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Cited by 215Hormonal and reproductive studiesMuscle Physiology and DisordersMuscle metabolism and nutrition

The Mechanisms of Androgen Effects on Body Composition: Mesenchymal Pluripotent Cell as the Target of Androgen Action

Bhasin, S., Taylor, W. E., Singh, R., Artaza, J., Sinha-Hikim, I., Jasuja, R., Choi, H., Gonzalez-Cadavid, N. F.·2003·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
DOI 10.1093/gerona/58.12.m1103
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Abstract

Testosterone supplementation increases muscle mass primarily by inducing muscle fiber hypertrophy; however, the mechanisms by which testosterone exerts its anabolic effects on the muscle are poorly understood. The prevalent view is that testosterone improves net muscle protein balance by stimulating muscle protein synthesis, decreasing muscle protein degradation, and improving the reutilization of amino acids. However, the muscle protein synthesis hypothesis does not adequately explain testosterone-induced changes in fat mass, myonuclear number, and satellite cell number. We postulate that testosterone promotes the commitment of pluripotent stem cells into the myogenic lineage and inhibits their differentiation into the adipogenic lineage. The hypothesis that the primary site of androgen action is the pluripotent stem cell provides a unifying explanation for the observed reciprocal effects of testosterone on muscle and fat mass.

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Crossref · 10.1093/gerona/58.12.m1103

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  • Data obtained from in vitro experiments show that testosterone and DHT can inhibit the differentiation of human and BM-mesenchymal pluripotent cells into adipocytes via AR dependent pathway.

    “Data obtained from in vitro experiments show that testosterone and DHT can inhibit the differentiation of human and BM‐mesenchymal pluripotent cells into adipocytes via AR dependent pathway. 110 , 111 , 112 , 113”

    From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [112]

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Authors
Bhasin, S., Taylor, W. E., Singh, R., Artaza, J., Sinha-Hikim, I., Jasuja, R., Choi, H., & Gonzalez-Cadavid, N. F.
Affiliations
Charles R. Drew University of Medicine and Science (US)
ORCID
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher
Oxford University Press (OUP)
Published
2003-12-01
Volume
58
Issue
12
Pages
M1103-M1110
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
DOI
10.1093/gerona/58.12.m1103
OpenAlex
W2119860085
Cited by
215
References
63
Citations by year
2025: 11 · 2024: 7 · 2023: 2 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 15 · 2018: 5 · 2017: 13 · 2016: 9 · 2015: 3 · 2014: 7 · 2013: 7 · 2012: 12
FWCI
2.02
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
testosterone, androgens, body composition, muscle mass, fat mass, myogenic lineage, adipogenesis, muscle protein synthesis, muscle protein degradation, satellite cells, myonuclear number, muscle fiber hypertrophy, anabolic effects
MeSH terms
Adolescent, Adult, Biopsy, Needle, Body Composition, Child, Child, Preschool, Humans, Immunohistochemistry, Male, Muscle Proteins, Sensitivity and Specificity, Stem Cells, Testosterone, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Development, Pluripotent Stem Cells

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