The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Increased Anxiety‐Like Behavior and Ethanol Self‐Administration in Dependent Rats: Reversal via Corticotropin‐Releasing Factor‐2 Receptor Activation
Abstract
Background: Corticotropin‐releasing factor (CRF) has been hypothesized to be one of the main regulators of the stress response observed during alcohol withdrawal. The CRF receptor subtypes seem to have a differential role in the regulation of stress‐related behavior. Given the behavioral characterization of these receptors, the objective of the following experiments was to characterize the role of CRF 2 receptors in the interaction between alcohol and stress by examining the effects of CRF 2 receptor activation in the behavioral stress response and ethanol self‐administration during early ethanol withdrawal in dependent rats. Methods: Male Wistar rats were made dependent on ethanol via chronic exposure to an ethanol containing liquid diet. Behavior in the elevated plus maze and ethanol self‐administration were measured at 2 hr after removal of the diet. The role of the CRF 2 receptor in the regulation of these behaviors during the early stages of withdrawal was examined via central injection of the highly selective CRF 2 receptor agonist urocortin 3. Results: Rats showed decreased exploration of the open arms of the elevated plus maze, an indication of a heightened behavioral stress response, after chronic ethanol exposure. This effect was attenuated by central injection of urocortin 3. In addition, urocortin 3 injections reversed the increase in ethanol self‐administration observed during early withdrawal in dependent rats. Conclusions: Reversal of the increased stress‐related behavior in the elevated plus maze observed after injections of urocortin 3 indicates that the decreased responding for ethanol also seen after urocortin 3 administration is likely due to a diminished anxiety‐like state. These data suggest that activation of the CRF 2 receptor may provide a novel target in the attenuation of the stress response characteristic of the early stages of ethanol withdrawal.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Nonselective CRF antagonists, as well as CRF-R1 antagonists, selectively block excessive consumption of several drugs of abuse in dependent rats, but not in non-dependent rats (Valdez et al 2004; Funk et al 2006; Funk et al 2007).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Valdez et al 2004
In the citing paper
“However, a CRF-R2 agonist also blocked excessive alcohol consumption in dependent rats, suggesting opposite roles for these two receptors (Valdez et al 2004).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Valdez et al 2004
In the citing paper
“CRF-R1 activation mediates many of these stress effects in rats, while CRF-R2 activation is alternately the same as CRF-R1, opposing CRF-R1, or ineffective in modulating stress, depending on the assay and the brain region (Ho et al 2001; Takahashi et al 2001; Valdez et al 2004; Zhao et al 2007; for a review see Heinrichs and Koob, 2004).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Valdez et al 2004
Citations
Cites
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
A stereotaxic atlas of the rat brain
Pellegrino, L. J., & Cushman, A. J. (1967) · Plenum Press eBooks · Cited by 4,688
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
Guide for the care and use of laboratory animals
(1997) · Choice Reviews Online · doi:10.5860/choice.34-3310 · Cited by 2,930
A stereotaxic atlas of the rat brain
Brodal, P. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90013-5 · Cited by 2,793
Neurogenetic Adaptive Mechanisms in Alcoholism
Cloninger, C. R. (1987) · Science · doi:10.1126/science.2882604 · Cited by 2,203
Kessler, R. C. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830160031005 · Cited by 2,085
