Chronic glucocorticoid treatment induced circadian clock disorder leads to lipid metabolism and gut microbiota alterations in rats
Abstract
Aim Glucocorticoids (GCs), steroid hormones synthetized by the adrenal gland, are regulated by circadian cycles, and dysregulation of GC signaling can lead to the development of metabolic syndrome. The effects and potential mechanism of GCs in physiology were investigated in the present study.Main methods Male Wistar rats were orally administered dexamethasone sodium phosphate (DEX, 0.01 and 0.05mg/kg body weight per day) for 7weeks.Key finding DEX treatment attenuated body weight gain and reduced food intake, whereas it induced the accumulation of fat. Administration of DEX induced dysregulation of the expression of lipogenic genes in both fat and liver. Moreover, the mRNA levels of genes related to mitochondrial biogenesis and function were significantly downregulated in the liver and fat of DEX-treated rats. Furthermore, DEX treatment caused a significant reduction in the richness and diversity of the microbiota in the colon, as assessed using high-throughput sequencing of the 16s rRNA gene V3-V4 region, an increase in inflammatory cell infiltration, and a decrease in mucus secretion in the colon. Additionally, DEX administration induced phase shift or loss of circadian rhythmicity of clock-related genes in peripheral tissues. These results were associated with higher serum corticosterone levels and upregulation of GC receptor (GR) expression in peripheral tissues.Significance Our findings indicate that long-term administration of GC caused lipid accumulation, changes in the structure of the intestinal flora, and reduced colonic mucus secretion in vivo. The mechanism of these physiological changes may involve a circadian rhythm disorder and dysregulation of GR expression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Experimental administration of glucocorticoid synchronizes peripheral clocks in liver, muscle, adipose tissue, pancreas, and gut.
“Experimental administration of glucocorticoid synchronizes the peripheral clocks located in liver, muscle, and adipose tissue which are the major storage sites for glycogen, protein, and fat, respectively, as well as other metabolically relevant organs such as pancreas and gut [60–63].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [61]
Cortisol, not melatonin, is the key metabolic central synchronizing signal.
“This rhythm is important for its action because cortisol, not melatonin, is recognized to be the key metabolic central synchronizing signal [60–62].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [61]
Effects of glucocorticoids on the composition and functioning of the microbiota vary, with some studies indicating disruption and others showing beneficial effects, likely depending on the degree of exposure (dose and period) and the type of glucocorticoid studied.
“Regarding the effects of glucocorticoids on the composition and functioning of the microbiota, some studies have indicated microbiota disruption, while others have shown beneficial effects, which likely depend on the degree of exposure (dose and period) and the type of glucocorticoid studied (434–437)”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [434]
Cites
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135 · see citing works
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068 · see citing works
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works
Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684 · see citing works
Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms
Barnes, P. J. (1998) · Clinical Science · doi:10.1042/cs0940557 · Cited by 1,591 · see citing works
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483 · see citing works
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449 · see citing works
Circadian physiology of metabolism
Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092 · see citing works
de La Serre, C. B., Ellis, C. L., Lee, J., Hartman, A. L., Rutledge, J. C., & Raybould, H. E. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2010 · Cited by 949 · see citing works
IBD—what role do Proteobacteria play?
Mukhopadhya, I., Hansen, R., El-Omar, E. M., & Hold, G. L. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.14 · Cited by 810 · see citing works
Touitou, Y., Reinberg, A., & Touitou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.008 · Cited by 738 · see citing works
Bloom, S. M., Bijanki, V. N., Nava, G. M., Sun, L., Malvin, N. P., Donermeyer, D. L., Dunne, W. M., Allen, P. M., & Stappenbeck, T. S. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.009 · Cited by 488 · see citing works
Genome-scale analyses of health-promoting bacteria: probiogenomics
Ventura, M., O'Flaherty, S., Claesson, M. J., Turroni, F., Klaenhammer, T. R., van Sinderen, D., & O'Toole, P. W. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2047 · Cited by 471 · see citing works
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
Wang, Y., Kuang, Z., Yu, X., Ruhn, K. A., Kubo, M., & Hooper, L. V. (2017) · Science · doi:10.1126/science.aan0677 · Cited by 456 · see citing works
Interactions of the circadian CLOCK system and the HPA-axis
Nader, N., Chrousos, G. P., & Kino, T. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.12.011 · Cited by 449 · see citing works
Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature
McNamara, P., Seo, S., Rudic, R. D., Sehgal, A., Chakravarti, D., & FitzGerald, G. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00401-9 · Cited by 441 · see citing works
Intracellular Receptor Concentration Limits Glucocorticoid-Dependent Enhancer Activity*
Vanderbilt, J. N., Miesfeld, R. L., Maler, B. A., & Yamamoto, K. R. (1987) · Molecular Endocrinology · doi:10.1210/mend-1-1-68 · Cited by 349 · see citing works
The Human Gut Microbiome and Body Metabolism: Implications for Obesity and Diabetes
Devaraj, S., Hemarajata, P., & Versalovic, J. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2012.187617 · Cited by 321 · see citing works
Direct Effect of Glucocorticoids on Lipolysis in Adipocytes
Xu, C., He, J., Jiang, H., Zu, L., Zhai, W., Pu, S., & Xu, G. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0464 · Cited by 291 · see citing works
Glucocorticoids: exemplars of multi-tasking
Buckingham, J. C. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706456 · Cited by 276 · see citing works
Adverse effects of corticosteroids on the cardiovascular system.
