Cited by 107Lipoproteins and Cardiovascular HealthLipid metabolism and disordersCholesterol and Lipid Metabolism

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Remnant lipoproteins as therapeutic targets

Havel, Richard J.·2000·Current Opinion in Lipidology

DOI 10.1097/00041433-200012000-00008

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Abstract

Increasing evidence suggests that subsets of triglyceride-rich lipoproteins are particularly atherogenic. These include particles with some, but not necessarily all the properties classically attributed to remnants. Cholesteryl ester-enrichment seems to be a common feature of these particles, some of which can be taken up by macrophages by a novel receptor that recognizes species of apolipoprotein B but not apolipoprotein E. These characteristics seem to be common to postprandial and hypertriglyceridemic very low density lipoproteins as well as chylomicron remnants. Remnant-like triglyceride-rich lipoproteins that exhibit several potentially atherogenic properties can be quantified by a simple test that shows promise for identifying individuals at high risk for lesion formation and clinical events. Available hygienic and pharmaceutical measures that effectively lower the concentration of atherogenic triglyceride-rich lipoproteins deserve wider use.

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Authors: Havel, R. J.
Affiliations: University of California, San Francisco (US)
Corresponding author: Havel, Richard J.
Venue: Current Opinion in Lipidology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-12
Volume: 11
Issue: 6
Pages: 615-620
ISSN: 0957-9672 (ISSN-L)
DOI: 10.1097/00041433-200012000-00008
OpenAlex: W2084853272
Cited by: 107
References: 59
Citations by year: 2026: 2 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 3
FWCI: 1.58
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Lipidology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: remnant lipoproteins, triglyceride-rich lipoproteins, atherogenic lipoproteins, macrophage uptake, chylomicron remnants, VLDL, postprandial lipemia, hypertriglyceridemia, atherosclerosis risk assessment, therapeutic target, lipid-lowering therapy
MeSH terms: Animals, Apolipoproteins B, Apolipoproteins E, Arteriosclerosis, Cholesterol Esters, Chylomicrons, Humans, Lipoproteins, Lipoproteins, HDL, Lipoproteins, VLDL, Macrophages, Triglycerides, Hypertriglyceridemia, Chylomicron Remnants

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