Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats
Abstract
The densities of dopamine D2 recognition sites labelled with [3H]sulpiride were determined in the caudate-putamen, nucleus accumbens (medial and lateral portions), olfactory tubercle, substantia nigra (pars reticulata and pars compacta), and ventral tegmental area (VTA) of alcohol-naive, selectively bred P (N = 7) and NP (N = 7) rats using quantitative autoradiography. The binding of [3H]sulpiride was 20-25% lower (P < 0.05) in the caudate-putamen, medial and lateral nucleus accumbens, and VTA of the P compared with the NP rats. No significant differences were observed between the P and NP rats in the olfactory tubercle or substantia nigra. [3H]Sulpiride binding, using standard membrane preparations, established with Scatchard analysis that the difference in the densities of D2 recognition sites in the caudate-putamen between the P and NP rats was due to lower Bmax values for the P line. The results indicate that the number of dopamine D2 receptor sites is lower in several central nervous system regions of the P rats compared to NP rats.
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Animals with low D2 receptor levels in the striatum before drug or alcohol exposure subsequently display greater cocaine or alcohol self-administration.
“Strikingly, animals with low D2 receptor levels in the striatum prior to drug or alcohol exposure subsequently display greater cocaine or alcohol self-administration (Czoty et al., 2004; Dalley et al., 2007; McBride et al., 1993; Morgan et al., 2002; Nader et al., 2006; Stefanini et al., 1992).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as McBride et al., 1993
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Allelic Association of Human Dopamine D2 Receptor Gene in Alcoholism
Blum, K. (1990) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1990.03440150063027 · Cited by 1,055 · see citing works
Impérato, A., & Chiara, G. D. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23929-5 · Cited by 858 · see citing works
Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area
Gessa, G. L., Francesco Muntoni, A., Collu, M., Vargiu, L., & Mereu, G. (1985) · Brain Research · doi:10.1016/0006-8993(85)90381-6 · Cited by 770 · see citing works
Noble, E. P. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310066012 · Cited by 655 · see citing works
Rossetti, Z. L., Hmaidan, Y., & GESSA, G. L. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90706-a · Cited by 526 · see citing works
Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90134-1 · Cited by 280 · see citing works
Self-citationBolos, A. M. (1990) · JAMA · doi:10.1001/jama.1990.03450240058040 · Cited by 272 · see citing works
Wolf, M. E., White, F. J., Nassar, R., Brooderson, R. J., & Khansa, M. R. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10260-7 · Cited by 258 · see citing works
Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats
Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90026-0 · Cited by 257 · see citing works
Self-citationAlcoholism and Alleles of the Human D2 Dopamine Receptor Locus
Parsian, A. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310073013 · Cited by 248 · see citing works
NEW STRAINS OF RATS WITH ALCOHOL PREFERENCE AND NONPREFERENCE
Lumeng, L., Hawkins, T., & Li, T.-K. (1977) · Elsevier eBooks · doi:10.1016/b978-0-12-691403-0.50056-2 · Cited by 240 · see citing works
Self-citationAssociation of the A1 allele of the D2 dopamine receptor gene with severe alcoholism
Blum, K., Noble, E. P., Sheridan, P. J., Finley, O., Montgomery, A., Ritchie, T., Ozkaragoz, T., Fitch, R. J., Sadlack, F., Sheffield, D., et al. (1991) · Alcohol · doi:10.1016/0741-8329(91)90693-q · Cited by 213 · see citing works
Allelic association of human dopamine D2 receptor gene in alcoholism
Blum, K. (1990) · JAMA · doi:10.1001/jama.263.15.2055 · Cited by 181 · see citing works
Samson, H. H., Hodge, C. W., Tolliver, G. A., & Haraguchi, M. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90049-h · Cited by 176 · see citing works
Seeman, P. M., Ulpian, C., WREGGETT, K. A., & Wells, J. W. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb06700.x · Cited by 169 · see citing works
Effect of spontaneous ingestion of ethanol on brain dopamine metabolism
Fadda, F., Mosca, E., Colombo, G., & Gessa, G. L. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90186-0 · Cited by 156 · see citing works
Neurochemical Correlates of Cocaine and Ethanol Self‐Administrationa
Weiss, F., Hurd, Y. L., Ungerstedt, U., Markou, A., Plotsky, P. M., & Koob, G. F. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25970.x · Cited by 151 · see citing works
RAPID COMMUNICATION: ALCOHOL-PREFERRING RATS HAVE FEWER DOPAMINE D2 RECEPTORS IN THE LIMBIC SYSTEM
Stefanini, E., FRAU, M., GARAU, M. G., GARAU, B., Fadda, F., & GESSA, G. L. (1992) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045210 · Cited by 105 · see citing works
CNS mechanisms of alcohol self-administration.
