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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Maternal Body Mass Index and the Risk of Preeclampsia: A Systematic Overview

O’Brien, Tara E., Ray, Joel G., Chan, Wee-Shian·2003·Epidemiology
DOI 10.1097/01.ede.0000059921.71494.d1
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Abstract

Background. Maternal obesity, both in itself and as part of the insulin resistance syndrome, is an important risk factor for the development of preeclampsia. Accurately quantifying the relation between prepregnancy maternal body mass index and the risk of preeclampsia may better identify those at highest risk. We performed a systematic overview of the literature to determine the association between prepregnancy body mass index and the risk of preeclampsia. Methods. Two reviewers independently retrieved all relevant English language cohort studies through a systematic search of Medline and Embase between 1980 and June 2002. Study data were abstracted in a similar fashion. For each study, the risk ratio of preeclampsia was calculated by comparing the risk of preeclampsia among women with the highest body mass index with those with the lowest. Results. We identified thirteen cohort studies, comprising nearly 1.4 million women. The risk of preeclampsia typically doubled with each 5–7 kg/m 2 increase in prepregnancy body mass index. This relation persisted in studies that excluded women with chronic hypertension, diabetes mellitus or multiple gestations, or after adjustment for other confounders. Conclusions. Most observational studies demonstrate a consistently strong positive association between maternal prepregnancy body mass index and the risk of preeclampsia. Increasing obesity in developed countries is likely to increase the occurrence of preeclampsia. Consideration should be given to the potential benefits of prepregnancy weight reduction programs.

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Research works printed but not linked: 37

