Structural and synaptic plasticity in stress-related disorders

Christoffel, Daniel J.; Golden, Sam A.; Russo, Scott J.

doi:10.1515/rns.2011.044

Cited by 334Neuroscience and Neuropharmacology ResearchStress Responses and CortisolTreatment of Major Depression

Structural and synaptic plasticity in stress-related disorders

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Christoffel, Daniel J., Golden, Sam A., Russo, Scott J.·2011·Reviews in the Neurosciences

DOI 10.1515/rns.2011.044PMC PMC3212803

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Abstract

Abstract Stress can have a lasting impact on the structure and function of brain circuitry that results in long-lasting changes in the behavior of an organism. Synaptic plasticity is the mechanism by which information is stored and maintained within individual synapses, neurons, and neuronal circuits to guide the behavior of an organism. Although these mechanisms allow the organism to adapt to its constantly evolving environment, not all of these adaptations are beneficial. Under prolonged bouts of physical or psychological stress, these mechanisms become dysregulated, and the connectivity between brain regions becomes unbalanced, resulting in pathological behaviors. In this review, we highlight the effects of stress on the structure and function of neurons within the mesocorticolimbic brain systems known to regulate mood and motivation. We then discuss the implications of these spine adaptations on neuronal activity and pathological behaviors implicated in mood disorders. Finally, we end by discussing recent brain imaging studies in human depression within the context of these basic findings to provide insight into the underlying mechanisms leading to neural dysfunction in depression.