De, S., & Armstrong, P. W. (2000) · PubMed · Cited by 265 · see citing works
Leleu, X. P., Attal, M., Arnulf, B., Moreau, P., Traullé, C., Marit, G., Mathiot, C., Petillon, M. O., Macro, M., Roussel, M., et al. (2013) · Blood · doi:10.1182/blood-2012-09-452375 · Cited by 206 · see citing works
Abnormal Cortisol Metabolism and Tissue Sensitivity to Cortisol in Patients with Glucose Intolerance
Andrews, R. C., Herlihy, O., Livingstone, D. E. W., Andrew, R., & Walker, B. R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020048 · Cited by 199 · see citing works
Circadian regulation of lipid metabolism
Gooley, J. J. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000288 · Cited by 186 · see citing works
The Metabolic Syndrome and Cardiovascular Risk in Cushing's Syndrome
Pivonello, R., Faggiano, A., Lombardi, G., & Colao, A. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.01.010 · Cited by 173 · see citing works
Jin, Y., Zeng, Z., Wu, Y., Zhang, S., & Fu, Z. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv115 · Cited by 149 · see citing works
Self-citationFRIEDMAN, T. C., MASTORAKOS, G., NEWMAN, T. D., MULLEN, N. M., HORTON, E. G., COSTELLO, R., PAPADOPOULOS, N. M., & CHROUSOS, G. P. (1996) · Endocrine Journal · doi:10.1507/endocrj.43.645 · Cited by 145 · see citing works
Bhandari, R., Juluri, K. R., Resnick, A. C., & Snyder, S. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712227105 · Cited by 145 · see citing works
On communication between gut microbes and the brain
Forsythe, P., Kunze, W. A., & Bienenstock, J. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283572ffa · Cited by 137 · see citing works
Demonacos, C., Djordjevic-Markovic, R., Tsawdaroglou, N., & Sekeris, C. E. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00159-w · Cited by 131 · see citing works
Insulin action and signalling in fat and muscle from dexamethasone-treated rats
Burén, J., Lai, Y. C., Lundgren, M., Eriksson, J. W., & Jensen, J. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.02.034 · Cited by 125 · see citing works
Peripheral Circadian Oscillators in Mammals
Brown, S. A., & Azzi, A. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_3 · Cited by 120 · see citing works
Das, I., Png, C. W., Oancea, I., Hasnain, S. Z., Lourie, R., Proctor, M. A., Eri, R. D., Sheng, Y., Crane, D. I., Florin, T. H., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121268 · Cited by 114 · see citing works
Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH)2D3
Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.066 · Cited by 114 · see citing works
Glucocorticoid hormones and energy homeostasis
de Guia, R. M., Rose, A. J., & Herzig, S. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0021 · Cited by 85 · see citing works
Jiang, W., Li, S., Zhou, S., Sun, Y., Shi, J., & Lü, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.001 · Cited by 83 · see citing works
Hoskins, L. C. (1993) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199304000-00004 · Cited by 69 · cited 1× · see citing works
“Changes in mucus secretion will lead directly to changes in the bacterial structure [38].”
