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Cited by 143Stress Responses and CortisolNeuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

Anti-Stress Action of a Corticotropin-Releasing Factor Antagonist on Behavioral Reactivity to Stressors of Varying Type and Intensity

Heinrichs, Stephen C, Menzaghi, Frédérique, Pich, Emilio Merlo, Baldwin, Helen A, Rassnick, Stefanie, Britton, Karen T, Koob, George F·1994·Neuropsychopharmacology
DOI 10.1038/sj.npp.1380104
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Abstract

Central administration of a Corticotropin-Releasing Factor (CRF) antagonist is well documented to attenuate a variety of behavioral responses to several distinct stressors; however, it is not yet clear whether the activation of CRF neurons is dependent on the type or intensity of the experimental stressor, or rather on the particular behavioral response to stress under study. To test the generality of the stress-protective effect of the CRF antagonist, alpha-helical CRF9-41, (1, 5 or 25 micrograms intracerebroventricularly), the present experiments employed a sensitive index of anxiogenic-like behavior by measuring suppression in exploration on the elevated plus-maze following exposure to social, swim, or restraint stressors. A 1 but not 5 or 25 micrograms dose of the CRF antagonist administered just prior to social, swim, or restraint stress reversed the stress-induced inhibition of exploratory behavior. Chlordiazepoxide and the steroid anesthetic, alphaxalone, also attenuated the anxiogenic-like effect of restraint stress and elevated the baseline exploratory behavior of nonstressed control groups. Although the stressors produced a graded secretion of adrenocorticotropin (ACTH) with the ranking restraint > swim > social, the relative amplitude of behavioral reactivity to social, swim, and restraint stress was comparable. The relative efficacy of the CRF antagonist to reverse the stressor effects was also comparable. These results suggest that antagonism of activated brain CRF systems attenuates the behavioral response to stress regardless of the type or intensity of the stressor as measured by ACTH secretion.

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  • CRF administration into rat brain reproduces many stress-like behavioral responses, while CRF antagonists reduce or prevent stress responses.

    “Administration of CRF into the brain of rats reproduces many different behavioral responses analogous to stress, while CRF antagonists reduce or prevent stress responses (Dunn and Berridge 1990; Heinrichs et al 1994; Menzaghi et al 1994).”

    From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Heinrichs et al 1994

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Related

Authors
Heinrichs, S. C., Menzaghi, F., Pich, E. M., Baldwin, H. A., Rassnick, S., Britton, K. T., & Koob, G. F.
Affiliations
  • Scripps Research Institute (US)
  • VA San Diego Healthcare System (US)
ORCID
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1994-11
Volume
11
Issue
3
Pages
179-186
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
DOI
10.1038/sj.npp.1380104
OpenAlex
W2043776042
Cited by
143
References
23
Citations by year
2023: 2 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 9 · 2015: 1 · 2014: 7 · 2013: 3 · 2012: 7
FWCI
1.62
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (NIAAA-07456/06420, T32AA007456)
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK 26741, P01DK026741)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
corticotropin-releasing factor, CRF antagonist, stress, anxiogenic behavior, elevated plus maze, restraint stress, swim stress, social stress, adrenocorticotropin secretion, exploration, chlordiazepoxide, alfaxalone, stressor intensity
MeSH terms
Adrenocorticotropic Hormone, Analysis of Variance, Animals, Behavior, Animal, Corticosterone, Corticotropin-Releasing Hormone, Male, Peptide Fragments, Stress, Psychological, Rats, Wistar, Rats

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