Vaughan, J. M., Donaldson, C. J., Bittencourt, J. C., Perrin, M. H., Lewis, K., Sutton, S. W., Chan, R. K. W., Turnbull, A. V., Lovejoy, D. A., RIVIER, C. L., et al. (1995) · Nature · doi:10.1038/378287a0 · Cited by 1,479
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352
Chalmers, D., Lovenberg, T. W., & Souza, E. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06340.1995 · Cited by 925
Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J. M. H. M., Stalla, G. K., Blanquet, V., Steckler, T., Holsboer, F., & Wurst, W. (1998) · Nature Genetics · doi:10.1038/520 · Cited by 919
Smith, G. W., Aubry, J.-M., Dellu, F., Contarino, A., Bilezikjian, L. M., Gold, L. H., Chen, R., Marchuk, Y., Hauser, C., Bentley, C. A., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80491-2 · Cited by 892
Self-citationReyes, T. M., Lewis, K., Perrin, M. H., Kunitake, K. S., Vaughan, J., Arias, C. A., Hogenesch, J. B., Gulyas, J., Rivier, J., Vale, W. W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051626398 · Cited by 887
Bale, T. L., Contarino, A., Smith, G. W., Chan, R. K. W., Gold, L. H., Sawchenko, P. E., Koob, G. F., Vale, W. W., & Lee, K. (2000) · Nature Genetics · doi:10.1038/74263 · Cited by 850
Self-citationLovenberg, T. W., Liaw, C. W., Grigoriadis, D. E., Clevenger, W., Chalmers, D. T., Souza, E. B. D., & Oltersdorf, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.836 · Cited by 846
Ethopharmacological analysis of rat behavior on the elevated plus-maze
Cruz, A. P. D. M., Frei, F., & Graeff, F. G. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90472-3 · Cited by 822
Alcoholism: Allostasis and Beyond
Koob, G. F. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000057122.36127.c2 · Cited by 747
Self-citationSamson, H. H. (1986) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1986.tb05120.x · Cited by 670
Pich, E., Lorang, M., Yeganeh, M., Rodriguez de Fonseca, F., Raber, J., Koob, G., & Weiss, F. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05439.1995 · Cited by 565
Self-citationAppetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide
Spina, M. G., Merlo‐Pich, E., Chan, R. K. W., Basso, A. M., Rivier, J., Vale, W., & Koob, G. F. (1996) · Science · doi:10.1126/science.273.5281.1561 · Cited by 564
Self-citationIntraventricular corticotropin-releasing factor enhances behavioral effects of novelty
Britton, D. R., Koob, G. F., Rivier, J., & Vale, M. L. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90416-7 · Cited by 534
Self-citationDeletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
Kishimoto, T., Radulović, J., Radulović, M., Lin, C. R., Schrick, C., Hooshmand, F., Hermanson, O., Rosenfeld, M. G., & Spiess, J. (2000) · Nature Genetics · doi:10.1038/74271 · Cited by 502
Kindling as a Model for Alcohol Withdrawal Syndromes
Ballenger, J. C., & Post, R. M. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.1.1 · Cited by 463
Changes in depression among abstinent alcoholics
Brown, S. A., & Schuckit, M. A. (1988) · Journal of Studies on Alcohol · doi:10.15288/jsa.1988.49.412 · Cited by 412
Rassnick, S., Heinrichs, S. C., Britton, K. T., & Koob, G. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)91352-s · Cited by 407
Self-citationRadulovic, J., Rühmann, A., Liepold, T., & Spiess, J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05016.1999 · Cited by 402
Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02448.x · Cited by 387
Self-citationAlcohol dependence and anxiety disorders: what is the relationship?
Schuckit, M. A., & HESSELBROCK, V. M. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.12.1723 · Cited by 383
Chemical and Biological Characterization of Corticotropin Releasing Factor