Tonsfeldt, K. J., & Chappell, P. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.003 · Cited by 66 · see citing works
Tsiriyotis, C., Spandidos, D. A., & Sekeris, C. E. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6787 · Cited by 61 · see citing works
Abad, V., Chrousos, G. P., Reynolds, J. C., Nieman, L. K., Hill, S. C., Weinstein, R. S., & Leong, G. M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.10.1879 · Cited by 57 · see citing works
Glucocorticoid Regulation of Clock Gene Expression in the Mammalian Limbic Forebrain
Segall, L. A., & Amir, S. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9341-1 · Cited by 45 · see citing works
Li, Z., Fan, M.-B., Zhang, S.-L., Qu, Y., Zheng, S., Song, J., & Miao, C. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.70 · Cited by 44 · see citing works
Mitophagy and Mitoptosis in Disease Processes
Mijaljica, D., Prescott, M., & Devenish, R. J. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-756-3_6 · Cited by 38 · see citing works
Light and food signals cooperate to entrain the rat pineal circadian system
Wu, T., Jin, Y., Kato, H., & Fu, Z. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21769 · Cited by 34 · see citing works
Self-citationl-Carnitine intake prevents irregular feeding-induced obesity and lipid metabolism disorder
Wu, T., Guo, A., Shu, Q., Qi, Y., Kong, Y., Sun, Z., Sun, S., & Fu, Z. (2014) · Gene · doi:10.1016/j.gene.2014.10.040 · Cited by 34 · see citing works
Self-citationLee, K., Youm, J., Lee, W. J., Kang, S., & Kim, Y. J. (2017) · Experimental Dermatology · doi:10.1111/exd.13319 · Cited by 33 · see citing works
Priyadarshini, E., & Anuradha, C. V. (2016) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2016.06.003 · Cited by 27 · see citing works
3 Rationale for treatment and therapeutic options in Cushing's disease
Stewart, P. M., & Petersenn, S. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/s1521-690x(09)70004-1 · Cited by 26 · see citing works
1H NMR-based metabonomic study on the effects of Epimedium on glucocorticoid-induced osteoporosis
Pan, S., Chen, A., Han, Z., Wang, Y., Lu, X., & Yang, Y. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.10.015 · Cited by 26 · see citing works
Self-citationWu, T., Jiang, J., Yang, L., Li, H., Zhang, W., Chen, Y., Zhao, B., Kong, B., Lü, P., Zhao, Z., et al. (2016) · Chronobiology International · doi:10.1080/07420528.2016.1238831 · Cited by 25 · see citing works
Self-citationEffects of Glucocorticoids on Bone: What we can Learn from Pediatric Endogenous Cushing’s Syndrome
Tack, L. J. W., Tatsi, C., Stratakis, C. A., & Lodish, M. B. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-117721 · Cited by 22 · see citing works
Minami, I., Tateno, T., Yoshimoto, T., Doi, M., Izumiyama, H., Akashi, T., & Hirata, Y. (2006) · Internal Medicine · doi:10.2169/internalmedicine.45.1809 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
The Role of Microbiome in Insomnia, Circadian Disturbance and Depression
Li, Y., Hao, Y., Fan, F., & Zhang, B. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00669 · Cited by 294 · see citing works
Cortellini, A., Tucci, M., Adamo, V., Stucci, L. S., Russo, A., Tanda, E. T., Spagnolo, F., Rastelli, F., Bisonni, R., Santini, D., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001361 · Cited by 275 · see citing works
Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders
Tabouy, L., Getselter, D., Ziv, O., Karpuj, M., Tabouy, T., Lukic, I., Maayouf, R., Werbner, N., Ben-Amram, H., Nuriel-Ohayon, M., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.05.015 · Cited by 214 · see citing works
A Review of Microbiota and Irritable Bowel Syndrome: Future in Therapies
Rodiño‐Janeiro, B. K., Vicario, M., Alonso, C., Pascua-García, R., & Santos, J. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0673-5 · Cited by 211 · see citing works
Chen, C., Rao, S., Yue, T., Tan, Y., Yin, H., Chen, L.-J., Luo, M., Wang, Z., Wang, Y., Hong, C., et al. (2022) · Science Advances · doi:10.1126/sciadv.abg8335 · Cited by 210 · see citing works
When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis
Teichman, E. M., O’Riordan, K. J., Gahan, C. G. M., Dinan, T. G., & Cryan, J. F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.008 · Cited by 198 · see citing works
Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism
Frazier, K., & Chang, E. B. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.08.013 · Cited by 169 · see citing works
Circadian rhythms and obesity: Timekeeping governs lipid metabolism
Li, Y., Ma, J., Kang, Y., Su, W., Tan, B., Wu, X., Huang, X., Li, T., Yin, Y., Tosini, G., et al. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12682 · Cited by 159 · see citing works
Sleep and circadian regulation of cortisol: A short review
O'Byrne, N. A., Yuen, F., Butt, W. Z., & Liu, P. Y. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.03.011 · Cited by 145 · see citing works
Mitochondrial quality surveillance as a therapeutic target in myocardial infarction
Zhu, H., Toan, S., Mui, D., & Zhou, H. (2020) · Acta Physiologica · doi:10.1111/apha.13590 · Cited by 142 · see citing works
Buti, S., Bersanelli, M., Perrone, F., Tiseo, M., Tucci, M., Adamo, V., Stucci, L. S., Russo, A., Tanda, E. T., Spagnolo, F., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.09.033 · Cited by 115 · see citing works
Commensal bacteria‐immunity crosstalk shapes mucosal homeostasis in teleost fish
Yu, Y., Ding, L., Huang, Z., Xu, H., & Xu, Z. (2021) · Reviews in Aquaculture · doi:10.1111/raq.12570 · Cited by 114 · see citing works
Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?
