Cited by 104Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

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Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats

Rygula, Rafal, Abumaria, Nashat, Flügge, Gabriele, Hiemke, Christoph, Fuchs, Eberhard, Rüther, Eckart, Havemann-Reinecke, Ursula·2006·Behavioural Pharmacology

DOI 10.1097/01.fbp.0000186631.53851.71

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Abstract

Recently, we have described a new model of chronic social stress in rats, based on the resident-intruder paradigm. In this model, rats show behavioural changes that may be considered correlates of depressive symptoms, such as anhedonia and motivational deficits. The present study was designed for pharmacological validation of this model. Animals were socially stressed for 5 weeks and, in parallel, after the first week of stress, they were subjected to chronic (4 weeks) treatment with the antidepressant drug citalopram. The drug was administered via drinking water (30 mg/kg). The optimal dose of citalopram was determined in a pilot study. After 4 weeks of treatment, plasma levels of citalopram and its metabolite were found to be within the human therapeutic range. The effects of social stress and citalopram treatment were assessed by behavioural tests. Chronically stressed rats showed reduced locomotor and exploratory activity, reduced sucrose preference and increased immobility time in the forced swimming test. Chronic oral administration of citalopram abolished those effects and normalized behaviours related to motivation and reward sensitivity. These observations provide evidence for the predictive validity of the chronic social stress paradigm as a model of depressive symptoms in rats.

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Authors: Rygula, R., Abumaria, N., Flügge, G., Hiemke, C., Fuchs, E., Rüther, E., & Havemann-Reinecke, U.
Affiliations: German Primate Center (DE)
Johannes Gutenberg University Mainz (DE)
University of Göttingen (DE)
Corresponding author: Abumaria, Nashat
ORCID: Abumaria, Nashat
Hiemke, Christoph
Venue: Behavioural Pharmacology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-02
Volume: 17
Issue: 1
Pages: 19-29
ISSN: 0955-8810 (ISSN-L)
DOI: 10.1097/01.fbp.0000186631.53851.71
OpenAlex: W1963953631
Cited by: 104
References: 56
Citations by year: 2026: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 1 · 2013: 6 · 2012: 9
FWCI: 3.62
Type: journal article
Language: en
Open access: closed
Locations: Behavioural Pharmacology (publishedVersion)
PubMed (publishedVersion)
GRO (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
H. Lundbeck A/S
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: citalopram, chronic social stress, resident-intruder paradigm, antidepressant efficacy, anhedonia, motivational deficits, reward sensitivity, sucrose preference, forced swim test, locomotor activity, exploratory activity, plasma drug concentration, model validation
MeSH terms: Administration, Oral, Animals, Antidepressive Agents, Depression, Disease Models, Animal, Dominance-Subordination, Dose-Response Relationship, Drug, Exploratory Behavior, Food Preferences, Male, Motivation, Motor Activity, Social Behavior, Social Environment, Stress, Psychological, Sucrose, Swimming, Taste, Citalopram, Rats, Wistar, Rats

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Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats

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