Cited by 457Hormonal and reproductive studiesMuscle Physiology and DisordersMuscle metabolism and nutrition

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Testosterone action on skeletal muscle

Herbst, Karen L, Bhasin, Shalender·2004·Current Opinion in Clinical Nutrition and Metabolic Care

DOI 10.1097/00075197-200405000-00006

Open this paper in CoChat — free account

Abstract

PURPOSE OF REVIEW: To highlight recent data demonstrating direct anabolic effects of androgens on the mammalian skeletal muscle and review the mechanisms by which testosterone regulates body composition. RECENT FINDINGS: Testosterone increases lean body mass and decreases fat mass in young men; the magnitude of the changes induced by testosterone in lean and fat mass are correlated with testosterone dose and the prevalent testosterone concentrations. Older men are as responsive to the anabolic effects of testosterone on the muscle as young men, but have increased frequency of adverse events with higher testosterone doses. This reciprocal change in lean and fat mass induced by androgens is best explained by the hypothesis that androgens promote the commitment of mesenchymal pluripotent cells into myogenic lineage and inhibit adipogenesis through an androgen receptor mediated pathway. Resident muscle satellite cells increase in number with testosterone administration forming myoblasts leading to greater numbers of myonuclei in larger myofibers. Testosterone administration is associated with increased size of motor neurons. The roles of 5-alpha reduction and aromatization of testosterone into dihydrotestosterone and estradiol, respectively, in mediating testosterone effects on body composition are poorly understood. SUMMARY: Testosterone induces skeletal muscle hypertrophy by multiple mechanisms, including its effects in modulating the commitment of pluripotent mesenchymal cells. These changes in skeletal muscle lead to improved muscle strength and leg power; however, further studies are needed to determine the effects of testosterone on physical function and health-related outcomes in sarcopenia associated with aging and chronic illness.

Integrity signals

Registry

Crossref · 10.1097/00075197-200405000-00006

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Adipose-derived adult stem cells: isolation, characterization, and differentiation potential
Gimble, J. M., & Guilak, F. (2003) · Cytotherapy · doi:10.1080/14653240310003026 · Cited by 1,103
Transcriptional activation and nuclear targeting signals of the human androgen receptor.
Simental, J. A., Sar, M., Lane, M. V., French, F. S., & Wilson, E. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52466-2 · Cited by 631
Measures of Bioavailable Serum Testosterone and Estradiol and Their Relationships with Muscle Strength, Bone Density, and Body Composition in Elderly Men
van den Beld, A. W., de Jong, F. H., Grobbee, D. E., Pols, H. A. P., & Lamberts, S. W. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6825 · Cited by 618
Androgens Stimulate Myogenic Differentiation and Inhibit Adipogenesis in C3H 10T1/2 Pluripotent Cells through an Androgen Receptor-Mediated Pathway
Singh, R., Artaza, J. N., Taylor, W. E., Gonzalez-Cadavid, N. F., & Bhasin, S. (2003) · Endocrinology · doi:10.1210/en.2003-0741 · Cited by 555
Testosterone administration to older men improves muscle function: molecular and physiological mechanisms
Ferrando, A. A., Sheffield-Moore, M., Yeckel, C. W., Gilkison, C., Jiang, J., Achacosa, A., Lieberman, S. A., Tipton, K., Wolfe, R. R., & Urban, R. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00362.2001 · Cited by 522
Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy
Sinha-Hikim, I., Artaza, J., Woodhouse, L., Gonzalez-Cadavid, N., Singh, A. B., Lee, M. I., Storer, T. W., Casaburi, R., Shen, R., & Bhasin, S. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00502.2001 · Cited by 464
Self-citation
Transfection of a DNA locus that mediates the conversion of 10T12 fibroblasts to myoblasts
Lassar, A. B., Paterson, B. M., & Weintraub, H. (1986) · Cell · doi:10.1016/0092-8674(86)90507-6 · Cited by 375
Testosterone Replacement and Resistance Exercise in HIV-Infected Men With Weight Loss and Low Testosterone Levels
Bhasin, S. (2000) · JAMA · doi:10.1001/jama.283.6.763 · Cited by 367
Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men
Sinha-Hikim, I., Roth, S. M., Lee, M. I., & Bhasin, S. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00370.2002 · Cited by 344
Self-citation
Oral Testosterone Supplementation Increases Muscle and Decreases Fat Mass in Healthy Elderly Males With Low-Normal Gonadal Status
Wittert, G., Chapman, I. M., Haren, M. T., Mackintosh, S. F., Coates, P. S., & Morley, J. E. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.7.m618 · Cited by 342

