Cited by 160Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats

McBride, W.J., Chernet, E., Dyr, W., Lumeng, L., Li, T.-K.·1993·Alcohol

Abstract

The densities of dopamine D2 recognition sites labelled with [3H]sulpiride were determined in the caudate-putamen, nucleus accumbens (medial and lateral portions), olfactory tubercle, substantia nigra (pars reticulata and pars compacta), and ventral tegmental area (VTA) of alcohol-naive, selectively bred P (N = 7) and NP (N = 7) rats using quantitative autoradiography. The binding of [3H]sulpiride was 20-25% lower (P < 0.05) in the caudate-putamen, medial and lateral nucleus accumbens, and VTA of the P compared with the NP rats. No significant differences were observed between the P and NP rats in the olfactory tubercle or substantia nigra. [3H]Sulpiride binding, using standard membrane preparations, established with Scatchard analysis that the difference in the densities of D2 recognition sites in the caudate-putamen between the P and NP rats was due to lower Bmax values for the P line. The results indicate that the number of dopamine D2 receptor sites is lower in several central nervous system regions of the P rats compared to NP rats.

Integrity signals

Registry

Crossref · 10.1016/0741-8329(93)90025-j

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Animals with low D2 receptor levels in the striatum before drug or alcohol exposure subsequently display greater cocaine or alcohol self-administration.

    “Strikingly, animals with low D2 receptor levels in the striatum prior to drug or alcohol exposure subsequently display greater cocaine or alcohol self-administration (Czoty et al., 2004; Dalley et al., 2007; McBride et al., 1993; Morgan et al., 2002; Nader et al., 2006; Stefanini et al., 1992).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
McBride, W. J., Chernet, E., Dyr, W., Lumeng, L., & Li, T.-K.
Affiliations
Richard L. Roudebush VA Medical Center (US)
Corresponding author
McBride, W.J.
Venue
Alcohol
Publisher
Elsevier BV
Published
1993-09
Volume
10
Issue
5
Pages
387-390
ISSN
0741-8329 (ISSN-L)
OpenAlex
W2062725718
Cited by
160
References
30
Citations by year
2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 6
FWCI
1.45
Type
journal article
Language
en
Open access
closed
Locations
  • Alcohol (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01aa008553-03)
  • National Institute on Alcohol Abuse and Alcoholism (AA-07611, AA-07462, AA 08553, T32AA007462)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
dopamine D2 receptor, receptor density, alcohol-preferring rats, caudate-putamen, nucleus accumbens, olfactory tubercle, substantia nigra, ventral tegmental area, alcohol preference
MeSH terms
Alcohol Drinking, Animals, Brain, Male, Nucleus Accumbens, Olfactory Pathways, Rats, Inbred Strains, Substantia Nigra, Sulpiride, Tegmentum Mesencephali, Rats, Wistar, Receptors, Dopamine D2, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review