CoChat
Sign Up
Cited by 125Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

DRD2 Gene Transfer Into the Nucleus Accumbens Core of the Alcohol Preferring and Nonpreferring Rats Attenuates Alcohol Drinking

Thanos, Panayotis K., Taintor, Nicholas B., Rivera, Seth N., Umegaki, Hiroyuki, Ikari, Hiroyuki, Roth, George, Ingram, Donald K., Hitzemann, Robert, Fowler, Joanna S., Gatley, S. John, Wang, Gene‐Jack, Volkow, Nora D.·2004·Alcoholism Clinical and Experimental Research
DOI 10.1097/01.alc.0000125270.30501.08
Open this paper in CoChat — free account

Abstract

BACKGROUND: Transient overexpression of the dopamine D2 receptor (DRD2) gene in the nucleus accumbens (NAc) using an adenoviral vector has been associated with a significant decrease in alcohol intake in Sprague Dawley rats. This overexpression of DRD2 reduced alcohol consumption in a two-bottle-choice paradigm and supported the view that high levels of DRD2 may be protective against alcohol abuse. METHODS: Using a limited access (1 hr) two-bottle-choice (water versus 10% ethanol) drinking paradigm, we examined the effects of the DRD2 vector in alcohol intake in the genetically inbred alcohol-preferring (P) and -nonpreferring (NP) rats. In addition, micro-positron emission tomography imaging was used at the completion of the study to assess in vivo the chronic (7 weeks) effects of ethanol exposure on DRD2 levels between the two groups. RESULTS: P rats that were treated with the DRD2 vector (in the NAc) significantly attenuated their alcohol preference (37% decrease) and intake (48% decrease), and these measures returned to pretreatment levels by day 20. A similar pattern of behavior (attenuation of ethanol drinking) was observed in NP rats. Analysis of the [C]raclopride micro-positron emission tomography data after chronic (7 weeks) exposure to ethanol revealed clear DRD2 binding differences between the P and NP rats. P rats showed 16% lower [C]raclopride specific binding in striatum than the NP rats. CONCLUSIONS: These findings further support our hypothesis that high levels of DRD2 are causally associated with a reduction in alcohol consumption and may serve as a protective factor against alcoholism. That this effect was seen in P rats, which are predisposed to alcohol intake, suggests that they are protective even in those who are genetically predisposed to high alcohol intake. It is noteworthy that increasing DRD2 significantly decreased alcohol intake but did not abolish it, suggesting that high DRD2 levels may specifically interfere with the administration of large quantities of alcohol. The significantly higher DRD2 concentration in NP than P rats after 7 weeks of ethanol therefore could account for low alcohol intake.

Overview

Integrity signals

Registry

Crossref · 10.1097/01.alc.0000125270.30501.08

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 5

  1. Caine SB, 1999, Effects of dopamine D(1‐like) and D(2‐like) agonists in rats that self‐administer cocaine, J Pharmacol Exp Ther, 291, 353
  2. Koob GF, 1987, Positive Reinforcement Properties of Drugs: Search for Neural Substrates, in Brain Reward Systems and Abuse
  3. Samson HH, 1996, Neurobehavioral Regulation of Ethanol In‐take, 203
  4. Thanos P, 2002, 2002 Abstract Viewer/Itinerary Planner
  5. Thanos PK, 2000, Dopamine D2 Receptor upregulation in the nucleus accumbens of the rat after treatment with a D2 adenovirus vector and its effects on alcohol abuse, Alcohol Clin Exp Res, 24, 154.A.A

Cited by

Sorted by citations

See all 125

Related

See all

Metadata

Authors
Thanos, P. K., Taintor, N. B., Rivera, S. N., Umegaki, H., Ikari, H., Roth, G., Ingram, D. K., Hitzemann, R., Fowler, J. S., Gatley, S. J., Wang, G., & Volkow, N. D.
Affiliations
National Institutes of Health (US)
Corresponding author
Thanos, Panayotis K.
ORCID
Venue
Alcoholism Clinical and Experimental Research
Publisher
Wiley
Published
2004-05
Volume
28
Issue
5
Pages
720-728
ISSN
  • 0145-6008 (ISSN-L)
  • 1530-0277
DOI
10.1097/01.alc.0000125270.30501.08
OpenAlex
W2145340134
Cited by
125
References
76
Citations by year
2026: 1 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 10 · 2014: 6 · 2013: 9 · 2012: 7
FWCI
3.05
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 712 d)
Locations
  • Alcoholism Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (AA-07611, R01AA011034, AA 07574, AA11034, T32AA007574)
  • Indiana Alcohol Research Center
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
dopamine D2 receptor, nucleus accumbens, alcohol preference, alcohol consumption, alcohol-preferring rats, alcohol-nonpreferring rats, adenoviral vector, genetic predisposition to alcoholism, chronic ethanol exposure, striatum, alcoholism prevention
MeSH terms
Alcohol Drinking, Ethanol, Animals, Male, Nucleus Accumbens, Self Administration, Species Specificity, Rats, Sprague-Dawley, Receptors, Dopamine D2, Gene Transfer Techniques, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review