Show all 46 references

Research works printed but not linked: 3

van den Beld, 2000, J Clin Endocrinol Metab, 85, 3276
Harman, 2003, Horm Res, 60, 121
Bolanowski, 2001, Med Sci Monit, 7, 1029

Sorted by citations

Items 301–400 of 456

Discovery of Novel Trans-Ancestry and Ancestry-Specific Gene Loci for Total Testosterone in a Multi-Ancestral Analysis of Men in the Million Veteran ProgramPreprint
Pagadala, M. S., Jasuja, G. K., Palnati, M., Lynch, J. A., Anglin-Foote, T. R., Chang, N., Deka, R., Lee, K. M., Agiri, F. Y., Seibert, T. M., et al. (2022) · medRxiv · doi:10.1101/2022.02.16.21265846 · Cited by 5
“We 6 identified 17 ancestry-specific variants in European (8), African (5), and Hispanic (4) ancestries of which 15 were 7 novel.”
Background
Unraveling functional decline: the relationship between muscle strength and ultrasound evaluation of biceps brachii thickness
Brunese, M. C., Femminella, G. D., Bencivenga, L., Tafuri, F., Caiazzo, C., Rengo, G., Guerra, G., & Komici, K. (2025) · GeroScience · doi:10.1007/s11357-025-01801-8 · Cited by 4
Concurrent Ingestion of Alkaline Water and L-Glutamine Enhanced Salivary α-Amylase Activity and Testosterone Concentration in Boxing Athletes
Lu, T.-L., He, C.-S., Suzuki, K., Lu, C., Wang, C.-Y., & Fang, S. (2024) · Nutrients · doi:10.3390/nu16030454 · Cited by 6
“Testosterone represents the body’s anabolic state and induces skeletal muscle hypertrophy by multiple mechanisms, including its effects on modulating the commitment of pluripotent mesenchymal cells, leading to improved muscle strength and power [17].”
Background
Effects of testosterone suppression, hindlimb immobilization, and recovery on [3H]ouabain binding site content and Na+, K+-ATPase isoforms in rat soleus muscle
Altarawneh, M. M., Hanson, E. D., Betik, A. C., Petersen, A. C., Hayes, A., & McKenna, M. J. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01077.2018 · Cited by 4
Prevalence of Hand Joint Symptoms in Androgen Deprivation Therapy Among Japanese Patients with Prostate Cancer
Inoue, S., Hayashi, T., Teishima, J., & Matsubara, A. (2020) · Urological Science · doi:10.4103/uros.uros_41_19 · Cited by 4
“[19] Motor neurons and skeletal muscles both have androgen receptors.[29] Testosterone increases the number of androgen receptors in motor neurons, as well as the size and number of motor neurons in the spinal cord.”
Background
Adaptation to full weight‐bearing following disuse in rats: The impact of biological sex on musculoskeletal recovery
Issertine, M., Rosa‐Caldwell, M. E., Sung, D., Bouxsein, M., Rutkove, S. B., & Mortreux, M. (2024) · Physiological Reports · doi:10.14814/phy2.15938 · Cited by 4
“Although testosterone is a steroidal sex hormone known to be involved in musculoskeletal function (Florini, 1970; Herbst & Bhasin, 2004), the exact mechanisms at play remain elusive and numerous studies have described conflicting results (Brown, 2008; Gharahdaghi et al., 2021).”
Result
Is there a relationship between physical performance and orchiectomy?
Petroianu, A., Veloso, D. F. M., Alberti, L. R., Figueiredo, J. A., & Rodrigues, F. H. O. C. (2010) · Andrologia · doi:10.1111/j.1439-0272.2009.00997.x · Cited by 4
“Testosterone is an anabolic steroid from the androgen group which stimulates protein synthesis and promotes a high muscle mass/fat mass ratio (Herbst & Bhasin, 2004).”
Background
Lean body mass accretion is elevated in response to dietary vitamin D: A dose–response study in female weanling rats
Razaghi, M., Djekić-Ivanković, M., Agellon, S., Mak, I. L., Lavery, P., & Weiler, H. A. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.07.004 · Cited by 4
Prevalence of anabolic androgenic steroid use, its effect on the male pituitary-gonadal axis, and the possibility of reproductive rehabilitation
Lykhonosov, M. P., & Babenko, A. Y. (2019) · Problems of Endocrinology · doi:10.14341/probl9997 · Cited by 4
“1) все ААС обладают свойствами увеличивать объем мышечной массы и уменьшать жировую массу [25]; 2) играют роль агонистов минералокортикоидных рецепторов, что приводит к задержке жидкости и натрия [26]; 3) обладают антагонистическим действием на глюкокортикоидные рецепторы [27]; 4) повреждают допаминергическую-мезолимб…”
Associations of serum 25(OH)D levels with physical performance and anabolic hormones in young men
Laaksi, A., Laaksi, I., PIHLAJAMÄKI, H. K., Vaara, J. P., Luukkaala, T. H., & Kyröläinen, H. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1049503 · Cited by 4
