Exercise Prevents the Accumulation of Triglyceride-Rich Lipoproteins and Their Remnants Seen When Changing to a High-Carbohydrate Diet
Abstract
We tested the hypothesis that daily aerobic exercise opposes the fasting hypertriglyceridemia and exaggerated postprandial lipemia observed after substituting dietary fat with carbohydrate. Eight healthy postmenopausal women aged 51 to 66 years consumed the same high-fat mixed meal on 3 occasions: (1) after 3 days on a low-carbohydrate diet (35%, 50%, and 15% energy from carbohydrate, fat, and protein, respectively); (2) after 3 days on an isoenergetic high-carbohydrate diet (corresponding values 70%, 15%, and 15%); and (3) after 3 days on the same high-carbohydrate diet with 60 minutes of brisk walking daily. Plasma triglycerides were higher after the high-carbohydrate diet than after the low-carbohydrate diet: fasting, 1.58+/-0.19 versus 0.96+/-0.12 mmol/L, respectively; 6-hour postprandial area under concentration versus time curve, 13.74+/-1.57 versus 10.12+/-1.15 (mmol/L)xhour, respectively (both P<0.01). In the fasted and postprandial states, concentrations of apolipoproteins B-48 and B-100 in the triglyceride-rich lipoprotein fraction were significantly higher after the high-carbohydrate diet, as was the concentration of remnant-like lipoprotein particle cholesterol (a measure of lipoprotein remnants). These carbohydrate-induced increases in the number of circulating triglyceride-rich particles and their remnants were abolished when subjects had exercised daily during the high-carbohydrate diet.
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In patients with hypertriglyceridemia, daily aerobic exercise attenuates the postprandial increase in circulating triglyceride-rich particles and their remnants.
“In patients with hypertriglyceridemia, daily aerobic exercise attenuates the postprandial increase in circulating triglyceride-rich particles and their remnants (60).”
From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [60]
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- Authors
- Koutsari, C., Karpe, F., Humphreys, S. M., Frayn, K. N., & Hardman, A. E.
- Affiliations
- Loughborough University (GB)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2001-09
- Volume
- 21
- Issue
- 9
- Pages
- 1520-1525
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2143243519
- Cited by
- 79
- References
- 0
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 2 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- British Heart Foundation
- State Scholarships Foundation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- aerobic exercise, high-carbohydrate diet, triglyceride-rich lipoproteins, remnant lipoproteins, remnant-like particle cholesterol, postprandial lipemia, apolipoprotein B-48, apolipoprotein B-100, low-carbohydrate diet, postmenopausal women, brisk walking
- MeSH terms
- Aged, Apolipoproteins B, Dietary Carbohydrates, Female, Humans, Insulin, Kinetics, Lipoproteins, Middle Aged, Triglycerides, Exercise, Postprandial Period, Area Under Curve, 3-Hydroxybutyric Acid, Apolipoprotein B-48, Apolipoprotein B-100
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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