The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
??-Linolenic acid metabolism in men and women: nutritional and biological implications
Abstract
PURPOSE OF REVIEW: This review critically evaluates current knowledge of alpha-linolenic acid metabolism in adult humans based on the findings of studies using stable isotope tracers and on increased dietary alpha-linolenic acid intake. The relative roles of alpha-linolenic acid and of longer-chain polyunsaturated fatty acids in cell structure and function are discussed together with an overview of the major metabolic fates of alpha-linolenic acid. The extent of partitioning towards beta-oxidation and carbon recycling in humans is described. The use and limitations of stable isotope tracers to estimate alpha-linolenic acid desaturation and elongation are discussed. A consensus view of the extent of alpha-linolenic acid conversion to longer-chain fatty acids in humans is presented. The extent to which increasing dietary alpha-linolenic acid intake alters the concentrations of longer-chain n-3 fatty acids is described. The biological and nutritional implications of these findings are discussed. RECENT FINDINGS: Conversion of alpha-linolenic acid to eicosapentaenoic acid is limited in men and further transformation to docosahexaenoic acid is very low. A lower proportion of alpha-linolenic acid is used as a substrate for beta-oxidation in women compared with men, while the fractional conversion to longer-chain fatty acids is greater, possibly due to the regulatory effects of oestrogen. SUMMARY: Overall, alpha-linolenic acid appears to be a limited source of longer-chain n-3 fatty acids in man and so adequate intakes of preformed n-3 polyunsaturated fatty acids, in particular docosahexaenoic acid, may be important for maintaining optimal tissue function. Capacity to upregulate alpha-linolenic acid transformation in women may be important for meeting the demands of the fetus and neonate for docosahexaenoic acid.
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Metadata
- Authors
- Burdge, G.
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2004-03
- Volume
- 7
- Issue
- 2
- Pages
- 137-144
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W2008292459
- Cited by
- 426
- References
- 4
- FWCI
- 15.97
- Type
- journal article
- Language
- en
- Open access
- closed
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