“This leads to increased muscular strength and mass (Kautiainen et al., 2002; Herbst and Bhasin, 2004; Kadi, 2008) Therefore, it can be concluded TABLE 3 Differences of themean (±SD) anabolic hormone levels and physical performance test results between the subgroups divided by sufficient level (75 nmol/L) of serum 25 (…”
Background
The Effects of a Multi-Ingredient Performance Supplement on Hormonal Profiles and Body Composition in Male College Athletes
Sharp, M. H., Shields, K. A., Rauch, J. T., Lowery, R. P., Durkee, S., Wilson, G., & Souza, E. D. (2016) · Sports · doi:10.3390/sports4020026 · Cited by 4
“In addition, higher testosterone levels have been demonstrated to contribute to increased muscle growth and activation of the nervous system, resulting in enhanced power and strength, mood, libido, and several other benefits [1].”
Background
[Comparative analysis of growth and sexual maturation in girls of Santa Rosa (La Pampa) and La Plata (Buenos Aires), Argentina].
Torres, M. F., Ma, L., Rossi, M. F. C., Luna, M. E., Castro, L. E., Quintero, F., & Oyhenart, E. E. (2011) · PubMed · Cited by 4
The effects of creatine supplementation on sprint running performance and selected hormonal responses
Faraji, H., Arazi, H., Vatani, D. S. A., & Hakimi, M. (2010) · South African Journal for Research in Sport Physical Education and Recreation · doi:10.4314/sajrs.v32i2.59293 · Cited by 4
Frailty and its relationship to late onset hypogonadism
Gooren, L. J. (2007) · The Journal of Men s Health and Gender · doi:10.1016/j.jmhg.2007.09.002 · Cited by 4
“Testosterone administration is also associated with increased size in motor neurons [28].”
Androgens Receptor Expression and Steroid Action in Bone
Wiren, K. M. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00062-8 · Cited by 4
Effects of physiological caffeine concentration on isolated skeletal muscle force, power and fatigue resistance
Tallis, J. A. (2013) · Coventry University Open Collections (Coventry university) · Cited by 4
Resistance Exercise Training, a Simple Intervention to Preserve Muscle Mass and Strength in Prostate Cancer Patients on Androgen Deprivation Therapy
Houben, L. H. P., Beelen, M., van Loon, L. J. C., & Beijer, S. (2023) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2023-0075 · Cited by 6
“…the differentiation of pluripotent stem cells toward the myogenic lineage instead of the adipogenic lineage (Herbst & Bhasin, 2004; Singh et al., 2003) and, as such, induce hypertrophy by increasing satellite cell number and myonuclear number (Herbst & Bhasin, 2004; Sinha-Hikim et al., 2003).”
BackgroundInfluential
Transcriptome Analysis of Left Versus Right Intrinsic Laryngeal Muscles Associated with Innervation
Kemfack, A. M., Hernández‐Morato, I., Moayedi, Y., & Pitman, M. J. (2024) · The Laryngoscope · doi:10.1002/lary.31487 · Cited by 3
Testosterone Replacement Therapy in Athletes: Implications for Injury Recovery and Musculoskeletal Performance
de Velasco, L. M. C., Flores, J. E. G., Cervera, A. A., Arteaga, J. L. M., & Casas, M. J. O. (2026) · Cureus · doi:10.7759/cureus.103530 · Cited by 3
“Experimental data suggest that testosterone may promote myofiber regeneration, tendon remodeling, and reduce catabolic effects during immobilization or surgical recovery [5].”
Testosterone Replacement Therapy as a Potential Strategy to Preserve Lean Mass in Men With Persistently Low Serum Testosterone Receiving GLP-1 Receptor Agonists: A Narrative Review
de Velasco, L. M. C., Flores, J. E. G., Kraus-Fischer, G., Arteaga, J. L. M., Casas, M. J. O., Nava, K. N. A., & Morales, F. M. M. (2026) · Cureus · doi:10.7759/cureus.105734 · Cited by 3
“Experimental data demonstrate that testosterone enhances muscle protein synthesis, increases nitrogen retention, and promotes myogenic differentiation, thereby contributing to the maintenance of lean mass across the adult lifespan [10,11,12].”
Influential
Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults
Zhu, K., Oddy, W. H., Holt, P. G., Ping‐Delfos, W. C. S., McVeigh, J. A., Straker, L. M., Mori, T. A., Lye, S. J., Pennell, C. E., & Walsh, J. P. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2018-00349 · Cited by 3
“The positive association we observed between 25(OH)D and LBM inmales but not females could reflect an interaction of vitamin D with testosterone, which has anabolic effects on muscle [33].”
Background
Effect of Regular Physical Exercise on the Progression of Erectile Dysfunction Among Male Patients with Diabetes Mellitus
Alyafei, A. A. (2020) · Clinical Medicine Research · doi:10.11648/j.cmr.20200904.12 · Cited by 3
The impact of preoperative 5-alpha reductase inhibitors on functional outcomes and health-related quality of life following radical prostatectomy – A propensity score matched longitudinal study