Vale, W. W., RIVIER, C. L., Brown, M. R., SPIES, J., Koob, G. F., Swanson, L. W., Bilezikjian, L. M., Bloom, F. E., & Rivier, J. (1983) · Elsevier eBooks · doi:10.1016/b978-0-12-571139-5.50010-0 · Cited by 376
Self-citationBittencourt, J. C., Vaughan, J. M., Arias, C., Rissman, R. A., Vale, W., & Sawchenko, P. E. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991220)415:3 · Cited by 367
CRF antagonist reverses the “anxiogenic” response to ethanol withdrawal in the rat
Baldwin, H. A., Rassnick, S., Rivier, J., Koob, G. F., & Britton, K. T. (1991) · Psychopharmacology · doi:10.1007/bf02244208 · Cited by 353
Self-citationExcessive Ethanol Drinking Following a History of Dependence Animal Model of Allostasis
Roberts, A. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00167-0 · Cited by 349
Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats
Roberts, A. J., Cole, M., & Koob, G. F. (1996) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01125.x · Cited by 340
Self-citationCorticotropin-Releasing Factor*
YASUDA, N., Greer, M. A., & Aizawa, T. (1982) · Endocrine Reviews · doi:10.1210/edrv-3-2-123 · Cited by 322
Lê, A. D., Harding, S. E., Juzytsch, W., Watchus, J., Shalev, U., & Shaham, Y. (2000) · Psychopharmacology · doi:10.1007/s002130000411 · Cited by 310
Becker, H. C., & Hale, R. L. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00731.x · Cited by 277
Deak, T., Nguyen, K. T., Ehrlich, A. L., Watkins, L. R., Spencer, R. L., Maier, S. F., Licinio, J., Wong, M.-L., Chrousos, G. P., Webster, E., et al. (1999) · Endocrinology · doi:10.1210/endo.140.1.6415 · Cited by 242
Li, C., Vaughan, J. M., Sawchenko, P. E., & Vale, W. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00991.2002 · Cited by 241
Stress, Corticotropin‐releasing Factor, and Drug Addiction
Koob, G. F. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07876.x · Cited by 234
Self-citationContarino, A., Dellu-Hagedorn, F., Koob, G. F., Smith, G. W., Lee, K., Vale, W., & Gold, L. H. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01158-5 · Cited by 228
Self-citationPerrault, G., Griebel, G., & Sanger, D. J. (1998) · Psychopharmacology · doi:10.1007/s002130050645 · Cited by 210
Behan, D. P., Grigoriadis, D. E., Lovenberg, T. W., Chalmers, D. T., Heinrichs, S. C., Liaw, C. W., & Souza, E. B. D. (1996) · PubMed · Cited by 191
Valdez, G. R., Zorrilla, E. P., Roberts, A. J., & Koob, G. F. (2003) · Alcohol · doi:10.1016/s0741-8329(03)00020-x · Cited by 186
Self-citationMacey, D. J., Schulteis, G., Heinrichs, S. C., & Koob, G. F. (1996) · Alcohol · doi:10.1016/0741-8329(95)02030-6 · Cited by 164
Self-citationZorrilla, E. P., Valdez, G. R., Nozulak, J., Koob, G. F., & Markou, A. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03189-x · Cited by 159
Self-citationComorbidity in Generalized Anxiety Disorder
Noyes, R. (2001) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70205-7 · Cited by 153
Heinrichs, S. C., Menzaghi, F., Pich, E. M., Baldwin, H. A., Rassnick, S., Britton, K. T., & Koob, G. F. (1994) · Neuropsychopharmacology · doi:10.1038/sj.npp.1380104 · Cited by 143
Self-citationValdez, G. R., Inoue, K., Koob, G. F., Rivier, J., Vale, W., & Zorrilla, E. P. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02707-5 · Cited by 143
Self-citationCorticotropin releasing factor, stress and behavior
Koob, G. F., Heinrichs, S. C., Menzaghi, F., Pich, E. M., & Britton, K. T. (1994) · Seminars in Neuroscience · doi:10.1006/smns.1994.1029 · Cited by 141
Self-citationValdez, G. R., Zorrilla, E. P., Rivier, J., Vale, W., & Koob, G. F. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02971-8 · Cited by 140
Self-citationLateral and Medial Septal Lesions Reduce Anxiety in the Plus-Maze and Probe-Burying Tests
Menard, J. L., & Treit, D. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(96)00138-2 · Cited by 140
Alcohol withdrawal symptoms and drinking behavior.
