Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
Open accessAbstract
The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation of energy homeostasis and insulin sensitivity. In this study, we analyzed globular domain adiponectin (gAd) transgenic (Tg) mice crossed with leptin-deficient ob/ob or apoE-deficient mice. Interestingly, despite an unexpected similar body weight, gAd Tg ob/ob mice showed amelioration of insulin resistance and beta-cell degranulation as well as diabetes, indicating that globular adiponectin and leptin appeared to have both distinct and overlapping functions. Amelioration of diabetes and insulin resistance was associated with increased expression of molecules involved in fatty acid oxidation such as acyl-CoA oxidase, and molecules involved in energy dissipation such as uncoupling proteins 2 and 3 and increased fatty acid oxidation in skeletal muscle of gAd Tg ob/ob mice. Moreover, despite similar plasma glucose and lipid levels on an apoE-deficient background, gAd Tg apoE-deficient mice showed amelioration of atherosclerosis, which was associated with decreased expression of class A scavenger receptor and tumor necrosis factor alpha. This is the first demonstration that globular adiponectin can protect against atherosclerosis in vivo. In conclusion, replenishment of globular adiponectin may provide a novel treatment modality for both type 2 diabetes and atherosclerosis.
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ApN-Tg ob/ob mice showed partial attenuation of insulin resistance and diabetes.
“Finally, ApN-Tg ob/ob mice (obese mice overexpressing ApN) showed partial attenuation of insulin resistance and diabetes [49].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [49]
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- Authors
- Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., Takata, M., Eto, K., Terauchi, Y., Komeda, K., Tsunoda, M., Murakami, K., Ohnishi, Y., Naitoh, T., Yamamura, K., Ueyama, Y., Froguel, P., Kimura, S., Nagai, R., & Kadowaki, T.
- Affiliations
- The University of Tokyo (JP)
- Nissan Chemical Corporation (Japan) (JP)
- Central Institute for Experimental Animals (JP)
- Tokyo Medical University (JP)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Kadowaki, Takashi
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 278
- Issue
- 4
- Pages
- 2461-2468
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2107865201
- Cited by
- 911
- References
- 33
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 22 · 2021: 22 · 2020: 19 · 2019: 18 · 2018: 15 · 2017: 25 · 2016: 38 · 2015: 40 · 2014: 38 · 2013: 51 · 2012: 48
- FWCI
- 56.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- globular adiponectin, adiponectin, ob/ob mice, leptin deficiency, type 2 diabetes, insulin resistance, beta cell degranulation, atherosclerosis, ApoE-deficient mice, fatty acid oxidation, acyl-CoA oxidase, uncoupling proteins, skeletal muscle, scavenger receptor A, TNF-α, transgenic mice
- MeSH terms
- Animals, Apolipoproteins E, Arteriosclerosis, Diabetes Mellitus, Dose-Response Relationship, Drug, Insulin, Insulin Resistance, Islets of Langerhans, Ligands, Male, Mice, Obese, Mice, Transgenic, Proteins, Risk Factors, Time Factors, Transcription Factors, Immunoblotting, Blotting, Northern, DNA, Complementary, Receptors, Cytoplasmic and Nuclear, Muscle, Skeletal, Intercellular Signaling Peptides and Proteins, Lipid Metabolism, Mice, Adiponectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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