Westhofen, T., Frank, K., Büchner, A., Becker, A. J., Eismann, L., Rodler, S., Aydogdu, C. D., Berg, E., Jokisch, F., Kazmierczak, P. M., et al. (2024) · World Journal of Urology · doi:10.1007/s00345-024-05108-9 · Cited by 3
“While testosterone induces skeletal muscle hypertrophy through multiple pathways, for instance through modulation of pluripotent mesenchymal cells [15], there is no evidence that preoperative low serum testosterone leads to delayed urinary function recovery post-RP [19].”
Background
¿Los niveles de Testosterona y Cortisol influyen en el rendimiento en el rugby? Una mirada al rugby sevens.
Zúñiga-Vergara, P., & Mauricio Castro, S. (2022) · Archivos de la Sociedad Chilena de Medicina del Deporte · doi:10.59856/rev.sochmedep.vol67-n1.23 · Cited by 3
Asthma and allergic disease
Pollard, T. M. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511841118.008 · Cited by 3
Efectos de la suplementación con testosterona sobre el rendimiento en resistencia
Fernández-Díaz, P., & Domínguez, R. (2016) · Revista Andaluza de Medicina del Deporte · doi:10.1016/j.ramd.2015.02.011 · Cited by 3
The Role of Androgens for Body Composition and Physical Performance in Women
Hirschberg, A. L. (2019) · ISGE series · doi:10.1007/978-3-030-14358-9_4 · Cited by 3
Causes and treatment of protein-energy wasting in kidney disease
Sumida, K., & Kovesdy, C. P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818540-7.00024-0 · Cited by 3
On the problem of intersystem correlations in modern anthropology: the relationship between the somatic and hormonal indicators in Moscow youth
Permiakova, E. Y., Negasheva, M. A., Николаевна, З. С., Khafizova, A. A., Iudina, A. M., & Sineva, I. M. (2022) · Vestnik arheologii, antropologii i ètnografii · doi:10.20874/2071-0437-2022-56-1-13 · Cited by 3
Effects of Caponization on Growth Performance and Carcass Composition of Yangzhou Ganders
Lei, M., Qu, X., Dai, Z., Chen, R., Zhu, H., & Shi, Z. (2022) · Animals · doi:10.3390/ani12111364 · Cited by 3
“Testosterone plays an important role in the regulation of muscle growth in males [30,34,35].”
Background
Boosting Muscle Regeneration
Nastasi, T., & Rosenthal, N. A. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6768-6_15 · Cited by 3
Muscle parameters in men and oxidative stress markers
Pietruszewski, M., Nowak, J., Żelaźniewicz, A., & Pawłowski, B. (2025) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-025-00385-8 · Cited by 2
The musculotendinous interface: insights into development, injury, and recovery for military medical applications
Adams, A. T., Davis, Z. G., Browder, K. F., Dearth, C. L., & Goldman, S. M. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1555199 · Cited by 1
“Testosterone generally accelerates healing in men by boosting protein synthesis, which can result in faster, more robust muscle recovery and growth post-injury (Herbst and Bhasin, 2004).”
Effects of testosterone treatment on anal sphincter damage repair in ovariectomized rats
Şenyuva, İ., Acar, D. B., Demirel, H. H., & TUNÇ, E. (2023) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.55730/1300-0144.5607 · Cited by 2
In ovo corticosterone exposure does not influence yolk steroid hormone relative abundance or skeletal muscle development in the embryonic chicken
Angove, J. L., Willson, N.-L., Barekatain, R., Rosenzweig, D., & Forder, R. E. A. (2023) · Poultry Science · doi:10.1016/j.psj.2023.102735 · Cited by 2
“, 2020) and aid in the commitment of mesenchymal stem cells to the myogenic line (Herbst and Bhasin, 2004).”
Background
A cross-sectional study of breakfast skipping and body composition among young adults
Kim, E., Choi, K., Jeong, S., & Joh, H. (2025) · Korean Journal of Family Medicine · doi:10.4082/kjfm.24.0217 · Cited by 2
Testosterone Therapy for Dropped Head Syndrome: A Case Report
Felong, T. J., Balos, L. L., & Silvestri, N. J. (2022) · Journal of Clinical Neuromuscular Disease · doi:10.1097/cnd.0000000000000372 · Cited by 2
The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Strength and Conditioning
Stapley, P. J., McAndrew, D. J., Walsh, J. A., Kellis, E., Mickel, C., & Paoli, A. (2017) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk2040036 · Cited by 2
“Therefore, even with low serum concentrations in testosterone, which is still regarded as a primary stimulator of anabolic processes in skeletal muscle [42], morphological adaptations are possible.”
Background
Digit Ratio and its Influence on Physical Performance: A Literature Review
dos Santos, S. L. C. (2019) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2019.14.002612 · Cited by 2