McBride, W. J., Murphy, J. M., Gj, G., Ad, L., Yoshimoto, K., Lumeng, L., & Li, T. (1993) · PubMed · Cited by 97 · see citing works
Self-citationAlcoholism and the D2 Receptor Gene
Cook, B. L., Wang, Z. W., Crowe, R., Hauser, R. L., & Freimer, M. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb00683.x · Cited by 93 · see citing works
Serotonin and dopamine systems regulating alcohol intake.
McBride, W. J., Murphy, J. M., Gatto, G. J., Levy, A. D., Lumeng, L., & Li, T. (1991) · PubMed · Cited by 74 · see citing works
Self-citationLocalization of nigrostriatal dopamine receptor subtypes and adenylate cyclase
Filloux, F. M., Dawson, T. M., & Wamsley, J. K. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90134-7 · Cited by 73 · see citing works
Ad, L., Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T. (1991) · PubMed · Cited by 71 · see citing works
Self-citationRommelspacher, H., Raeder, C., Kaulen, P., & Brüning, G. (1992) · Alcohol · doi:10.1016/0741-8329(92)90032-6 · Cited by 67 · see citing works
Ariano, M. A., Monsma, F. J., Barton, A. C., Kang, H., Haugland, R. P., & Sibley, D. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.21.8570 · Cited by 54 · see citing works
Biochemical evidence for activation of specific monoanine pathways by ethanol
Khatib, S. A., Murphy, J. M., & McBride, W. J. (1988) · Alcohol · doi:10.1016/0741-8329(88)90068-7 · Cited by 53 · see citing works
Self-citationMorelli, M., Mennini, T., & Chiara, G. D. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90189-3 · Cited by 46 · see citing works
Bolos, A. M. (1990) · JAMA · doi:10.1001/jama.264.24.3156 · Cited by 42 · see citing works
Harrison, M. B., Wiley, R. G., & Wooten, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91567-x · Cited by 16 · see citing works
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Blum, K., Braverman, E. R., Holder, J. M., Lubar, J. F., Monastra, V. J., Miller, D., Lubar, J. O., Chen, T. J. H., & Comings, D. E. (2000) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2000.10736099 · Cited by 977 · see citing works
D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes
Noble, E. P. (2003) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10005 · Cited by 501 · see citing works
Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum
Martinez, D., Gil, R., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Kegeles, L., Talbot, P., Evans, S., Krystal, J., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.044 · Cited by 445 · see citing works
The D <sub>2</sub> Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome
Blum, K., Sheridan, P. J., Wood, R. C., Braverman, E. R., Chen, T. J. H., phd, J. G. C., & Comings, D. E. (1996) · Journal of the Royal Society of Medicine · doi:10.1177/014107689608900711 · Cited by 443 · see citing works
Goodman, A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.030 · Cited by 412 · see citing works
Genetics of dopamine receptors and drug addiction: a comprehensive review
Foll, B. L., Gallo, A., Strat, Y. L., Lü, L., & Gorwood, P. A. P. M. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283242f05 · Cited by 387 · see citing works
Guerri, C., & Pascual, M. (2010) · Alcohol · doi:10.1016/j.alcohol.2009.10.003 · Cited by 344 · see citing works
Murphy, J. M., Stewart, R. B., Bell, R. L., Badia‐Elder, N. E., Carr, L. G., McBride, W. J., Lumeng, L., & Li, T. (2002) · Behavior Genetics · doi:10.1023/a:1020266306135 · Cited by 325 · see citing works
Self-citationOverexpression of dopamine D2 receptors reduces alcohol self‐administration
Thanos, P. K., Volkow, N. D., Freimuth, P., Umegaki, H., Ikari, H., Roth, G., Ingram, D. K., & Hitzemann, R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00492.x · Cited by 324 · see citing works
Pascual, M., Boix, J., Felipo, V., & Guerri, C. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05835.x · Cited by 319 · see citing works
REVIEW: The alcohol‐preferring P rat and animal models of excessive alcohol drinking
Bell, R. L., Rodd, Z. A., Lumeng, L., Murphy, J. M., & McBride, W. J. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2005.00029.x · Cited by 307 · see citing works
Self-citationAlcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors
Phillips, T. J., Brown, K. J., Burkhart‐Kasch, S., Wenger, C. D., Kelly, M. A., Rubinstein, M., Grandy, D. K., & Low, M. J. (1998) · Nature Neuroscience · doi:10.1038/2843 · Cited by 272 · see citing works
Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism
Nevo, I. (1995) · Neurochemistry International · doi:10.1016/0197-0186(94)00139-l · Cited by 260 · see citing works
Ethanol self-infusion into the ventral tegmental area by alcohol-preferring rats
Gatto, G. J., McBride, W. J., Murphy, J. M., Lumeng, L., & Li, T. (1994) · Alcohol · doi:10.1016/0741-8329(94)90083-3 · Cited by 261 · see citing works
Self-citationMolecular and behavioral aspects of the actions of alcohol on the adult and developing brain
Alfonso-Loeches, S., & Guerri, C. (2011) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2011.580567 · Cited by 254 · see citing works
Attention-deficit-hyperactivity disorder and reward deficiency syndrome
Oscar Berman, M., Blum, K., Chen, T. J., Braverman, E., Waite, R., Downs, W., Arcuri, V., Notaro, A., Palomo, T., & Comings (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s2627 · Cited by 248 · see citing works
“Thus, Li and colleagues (Russell et al 1988; Zhou et al 1991; McBride et al 1993, 1994; Li et al 2006) developed strains of alcohol-preferring (P) and non-preferring (NP) rat lines.”
BackgroundUrban, N. B. L., Kegeles, L. S., Slifstein, M., Xu, X., Martinez, D., Sakr, E., Castillo, F., Moadel, T., O'Malley, S. S., Krystal, J. H., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.005 · Cited by 223 · see citing works
Dopamine and alcoholism: neurobiological basis of ethanol abuse.
Tupala, E., & Tiihonen, J. (2004) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.06.022 · Cited by 209 · see citing works
Flupenthixol as a potential pharmacotreatment of alcohol and cocaine abuse/dependence
Soyka, M., & Vry, J. D. (2000) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(00)00088-2 · Cited by 187 · see citing works
Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study
Volkow, N. D., Wang, G., Maynard, L. J., Fowler, J. S., Jayne, B., Telang, F., Logan, J., Ding, Y., Gatley, S. J., HITZEMANN, R. J., et al. (2002) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(02)00087-2 · Cited by 185 · see citing works
Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele
Lawford, B. R., Young, R. M., Rowell, J., Qualichefski, J., Fletcher, B. H., Syndulko, K., Ritchie, T. L., & Noble, E. P. (1995) · Nature Medicine · doi:10.1038/nm0495-337 · Cited by 176 · see citing works
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171 · see citing works
Huang, S., Lin, W., Ko, H., Lee, J., Wang, T., Chou, Y. H., Yin, S., & Lu, R. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000117832.62901.61 · Cited by 155 · see citing works
Attenuation of alcohol intake by Ibogaine in three strains of alcohol-preferring rats
Rezvani, A. H., Overstreet, D. H., & Leef, Y.-W. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00152-m · Cited by 139 · see citing works
Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders
Maria-Rios, C. E., & Morrow, J. D. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00006 · Cited by 141 · see citing works
What We Have Learned about Addiction from Animal Models of Drug Self‐Administration
Gardner, E. L. (2000) · American Journal on Addictions · doi:10.1080/105504900750047355 · Cited by 130 · see citing works
Handbook of Motivational Counseling
(2003) · Wiley eBooks · doi:10.1002/9780470713129 · Cited by 135 · see citing works
ESBRA-NORDMANN 1996 AWARD LECTURE: ETHANOL DRINKING BEHAVIOUR IN SARDINIAN ALCOHOL-PREFERRING RATS
Colombo, G. (1997) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008279 · Cited by 129 · see citing works
Thanos, P. K., Taintor, N. B., Rivera, S. N., Umegaki, H., Ikari, H., Roth, G., Ingram, D. K., Hitzemann, R., Fowler, J. S., Gatley, S. J., et al. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000125270.30501.08 · Cited by 125 · see citing works
The role of opioid-dopamine interactions in the induction and maintenance of ethanol consumption
Cowen, M. S., & Lawrence, A. J. (1999) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00060-3 · Cited by 121 · see citing works
Bell, R. L., Sable, H. J. K., Colombo, G., Hyytiä, P., Rodd, Z. A., & Lumeng, L. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.07.007 · Cited by 119 · see citing works
