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Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokines
Abstract
PURPOSE OF REVIEW: The aim of this review is to assess the role of adipose tissue-derived hormones and inflammatory cytokines in the pathogenesis of obesity-linked type II diabetes, with a special focus on articles published between December 2002 and December 2003. RECENT FINDINGS: Insulin resistance is widely recognized as a fundamental defect seen in obesity and type II diabetes. Although the molecular mechanisms triggering the development of insulin resistance remain elusive, recent studies have suggested that adipose tissue and adipose tissue-derived hormones and inflammatory cytokines play essential roles in the overall insulin sensitivity in vivo. Dysfunctions of adipose tissue can lead to systemic insulin resistance. SUMMARY: Understanding the regulation of the metabolic and secretory functions of adipose tissue, as well as its subsequent impact on overall insulin sensitivity, is becoming increasingly important given the therapeutic potential of targeting the root causes of insulin resistance in the treatment of type 2 diabetes and its associated complications, such as cardiovascular and cerebrovascular diseases.
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These adipokine changes include increased production of inflammatory cytokines, plasminogen activator inhibitor-1, and other bioactive products, while the protective adipokine adiponectin is reduced.
“These include increased production of inflammatory cytokines, 35,36 plasminogen activator inhibitor-1, 37 and other bioactive products 38 -40 ; at the same time the potentially protective adipokine, adiponectin, is reduced.41,42”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [40]
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Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
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Metadata
- Authors
- Ruan, H., & Lodish, H. F.
- Affiliations
- Whitehead Institute for Biomedical Research (US)
- Corresponding author
- Lodish, Harvey F
- ORCID
- Lodish, Harvey F
- Venue
- Current Opinion in Lipidology
- Published
- 2004-06
- Volume
- 15
- Issue
- 3
- Pages
- 297-302
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W2046711905
- Cited by
- 65
- References
- 48
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Lipidology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- American Diabetes Association
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R37 DK47618, R37DK047618)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- insulin resistance, insulin sensitivity, adipose tissue hormones, adipokines, inflammatory cytokines, obesity, type 2 diabetes, adipose tissue dysfunction
- MeSH terms
- Adipose Tissue, Animals, Blood Glucose, Diabetes Mellitus, Type 2, Hormones, Humans, Insulin Resistance, Obesity, Tumor Necrosis Factor-alpha, Cytokines
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