Sharma, V., Singh, T. G., Garg, N., Dhiman, S., Gupta, S., Rahman, M. H., Najda, A., Walasek-Janusz, M., Kamel, M. S., Albadrani, G. M., et al. (2021) · Biomolecules · doi:10.3390/biom11050678 · Cited by 111 · see citing works
Cortisol-Related Signatures of Stress in the Fish Microbiome
Webster, T. M. U., Rodríguez‐Barreto, D., Consuegra, S., & de Leániz, C. G. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01621 · Cited by 112 · see citing works
Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL)
Huang, J.-K., & Lee, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084300 · Cited by 111 · see citing works
Metabolomics Based Profiling of Dexamethasone Side Effects in Rats
Malkawi, A. K., Alzoubi, K. H., Jacob, M., Matic, G., Ali, A., Faraj, A. A., Al-Mohanna, F., Dasouki, M., & Rahman, A. M. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00046 · Cited by 95 · see citing works
Sleep, testosterone and cortisol balance, and ageing men
Liu, P. Y., & Reddy, R. T. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09755-4 · Cited by 80 · see citing works
Gabarre, P., Loens, C., Tamzali, Y., Barrou, B., Jaisser, F., & Tourret, J. (2021) · American Journal of Transplantation · doi:10.1111/ajt.16836 · Cited by 72 · see citing works
Ferreira, C., Viana, S., & Reis, F. (2020) · Microorganisms · doi:10.3390/microorganisms8101514 · Cited by 66 · see citing works
Huang, H., Jiang, J., Wang, X., Jiang, K., & Cao, H. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102428 · Cited by 67 · see citing works
Self-citationModulation of intestinal barrier function by glucocorticoids: Lessons from preclinical models
Tena‐Garitaonaindia, M., Arredondo‐Amador, M., Mascaraque, C., Asensio, M., Marı́n, J. J. G., Martínez‐Augustin, O., & de Medina, F. S. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106056 · Cited by 63 · see citing works
Spakowicz, D. J., Hoyd, R., Muniak, M., Husain, M., Bassett, J. S., Wang, L., Tinoco, G., Patel, S. H., Burkart, J. T., Miah, A., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-06882-6 · Cited by 62 · see citing works
Ni, Y., Wu, L., Jiang, J., Yang, T., Wang, Z., Ma, L., Zheng, L., Yang, X., Wu, Z., & Fu, Z. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900867 · Cited by 57 · see citing works
Self-citationLiu, P. Y. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00683 · Cited by 55 · see citing works
Wang, M., Zhu, Z., Lin, X., Li, H., Wen, C., Bao, J., & He, Z. (2021) · Arthritis Research & Therapy · doi:10.1186/s13075-021-02620-w · Cited by 52 · see citing works
Xie, X., Xiao, Q., Xiong, Z., Yu, C., Zhou, J., & Fu, Z. (2019) · Food & Function · doi:10.1039/c9fo01533g · Cited by 53 · see citing works
Self-citationContributions of White and Brown Adipose Tissues to the Circadian Regulation of Energy Metabolism
Heyde, I., Begemann, K., & Oster, H. (2021) · Endocrinology · doi:10.1210/endocr/bqab009 · Cited by 54 · see citing works
Intestinal microorganisms involved in colorectal cancer complicated with dyslipidosis
Han, S., Pan, Y., Xi, Y., Da, M., Wei, Q., Gao, Y., Quan, Q., & Ru, L. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2018.1507255 · Cited by 50 · see citing works
Ni, Y., Wang, Z., Ma, L., Yang, L., Wu, T., & Fu, Z. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.01.005 · Cited by 54 · see citing works
Self-citationWang, C., Gu, Y., Chu, Q., Wang, X., Ding, Y.-Y., Qin, X., Liu, T.-Y., Wang, S.-N., Liu, X., Wang, B.-M., et al. (2024) · Microbiology Research · doi:10.1016/j.micres.2024.127660 · Cited by 45 · see citing works
Li, J., Yang, M., Lu, C., Han, J., Tang, S., Zhou, J., Li, Y., Ming, T., Wang, Z. J., & Su, X. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900861 · Cited by 49 · see citing works
