Cited by 93Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

New factors in the regulation of adipose differentiation and metabolism

Holst, Dorte, Grimaldi, Paul A.·2002·Current Opinion in Lipidology

Abstract

Obesity and lipoatrophy are major risks for insulin resistance, type 2 diabetes and cardiovascular diseases. The molecular links between adipocyte dysfunction and metabolic disorders were elusive until the discovery that adipose tissue operates as an endocrine organ and releases factors targeting a wide range of organs. This article attempts to review the more recent advances from research on the transcriptional control of adipogenesis and on new adipocyte-secreted proteins that have been proposed as molecular links between adipose tissue and insulin resistance.

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Registry

Crossref · 10.1097/00041433-200206000-00002

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44 of 44 references verified0 citation errors · 0 not checkable

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Authors
Holst, D., & Grimaldi, P. A.
Affiliations
Inserm (FR)
Corresponding author
Grimaldi, Paul A.
Venue
Current Opinion in Lipidology
Published
2002-06
Volume
13
Issue
3
Pages
241-245
ISSN
0957-9672 (ISSN-L)
OpenAlex
W2320054147
Cited by
93
References
44
Citations by year
2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 5
FWCI
1.76
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Lipidology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
adipose tissue, adipogenesis, adipocyte metabolism, adipokines, adipose tissue endocrine function, insulin resistance, type 2 diabetes, obesity, lipoatrophy, transcriptional regulation
MeSH terms
Adipose Tissue, Animals, Cell Differentiation, Gene Expression Regulation, Hormones, Ectopic, Humans, Insulin Resistance, Obesity, Proteins, Transcription Factors, Transcription, Genetic, Receptors, Cytoplasmic and Nuclear, Nerve Growth Factor, Intercellular Signaling Peptides and Proteins, Mice, Adiponectin, Resistin

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