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Cited by 156Obstructive Sleep Apnea ResearchCardiovascular Function and Risk FactorsCardiovascular Disease and Adiposity

Impact of Obstructive Sleep Apnea on Left Ventricular Mass and Diastolic Function

NIROUMAND, MITRA, KUPERSTEIN, RAFFAEL, SASSON, ZION, HANLY, PATRICK J.·2001·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/ajrccm.163.7.2007014
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Abstract

We wished to determine if obstructive sleep apnea (OSA) is associated with increased left ventricular mass (LVM) and impaired left ventricular diastolic function (LVDF) independently of coexisting obesity, hypertension (HTN), and diabetes mellitus (DM). Patients without primary cardiac disease, referred for evaluation of OSA (n = 533), had overnight polysomnography and Doppler echocardiography while awake. Patients were divided, according to the apnea–hypopnea index (AHI), into an OSA group (AHI ⩾ 5/h, n = 353) and a non-OSA group (AHI < 5/h, n = 180). In men, LVM was greater in the OSA group (98.9 ± 25.6 versus 92.3 ± 22.5 g/m, p = 0.023) despite exclusion of those with HTN and DM. A similar trend was noted in women. Regression analysis revealed that LVM was correlated with body mass index (BMI) (β = 0.480, p < 0.0005), age (β = 0.16, p = 0.001), and the presence of HTN (β = 0.137, p = 0.003) in men and with BMI (β = 0.501, p < 0.0005) in women, but not with AHI or oxygen saturation during sleep. The ratio of peak early filling velocity to peak late filling velocity (E/A), an index of LVDF, was similar in both groups (1.28 ± 0.32 versus 1.34 ± 0.31, p = 0.058); it was correlated with age (β = − 0.474, p < 0.0005), but not with AHI or oxygen saturation during sleep. We conclude that OSA is not associated with increased LVM or impaired LVDF independently of obesity, HTN, or advancing age.

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  • Although some studies have failed to show a relationship between sleep apnea and LV hypertrophy, the majority do support such an association.

    “Although some studies have failed to show a relationship between sleep apnea and LV hypertrophy, the majority do support such an association (18, 22, 69, 250, 256–258, 284, 287, 331, 373).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [256]

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Authors
NIROUMAND, M., KUPERSTEIN, R., SASSON, Z., & HANLY, P. J.
Affiliations
St. Michael's Hospital (CA)
ORCID
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2001-06-01
Volume
163
Issue
7
Pages
1632-1636
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/ajrccm.163.7.2007014
OpenAlex
W2020713898
Cited by
156
References
32
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 10 · 2015: 12 · 2014: 8 · 2013: 9 · 2012: 11
FWCI
2.55
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Journal of Respiratory and Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
obstructive sleep apnea, left ventricular mass, left ventricular diastolic function, apnea-hypopnea index, obesity, hypertension, diabetes mellitus, body mass index, E/A ratio, cardiac remodeling
MeSH terms
Adult, Cardiovascular Diseases, Diastole, Echocardiography, Female, Heart Ventricles, Humans, Male, Middle Aged, Risk Factors, Body Mass Index, Ventricular Function, Left, Hypertrophy, Left Ventricular, Sleep Apnea, Obstructive

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