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Psychedelics promote structural and functional neural plasticity
Ly, C., Greb, A. C., Cameron, L. P., Wong, J. M., Barragan, E. V., Wilson, P. C., Burbach, K. F., Soltanzadeh Zarandi, S., Sood, A., Paddy, M. R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.022 · Cited by 1,207 · see citing works
Neurobiology of resilience
Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206 · see citing works
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Sex differences in stress-related psychiatric disorders: neurobiological perspectives
Bangasser, D. A., & Valentino, R. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.008 · Cited by 737 · see citing works
Integrating neuroimmune systems in the neurobiology of depression
Wohleb, E. S., Franklin, T., Iwata, M., & Duman, R. S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.69 · Cited by 668 · see citing works
Pathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works
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Dendritic Spines in Depression: What We Learned from Animal Models
Qiao, H., Li, M.-X., Xu, C. S., Chen, H.-B., An, S.-C., & Ma, X. (2016) · Neural Plasticity · doi:10.1155/2016/8056370 · Cited by 442 · see citing works
Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior
Wohleb, E. S., McKim, D. B., Sheridan, J. F., & Godbout, J. P. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00447 · Cited by 420 · see citing works
Immune and neuroendocrine mechanisms of stress vulnerability and resilience
Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.90 · Cited by 374 · see citing works
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Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
Golden, S. A., Christoffel, D. J., Heshmati, M., Hodes, G. E., Magida, J., Davis, K., Cahill, M. E., Dias, C., Ribeiro, E., Ables, J. L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3090 · Cited by 322 · see citing works
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Synaptic plasticity in depression: Molecular, cellular and functional correlates
Marsden, W. N. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.012 · Cited by 315 · see citing works
Neurobiology of Resilience: Interface Between Mind and Body
Cathomas, F., Murrough, J. W., Nestler, E. J., Han, M.-H., & Russo, S. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.011 · Cited by 296 · see citing works
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Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior
Wohleb, E. S., Terwilliger, R., Duman, C. H., & Duman, R. S. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.026 · Cited by 288 · see citing works
Synaptic circuit remodelling by matrix metalloproteinases in health and disease
Huntley, G. W. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3320 · Cited by 282 · see citing works
Stress, anxiety, and dendritic spines: What are the connections?
Leuner, B., & Shors, T. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.021 · Cited by 284 · see citing works
Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
Wang, J., Hodes, G. E., Zhang, H., Zhang, S., Zhao, W., Golden, S. A., Bi, W., Menard, C., Kana, V., Leboeuf, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02794-5 · Cited by 274 · see citing works
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Integrating Interleukin-6 into depression diagnosis and treatment
Hodes, G. E., Ménard, C., & Russo, S. J. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.03.003 · Cited by 271 · see citing works
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Dendritic spines: Revisiting the physiological role
Chidambaram, S. B., Rathipriya, A. G., Bolla, S. R., Bhat, A., Ray, B., Mahalakshmi, A. M., Manivasagam, T., Thenmozhi, A. J., Essa, M. M., Guillemin, G. J., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.005 · Cited by 255 · see citing works
Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation
Leng, L., Zhuang, K., Liu, Z., Huang, C., Gao, Y., Chen, G., Lin, H. Z., Hu, Y., Wu, D., Shi, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.031 · Cited by 233 · see citing works
Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
Douma, E. H., & de Kloet, E. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.015 · Cited by 226 · see citing works
Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan
Tay, T. L., Béchade, C., D’Andrea, I., St‐Pierre, M., Henry, M. S., Roumier, A., & Tremblay, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00421 · Cited by 211 · see citing works
Structural and functional plasticity of dendritic spines – root or result of behavior?
Gipson, C. D., & Olive, M. F. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12324 · Cited by 192 · see citing works
Autophagy in the presynaptic compartment in health and disease
Vijayan, V., & Verstreken, P. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201611113 · Cited by 167 · see citing works
Peripheral and central mechanisms of stress resilience
Pfau, M. L., & Russo, S. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.004 · Cited by 170 · see citing works
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Neuron–Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”
Wohleb, E. S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00544 · Cited by 164 · see citing works
Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling
Cavalleri, L., Merlo Pich, E., Millan, M. J., Chiamulera, C., Kunath, T., Spano, P. F., & Collo, G. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.241 · Cited by 156 · see citing works