Self-citationKimpel, M. W., Strother, W. N., McClintick, J. N., Carr, L. G., Liang, T., Edenberg, H. J., & McBride, W. J. (2007) · Alcohol · doi:10.1016/j.alcohol.2007.03.003 · Cited by 117 · see citing works
Self-citationLack of operant ethanol self-administration in dopamine D2 receptor knockout mice
Risinger, F. O., Freeman, P. A., Rubinstein, M., Low, M. J., & Grandy, D. K. (2000) · Psychopharmacology · doi:10.1007/s002130000548 · Cited by 116 · see citing works
Flupenthixol decanoate and relapse prevention in alcoholics: results from a placebo-controlled study
Wiesbeck, G. A. (2001) · Alcohol and Alcoholism · doi:10.1093/alcalc/36.4.329 · Cited by 110 · see citing works
Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking
Thanos, P. K., Rivera, S. N., Weaver, K., Grandy, D. K., Rubinstein, M., Umegaki, H., Wang, G. J., Hitzemann, R., & Volkow, N. D. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.10.061 · Cited by 108 · see citing works
Acute effects of Naltrexone and GBR 12909 on ethanol drinking-in-the-dark in C57BL/6J mice
Kamdar, N., Miller, S. A., Syed, Y. M., Bhayana, R., Gupta, T., & Rhodes, J. S. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0711-5 · Cited by 108 · see citing works
Smith, A. D., & Weiss, F. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38077-2 · Cited by 106 · see citing works
Effects of Raclopride in the Nucleus Accumbens on Ethanol Seeking and Consumption
Czachowski, C. L., Chappell, A. M., & Samson, H. H. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02144.x · Cited by 102 · see citing works
Mesolimbic dopamine system in alcohol-preferring rats
Zhou, F. C., Zhang, J. K., Lumeng, L., & Li, T. (1995) · Alcohol · doi:10.1016/0741-8329(95)00010-o · Cited by 102 · see citing works
Self-citationTupala, E., Hall, H., Bergström, K., Särkioja, T., Räsänen, P. K., Mantere, T., Callaway, J. C., Hiltunen, J. O., & Tiihonen, J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000859 · Cited by 96 · see citing works
Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines
Bice, P. J., Foroud, T., Bo, R., & Castelluccio, P. (1998) · Mammalian Genome · doi:10.1007/s003359900905 · Cited by 94 · see citing works
Evidence for incentive salience sensitization as a pathway to alcohol use disorder
Cofresí, R. U., Bartholow, B. D., & Piasecki, T. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.009 · Cited by 90 · see citing works
Katner, S. N., & Weiss, F. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02199.x · Cited by 85 · see citing works
Barker, J. M., & Taylor, J. R. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.09.027 · Cited by 84 · see citing works
A Possible Mechanism Underlying the Effectiveness of Acupuncture in the Treatment of Drug Addiction
Yang, C. H., Lee, B. H., & Sohn, S. H. (2007) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nem081 · Cited by 81 · see citing works
Alcoholism and the dopaminergic system: a review
Noble, E. P. (1996) · Addiction Biology · doi:10.1080/1355621961000124956 · Cited by 76 · see citing works
Yokoi, F., Dang, M. T., Li, J., Standaert, D. G., & Li, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024539 · Cited by 74 · see citing works
Pharmacogenetic Treatments for Drug Addiction: Cocaine, Amphetamine and Methamphetamine
Haile, C. N., Kosten, T. R., & Kosten, T. A. (2009) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990902825447 · Cited by 73 · see citing works
Sangrajrang, S., Sato, Y., Sakamoto, H., Ohnami, S., Khuhaprema, T., & Yoshida, T. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0804-4 · Cited by 72 · see citing works
Huang, S., Lin, W.-W., Wan, F.-J., Chang, A.-J., Ko, H., Wang, T.-J., Wu, P., & Lu, R. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0718 · Cited by 68 · see citing works
Gilman, S., Koeppe, R. A., Adams, K. M., Junck, L., Kluin, K. J., Johnson‐Greene, D., Martorello, S., Heumann, M., & Bandekar, R. (1998) · Annals of Neurology · doi:10.1002/ana.410440307 · Cited by 67 · see citing works
Hall, F. S., Sora, I., & Uhl, G. R. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300070 · Cited by 62 · see citing works
Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior.
