Following alcohol consumption, nontreatment-seeking alcoholics report greater stimulation but similar sedation compared with social drinkers
Abstract
OBJECTIVE: Drinking behavior, and consequently the risk to develop alcohol problems, is influenced in part by one's subjective response to alcohol. Studies have shown that individuals at risk for alcoholism report greater stimulation, less sedation and/or "low response" to alcohol. Whether this effect exists in early-stage alcoholics has not been examined. The present study was conducted to determine whether alcoholics and social drinkers differ in response following a challenge dose of alcohol in a clinical laboratory procedure. METHOD: Nontreatment-seeking alcoholics (n = 38) and social drinkers (n = 30) randomized to a placebo in a medication study were given a standard dose of alcohol (0.34 g/kg women; 0.4 g/kg men) in a bar-laboratory setting. Assessments, including blood alcohol concentrations and the Biphasic Alcohol Effects Scale, were conducted four times (from 10 to 60 minutes following initiation of consumption). RESULTS: Alcoholics reported greater stimulation, but similar sedation, compared with social drinkers, following alcohol consumption. CONCLUSIONS: This study provides the first evidence of greater stimulation following alcohol in alcoholics not seeking treatment.
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The results support prior work showing high alcohol-induced stimulation, reward, and craving in heavy drinkers or alcoholics as well as low alcohol-induced sedation and cortisol in other at-risk drinkers.
“The results support prior work showing high alcohol-induced stimulation, reward, and craving in heavy drinkers or alcoholics(33, 79, 80) as well as low alcohol-induced sedation and cortisol in other at-risk drinkers(81).”
From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as [80]
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- Authors
- Thomas, S. E., Drobes, D. J., Voronin, K., & Anton, R. F.
- Affiliations
- Medical University of South Carolina (US)
- Venue
- Journal of Studies on Alcohol
- Publisher
- Alcohol Research Documentation, Inc.
- Published
- 2004-05
- Volume
- 65
- Issue
- 3
- Pages
- 330-335
- ISSN
- 0096-882X (ISSN-L)
- 1934-2683
- OpenAlex
- W1964314453
- Cited by
- 27
- References
- 24
- Citations by year
- 2022: 1 · 2020: 2 · 2019: 1 · 2016: 2 · 2015: 2 · 2013: 3 · 2012: 2
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Studies on Alcohol (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical University of South Carolina
- National Institute on Alcohol Abuse and Alcoholism (P50AA010761)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- alcoholism, subjective response to alcohol, social drinkers, blood alcohol concentration
- MeSH terms
- Adult, Alcohol Drinking, Ethanol, Alcoholism, Cognition, Female, Humans, Male, Patient Acceptance of Health Care, Surveys and Questionnaires, Risk Factors, Social Behavior
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