Zhang, P., Sun, F., Cheng, X., Li, X., Mu, H., Wang, S., Geng, H., & Duan, J. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.139 · Cited by 47 · see citing works
Kang, Y., Feng, D., Law, H., Qu, W., Wu, Y., Zhu, G., & Huang, W. (2019) · BMC Nephrology · doi:10.1186/s12882-019-1615-4 · Cited by 46 · see citing works
Si, Y., Wei, W., Chen, X., Xie, X., Guo, T., Sasaki, Y., Zhang, Y.-B., Wang, L., Zhang, F., & Feng, S. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2021.2019283 · Cited by 46 · see citing works
He, Z.-X., Kong, X.-Y., Shao, T., Zhang, Y., & Wen, C.-P. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00978 · Cited by 42 · see citing works
Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role
Jiang, H., Deng, S., Zhang, J., Chen, J., Li, B., Zhu, W., Zhang, M., Zhang, C., & Meng, Z. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1146946 · Cited by 40 · see citing works
Petrullo, L. A., Ren, T., Wu, M., Boonstra, R., Palme, R., Boutin, S. A., McAdam, A. G., & Dantzer, B. (2022) · Scientific Reports · doi:10.1038/s41598-022-06359-5 · Cited by 39 · see citing works
Microbial circadian clocks: host-microbe interplay in diel cycles
Wollmuth, E. M., & Angert, E. R. (2023) · BMC Microbiology · doi:10.1186/s12866-023-02839-4 · Cited by 38 · see citing works
Rhythms in cortisol mediate sleep and circadian impacts on health
Liu, P. Y. (2024) · SLEEP · doi:10.1093/sleep/zsae151 · Cited by 38 · see citing works
Krogsgaard, L. R., Munck, L. K., Bytzer, P. M., & Wildt, S. (2019) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2019.1599064 · Cited by 36 · see citing works
Camponogara, C., Silva, C. R., Brusco, I., Piana, M., Faccin, H., de Carvalho, L. M., Schuch, A. P., Trevisan, G., & Oliveira, S. M. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.10.011 · Cited by 32 · see citing works
Circadian rhythms: a possible new player in non-alcoholic fatty liver disease pathophysiology
Gnocchi, D., Custodero, C., Sabbà, C., & Mazzocca, A. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01780-2 · Cited by 31 · see citing works
Si, Y., Chen, X., Guo, T., Wei, W., Wang, L., Zhang, F., Sun, X., & Liu, M. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03466-z · Cited by 28 · see citing works
Takada, K., Buti, S., Bersanelli, M., Shimokawa, M., Takamori, S., Matsubara, T., Takenaka, T., Okamoto, T., Hamatake, M., Tsuchiya‐Kawano, Y., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.06.002 · Cited by 27 · see citing works
Ma, L., Shen, Q., Yang, S. T., Xie, X., Xiao, Q., Yu, C., Cao, L., & Fu, Z. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy132 · Cited by 27 · see citing works
Self-citationAranda, C. J., Arredondo‐Amador, M., Ocón, B., Lavín, J. L., Aransay, A. M., Martínez‐Augustin, O., & de Medina, F. S. (2019) · The FASEB Journal · doi:10.1096/fj.201900404rr · Cited by 25 · see citing works
The Lachnospiraceae-butyric acid axis and its role in glucocorticoid-associated osteonecrosis
Guo, M., He, S., Song, W., Mai, J., Yuan, X., Huang, Y., Xi, H., Sun, G., Chen, Y., Du, B., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05813-4 · Cited by 24 · see citing works
Mei, W., Hao, Y., Xie, H., Ni, Y., & Zhao, R. (2020) · Animals · doi:10.3390/ani10030514 · Cited by 24 · see citing works
Self-citationYang, Y., Han, W., Zhang, A., Zhao, M., Cong, W., Jia, Y., Wang, D., & Zhao, R. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00677-4 · Cited by 23 · see citing works
The association between disruption of the circadian rhythm and aggravation of colitis in mice
Chen, Y., Zhao, R., Zheng, G., Ling, F., Li, J., Xu, M., Guo, D., Zhang, Q.-L., Li, S., & Zhu, L. (2022) · Gastroenterology report · doi:10.1093/gastro/goac028 · Cited by 24 · see citing works
