Prevalence of Left Ventricular Hypertrophy in Persons With and Without Obstructive Sleep Apnea
Abstract
We investigated the prevalence of left ventricular hypertrophy (LVH) in persons with and without obstructive sleep apnea (OSA). Fifty-three persons had a nocturnal polysomnogram to diagnose OSA and 2-dimensional echocardiograms to measure left ventricular mass. OSA was considered mild if the respiratory disturbance index (RDI) was 5 to 15, moderate if the RDI was 15 to 30, and severe if the RDI was >30. LVH was diagnosed if the left ventricular mass index was >110 g/m in women and >134 g/m in men. LVH was present in 21 of 27 persons (78%) with moderate or severe OSA, in 6 of 13 persons (46%) with mild OSA, and in 3 of 13 persons (23%) with no OSA (P < 0.001 comparing moderate or severe OSA with no OSA and P < 0.05 comparing moderate or severe OSA with mild OSA). OSA was a significant independent predictor of LVH after controlling the confounding effects of hypertension with an odds ratio of 3.579 (95% confidence interval, 1.589-8.058).
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Although some studies have failed to show a relationship between sleep apnea and LV hypertrophy, the majority do support such an association.
“Although some studies have failed to show a relationship between sleep apnea and LV hypertrophy, the majority do support such an association (18, 22, 69, 250, 256–258, 284, 287, 331, 373).”
From Cardiac remodeling in obesity (2008) · cites this paper as [331]
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Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
- Authors
- Sukhija, R., Aronow, W. S., Sandhu, R., Kakar, P., Maguire, G. P., Ahn, C., & Lehrman, S. G.
- Affiliations
- Westchester Medical Center (US)
- Corresponding author
- Sukhija, Rishi
- Aronow, Wilbert S.
- Sandhu, Rasham
- Kakar, Priyanka
- Maguire, George P.
- Lehrman, Stuart G.
- Venue
- Cardiology in Review
- Published
- 2006-07
- Volume
- 14
- Issue
- 4
- Pages
- 170-172
- ISSN
- 1061-5377 (ISSN-L)
- OpenAlex
- W2090504874
- Cited by
- 25
- References
- 12
- Citations by year
- 2024: 1 · 2023: 1 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 3 · 2014: 3 · 2013: 2
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiology in Review (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- left ventricular hypertrophy, obstructive sleep apnea, left ventricular mass, prevalence, respiratory disturbance index, hypertension, cardiovascular risk
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Prevalence, Hypertrophy, Left Ventricular, Sleep Apnea, Obstructive
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