“Great levels of fetal androgens, especially testosterone, promote the development and maintenance of various capacities, such as resistance, rhythm, velocity, better visuospatial abilities [12], muscular hypertrophy [13], increased strength [14,15], decrease in fat body mass, increase in hematocrit, reduced reaction t…”
Background
Breaking the athletics world record in the 100 and 400 meters: an alternative method for assessment
Santos, P. A., Sousa, C. V., Barbosa, L. P., Aguiar, S. D. S., Sales, M. M., Simões, H. G., Nikolaidis, P. Τ., & Knechtle, B. (2020) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.20.10753-9 · Cited by 2
“possibly due to the higher production of hormones involved in protein synthesis such 177 as testosterone (25, 26).”
Background
Evaluation of bilateral vasocystostomy for canine sterilization
Nikpasand, A., Behfar, M., Hashemi‐Asl, S. M., Tehrani, A., & Mohammadi, V. (2020) · Theriogenology · doi:10.1016/j.theriogenology.2020.07.015 · Cited by 2
The Impact of Physical Exercise on Male Fertility
Martín, D. M. V., Silva‐Grigoletto, M. E. D., Abbasi, A., & Manso, J. M. G. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1040-3_4 · Cited by 2
Prevention of Skeletal Muscle Wasting: Disuse Atrophy and Sarcopenia
Naomi, E., & Kathryn, H. (2012) · InTech eBooks · doi:10.5772/47856 · Cited by 2
“Testosterone has been shown to regulate skeletal muscle mass in humans [91] and anabolic”
Background
Localized Rhabdomyolysis Associated With Testosterone Enanthate for Gender-Affirming Hormonal Therapy
Reddy, R., Lizama-Hernández, S., & Port, A. M. (2022) · AACE Clinical Case Reports · doi:10.1016/j.aace.2022.09.005 · Cited by 2
Hormone-mediated strategies to enhance training and performance
Beaven, C. M. (2010) · Tuwhera (Auckland University of Technology) · Cited by 2
Androgen Action in Bone: Basic Cellular and Molecular Aspects
Wiren, K. M. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-459-9_16 · Cited by 2
“These effects on stromal differentiation could underlie some of the well-described consequences of androgen administration on body composition including increased muscle mass ( 58 ).”
Background
Urinary steroid profiles in doping testing : in relation to natural variation and drug administration
Mullen, J. (2018) · Figshare · Cited by 2
Androgens and Skeletal Biology
Wiren, K. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00015-7 · Cited by 2
Beyond sex: the effects of testosterone on visuomotor performance in men and women
Smeha, N., Gorbet, D. J., Edgell, H., Macpherson, A., & Sergio, L. E. (2026) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1718846 · Cited by 2
Prenatal Hormonal Markers in Individuals With Joint Hypermobility: The Role of the 2D : 4D Digit Ratio
Zorlular, R., & Zorlular, A. (2026) · American Journal of Human Biology · doi:10.1002/ajhb.70217 · Cited by 1
“In addition, the effect of testosterone in increasing muscle mass and muscle strength increases dynamic stability through the muscles surrounding the joint (Hama et al. 1976; Herbst and Bhasin 2004).”
The thrifty genotype versus thrifty phenotype debate: efforts to explain between population variation in rates of type 2 diabetes and cardiovascular disease
Pollard, T. M. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511841118.005 · Cited by 1
The Effects of a Single Dosage of Creatine Hydrochloride on Total Training Volume in Resistance Trained Men Versus Women
Reuland, E. M. (2016) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1
Female rats are more susceptible to metabolic effects of dehydroepiandrosterone treatment
Hoefel, A. L., Arbo, B. D., Marques, C. V., Cecconello, A. L., Cozer, A. G., Ribeiro, M. F. M., & Kucharski, L. C. (2018) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0159 · Cited by 1
Glutamine supplementation influences the secretory apparatus in the right atrial cardiomyocytes of resistance trained aged rats
de Souza, R. R., Pacheco, C. F., Caperuto, É. C., Maifrino, L. B. M., & Gama, E. F. (2018) · Revista Brasileira de Ciências do Esporte · doi:10.1016/j.rbce.2018.08.005 · Cited by 1
“, 2007), which increase protein synthesis (Herbst and Bhasin, 2004; Olsen et al., 2006).”
Muscle Hypertrophy
Alway, S. E. (2006) · CRC Press eBooks · doi:10.1201/9781420019322.ch20 · Cited by 1
Diagnóstico e tratamento da deficiência de testosterona: uma revisão / Diagnosis and treatment of testosterone deficiency: a review
Sobreiro, B. P. (2022) · Brazilian Journal of Health Review · doi:10.34119/bjhrv5n3-007 · Cited by 2
Cord blood myostatin concentrations by gestational diabetes mellitus and fetal sex