Nontraditional Risk Factors for Obesity in Modern Society
Han, S.-J., & Lee, S. (2021) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes21004 · Cited by 22 · see citing works
Liu, C., Liu, T., Ohlson, E. W., Wang, L., Wu, D., Guo, Q., Timko, M. P., & Liang, G. (2018) · Scientia Horticulturae · doi:10.1016/j.scienta.2018.10.068 · Cited by 21 · see citing works
de Souza, C. F., Stopa, L. R. S., Santos, G. F., Takasumi, L. C. N., Martins, A. B., Garnica-Siqueira, M. C., Ferreira, R. N., de Andrade, F. G., Leite, C. M., Zaia, D. A. M., et al. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.12.037 · Cited by 21 · see citing works
Shittu, S.-T. T., Lasisi, T. J., Shittu, S.-S., Adeyemi, A. A., Adeoye, T., & Alada, A. R. A. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00850-y · Cited by 20 · see citing works
Camponogara, C., Casoti, R., Brusco, I., Piana, M., Boligon, A. A., Cabrini, D. A., Trevisan, G., Ferreira, J., Silva, C. R., & Oliveira, S. M. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.11.021 · Cited by 20 · see citing works
Fan, Y., Wang, Y., Han, X., & Sun, H. (2024) · BMC Nephrology · doi:10.1186/s12882-024-03646-3 · Cited by 20 · see citing works
Chen, L., Fan, Z., Sun, X., Qiu, W., Chen, Y., Zhou, J., & Lv, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.891410 · Cited by 20 · see citing works
Pathogenesis from the microbial-gut-brain axis in white matter injury in preterm infants: A review
Wang, Y., Zhu, J., Zou, N., Zhang, L., Wang, Y., Zhang, M., Wang, C., & Yang, L. L. (2023) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2023.1051689 · Cited by 21 · see citing works
Self-citationRajkhowa, B., Mehan, S., Sethi, P., & Prajapati, A. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00480-z · Cited by 17 · see citing works
Colard‐Thomas, J., Thomas, Q. D., & Viala, M. (2023) · Cancers · doi:10.3390/cancers15082276 · Cited by 17 · see citing works
The Role of the Adrenal–Gut–Brain Axis on Comorbid Depressive Disorder Development in Diabetes
Mázala-de-Oliveira, T., da Silva, B. P. B., Campello‐Costa, P., & Carvalho, V. F. (2023) · Biomolecules · doi:10.3390/biom13101504 · Cited by 17 · see citing works
Salvadori, M., & Rosso, G. (2024) · World Journal of Transplantation · doi:10.5500/wjt.v14.i1.90194 · Cited by 17 · see citing works
Fedele, M. L. M., Galiana, M. D., Golombek, D. A., Muñoz, E. M., & Plano, S. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00370 · Cited by 16 · see citing works
Li, J.-S., Su, S., Xu, Z., Zhao, L.-H., Fan, R.-Y., Guo, J., Qian, D., & Duan, J. (2022) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223221091177 · Cited by 18 · see citing works
Kłak, K., Maciuszek, M., Michalik, A., Mazur, M., Zawisza, M., Pecio, A., Nowak, B. F., & Chadzińska, M. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110301 · Cited by 17 · see citing works
Mithani, S., Yun, S., Leete, J. J., Guedes, V. A., Fink, A. M., Pattinson, C. L., Kim, H., Weljie, A. M., Gill, J., & Gehrman, P. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.01.013 · Cited by 15 · see citing works
The Effect of the Gut Microbiota on Transplanted Kidney Function
Przybyciński, J., Drożdżal, S., Wilk, A., Dziedziejko, V., Szumilas, K., & Pawlik, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021260 · Cited by 15 · see citing works
Nara, K., Taguchi, S., Buti, S., Kawai, T., Uemura, Y., Yamamoto, T., Kume, H., & Takada, T. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-008806 · Cited by 15 · see citing works
Jeong, Y., Kim, J., Jung, Y., Kwak, M., Sung, M., & Imm, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137499 · Cited by 15 · see citing works
Lu, Y., Jiang, J., Yang, G., Ding, H., Zheng, Q., Ji, L., Wang, Y., Dong, Z., Zhai, Z., Tian, J., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1324181 · Cited by 13 · see citing works