Trifilieff, P., Ducrocq, F., van der Veldt, S., & Martinez, D. (2017) · Seminars in nuclear medicine · doi:10.1053/j.semnuclmed.2016.09.003 · Cited by 47 · see citing works
Nowak, K., McBride, W. J., Lumeng, L., Li, T., & Murphy, J. M. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200004000-00021 · Cited by 56 · see citing works
Self-citationKohno, M., Dennis, L. E., McCready, H. D., & Hoffman, W. F. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00182 · Cited by 53 · see citing works
McBride, W. J., Chernet, E., Russell, R., Wong, D. T., Guan, X.-M., Lumeng, L., & Li, T. (1997) · Alcohol · doi:10.1016/s0741-8329(96)00117-6 · Cited by 52 · see citing works
Self-citationThe dopamine system and alcohol dependence.
Ma, H., & Zhu, G. (2014) · PubMed Central · doi:10.3969/j.issn.1002-0829.2014.02.002 · Cited by 51 · see citing works
Decreased Ethanol Preference and Consumption in Dopamine Transporter Female Knock-Out Mice
Savelieva, K. V., Caudle, W. M., Findlay, G. S., Caron, M. G., & Miller, G. W. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02602.x · Cited by 50 · see citing works
Gallo, E. F., Salling, M. C., Feng, B., Morón, J. A., Harrison, N. L., Javitch, J. A., & Kellendonk, C. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.11 · Cited by 48 · see citing works
Imaging the Neurochemistry of Alcohol and Substance Abuse
Martínez, D., Kim, J., Krystal, J. H., & Abi‐Dargham, A. (2007) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2007.07.004 · Cited by 49 · see citing works
Toward a definition of a valid model of alcoholism: Multiple animal models for multiple diseases
McMillen, B. A. (1997) · Alcohol · doi:10.1016/s0741-8329(97)90012-4 · Cited by 49 · see citing works
Adolescent Alcohol Drinking and Its Long-Range Consequences
McBride, W. J., Bell, R. L., Rodd, Z. A., Strother, W. N., & Murphy, J. M. (2005) · Kluwer Academic Publishers-Plenum Publishers eBooks · doi:10.1007/0-306-48626-1_6 · Cited by 48 · see citing works
Self-citationApomorphine and 7-OH DPAT reduce ethanol intake of P and HAD rats
Russell, R., McBride, W. J., Lumeng, L., Li, T., & Murphy, J. M. (1996) · Alcohol · doi:10.1016/0741-8329(95)00062-3 · Cited by 47 · see citing works
Self-citationEffects of Caffeine on Alcohol Consumption and Nicotine Self-Administration in Rats
Rezvani, A. H., Sexton, H. G., Johnson, J. E., Wells, C., Gordon, K., & Levin, E. D. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12127 · Cited by 46 · see citing works
Striatal dopamine release and family history of alcoholism.
Munro, C. A., Mccaul, M., Oswald, L., Wong, D., Zhou, Y., Brašić, J. R., Kuwabara, H., Kumar, A., Alexander, M., Ye, W., et al. (2006) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00130.x · Cited by 44 · see citing works
Engleman, E. A., McBride, W. J., Wilber, A. A., Shaikh, S. R., Eha, R. D., Lumeng, L., Li, T., & Murphy, J. M. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200006000-00008 · Cited by 46 · see citing works
Self-citationA Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction
Bell, R. L., Hauser, S. R., Rodd, Z. A., Liang, T., Sari, Y., McClintick, J. N., Rahman, S., & Engleman, E. A. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.02.017 · Cited by 45 · see citing works
Tupala, E., Hall, H., Bergström, K., Mantere, T., Räsänen, P. K., Särkioja, T., & Tiihonen, J. (2003) · Human Brain Mapping · doi:10.1002/hbm.10129 · Cited by 45 · see citing works
Chronic mild stress increases alcohol intake in mice with low dopamine D2 receptor levels.