Huang, R., Kibschull, M., Briollais, L., Pausová, Z., Murphy, K. E., Kingdom, J. C., Lye, S. J., & Luo, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1018779 · Cited by 1
“Testosterone promotes protein synthesis, skeletal and muscle growth (19, 20).”
Background
Discovery of novel ancestry specific genes for androgens and hypogonadism in Million Veteran Program Men
Pagadala, M. S., Teerlink, C. C., Jasuja, G. K., Palnati, M., Anglin-Foote, T. R., Chang, N.-C. N., Deka, R., Lee, K. M., Agiri, F. Y., Amariuta, T., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57372-x · Cited by 1
Androgens and Skeletal Biology: Basic Mechanisms
Wiren, K. M. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-375098-3.50016-0 · Cited by 1
H ormonal T reatment E ffects on the C ross‐sectional A rea of P ubococcygeus M uscle F ibers A fter D enervation and C astration in M ale R ats
Lara‐García, M., Alvarado-Olivarez, M., Cuevas‐Romero, E., Lara‐García, O., Sengelaub, D. R., & Pacheco, P. (2017) · The Anatomical Record · doi:10.1002/ar.23565 · Cited by 1
“For example, androgens can act directly on skeletal muscle to promote myogenesis, resulting in skeletal muscle hypertrophy (Herbst and Bhasin, 2004).”
Background
Chapter 15 – Androgens and Skeletal Biology: Basic Mechanisms
Wiren, K. M. (2013) · Cited by 1
12-week treadmill exercise program elicits lower energy availability without changes in serum testosterone in male rats
Clark, L. R., Dellogono, M., Chenette, E., Mangano, K. M., & Wilson, T. A. (2018) · Sport Sciences for Health · doi:10.1007/s11332-018-0455-0 · Cited by 1
“Testosterone plays an important anabolic role in protein synthesis [23] and the maintenance of bone mass in males [24, 25], and hypogonadism has been determined to be a clinical risk factor for bone demineralization and osteoporosis [24, 25].”
Background
The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights of Recent Papers in Pediatric Exercise
Pavone, V., Vescio, A., Testa, G., Chaabène, H., & Bianco, A. (2019) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk4020021 · Cited by 1
“, testosterone) in the pre-pubertal age, among others, which are necessary to trigger morphological adaptations [13,17].”
Some carcass traits and meat chemical characteristics of karadi lambs injected with testosterone enanthate
Mahmood, A. B., Al-Obaidi, A. S. A., & Omar, C. A. (2019) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/388/1/012025 · Cited by 1
Sex Hormone Disturbances in Athletes: Implications for Voice
Hamdan, A., Sataloff, R. T., & Hawkshaw, M. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-69831-7_10 · Cited by 1
Perbandingan karakteristik lompat vertikal pada atlet bulutangkis pria dengan atlet bulutangkis wanita
APRIANTONO, T. A., Herman, I., Syafriani, R., Adiprawita, W., Winata, B., & Juniarsyah, A. D. (2021) · Journal Of Sport Education (JOPE) · doi:10.31258/jope.4.1.10-18 · Cited by 1
Pharmacological management of osteosarcopenia
Feehan, J., & Duque, G. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-820088-9.00003-2 · Cited by 1
Hormonal Supplements
Landis, J. A., & Ziegenfuss, T. N. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-302-8_23 · Cited by 1
Are Older People Starving to Death in a World of Plenty?
Thomas, D. R. (2005) · KARGER eBooks · doi:10.1159/000083261 · Cited by 1
The Effects of Training with Free Weights or Machines on Muscle Mass, Strength, and Testosterone and Cortisol Levels
Schwanbeck, S. (2008) · University Library - University of Saskatchewan (University of Saskatchewan) · Cited by 1
The role of myostatin during postnatal myogenesis and sarcopenia
Siriett, V. (2007) · Research Commons (University of Waikato) · Cited by 1
Muscle Atrophy During Aging
Short, K. R. (2006) · CRC Press eBooks · doi:10.1201/9781420019322.ch18 · Cited by 1
The role of steroid hormones in skeletal muscle metabolism
Salehzadeh, F. (2011) · Figshare
Effects of resistance exercise (intensity and volume) with or without leucine enriched protein supplementation on human myofibrillar protein synthesis and cell anabolic signalling
Kumar, V. (2010) · Nottingham ePrints (University of Nottingham)
Biomedizinische Grundlagen zum Krafttraining im Kindes- und Jugendalter
Behringer, M. (2012)
Improvement of muscle mass and force by certain hormones and endogen factors, contributing in muscle development
Apor, P., Tihanyi, J., & Costa, A. (2007) · Orvosi Hetilap · doi:10.1556/oh.2007.27793
The effects of eccentric training on strength and muscle development in pre-pubertal and pubertal boys
Allen, J. B. (2009) · University Library - University of Saskatchewan (University of Saskatchewan)