Self-citationJardou, M., Brossier, C., Marquet, P., Picard, N., Druilhe, A., & Lawson, R. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1342354 · Cited by 12 · see citing works
Weger, B. D., Rawashdeh, O., & Gachon, F. (2019) · BioEssays · doi:10.1002/bies.201900059 · Cited by 12 · see citing works
Chronic corticosterone exposure disrupts hepatic and intestinal bile acid metabolism in chicken
Wu, L., Liu, X., Zhang, A., Chen, H., Zhao, R., & Jia, Y. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1147024 · Cited by 11 · see citing works
Li, F., Chen, X., Xu, X., Wang, L., Yan, J., Yu, Y., Shan, X., Zhang, R., Hua, X., Zhang, T., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.03473-23 · Cited by 12 · see citing works
Faucher, Q., Jardou, M., Brossier, C., Picard, N., Marquet, P., & Lawson, R. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.898878 · Cited by 11 · see citing works
Zaragoza-García, Ó., Castro-Alarcón, N., Pérez-Rubio, G., Falfán‐Valencia, R., Briceño, O., Navarro‐Zarza, J. E., Parra‐Rojas, I., Tello, M., & Guzmán‐Guzmán, I. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031958 · Cited by 11 · see citing works
Green, G. B. H., Cox-Holmes, A. N., Backan, O., Valbak, O., Potier, A. C., Chen, D., Morrow, C. D., Willey, C. D., & McFarland, B. (2024) · Microorganisms · doi:10.3390/microorganisms12051015 · Cited by 10 · see citing works
Zhang, R., Sun, J., Wang, Y., Yu, H., Wang, S., & Feng, X. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109822 · Cited by 10 · see citing works
Gut Microbial Dysbiosis and Implications in Solid Organ Transplantation
Medina, C. K., & Aykut, B. (2024) · Biomedicines · doi:10.3390/biomedicines12122792 · Cited by 10 · see citing works
I "Gut" Rhythm: the microbiota as a modulator of the stress response and circadian rhythms
Tofani, G. S. S., Clarke, G. A., & Cryan, J. F. (2025) · FEBS Journal · doi:10.1111/febs.17400 · Cited by 10 · see citing works
Immunosuppressant imprecision: multidirectional effects on metabolism and microbiome
Kensiski, A., Gavzy, S. J., Wu, L., Mas, V. R., Ma, B., & Bromberg, J. S. (2025) · Clinical Microbiology Reviews · doi:10.1128/cmr.00178-24 · Cited by 9 · see citing works
Leardini, D., Venturelli, F., Baccelli, F., Cerasi, S., Muratore, E., Brigidi, P., Pession, A., Prete, A., & Masetti, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315387 · Cited by 10 · see citing works
Gut microbiota causally impacts adrenal function: a two-sample mendelian randomization study
Liu, T., Ji, H.-F., Li, Z., Luan, Y., Zhu, C.-C., Li, D.-X., Gao, Y.-K., & Yan, Z.-C. (2024) · Scientific Reports · doi:10.1038/s41598-024-73420-w · Cited by 9 · see citing works
Casearia decandra leaves present anti-inflammatory efficacy in a skin inflammation model in mice
Camponogara, C., Brum, E. D. S., Belke, B. V., de Brum, T. F., Jesus, R. D. S., Piana, M., Bauermann, L. D. F., & Oliveira, S. M. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112436 · Cited by 9 · see citing works
Corticosteroids and circadian rhythms in the cardiovascular system
Kanki, M., & Young, M. J. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.10.007 · Cited by 9 · see citing works
Fukuokaya, W., Mori, K., Yanagisawa, T., Akazawa, K., Shimomura, T., & Kimura, T. (2023) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-023-00695-x · Cited by 7 · see citing works
The Effects of Probiotic Bacillus Spores on Dexamethasone-Treated Rats
Inceu, A.-I., Neag, M. A., Cătinean, A., Bocșan, I. C., Craciun, C. I., Melincovici, C. S., Muntean, D. M., Onofrei, M. M., Pop, R. M., & Buzoianu, A. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015111 · Cited by 7 · see citing works