Stress, Arousal, and Sleep
Sanford, L. D., Suchecki, D., & Meerlo, P. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_314 · Cited by 155 · see citing works
Brodmann area 10: Collating, integrating and high level processing of nociception and pain
Peng, K., Steele, S. C., Becerra, L. R., & Borsook, D. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.11.004 · Cited by 159 · see citing works
Neurobiology of resilience in depression: immune and vascular insights from human and animal studies
Dudek, K., Dion‐Albert, L., Kaufmann, F. N., Tuck, E., Lebel, M., & Ménard, C. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14547 · Cited by 156 · see citing works
Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine
Wohleb, E. S., Gerhard, D. M., Thomas, A., & Duman, R. S. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160309114549 · Cited by 151 · see citing works
Stress induced microglial activation contributes to depression
Li, B., Yang, W., Ge, T., Wang, Y., & Cui, R. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106145 · Cited by 147 · see citing works
Longitudinal Effects of Ketamine on Dendritic Architecture<i>In Vivo</i>in the Mouse Medial Frontal Cortex
Phoumthipphavong, V., Barthas, F., Hassett, S., & Kwan, A. C. (2016) · eneuro · doi:10.1523/eneuro.0133-15.2016 · Cited by 132 · see citing works
Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases
Zhang, X., Ge, T., Yin, G., Cui, R., Zhao, G., & Yang, W. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00367 · Cited by 139 · see citing works
Astrocyte, a Promising Target for Mood Disorder Interventions
Zhou, X., Xiao, Q., Xie, L., Yang, F., Wang, L., & Tu, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00136 · Cited by 120 · see citing works
Checks and balances: The glucocorticoid receptor and NFĸB in good times and bad
Bekhbat, M., Rowson, S. A., & Neigh, G. N. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.05.001 · Cited by 133 · see citing works
Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens
Bessa, J. M., Morais, M., Marques, F., Pinto, L., Palha, J. A., Almeida, O. F. X., & Sousa, N. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.39 · Cited by 130 · see citing works
Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences
Wohleb, E. S., & Delpech, J.-C. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.04.013 · Cited by 128 · see citing works
The Dynamic Brain: Neuroplasticity and Mental Health
Kays, J. L., Hurley, R. A., & Taber, K. H. (2012) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.12050109 · Cited by 128 · see citing works
Electric foot shock stress: a useful tool in neuropsychiatric studies
Bali, A., & Jaggi, A. S. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0015 · Cited by 127 · see citing works
Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression
Ling, S., Ceban, F., Lui, L. M. W., Lee, Y., Teopiz, K. M., Rodrigues, N. B., Lipsitz, O., Gill, H., Subramaniapillai, M., Mansur, R. B., et al. (2022) · CNS Drugs · doi:10.1007/s40263-021-00877-y · Cited by 127 · see citing works
Molecular regulation of dendritic spine dynamics and their potential impact on synaptic plasticity and neurological diseases
Maiti, P., Manna, J., Ilavazhagan, G., Rossignol, J., & Dunbar, G. L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.020 · Cited by 118 · see citing works
Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats
Zhang, L., Luo, J., Zhang, M., Yao, W., Ma, X., & Yu, S. Y. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001661 · Cited by 109 · see citing works
Hippocampal BDNF in physiological conditions and social isolation
Zaletel, I. V., Filipović, D., & Puškaš, N. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0072 · Cited by 107 · see citing works
Alleviation of depression by glucagon-like peptide 1 through the regulation of Neuroinflammation, neurotransmitters, neurogenesis, and synaptic function
Kim, Y.-K., Kim, O. Y., & Song, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01270 · Cited by 109 · see citing works
Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience
Nowacka-Chmielewska, M. M., Grabowska, K., Grabowski, M., Meybohm, P., Burek, M., & Małecki, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113348 · Cited by 117 · see citing works
Fluoxetine Epigenetically Alters the CaMKIIα Promoter in Nucleus Accumbens to Regulate ΔFosB Binding and Antidepressant Effects
Robison, A. J., Vialou, V., Sun, H.-S., Labonte, B., A Golden, S., Dias, C., Turecki, G., Tamminga, C., Russo, S., Mazei-Robison, M., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.319 · Cited by 105 · see citing works
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Chromodomain Y-like Protein–Mediated Histone Crotonylation Regulates Stress-Induced Depressive Behaviors
Liu, Y., Li, M., Fan, M., Song, Y., Yu, H., Zhi, X., Xiao, K., Lai, S., Zhang, J., Jin, X., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.11.025 · Cited by 106 · see citing works
Progressive alterations of hippocampal CA3-CA1 synapses in an animal model of depression
Qiao, H., An, S.-C., Ren, W., & Ma, X. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.040 · Cited by 105 · see citing works
New translational perspectives for blood-based biomarkers of PTSD: From glucocorticoid to immune mediators of stress susceptibility
Daskalakis, N. P., Cohen, H., Nievergelt, C. M., Baker, D. G., Buxbaum, J. D., Russo, S. J., & Yehuda, R. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.024 · Cited by 105 · see citing works
