Cited by 106Cardiovascular and exercise physiologyLipoproteins and Cardiovascular HealthPhysical Activity and Health

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Aerobic Exercise and Lipids and Lipoproteins in Patients With Cardiovascular Disease: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

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Kelley, George A., Kelley, Kristi S., Franklin, Barry·2006·Journal of Cardiopulmonary Rehabilitation

DOI 10.1097/00008483-200605000-00002PMC PMC2447859

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Abstract

Purpose Use the meta-analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in adults with cardiovascular disease (CVD). Methods Studies were retrieved via electronic databases, review of reference lists from retrieved articles, including reviews, and hand searching. Inclusion criteria were: (1) randomized controlled trials, (2) aerobic exercise >or=4 weeks as an intervention, (3) studies published in English language only between January 1, 1955 and January 1, 2005, (4) studies published in journals or as dissertations or master's theses, (5) human subjects >or=18 years, (6) all subjects diagnosed with some type of CVD, and (7) pre and post data available for total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). Random-effects models were used for data analysis. Results Of the more than 3,000 studies reviewed, a total of 10 representing 1,260 subjects (580 exercise, 680 control) were included in our analysis. There was a statistically significant increase of 9% in HDL-C (mean +/- SEM, 3.7 +/- 1.3 mg/dL; 95% CI, 1.2 to 6.1 mg/dL) and a statistically significant decrease of 11% in TG (-19.3 +/- 5.4 mg/dL; 95% CI, -30.1 to -8.5 mg/dL), but no statistically significant decreases in TC or LDL-C (TC, -8.8 +/- 6.8 mg/dL; 95% CI, -22.3 to 4.7 mg/dL; LDL-C, -7.7 +/- 6.0 mg/dL; 95% CI, -19.5 to 4.2 mg/dL). Conclusions The present findings suggest that chronic aerobi…

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Authors: Kelley, G. A., Kelley, K. S., & Franklin, B.
Affiliations: West Virginia University (US)
Corresponding author: Kelley, George A.
Kelley, Kristi S.
ORCID: Kelley, George A.
Kelley, Kristi S.
Venue: Journal of Cardiopulmonary Rehabilitation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-05
Volume: 26
Issue: 3
Pages: 131-139
ISSN: 0883-9212 (ISSN-L)
DOI: 10.1097/00008483-200605000-00002
PMC: PMC2447859
OpenAlex: W2129735711
Cited by: 106
References: 37
Citations by year: 2026: 4 · 2025: 2 · 2023: 2 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 6
FWCI: 1.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Cardiopulmonary Rehabilitation (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL069802)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords: aerobic exercise, cardiovascular disease, lipids, lipoproteins, HDL cholesterol, triglycerides, total cholesterol, LDL cholesterol, exercise therapy, dyslipidemia, sex differences, men, adults, randomized controlled trials, cardiovascular risk reduction, lifestyle intervention, physical activity interventions, exercise intensity, exercise duration, exercise frequency
MeSH terms: Cardiac Rehabilitation, Cardiovascular Diseases, Exercise Therapy, Humans, Lipids, Lipoproteins, Retrospective Studies, Biomarkers, Exercise, Randomized Controlled Trials as Topic

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Aerobic Exercise and Lipids and Lipoproteins in Patients With Cardiovascular Disease: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

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