras et al., 2010
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- Authors
- Cukras, C., Agrón, E., Klein, M. L., Ferris, F. L., Chew, E. Y., Gensler, G., & Wong, W. T.
- Affiliations
- National Institutes of Health (US)
- Legacy Good Samaritan Medical Center (US)
- Emmes (United States) (US)
- Corresponding author
- Wong, Wai T.
- Venue
- Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 117
- Issue
- 3
- Pages
- 489-499
- ISSN
- 0161-6420 (ISSN-L)
- PMC
- PMC2947750
- OpenAlex
- W2058344658
- Cited by
- 170
- References
- 17
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 12 · 2023: 4 · 2022: 13 · 2021: 14 · 2020: 18 · 2019: 9 · 2018: 9 · 2017: 14 · 2016: 15 · 2015: 3 · 2014: 7 · 2013: 12 · 2012: 9
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
- Keywords
- age-related macular degeneration, natural history (disease), neovascular AMD, visual acuity loss, disease progression, fundus changes, retinal pigment epithelium, choroidal neovascularization, macular atrophy
- MeSH terms
- Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Macular Degeneration, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Retinal Detachment, Visual Acuity, Retinal Drusen, Disease Progression, Retinal Pigment Epithelium
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