Yang, Q. Z., Kang, Y., Tang, W., Li, M., & Zhao, C. (2025) · Future Microbiology · doi:10.1080/17460913.2025.2469432 · Cited by 7 · see citing works
Du, D., Yuan, Y., Guan, X., Xie, Q., Sun, X., & Dong, Z. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2561222 · Cited by 6 · see citing works
da Silva, F. N., Zimath, P. L., do Amaral, T. A., Martins, J. R. N., & Rafacho, A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121660 · Cited by 6 · see citing works
Light pollution: time to consider testicular effects
Liu, P. Y. (2024) · Frontiers in Toxicology · doi:10.3389/ftox.2024.1481385 · Cited by 5 · see citing works
Circadian rhythms and microbiota: molecular crosstalk and its implications for health and disease
Wu, G., Zhang, J., Yan, S., Liu, N., Chen, W., Wu, F., Wang, Z., Zhang, J., Yang, Y., Deng, Y., et al. (2026) · Biology Direct · doi:10.1186/s13062-026-00748-w · Cited by 4 · see citing works
The Effects of Social Experience on Host Gut Microbiome in Male Zebrafish ( Danio rerio )
Scott, E., Brewer, M. S., Peralta, A. L., & Issa, F. A. (2023) · Biological Bulletin · doi:10.1086/729377 · Cited by 3 · see citing works
The Aquatic Microbial Environment Shapes the Tadpole Microbiome and Antipredator Behavior
Emerson, K. J., Shaikh, S. S., Bradley-Slagle, D. P., & Woodley, S. K. (2025) · Integrative and Comparative Biology · doi:10.1093/icb/icaf009 · Cited by 3 · see citing works
Zhang, B., Luo, X., Lei, S., Gao, W., Chen, Z., Zhu, Q., Huang, L., & Long, Q. (2025) · Journal of Holistic Integrative Pharmacy · doi:10.1016/j.jhip.2025.02.001 · Cited by 3 · see citing works
Fiala, O., Buti, S., Fujita, K., de Liaño, A. G., Fukuokaya, W., Kimura, T., Yanagisawa, T., Giannatempo, P., Angel, M. O., Mennitto, A., et al. (2025) · Clinical & Experimental Metastasis · doi:10.1007/s10585-025-10335-4 · Cited by 3 · see citing works
Ahmed, S. A., & Elbahy, D. A. (2022) · Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences · doi:10.21608/rpbs.2022.150356.1155 · Cited by 3 · see citing works
Solymanzadeh, F., Rokhafroz, D., Asadizaker, M., & Dastoorpoor, M. (2023) · Journal of Human Behavior in the Social Environment · doi:10.1080/10911359.2023.2208628 · Cited by 3 · see citing works
Kaushal, A. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05587-9 · Cited by 3 · see citing works
- Authors
- Wu, T., Yang, L., Jiang, J., Ni, Y., Zhu, J., Zheng, X., Wang, Q., Lu, X., & Fu, Z.
- Affiliations
- Zhejiang University of Technology (CN)
- Corresponding author
- Fu, Zhengwei
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 192
- Pages
- 173-182
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2775302672
- Cited by
- 126
- References
- 53
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 22 · 2023: 15 · 2022: 15 · 2021: 14 · 2020: 14 · 2019: 13 · 2018: 12
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31200890)
- Open Research Fund Program of the Collaborative Innovation Center of Membrane Separation and Water Treatment, Zhejiang Province Public Welfare Research Project (2015C33178)
- Scientific Innovation Program for University Students in Zhejiang Province (2014R403060)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- glucocorticoids, dexamethasone, circadian clock, circadian rhythm disorders, lipid metabolism, gut microbiota, metabolic syndrome, lipogenic genes, mitochondrial biogenesis, colonic inflammation, corticosterone, glucocorticoid receptor, adipose tissue, liver
- MeSH terms
- Gastrointestinal Microbiome, Adipose Tissue, Animals, Cecum, Colon, Corticosterone, Dexamethasone, Eating, Glucose Tolerance Test, Glycolipids, Liver, Male, Mitochondria, Receptors, Glucocorticoid, Weight Gain, Rats, Wistar, Lipid Metabolism, Rats, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
