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Cited by 140Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorAlcohol Consumption and Health Effects

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Effects of naltrexone and nalmefene on subjective response to alcohol among non-treatment-seeking alcoholics and social drinkers

Drobes, David J., Anton, Raymond F., Thomas, Suzanne E., Voronin, Konstantin·2004·Alcoholism Clinical and Experimental Research
DOI 10.1097/01.alc.0000139704.88862.01
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Abstract

BACKGROUND: Despite the relative success of opiate antagonist medication within controlled clinical trials for alcoholism, laboratory studies have not fully examined potential mechanisms for their efficacy in alcohol-dependent persons. The present study evaluated the impact of naltrexone and nalmefene on craving and subjective effects after a moderate alcohol dose among non-treatment-seeking alcoholics (n = 125) and social drinkers (n = 90). METHODS: Participants were randomly assigned to receive placebo, naltrexone (titrated to 50 mg/day), or nalmefene (titrated to 40 mg/day) for seven days before an alcohol challenge clinical laboratory session. During the clinical laboratory session, a drink of alcohol (0.4 mg/kg for men, 0.34 mg/kg for women) was provided in a bar-like setting. The effects of the alcohol dose on subjective craving, stimulation, and sedation were measured before having free access to alcohol. RESULTS: Alcoholics reported higher levels of craving than social drinkers before and after the drink as well as higher levels of alcohol-induced stimulation. Both opiate antagonist medications suppressed initial increases in craving and stimulation. CONCLUSIONS: These findings demonstrate that both naltrexone and nalmefene are associated with reduced alcohol-induced craving and stimulation among alcoholics who are not actively attempting to reduce drinking. These data provide insights into potential mechanisms that may underlie opiate antagonists' effects in the context of treatment.

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Crossref · 10.1097/01.alc.0000139704.88862.01

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Research works printed but not linked: 3

  1. FirstMB SpitzerRL GibbonM WilliamsJBW(1994)Structured Clinical Interview for Axis I DSM‐IV Disorders—Patient Edition (SCID‐I/P version 2.0).Biometrics Research Department New York State Psychiatric Institute.
  2. National Advisory Council on Alcohol Abuse and Alcoholism, 1988, Recommended Council Guidelines on Ethyl Alcohol Administration in Human Experimentation
  3. Singleton EG, 1999, Alcohol Craving Questionnaire (ACQ‐NOW): Background, Scoring, and Administration

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Metadata

Authors
Drobes, D. J., Anton, R. F., Thomas, S. E., & Voronin, K.
Affiliations
Medical University of South Carolina (US)
Corresponding author
Drobes, David J.
ORCID
Venue
Alcoholism Clinical and Experimental Research
Publisher
Wiley
Published
2004-09
Volume
28
Issue
9
Pages
1362-1370
ISSN
  • 0145-6008 (ISSN-L)
  • 1530-0277
DOI
10.1097/01.alc.0000139704.88862.01
OpenAlex
W2032321294
Cited by
140
References
47
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 9 · 2016: 10 · 2015: 16 · 2014: 7 · 2013: 8 · 2012: 8
FWCI
3.58
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 609 d)
Locations
  • Alcoholism Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (P50AA010761)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
naltrexone, nalmefene, opioid antagonists, alcohol craving, subjective effects of alcohol, alcoholism, social drinkers
MeSH terms
Adult, Aged, Alcohol Drinking, Alcoholism, Analysis of Variance, Female, Humans, Male, Middle Aged, Naltrexone, Behavior, Addictive

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