Delis, F., Thanos, P. K., Rombola, C., Rosko, L. M., Grandy, D. K., Wang, G., & Volkow, N. D. (2012) · Behavioral Neuroscience · doi:10.1037/a0030750 · Cited by 44 · see citing works
Witzmann, F. A., Li, J., Strother, W. N., McBride, W. J., Hunter, L., Crabb, D. W., Lumeng, L., & Li, T. (2003) · PROTEOMICS · doi:10.1002/pmic.200300453 · Cited by 44 · see citing works
Self-citationMyers, R. D., & Robinson, D. E. (1999) · Alcohol · doi:10.1016/s0741-8329(99)00015-4 · Cited by 43 · see citing works
Liu, W., Thielen, R. J., Rodd, Z. A., & McBride, W. J. (2006) · Alcohol · doi:10.1016/j.alcohol.2007.01.001 · Cited by 43 · see citing works
Self-citationPre-clinical models of reward deficiency syndrome: A behavioral octopus
Gondré‐Lewis, M. C., Bassey, R. B., & Blum, K. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.021 · Cited by 42 · see citing works
Tupala, E., Hall, H., Mantere, T., Räsänen, P. K., Särkioja, T., & Tiihonen, J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00060-0 · Cited by 40 · see citing works
Schmidt, L., Kühn, S., Smolka, M. N., Schmidt, K., & Rommelspacher, H. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00214-7 · Cited by 38 · see citing works
Increased consumption of ethanol and sugar water in mice lacking the dopamine D2 long receptor
Bulwa, Z. B., Sharlin, J. A., Clark, P., Bhattacharya, T. K., Kilby, C. N., Wang, Y., & Rhodes, J. S. (2011) · Alcohol · doi:10.1016/j.alcohol.2011.06.004 · Cited by 37 · see citing works
McBride, W. J., Chernet, E., Russell, R., Chamberlain, J. K., Lumeng, L., & Li, T. (1997) · Alcohol · doi:10.1016/s0741-8329(97)00072-4 · Cited by 37 · see citing works
Self-citationThe Posterior Ventral Tegmental Area Mediates Alcohol-Seeking Behavior in Alcohol-Preferring Rats
Hauser, S. R., Ding, Z., Getachew, B., Toalston, J. E., Oster, S. M., McBride, W. J., & Rodd, Z. A. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.168260 · Cited by 36 · see citing works
Self-citationGehle, V. M., & Erwin, V. G. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03666.x · Cited by 36 · see citing works
Swagell, C. D., Lawford, B. R., Hughes, I. P., Voisey, J., Feeney, G. F. X., van Daal, A., Connor, J. P., Noble, E. P., Morris, C. P., & Young, R. M. (2012) · Alcohol and Alcoholism · doi:10.1093/alcalc/ags047 · Cited by 35 · see citing works
Disentangling the diverse roles of dopamine D2 receptors in striatal function and behavior
Gallo, E. F. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.01.022 · Cited by 34 · see citing works
Drd2 expression in the high alcohol-preferring and low alcohol-preferring mice
Bice, P. J., Liang, T., Zhang, L., Strother, W. N., & Carr, L. G. (2008) · Mammalian Genome · doi:10.1007/s00335-007-9089-2 · Cited by 34 · see citing works
Strother, W. N., Lumeng, L., Li, T., & McBride, W. J. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.11.003 · Cited by 33 · see citing works
Self-citationSyvälahti, E. K. G., Pohjalainen, T., Korpi, E. R., Pälvimäki, E.-P., Ovaska, T., Kuoppamäki, M., & Hietala, J. A. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb00078.x · Cited by 33 · see citing works
Thanos, P. K., Gopez, V., Delis, F., Michaelides, M., Grandy, D. K., Wang, G., Kunos, G., & Volkow, N. D. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01318.x · Cited by 31 · see citing works
Oberlin, B. G., Albrecht, D., Herring, C. M., Walters, J. W., Hile, K., Kareken, D., & Yoder, K. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3850-5 · Cited by 33 · see citing works
Rat strain differences in brain structure and neurochemistry in response to binge alcohol
Zahr, N. M., Mayer, D., Torsten Rohlfing, B., Hsu, O., Vinco, S., Orduna, J. M., Luong, R. H., Bell, R. L., Sullivan, E. V., & Pfefferbaum, A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3253-z · Cited by 30 · see citing works
