Effects of fluoxetine on behavioral deficits evoked by chronic social stress in rats
Abstract
Recently, we described an advanced model of chronic social stress in male rats based on the resident intruder paradigm. In this model, rats subjected to daily social stress for 5 weeks showed behavioral changes resembling anhedonia and motivational deficits in humans. In the present study, male Wistar rats were subjected to 5 weeks of daily social defeat by an aggressive conspecific and concomitant treatment with the antidepressant drug fluoxetine (10 mg/kg) after the first week of stress. Compared with controls, rats exposed to chronic stress had significantly reduced locomotor and exploratory activity (rearing and sniffing) and diminished preference for sucrose solution. These effects were paralleled by decreased body weight gain, increased adrenal weights and decreased plasma levels of testosterone measured post mortem. The stress-induced effects on locomotor activity and rearing behavior were counteracted by fluoxetine treatment.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Repeated exposures to social defeat stress in rodents cause a robust depression-like phenotype marked by anhedonia, anxiety and social-avoidance behaviors.
“Repeated exposures to social defeat stress in rodents, for example, cause a robust depression-like phenotype marked by anhedonia, anxiety and social-avoidance behaviors10,14–17.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [14]
Cites
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541 · see citing works
Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats
Rygula, R., Abumaria, N., Flügge, G., Hiemke, C., Fuchs, E., Rüther, E., & Havemann-Reinecke, U. (2006) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000186631.53851.71 · Cited by 104 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581 · see citing works
Pathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works
ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
Vialou, V., Robison, A. J., LaPlant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., Watts, E. L., Wallace, D. L., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2551 · Cited by 479 · see citing works
Structural and synaptic plasticity in stress-related disorders
Christoffel, D. J., Golden, S. A., & Russo, S. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.044 · Cited by 334 · see citing works
Epigenetic influence of social experiences across the lifespan
Champagne, F. A. (2010) · Developmental Psychobiology · doi:10.1002/dev.20436 · Cited by 273 · see citing works
Defeat stress in rodents: from behavior to molecules
Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.006 · Cited by 230 · see citing works
Sex differences in stress responses: focus on ovarian hormones
Ter Horst, G. J., Wichmann, R., Gerrits, M., Westenbroek, C., & Lin, Y. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.036 · Cited by 157 · see citing works
Papciak, J., Popik, P., Fuchs, E., & Rygula, R. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.036 · Cited by 101 · see citing works
Self-citationMattioli, L., Funari, C., & Perfumi, M. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108089872 · Cited by 91 · see citing works
Zhao, J., Niu, C., Wang, J., Yang, H., Du, Y., Wei, L., & Li, C. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s151107 · Cited by 49 · see citing works
mGluR5 Facilitates Long-Term Synaptic Depression in a Stress-Induced Depressive Mouse Model
Jiang, X., Lin, W., Cheng, Y., & Wang, D. (2020) · The Canadian Journal of Psychiatry · doi:10.1177/0706743719874162 · Cited by 18 · see citing works
Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants
Verkhratsky, A., Parpura, V., Scuderi, C., & Li, B. (2021) · Advances in Neurobiology · doi:10.1007/978-3-030-77375-5_13 · Cited by 19 · see citing works
- Authors
- RYGULA, R., ABUMARIA, N., DOMENICI, E., HIEMKE, C., & FUCHS, E.
- Affiliations
- German Primate Center (DE)
- GlaxoSmithKline (Italy) (IT)
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- FUCHS, E
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2006-11-01
- Volume
- 174
- Issue
- 1
- Pages
- 188-192
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2122479540
- Cited by
- 126
- References
- 2
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 1 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 10 · 2012: 9
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
- GRO (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- fluoxetine, chronic social stress, social defeat, resident-intruder paradigm, anhedonia, motivational deficits, locomotor activity, exploratory behavior, sucrose preference, weight gain, adrenal weight, testosterone, antidepressant treatment, rats
- MeSH terms
- Adrenal Glands, Analysis of Variance, Animals, Behavior, Animal, Behavioral Symptoms, Body Weight, Exploratory Behavior, Fluoxetine, Food Preferences, Male, Motor Activity, Stress, Psychological, Testosterone, Rats, Wistar, Antidepressive Agents, Second-Generation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
