Assembly of the human intestinal microbiota

Dethlefsen, Les; Eckburg, Paul B.; Bik, Elisabeth M.; Relman, David A.

doi:10.1016/j.tree.2006.06.013

Cited by 509Gut microbiota and healthMicrobial Community Ecology and PhysiologyInfant Nutrition and Health

Assembly of the human intestinal microbiota

Dethlefsen, Les, Eckburg, Paul B., Bik, Elisabeth M., Relman, David A.·2006·Trends in Ecology & Evolution

DOI 10.1016/j.tree.2006.06.013

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Abstract

Complex microbial ecosystems occupy the skin, mucosa and alimentary tract of all mammals, including humans. Recent advances have highlighted the tremendous diversity of these microbial communities and their importance to host physiology, but questions remain about the ecological processes that establish and maintain the microbiota throughout life. The prevailing view, that the gastrointestinal microbiota of adult humans is a climax community comprised of the superior competitors for a stable set of niches, does not account for all of the experimental data. We argue here that the unique history of each community and intrinsic temporal dynamics also influence the structure of human intestinal communities.

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Human gut microbial composition differs substantially among individuals and depends on age, genetic background, physiological state, microbial interactions, environmental factors, and diet.
“Human studies have unveiled substantial differences in the gut microbial composition among individuals139–141 that depend on age, genetic background, physiological state, microbial interactions, environmental factors, and diet.142–144”
From The Gut Microbiome and the Brain (2014) · cites this paper as [144]

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Authors: Dethlefsen, L., Eckburg, P. B., Bik, E. M., & Relman, D. A.
Affiliations: Stanford Medicine (US)
Corresponding author: Dethlefsen, Les
ORCID: Dethlefsen, Les
Eckburg, Paul B.
Bik, Elisabeth M.
Relman, David A.
Venue: Trends in Ecology & Evolution
Publisher: Elsevier BV
Published: 2006-09
Volume: 21
Issue: 9
Pages: 517-523
ISSN: 0169-5347 (ISSN-L)
DOI: 10.1016/j.tree.2006.06.013
OpenAlex: W2127922913
Cited by: 509
References: 75
Citations by year: 2026: 4 · 2025: 6 · 2024: 9 · 2023: 16 · 2022: 19 · 2021: 26 · 2020: 32 · 2019: 48 · 2018: 25 · 2017: 22 · 2016: 19 · 2015: 27 · 2014: 40 · 2013: 33 · 2012: 28
FWCI: 1.91
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Ecology & Evolution (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (AI51259, R01AI051259)
National Institute of Dental and Craniofacial Research (DE 13541, R01DE013541)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: human gut microbiome, microbiota assembly, microbial community ecology, climax community, temporal dynamics, community structure, host-microbe interactions
MeSH terms: Humans, Intestines, Phylogeny, Species Specificity

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