  1. Roberts, 2001, Pathogenesis and genetics of pre-eclampsia, Lancet, 357, 53, 10.1016/S0140-6736(00)03577-7 · DOI · Paper page
  2. Dekker, 2001, Primary, secondary, and tertiary prevention of pre-eclampsia, Lancet, 357, 209, 10.1016/S0140-6736(00)03599-6 · DOI · Paper page
  3. Hayman, 1999, Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor, J Soc Gynecol Investig, 6, 3, 10.1177/107155769900600103 · DOI
  4. Solomon, 2001, Brief review: hypertension in pregnancy: a manifestation of the insulin resistance syndrome?, Hypertension, 37, 232, 10.1161/01.HYP.37.2.232 · DOI
  5. Barden, 1999, Does a predisposition to the metabolic syndrome sensitize women to develop pre-eclampsia?, J Hypertens, 17, 1307, 10.1097/00004872-199917090-00011 · DOI
  6. Ford, 2002, Prevalence of the metabolic syndrome among U.S. adults. Findings from the Third National Health and Nutrition Examination Survey, JAMA, 287, 356, 10.1001/jama.287.3.356 · DOI · Paper page
  7. Cnattingius, 1998, Prepregnancy weight and the risk of adverse pregnancy outcomes, N Engl J Med, 338, 147, 10.1056/NEJM199801153380302 · DOI · Paper page
  8. Edwards, 1996, Pregnancy complications and birth outcomes in obese and normal-weight women: effects of gestational weight change, Obstet Gynecol, 87, 389, 10.1016/0029-7844(95)00446-7 · DOI · Paper page
  9. Sibai, 1997, Risk factors associated with preeclampsia in healthy nulliparous women, Am J Obstet Gynecol, 177, 1003, 10.1016/S0002-9378(97)70004-8 · DOI · Paper page
  10. Ogunyemi, 1998, Prepregnancy body mass index, weight gain during pregnancy, and perinatal outcome in a rural Black population, J Matern Fetal Med, 7, 190
  11. Bianco, 1998, Pregnancy outcome and weight gain recommendations for the morbidly obese woman, Obstet Gynecol, 91, 97, 10.1016/S0029-7844(97)00578-4 · DOI · Paper page
  12. Bowers, 1999, Obesity and related pregnancy complications in an inner-city clinic, J Perinatol, 19, 216, 10.1038/sj.jp.7200143 · DOI
  13. Thadhani, 1999, High body mass index and hypercholesterolemia: risk of hypertensive disorders of pregnancy, Obstet Gynecol, 94, 543
  14. Steinfeld, 2000, Obesity-related complications of pregnancy vary by race, J Matern Fetal Med, 9, 238
  15. Baeten, 2001, Pregnancy complications and outcomes among overweight and obese nulliparous women, Am J Public Health, 91, 436, 10.2105/AJPH.91.3.436 · DOI · Paper page
  16. Ros, 1998, Comparison of risk factors for preeclampsia and gestational hypertension in a population-based cohort study, Am J Epiemiol, 147, 1062, 10.1093/oxfordjournals.aje.a009400 · DOI · Paper page
  17. Knuist, 1998, Risk factors for preeclampsia in nulliparous women in distinct ethnic groups: a prospective study, Obstet Gynecol, 92, 174
  18. Conde-Agudelo, 2000, Risk factors for pre-eclampsia in a large cohort of Latin American and Caribbean women, Br J Obstet Gynecol, 107, 75, 10.1111/j.1471-0528.2000.tb11582.x · DOI · Paper page
  19. Sebire, 2001, Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London, Int J Obes, 25, 1175, 10.1038/sj.ijo.0801670 · DOI · Paper page
  20. 1990, Report on high blood pressure in pregnancy, Am J Obstet Gynecol, 163, 1689
  21. 2000, Report of the National High Blood Pressure Education Program Working Group of High Blood Pressure in Pregnancy, Am J Obstet Gynecol, 183, S1, 10.1067/mob.2000.107928 · DOI · Paper page
  22. Ray, 2001, MOS HIP: McMaster outcome study of hypertension in pregnancy 1 (MOS HIP 1), Early Hum Dev, 64, 129, 10.1016/S0378-3782(01)00181-5 · DOI
  23. Ray, 2001, Maternal and neonatal outcomes in pregestational and gestational diabetes mellitus, and the influence of maternal obesity and weight gain: the DEPOSIT study, QJM, 94, 347, 10.1093/qjmed/94.7.347 · DOI · Paper page
  24. Willett, 1983, Cigarette smoking, relative weight and menopause, Am J Epidemiol, 117, 651, 10.1093/oxfordjournals.aje.a113598 · DOI · Paper page
  25. DeWolf, 1980, Fetal growth retardation and the maternal arterial supply in the human placenta in the absence of sustained hypertension, Br J Obstet Gynaecol, 87, 678, 10.1111/j.1471-0528.1980.tb04601.x · DOI · Paper page
  26. Roberts, 1991, Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome pre-eclampsia, Am J Hypertens, 4, 700, 10.1093/ajh/4.8.700 · DOI · Paper page
  27. de Man, 2000, Not acute but chronic hypertriglyceridemia is associated with impaired endothelium-dependent vasodilation: reversal after lipid-lowering therapy by atorvastatin, Arterioscler Thromb Vasc Biol, 20, 744, 10.1161/01.ATV.20.3.744 · DOI
  28. McCarthy, 1999, Maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentration, Am J Obstet Gynecol, 180, 731, 10.1016/S0002-9378(99)70280-2 · DOI
  29. Estelles, 1998, Abnormal expression of type 1 plasminogen activator and tissue factor in severe preeclampsia, Thromb Haemost, 79, 500, 10.1055/s-0037-1614933 · DOI
  30. Vince, 1995, Interleukin-6, tumour necrosis factor and soluble tumour factor receptors in women with pre-eclampsia, Br J Obstet Gynaecol, 102, 20, 10.1111/j.1471-0528.1995.tb09020.x · DOI · Paper page
  31. Berger, 2001, Sleep disordered breathing and hypertension, Curr Opin Pulm Med, 7, 386, 10.1097/00063198-200111000-00004 · DOI
  32. Maasilta, 2001, Sleep-related disordered breathing during pregnancy in obese women, Chest, 120, 1448, 10.1378/chest.120.5.1448 · DOI · Paper page
  33. Edwards, 2001, Hemodynamic responses to obstructive respiratory events during sleep are augmented in women with preeclampsia, Am J Hypertens, 14, 1090, 10.1016/S0895-7061(01)02190-2 · DOI
  34. Solomon, 1997, A prospective study of pregravid determinants of gestational diabetes mellitus, JAMA, 278, 1078, 10.1001/jama.1997.03550130052036 · DOI · Paper page
  35. Kiernan, 2000, Identifying patients for weight-loss treatment: an empirical evaluation of the NHLBI obesity education initiative expert panel treatment recommendations, Arch Intern Med, 160, 2169, 10.1001/archinte.160.14.2169 · DOI
  36. Lu, 2001, The effect of the increasing prevalence of maternal obesity on perinatal morbidity, Am J Obstet Gynecol, 185, 845, 10.1067/mob.2001.117351 · DOI · Paper page
  37. Brown, 2000, Body mass index and the prevalence of hypertension and dyslipidemia, Obes Res, 8, 605, 10.1038/oby.2000.79 · DOI · Paper page

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Metadata

Authors
O’Brien, T. E., Ray, J. G., & Chan, W.-S.
Venue
Epidemiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-05
Volume
14
Issue
3
Pages
368-374
ISSN
1044-3983 (ISSN-L)
DOI
10.1097/01.ede.0000059921.71494.d1
OpenAlex
W4251820864
Cited by
644
References
3
FWCI
15.69
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Maternal Body Mass Index and the Risk of Preeclampsia: A Systematic Overview. https://app.cochat.ai/papers/10.1097/01.ede.0000059921.71494.d1
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O’Brien, T. E., Ray, J. G., & Chan, W.-S. (2003). Maternal Body Mass Index and the Risk of Preeclampsia: A Systematic Overview. Epidemiology. https://doi.org/10.1097/01.ede.0000059921.71494.d1

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