Reproductive cancers
Pollard, T. M. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511841118.006
Efeito de diferentes doses de nandrolona associado ao treinamento de força sobre o perfil fenotípico e área de secção transversa do músculo de ratos
Verlengia, R., Prestes, J., Asano, R. Y., da Silva, W. J., Campos, G. E. R., Cavaglieri, C. R., de Souza, R. D., Boff, S. R., & Alves, S. C. C. (2013) · Revista Brasileira de Educação Física e Esporte · doi:10.1590/s1807-55092013000100009
Effect of rehabilitation program on GH/IGF-1/IGF-BP3 axis and Testosterone/Cortisol ratio in patients with COPD and in healthy subjects
Mkacher, W., Tabka, Z., Aouichaoui, C., Chaieb, F., Gueddes, M., Zaouali, M., Zbidi, A., & Trabelsi, Y. (2012) · International Journal of Therapies and Rehabilitation Research · doi:10.5455/ijtrr.00000009
“[34] showed a significant correlation between systemic inflammation (IL-6 levels, an important inflammatory cytokine) and decreased concentrations of testosterone known as a stimulator of protein anabolism [37].”
Background
Effect of creatine monohydrate supplementation for 3 weeks on testosterone conversion to dihydrotestosterone in young rugby players
van der Merwe, J. (2006) · SUNScholar (Stellenbosch University)
Izomero, izomtömeg növelése hormonokkal és egyéb szerekkel, edzésscl társítva
Apor, P., Tihanyi, J., & Costa, A. (2007) · Orvosi Hetilap
ARTICLE ORIGINAL/ORIGINAL ARTICLE TOXIC EFFECTS OF METHYL METHACRYLATE MONOMER ON MALE GENITAL TISSUES In vitro study in rats
Fakhouri, J., Sarkis, R., Chababi‐Atallah, M., Aftimos, G., Fakhouri, J., Sarkis, R., Chababi‐Atallah, M., & Toxic, A. G. (2015)
An evolutionary history of human disease
Pollard, T. M. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511841118.003
Novel Mass Spectrometric Analysis Methods for Anabolic Androgenic Steroids in Sports Drug Testing
Leinonen, A. (2006) · Työväentutkimus Vuosikirja
Conclusion
Pollard, T. M. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511841118.010
Atuação dos esteróides anabolizantes na regeneração músculo
Suffredini, T. S., Biagini, Â. P., & de Oliveira, N. M. L. (2008)
Testosterone, Dehydroepiandrosterone, and Physical Performance in Older Men: Results from the Massachusetts Male Aging Study
Meikle, A. W. (2007) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)70212-9
Fertility relevant hormones in men with spinal cord injury: case control study
Gökkaya, C. S., Güzel, Ö., Gökkaya, N. K. O., Demirdal, Ö., Bulut, S., Özden, C., Uçan, H., & Memiş, A. (2012) · Sakarya Medical Journal · doi:10.5505/sakaryamj.2012.75047
THE EFFECT OF VARIATION IN ENDOCRINE MECHANISMS ON NATURAL DISPLAY BEHAVIOR IN CARIBBEAN ANOLIS LIZARDS
Castro, D. J. (2013) · Digital Commons - Trinity University (Trinity University)
Reproductive function, breastfeeding and the menopause
Pollard, T. M. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511841118.007
Obesity, type 2 diabetes and cardiovascular disease
Pollard, T. M. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511841118.004
Intervention in the Elderly
Applegate, W. B., & Williamson, J. D. (2003) · Informa Healthcare eBooks · doi:10.1201/9780203912690.ch15
Theory and Methods
Futuyma, D. J. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511781193.002
Post Terbinafine Adrenal Gland and Testis Dysfunction that Imitated Fibromyalgia: Case Report
Jasinska, D., & Boczon, J. (2016) · Journal of Pain & Relief · doi:10.4172/2167-0846.1000264
“These changes in skeletal muscle lead to improved muscle strength and leg power [5].”
Background
A Comparison with the Physique and Physical Fitness Factors according to Finger Length Ratio(2D:4D ratio) of Elementary Students
Song, Y.-E., Kang, E., & Kim, C. (2016) · Exercise Science · doi:10.15857/ksep.2016.25.3.142
Functional Hypogonadism: Diabetes Mellitus, Obesity, Metabolic Syndrome, and Testosterone
Meirelles, R. M. D. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-46086-4_7
Effects of d-aspartic acid on testosterone and training outcomes in a resistance trained population : findings from an acute dosing study, and a three-month training study
Melville, G. W. (2016)
The Role of Testosterone in Nutrition and Sports
Lingen, J., Hofmann, H., & Schönfelder, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-396454-0.00031-x
Molecular Changes at the Post-Synapse and Improved Motor Function Suggest Accelerated Recovery with SARM Treatment in an Androgen-Depleted Animal Model of Nerve Injury
Bryant, J. (2017) · Journal of Musculoskeletal Disorders and Treatment · doi:10.23937/2572-3243.1510037

