Cited by 65Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokines

Ruan, Hong, Lodish, Harvey F·2004·Current Opinion in Lipidology

Abstract

PURPOSE OF REVIEW: The aim of this review is to assess the role of adipose tissue-derived hormones and inflammatory cytokines in the pathogenesis of obesity-linked type II diabetes, with a special focus on articles published between December 2002 and December 2003. RECENT FINDINGS: Insulin resistance is widely recognized as a fundamental defect seen in obesity and type II diabetes. Although the molecular mechanisms triggering the development of insulin resistance remain elusive, recent studies have suggested that adipose tissue and adipose tissue-derived hormones and inflammatory cytokines play essential roles in the overall insulin sensitivity in vivo. Dysfunctions of adipose tissue can lead to systemic insulin resistance. SUMMARY: Understanding the regulation of the metabolic and secretory functions of adipose tissue, as well as its subsequent impact on overall insulin sensitivity, is becoming increasingly important given the therapeutic potential of targeting the root causes of insulin resistance in the treatment of type 2 diabetes and its associated complications, such as cardiovascular and cerebrovascular diseases.

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Registry

Crossref · 10.1097/00041433-200406000-00009

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48 of 48 references verified0 citation errors · 0 not checkable

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Authors
Ruan, H., & Lodish, H. F.
Affiliations
Whitehead Institute for Biomedical Research (US)
Corresponding author
Lodish, Harvey F
Venue
Current Opinion in Lipidology
Published
2004-06
Volume
15
Issue
3
Pages
297-302
ISSN
0957-9672 (ISSN-L)
OpenAlex
W2046711905
Cited by
65
References
48
Citations by year
2026: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 1
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Lipidology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • American Diabetes Association
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R37 DK47618, R37DK047618)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
insulin resistance, insulin sensitivity, adipose tissue hormones, adipokines, inflammatory cytokines, obesity, type 2 diabetes, adipose tissue dysfunction
MeSH terms
Adipose Tissue, Animals, Blood Glucose, Diabetes Mellitus, Type 2, Hormones, Humans, Insulin Resistance, Obesity, Tumor Necrosis Factor-alpha, Cytokines

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