Hershon, H. I. (1977) · Journal of Studies on Alcohol · doi:10.15288/jsa.1977.38.953 · Cited by 139
Becker, H. C. (1994) · Psychopharmacology · doi:10.1007/bf02244867 · Cited by 118
Becker, H. C., Diaz‐Granados, J. L., & Weathersby, R. T. (1997) · Alcohol · doi:10.1016/s0741-8329(97)87949-9 · Cited by 116
The role of the lateral septum in anxiolysis
Yadin, E., Thomas, E., Grishkat, H. L., & Strickland, C. E. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90362-j · Cited by 105
The Edinger-Westphal–Lateral Septum Urocortin Pathway and Its Relationship to Alcohol Consumption
Bachtell, R. K., Weitemier, A. Z., Galván-Rosas, A., Tsivkovskaia, N. O., Risinger, F. O., Phillips, T. J., Grahame, N. J., & Ryabinin, A. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02477.2003 · Cited by 105
Chronic Daily Ethanol and Withdrawal: 2. Behavioral Changes During Prolonged Abstinence
Rasmussen, D. D., Mitton, D. R., Green, J., & Puchalski, S. S. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02308.x · Cited by 98
Operant Self‐Administration of Sweetened Versus Unsweetened Ethanol: Effects on Blood Alcohol Levels
Roberts, A. J., Heyser, C. J., & Koob, G. F. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04272.x · Cited by 94
Self-citationInoue, K., Valdez, G. R., Reyes, T. M., Reinhardt, L. E., Tabarin, A., Rivier, J., Vale, W., Sawchenko, P. E., Koob, G. F., & Zorrilla, E. P. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.047712 · Cited by 87
Self-citationThe Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism
Rezvani, A. H., Parsian, A., & Overstreet, D. H. (2002) · Psychiatric Genetics · doi:10.1097/00041444-200203000-00001 · Cited by 86
Schulteis, G., Hyytiä, P., Heinrichs, S. C., & Koob, G. F. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01060.x · Cited by 86
Self-citationRichter, R. M., Zorrilla, E. P., Basso, A. M., Koob, G. F., & Weiss, F. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb01979.x · Cited by 82
Self-citationLodge, D. J., & Lawrence, A. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00793-5 · Cited by 73
Exacerbation of Ethanol Withdrawal Seizures in Mice With a History of Multiple Withdrawal Experience
Becker, H. C., Diaz‐Granados, J. L., & Hale, R. L. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00303-6 · Cited by 63
Lee, S., & RIVIER, C. L. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00226-x · Cited by 62
Ehlers, C. L., & Chaplin, R. I. (1987) · Regulatory Peptides · doi:10.1016/0167-0115(87)90176-5 · Cited by 38
Posterodorsal amygdala lesions reduce feeding stimulated by 8-OH-DPAT
Coscina, D. V., Currie, P. J., Bishop, C., Parker, G. C., Rollins, B. L., & King, B. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02918-8 · Cited by 24
Alcohol Withdrawal Symptoms: Phenomenology and Implications
Hershon, H. I. (1973) · British Journal of Addiction to Alcohol & Other Drugs · doi:10.1111/j.1360-0443.1973.tb01260.x · Cited by 15
Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse
Van Pett, K., Viau, V., Bittencourt, J. C., Chan, R. K. W., Li, H.-Y., Arias, C., Prins, G. S., Perrin, M., Vale, W., & Sawchenko, P. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001211)428:2
Cited by
Sorted by citations
A Role for Brain Stress Systems in Addiction
Koob, G. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.012 · Cited by 1,056
Self-citationNeurobiological mechanisms for opponent motivational processes in addiction
Koob, G. F., & Moal, M. L. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0094 · Cited by 743
Self-citationAddiction as a stress surfeit disorder
Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.024 · Cited by 483
Self-citationRole of Corticotropin-Releasing Factor in Drug Addiction
Logrip, M. L., Koob, G. F., & Zorrilla, E. P. (2011) · CNS Drugs · doi:10.2165/11587790-000000000-00000 · Cited by 474
Self-citationNeurobiological substrates for the dark side of compulsivity in addiction
Koob, G. F. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.043 · Cited by 476
Self-citation
Metadata
- Authors
- Valdez, G. R., Sabino, V., & Koob, G. F.
- Affiliations
- Scripps Research Institute (US)
- University of Palermo (IT)
- Corresponding author
- Valdez, Glenn R.
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2004-06
- Volume
- 28
- Issue
- 6
- Pages
- 865-872
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- OpenAlex
- W1997296561
- Cited by
- 131
- References
- 70
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 11 · 2013: 4 · 2012: 8
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f31aa005563-02)
- National Institute on Alcohol Abuse and Alcoholism (AA12602, AA05563, AA-08459, R01AA012602)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- urocortin 3, ethanol withdrawal, anxiety-like behavior, ethanol self-administration, behavioral stress response, alcoholism, elevated plus maze, alcohol withdrawal treatment
- MeSH terms
- Ethanol, Alcoholism, Animals, Anxiety, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Exploratory Behavior, Male, Self Administration, Substance Withdrawal Syndrome, Rats, Wistar, Receptors, Corticotropin-Releasing Hormone, Rats, Urocortins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