Authors: Herbst, K. L., & Bhasin, S.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Bhasin, Shalender
ORCID: Herbst, Karen L
Bhasin, Shalender
Venue: Current Opinion in Clinical Nutrition and Metabolic Care
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-05
Volume: 7
Issue: 3
Pages: 271-277
ISSN: 1363-1950 (ISSN-L)
DOI: 10.1097/00075197-200405000-00006
OpenAlex: W2095240081
Cited by: 457
References: 46
Citations by year: 2026: 7 · 2025: 13 · 2024: 27 · 2023: 38 · 2022: 32 · 2021: 27 · 2020: 22 · 2019: 22 · 2018: 21 · 2017: 22 · 2016: 15 · 2015: 13 · 2014: 12 · 2013: 24 · 2012: 18
FWCI: 2.51
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: testosterone, skeletal muscle hypertrophy, androgen action, body composition, lean body mass, fat mass, androgen receptor, mesenchymal differentiation, myogenesis, adipogenesis, satellite cells, myonuclei, motor neurons, dihydrotestosterone, estradiol, aging, sarcopenia, muscle strength, leg power
MeSH terms: Aging, Animals, Body Composition, Female, Humans, Male, Testosterone, Muscle, Skeletal, Muscle Development, Pluripotent Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Testosterone action on skeletal muscle

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks