The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Testosterone action on skeletal muscle
Abstract
PURPOSE OF REVIEW: To highlight recent data demonstrating direct anabolic effects of androgens on the mammalian skeletal muscle and review the mechanisms by which testosterone regulates body composition. RECENT FINDINGS: Testosterone increases lean body mass and decreases fat mass in young men; the magnitude of the changes induced by testosterone in lean and fat mass are correlated with testosterone dose and the prevalent testosterone concentrations. Older men are as responsive to the anabolic effects of testosterone on the muscle as young men, but have increased frequency of adverse events with higher testosterone doses. This reciprocal change in lean and fat mass induced by androgens is best explained by the hypothesis that androgens promote the commitment of mesenchymal pluripotent cells into myogenic lineage and inhibit adipogenesis through an androgen receptor mediated pathway. Resident muscle satellite cells increase in number with testosterone administration forming myoblasts leading to greater numbers of myonuclei in larger myofibers. Testosterone administration is associated with increased size of motor neurons. The roles of 5-alpha reduction and aromatization of testosterone into dihydrotestosterone and estradiol, respectively, in mediating testosterone effects on body composition are poorly understood. SUMMARY: Testosterone induces skeletal muscle hypertrophy by multiple mechanisms, including its effects in modulating the commitment of pluripotent mesenchymal cells. These changes in skeletal muscle lead to improved muscle strength and leg power; however, further studies are needed to determine the effects of testosterone on physical function and health-related outcomes in sarcopenia associated with aging and chronic illness.
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“These studies did not report muscle strength, but other studies of testosterone dose-response relationships for muscle mass and strength show consistently positively correlation (65, 93, 117, 119), although with disproportionately greater effect on muscle strength than on muscle mass.”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [93]
In the citing paper
“These studies did not report muscle strength, but other studies of testosterone dose-response relationships for muscle mass and strength show consistently positively correlation (65, 93, 117, 119), although with disproportionately greater effect on muscle strength than on muscle mass.”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [93]
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“For humans and other mammals, the effects of testosterone and other steroids to increase muscle mass, increase power output, decrease protein degradation and increase amino acid utilization in mammals are well known (Herbst and Bhasin, 2004; Bhasin et al., 2001).”
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“Some research has shown that circulating concentrations of anabolic hormones such as growth hormone (GH), insulin-like growth factor-1 (IGF-I) and testosterone in older men are related to increased levels of physical activity, muscle function, and aerobic power [3,4].”
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“Alternately, testosterone increases protein synthesis by converting the androgen receptor to a transcription factor and by activating muscle satellite cells, important because gene transcription is an initial target for the modulation of protein synthesis (Herbst and Bhasin 2004).”
BackgroundAn overview on androgen-mediated actions in skeletal muscle and adipose tissue
Rizk, J. G., Sahu, R., & Duteil, D. (2023) · Steroids · doi:10.1016/j.steroids.2023.109306 · Cited by 54
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Western Diseases: An Evolutionary Perspective
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“Thus, androgens seem to generally exert effects on tissue size and strength (67) but also impact processes related to energy mobilization and cellular respiration to facilitate courtship.”
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“Testosterone is an anabolic hormone, which improves net muscle protein balance by stimulating muscle protein synthesis, decreasing muscle protein degradation, and improving the reuse of amino acids (18).”
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Target population for clinical trials on sarcopenia
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“A direct association between testosterone levels and appendicular muscle mass has been reported(77).”
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“Testosterone reduces fat mass and increases muscle strength and leg power (Herbst and Bhasin, 2004).”
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“For instance, testosterone stimulates muscle development (Herbst and Bhasin 2004; Huyghe et al. 2009), and therefore wholeorganism performance on traits that influence survival and intra-sexual competition and dominance, hence contributing to overall fitness (Ellis 1995; Husak and Fox 2008;…”
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“enhances neuronal excitability and facilitates the corticospinal pathways [53].”
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“Some research has shown that circulating concentrations of anabolic hormones such as testosterone in older men are related to increased levels of physical activity, muscle function, and aerobic power (Herbst and Bhasin, 2004).”
BackgroundMolecular Targets of Androgen Signaling that Characterize Skeletal Muscle Recovery and Regeneration
MacKrell, J. G., Yaden, B. C., Bullock, H. A., Chen, K., Shetler, P. K., Bryant, H. U., & Krishnan, V. (2015) · Nuclear Receptor Signaling · doi:10.1621/nrs.13005 · Cited by 38
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“This situation s associated to decreased libido, erectile dysfunction and also to epression, insomnia, irritability, abdominal obesity and decreased one and muscular mass [3–5].”
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Pérez-Castillo, Í. M., Rueda, R., Bouzamondo, H., Chicharro, J. L., & Mihic, N. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1167449 · Cited by 53
“Testosterone is also known to favor glycogen replenishment and reduce protein breakdown in muscle (Herbst and Bhasin, 2004; Kelly and Jones, 2013), thus counterbalancing the catabolic actions of cortisol.”
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Kuzawa, C. W., Georgiev, A. V., McDade, T. W., Bechayda, S. A., & Gettler, L. T. (2015) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-015-0038-0 · Cited by 39
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“I, targeting muscle, govern carbohydrate, lipid and protein metabolism [22], while T seemed to mainly affect the body composition [23].”
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Testosterone, physical activity, and somatic outcomes among Filipino males
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“T also stimulates lipolysis in adipose tissue and inhibits the differentiation of adipogenic precursor cells, reducing the development and maintenance of adipose stores (Singh et al., 2003; Herbst and Bhasin, 2004; Woodhouse et al., 2004).”
BackgroundAndrogen receptor CAG repeats and body composition among Ariaal men
Campbell, B., Gray, P. B., Eisenberg, D. T. A., Ellison, P. T., & Sorenson, M. D. (2007) · International Journal of Andrology · doi:10.1111/j.1365-2605.2007.00825.x · Cited by 37
“Interestingly, Ariaal men with shorter AR CAG repeats exhibit a stronger positive relationship between adipose tissue and current testosterone levels, contrary to expectations based on the lipolytic effects of circulating T (Herbst & Bhasin 2004).”
ResultNonsteroidal tissue selective androgen receptor modulators: a promising class of clinical candidates
Mohler, M. L., Nair, V. A., Hwang, D., Rakov, I. M., Patil, R., & Miller, D. D. (2005) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.15.11.1565 · Cited by 37
“Recently, testosterone has been demonstrated to have direct anabolic effects on skeletal muscle in mammals as measured by functional tests, such as increased grip strength and increased leg strength, and histological analysis, such as increased myogenesis and increased motor neuron number and size [55].”
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New perspectives in functional hypogonadotropic hypogonadism: beyond late onset hypogonadism
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Testosterone Replacement Therapy and Motor Function in Men with Spinal Cord Injury
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“Muscle loss is associated with a decline in the secretion of the androgenic hormone testosterone, required for the maintenance of lean body mass and strength.(3) Reductions in testosterone levels are also associated with SCI, suggesting that individuals with SCI are predisposed to age-related changes in body compositi…”
BackgroundClark, B. C., Manini, T. M., Hoffman, R. L., & Russ, D. W. (2009) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2008.06.032 · Cited by 33
Mammadov, R., Şimşir, A., Tuğlu, İ., Evren, V., Gurer, E., & Özyurt, C. (2011) · International Urology and Nephrology · doi:10.1007/s11255-011-9938-5 · Cited by 33
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“The liver plays a key role in whole-body metabolism, including gluconeogenesis, glycogenolysis, glycogen storage, amino acid synthesis, lipid synthesis and breakdown, and the production of insulin-like growth factor (Miura et al., 1992; Heubi, 1993).”
BackgroundThe evolution of androgen receptor expression and behavior in Anolis lizard forelimb muscles
Johnson, M. A., Kircher, B. K., & Castro, D. J. (2017) · Journal of Comparative Physiology A · doi:10.1007/s00359-017-1228-y · Cited by 33
“In particular, androgens influence the size, strength, and growth rates of skeletal muscles (Herbst and Bhasin 2004), often in sex- or species-specific patterns (e.”
BackgroundTestosterone and Resistance Training Improve Muscle Quality in Spinal Cord Injury
Holman, M. E., & Gorgey, A. S. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001975 · Cited by 32
“Testosterone is known to play many roles in the body including the maintenance of musculoskeletal tissue health and function (17,18).”
BackgroundDavey, R. A., Clarke, M. V., Russell, P. K., Rana, K., Seto, J. T., Roeszler, K. N., How, J. M. Y., Chia, L. Y., North, K. N., & Zajac, J. D. (2017) · Endocrinology · doi:10.1210/en.2017-00470 · Cited by 31
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“An additional review by these authors (16) states that testosterone likely acts to induce mesenchymal pluripotent cells to commit to the myogenic lineage, inhibit the differentiation of mesenchymal pluripotent cells into the adipogenic lineage, stimulate satellite cell replication, stimulate muscle protein synthesis,…”
BackgroundMass spectrometry of hydantoin‐derived selective androgen receptor modulators
Thevis, M., Kohler, M., Schlörer, N. E., Kamber, M., Kühn, A., Linscheid, M. W., & Schänzer, W. (2007) · Journal of Mass Spectrometry · doi:10.1002/jms.1364 · Cited by 32
Maintenance of muscle mass in adult male mice is independent of testosterone
Davidyan, A., Pathak, S. J., Baar, K., & Bodine, S. C. (2021) · PLoS ONE · doi:10.1371/journal.pone.0240278 · Cited by 30
“Because of its presumed role in muscle growth, there is much interest in the potential role testosterone might have in maintenance of muscle mass in adults, adaptive growth in response to anabolic signals such as increased load, recovery of muscle mass following injury, and prevention of muscle mass loss during disuse…”
BackgroundInfluentialRecent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity
Kim, Y.-C., Ki, S.-W., Kim, H., Kang, S., Kim, H., & Go, G. (2023) · Nutrients · doi:10.3390/nu15173854 · Cited by 33
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Tapper, J., Arver, S., Pencina, K. M., Martling, A., Blomqvist, L., Buchli, C., Li, Z., Gagliano‐Jucá, T., Travison, T. G., Huang, G. T.-W., et al. (2017) · Andrology · doi:10.1111/andr.12454 · Cited by 29
“The increase in lean mass and muscle strength is related to the administered testosterone dose and to the circulating on-treatment serum testosterone concentrations (Herbst & Bhasin, 2004).”
BackgroundUsing Machines or Free Weights for Resistance Training in Novice Males? A Randomized Parallel Trial
Aerenhouts, D., & D’Hondt, E. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17217848 · Cited by 34
“A higher activation and recruitment of more muscle mass when using free weights should increase testosterone levels to a greater extent [13], and thus induce more hypertrophic effects [14].”
BackgroundCollaer, M. L., Brook, C. G. D., Conway, G. S., Hindmarsh, P. C., & Hines, M. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.09.007 · Cited by 28
“Androgens are one potential cause of neuromuscular sex differences as they can stimulate myogenesis by influencing many of the aspects above (Herbst & Bhasin, 2004; Sinha-Hikim et al., 2004).”
BackgroundInfluentialCrewther, B. T., & Cook, C. J. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.03.015 · Cited by 27
“Traditionally, the training role of testosterone (T) has been presented as being anabolic and anti-catabolic to protein synthesis and degradation, respectively [5].”
BackgroundTestosterone improves muscle fiber asset and exercise performance in a metabolic syndrome model
Sarchielli, E., Comeglio, P., Filippi, S., Cellai, I., Guarnieri, G., Guasti, D., Rapizzi, E., Rastrelli, G., Bani, D., Vannelli, G. B., et al. (2020) · Journal of Endocrinology · doi:10.1530/joe-19-0532 · Cited by 27
“It is well known that testosterone exerts trophic effects on muscle, mainly promoting protein synthesis, fiber hypertrophy and satellite cells/myonuclei proliferation and differentiation (Herbst & Bhasin 2004).”
BackgroundBailly, M., Boscaro, A., Pereira, B., Féasson, L., Boirie, Y., Germain, N., Galusca, B., Courteix, D., Thivel, D., & Verney, J. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09650-4 · Cited by 27
Testosterone prevents protein loss via the hepatic urea cycle in human
Lam, T., Poljak, A., McLean, M. P., Bahl, N., Ho, K. K. Y., & Birzniece, V. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0868 · Cited by 27
Hepatic actions of androgens in the regulation of metabolism
Birzniece, V. (2018) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000405 · Cited by 28
The Association between Athleticism, Prenatal Testosterone, and Finger Length
Moffit, D. M., & Swanik, C. B. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181d4d409 · Cited by 27
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“Muscle satellite cells with T administration caused a remarkable increase in myoblasts number, and formed larger myofibers with more myonuclei [4].”
BackgroundTapper, J., Huang, G. T.-W., Pencina, K. M., Li, Z., Arver, S., Martling, A., Blomqvist, L., Buchli, C., Travison, T. G., Storer, T. W., et al. (2019) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001410 · Cited by 25
“Androgens are known to exert direct anabolic effects on skeletal muscle in both sexes.(5) Testosterone supplementation results in dose-dependent increases in both muscle mass and strength in men.”
BackgroundConsiderations for Sex-Cognizant Research in Exercise Biology and Medicine
O’Bryan, S. M., Connor, K. R., Drummer, D. J., Lavin, K. M., & Bamman, M. M. (2022) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2022.903992 · Cited by 26
“In skeletal muscle (SkM) satellite cells and myofibers testosteronemediated AR activation inducesmuscle satellite cell proliferation, myofiber hypertrophy, and myonuclear number (Sinha-Hikim et al., 2003; Herbst and Bhasin, 2004; Kadi, 2008).”
BackgroundWilloughby, D. S., Wilborn, C., Taylor, L. W., & Campbell, W. S. (2007) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.17.1.92 · Cited by 25
“In addition, testosterone increases fat-free mass and decreases fat mass in young men (2, 8).”
BackgroundCadwallader, A. B., Lim, C. S., Rollins, D. E., & Botrè, F. (2011) · Journal of Analytical Toxicology · doi:10.1093/anatox/35.9.594 · Cited by 25
“The results of this mechanism in skeletal muscle are hypertrophy of both type I and type II muscle fibers (but not an increase in the number of fibers) (36, 38-43), an increase in the number of myonuclei and satellite cells resulting in an increase in the number available for conversion to skeletal muscle fibers (38,…”
BackgroundEffects of Testosterone on Erythropoiesis in a Female Mouse Model of Anemia of Inflammation
Guo, W., Schmidt, P. J., Fleming, M. D., & Bhasin, S. (2016) · Endocrinology · doi:10.1210/en.2016-1150 · Cited by 25
“A greater increase in body weight from week 6 to week 10 was found in the BA_T group compared with the BA_V and the non_BA group (Supplemental Figure 1A), consistent with the known anabolic effects of T (30).”
ResultPollard, T. M. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511841118 · Cited by 25
Baik, M., Jeong, J. Y., Park, S. J., Yoo, S. P., Lee, J. O., Lee, J. S., Haque, M. N., & Lee, H.-J. (2020) · Genes & Nutrition · doi:10.1186/s12263-020-00673-1 · Cited by 24
Androgen receptor antagonists: a patent review (2008 – 2011)
Mohler, M. L., Coss, C. C., Duke, C. B., Patil, S. A., Miller, D. D., & Dalton, J. T. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2012.682571 · Cited by 25
“Androgenic processes supported by AR signaling include the development, growth and support of male primary sexual characteristics, as well as exerting influence on secondary gender dimorphic sexual characteristics such as body conformation (bone and muscle mass), skin quality, hair distribution and adipose tissue, whi…”
BackgroundThe Effect of Whole Egg Intake on Muscle Mass: Are the Yolk and Its Nutrients Important?
Santos, H. O., Gomes, G. K., Schoenfeld, B. J., & de Oliveira, E. P. (2021) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2021-0086 · Cited by 26
“Testosterone is an anabolic hormone that plays an essential role in the maintenance of muscle mass and strength (Herbst & Bhasin, 2004), and many consumer websites claim that ingesting whole eggs, and consequently cholesterol, is a viable strategy to increase testosterone levels; however, these…”
BackgroundGREEN, D. J., Chasland, L. C., Yeap, B. B., & Naylor, L. H. (2024) · Sports Medicine - Open · doi:10.1186/s40798-024-00703-x · Cited by 29
“The anabolic effects of T are well established, with mechanisms related to increased muscle protein synthesis [32, 33], stimulated satellite cell replication [34] and inhibition of muscle protein degradation [35, 36].”
BackgroundCobo, G., Gallar, P., Gioia, C. D., Lacalle, C. G., Camacho, R., Rodríguez, I., Ortega, O., Mon, C., Vigil, A., Lindholm, B., et al. (2016) · Nefrología · doi:10.1016/j.nefro.2016.04.009 · Cited by 24
Yu, Y.-L., Shen, Z., Zhou, X.-L., & Chen, S. (2009) · Urology · doi:10.1016/j.urology.2008.10.050 · Cited by 24
Non-classical localization of androgen receptor in the C2C12 skeletal muscle cell line
Pronsato, L., Boland, R., & Milanesi, L. M. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.12.011 · Cited by 24
Chaabène, H., Ramírez‐Campillo, R., Moran, J., Schega, L., Prieske, O., Sandau, I., Negra, Y., & Behrens, M. (2025) · Sports Medicine · doi:10.1007/s40279-025-02240-3 · Cited by 38
“The dominance of neural over muscular adaptations has largely been attributed to the low level of circulating anabolic hormones (e.g., testosterone) before maturation [207–209], although the central role of testosterone in this process has recently been questioned [210].”
How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging
Karasik, D. (2010) · AGE · doi:10.1007/s11357-010-9159-3 · Cited by 24
Hsu, B., Cumming, R. G., Naganathan, V., Blyth, F., Couteur, D. G. L., Seibel, M. J., Waite, L. M., & Handelsman, D. J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1124 · Cited by 22
Wilson, R. L., Taaffe, D. R., Newton, R. U., Hart, N. H., Lyons‐Wall, P., & Galvao, D. A. (2021) · Nutrients · doi:10.3390/nu13051664 · Cited by 22
“Given that testosterone plays roles in the activation of lipolysis and hypertrophy of lean mass (LM) [3,4], substantial body composition changes, as well as loss of muscle strength and physical function, can occur [5,6].”
BackgroundAutomated Methods for the Analysis of Skeletal Muscle Fiber Size and Metabolic Type
Kostrominova, T. Y., Reiner, D. S., Haas, R., Ingermanson, R. S., & McDonough, P. M. (2013) · International review of cytology · doi:10.1016/b978-0-12-407694-5.00007-9 · Cited by 22
Testosterone, frailty and physical function in older men
Hsu, B., Cumming, R. G., & Handelsman, D. J. (2018) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2018.1475227 · Cited by 22
“Individual components of FP frailty such as lean body mass, muscle strength and physical function are reported from previous observational studies to be significantly related to low serum T levels, but with a very modest strength of association [13,41].”
BackgroundDietary intake of branched-chain amino acids in relation to general and abdominal obesity
Asoudeh, F., Salari-Moghaddam, A., Keshteli, A. H., Esmaillzadeh, A., & Adibi, P. (2021) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-021-01266-6 · Cited by 22
Rosvall, K. A., & Peterson, M. P. (2014) · Current Zoology · doi:10.1093/czoolo/60.6.791 · Cited by 22
“Their down-regulation in response to T, however, may be related to the known effects that androgens have on increasing muscle cell size and number (Herbst and Bhasin, 2004), which could reduce the density of such contractile elements.”
Smilios, I., Tsoukos, P., Zafeiridis, A., Spassis, A. T., & Tokmakidis, S. P. (2013) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2013-0147 · Cited by 21
“…of testosterone, human growth hormone (hGH) and cortisol, which have been implicated in nerve and muscle tissue function, growth and metabolism as well as in regulation of inflammatory response (Bonifazi et al. 2004; Crewther et al. 2011; Herbst and Bhasin 2004; Liu et al. 2003; Miles 2005).”
BackgroundKim, N. R., David, K., Corbeels, K., Khalil, R., Antonio, L., Schollaert, D., Deboel, L., Ohlsson, C., Gustafsson, J.-Å., Vangoitsenhoven, R., et al. (2021) · Endocrinology · doi:10.1210/endocr/bqab045 · Cited by 21
Male hormonal contraception: Potential risks and benefits
Ilani, N., Swerdloff, R. S., & Wang, C. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9183-3 · Cited by 21
Endocrine differences among colour morphs in a lizard with alternative behavioural strategies
Yewers, M. S. C., Jessop, T. S., & Stuart-Fox, D. M. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.05.001 · Cited by 19
“…are known to further reinforce or potentially modulate behavioural phenotypes (Hau, 2007; Oliveira, 2004) and skeletal muscular hypertrophy (Herbst and Bhasin, 2004) with the dominant morph often showing higher levels of testosterone (Horton et al., 2014b; Küpper et al., 2016; Sinervo et…”
BackgroundPuberty in the Female and Its Disorders
Rosenfield, R. L., Cooke, D. W., & Radovick, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-62520-3.00016-6 · Cited by 23
Pronsato, L., Milanesi, L. M., Vasconsuelo, A., & la Colla, A. B. (2017) · Steroids · doi:10.1016/j.steroids.2017.05.012 · Cited by 20
“It is well known that skeletal muscle is one of the greatest target tissues of androgens, being the androgen-AR signaling pathway required for skeletal muscle development and for sustaining muscle mass, strength and protein synthesis, having thus an important role in determining body composition [63].”
Liu, T.-C., Lin, C.-H., Huang, C., Ivy, J. L., & Kuo, C. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2607-x · Cited by 19
“muscle mass and strength in the elderly (Herbst and Bhasin 2004; van den Beld et al. 2000).”
Lee, T.-W., Kao, P., Chen, Y., & Wang, S. (2023) · Gerontology · doi:10.1159/000532062 · Cited by 19
Subcellular effects of myocyte-specific androgen receptor overexpression in mice
Musa, M., Fernando, S. M., Chatterjee, D., & Monks, D. A. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0071 · Cited by 19
Cheung, A. S., de Rooy, C., Levinger, I., Rana, K., Clarke, M. V., How, J. M. Y., GARNHAM, A. P., McLean, C., Zajac, J. D., Davey, R. A., et al. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.07.029 · Cited by 19
“The proportion of fibre types and total number of muscle fibres are thought to remain the same [2, 12, 13].”
BackgroundPradhan, D. S., Ma, C., Schlinger, B. A., Soma, K. K., & Ramenofsky, M. (2018) · Journal of Comparative Physiology A · doi:10.1007/s00359-018-1308-7 · Cited by 19
Myostatin negatively regulates the expression of the steroid receptor co‐factor ARA70
Siriett, V., Nicholas, G., Berry, C., Watson, T. J., Hennebry, A., Thomas, M., Ling, N., Sharma, M., & Kambadur, R. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20456 · Cited by 19
“…well documented and include increased type I and II muscle fibre volume, myonuclear number, protein synthesis and satellite cell number, decreased protein degradation, and increased myogenesis and decreased adipogenesis of pluripotent stem cells (for a recent review see Herbst and Bhasin, 2004).”
BackgroundTao, C., Fan, Y., Niu, R., Li, Z., Qian, H., Yu, H., Xu, Q., Xu, Q., & Lu, C. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112215 · Cited by 18
Metadata
- Authors
- Herbst, K. L., & Bhasin, S.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Bhasin, Shalender
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2004-05
- Volume
- 7
- Issue
- 3
- Pages
- 271-277
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W2095240081
- Cited by
- 457
- References
- 46
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 27 · 2023: 38 · 2022: 32 · 2021: 27 · 2020: 22 · 2019: 22 · 2018: 21 · 2017: 22 · 2016: 15 · 2015: 13 · 2014: 12 · 2013: 24 · 2012: 18
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- testosterone, skeletal muscle hypertrophy, androgen action, body composition, lean body mass, fat mass, androgen receptor, mesenchymal differentiation, myogenesis, adipogenesis, satellite cells, myonuclei, motor neurons, dihydrotestosterone, estradiol, aging, sarcopenia, muscle strength, leg power
- MeSH terms
- Aging, Animals, Body Composition, Female, Humans, Male, Testosterone, Muscle, Skeletal, Muscle Development, Pluripotent Stem Cells
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