Effects of ethanol on startle responding in alcohol-preferring and -non-preferring rats
Jones, A. E., McBride, W. J., Murphy, J. M., Lumeng, L., Tk, L., Shekhar, A., & McKinzie, D. L. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00363-4 · Cited by 30 · see citing works
Self-citationSolanki, N., Abijo, T., Galvao, C., Darius, P. J., Blum, K., & Gondré‐Lewis, M. C. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112563 · Cited by 29 · see citing works
Engleman, E. A., McBride, W. J., Li, T., Lumeng, L., & Murphy, J. M. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000056618.57931.a5 · Cited by 29 · see citing works
Self-citationVTA Dopamine Neuron Activity Distinguishes Alcohol-Preferring (P) Rats from Wistar Rats
Morzorati, S. L. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-199806000-00013 · Cited by 29 · see citing works
Pucci, M., Bonaventura, M. V. M. D., Wille‐Bille, A., Fernández, M. S., Maccarrone, M., Pautassi, R. M., Cifani, C., & D’Addario, C. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.004 · Cited by 24 · see citing works
Tattoli, M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00225-6 · Cited by 25 · see citing works
Bell, R. L., Rodd, Z. A., Hsu, C. C., Lumeng, L., Murphy, J. M., & McBride, W. J. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00069-8 · Cited by 24 · see citing works
Self-citationImmune Disturbances in Treatment-Resistant Depression: Modulation by Antidepressive Treatments
Maes, M. H. J., Vandoolaeghe, E., Hunsel, F. V., Bril, T., Demedts, P., Wauters, A., & Neels, H. M. (1997) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/(sici)1099-1077(199703/04)12:2 · Cited by 19 · see citing works
Reduced TH-immunoreactive fibers in the limbic system of Sardinian alcohol-preferring rats
Casu, M. A., Colombo, G., Gessa, G. L., & Pani, L. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03296-6 · Cited by 23 · see citing works
Smith, D. G., Learn, J. E., McBride, W. J., Lumeng, L., Li, T., & Murphy, J. M. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02352.x · Cited by 23 · see citing works
Self-citationFranklin, K. M., Engleman, E. A., Ingraham, C. M., McClaren, J. A., Keith, C. M., McBride, W. J., & Murphy, J. M. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01009.x · Cited by 22 · see citing works
Self-citationMorzorati, S. L., & Marunde, R. L. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00113.x · Cited by 22 · see citing works
Alvanzo, A., Wand, G., Kuwabara, H., Wong, D. F., Xu, X., & Mccaul, M. (2015) · Addiction Biology · doi:10.1111/adb.12300 · Cited by 20 · see citing works
- Authors
- McBride, W. J., Chernet, E., Dyr, W., Lumeng, L., & Li, T.-K.
- Affiliations
- Richard L. Roudebush VA Medical Center (US)
- Corresponding author
- McBride, W.J.
- ORCID
- Venue
- Alcohol
- Publisher
- Elsevier BV
- Published
- 1993-09
- Volume
- 10
- Issue
- 5
- Pages
- 387-390
- ISSN
- 0741-8329 (ISSN-L)
- OpenAlex
- W2062725718
- Cited by
- 160
- References
- 30
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 6
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcohol (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01aa008553-03)
- National Institute on Alcohol Abuse and Alcoholism (AA-07611, AA-07462, AA 08553, T32AA007462)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- dopamine D2 receptor, receptor density, alcohol-preferring rats, caudate-putamen, nucleus accumbens, olfactory tubercle, substantia nigra, ventral tegmental area, alcohol preference
- MeSH terms
- Alcohol Drinking, Animals, Brain, Male, Nucleus Accumbens, Olfactory Pathways, Rats, Inbred Strains, Substantia Nigra, Sulpiride, Tegmentum Mesencephali, Rats, Wistar, Receptors, Dopamine D2, Rats
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