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Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress
Christoffel, D. J., Golden, S. A., Walsh, J. J., Guise, K. G., Heshmati, M., Friedman, A. K., Dey, A., Smith, M., Rebusi, N., Pfau, M., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4034 · Cited by 101 · see citing works
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Leptin in depression: a potential therapeutic target
Ge, T., Fan, J., Yang, W., Cui, R., & Li, B. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1129-1 · Cited by 102 · see citing works
Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior
Fox, M. E., Chandra, R., Menken, M. S., Larkin, E. J., Nam, H., Engeln, M., Francis, T. C., & Lobo, M. K. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0211-5 · Cited by 100 · see citing works
Chronic Gestational Stress Leads to Depressive-Like Behavior and Compromises Medial Prefrontal Cortex Structure and Function during the Postpartum Period
Leuner, B., Fredericks, P. J., Nealer, C., & Albin-Brooks, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089912 · Cited by 100 · see citing works
Neuromodulators and Long-Term Synaptic Plasticity in Learning and Memory: A Steered-Glutamatergic Perspective
Bazzari, A. H., & Parri, H. R. (2019) · Brain Sciences · doi:10.3390/brainsci9110300 · Cited by 99 · see citing works
Unpredictable chronic mild stress induces anxiety and depression-like behaviors and inactivates AMP-activated protein kinase in mice
Zhu, S., Wang, J., Zhang, Y., Li, V., Kong, J., He, J., & Li, X. (2014) · Brain Research · doi:10.1016/j.brainres.2014.06.002 · Cited by 100 · see citing works
Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress
Horchar, M. J., & Wohleb, E. S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.030 · Cited by 96 · see citing works
Effect of Serotonin on Paired Associative Stimulation-Induced Plasticity in the Human Motor Cortex
Batsikadze, G., Paulus, W., Kuo, M., & Nitsche, M. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.127 · Cited by 95 · see citing works
Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication
Pilar-Cuéllar, F., Vidal, R., Díaz, Á., Castro, E., dos Anjos, S., Pascual-Brazo, J., Linge, R., Vargas, V., Blanco, H., Martínez-Villayandre, B., et al. (2013) · Journal of Neural Transplantation and Plasticity · doi:10.1155/2013/537265 · Cited by 93 · see citing works
Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis
Ghazizadeh, J., Hamedeyazdan, S., Torbati, M., Farajdokht, F., Fakhari, A., Mahmoudi, J., Araj‐Khodaei, M., & Sadigh‐Eteghad, S. (2020) · Experimental Physiology · doi:10.1113/ep088254 · Cited by 89 · see citing works
Gene expression studies in Depression development and treatment: an overview of the underlying molecular mechanisms and biological processes to identify biomarkers
Mariani, N., Cattane, N., Pariante, C. M., & Cattaneo, A. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01469-6 · Cited by 91 · see citing works
Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses
Kvarta, M. D., Bradbrook, K. E., Dantrassy, H. M., Bailey, A. M., & Thompson, S. M. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00359.2015 · Cited by 86 · see citing works
Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination
Ng, L. H. L., Huang, Y., Han, L., Chang, R. C.-C., Chan, Y. S., & Lai, C. S. W. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0321-5 · Cited by 82 · see citing works
New insights on neurobiological mechanisms underlying alcohol addiction
Cui, C., Noronha, A., Morikawa, H., Alvarez, V. A., Stuber, G. D., Szumlinski, K. K., Kash, T. L., Roberto, M., & Wilcox, M. V. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.09.022 · Cited by 86 · see citing works
BDNF and VEGF in the pathogenesis of stress-induced affective diseases: An insight from experimental studies
Nowacka-Chmielewska, M. M., & Obuchowicz, E. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71031-4 · Cited by 82 · see citing works
Effects of Inhibitor of κB Kinase Activity in the Nucleus Accumbens on Emotional Behavior
Christoffel, D. J., Golden, S. A., Heshmati, M., Graham, A., Birnbaum, S., Neve, R. L., Hodes, G. E., & Russo, S. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.121 · Cited by 78 · see citing works
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Chronic stress exacerbates neuropathic pain via the integration of stress-affect–related information with nociceptive information in the central nucleus of the amygdala
Li, M.-J., Liu, L., Chen, L., Cai, J., Wan, Y., & Xing, G. (2016) · Pain · doi:10.1097/j.pain.0000000000000827 · Cited by 75 · see citing works
Enriched environment ameliorates depression-induced cognitive deficits and restores abnormal hippocampal synaptic plasticity
Mahati, K., Bhagya, V. R., Christofer, T., Sneha, A., & Rao, B. S. S. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.017 · Cited by 74 · see citing works
Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats
Hong-luan, Y., Fan, C., Yang, L., Yu, S., Song, Q., Wang, P., & Mao, X. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000492684 · Cited by 74 · see citing works
Psilocybin microdosing does not affect emotion-related symptoms and processing: A preregistered field and lab-based study
Marschall, J., Fejer, G., Lempe, P., Prochazkova, L., Kuchar, M., Hajkova, K., & van Elk, M. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811211050556 · Cited by 72 · see citing works
Brain Correlates of Persistent Postural-Perceptual Dizziness: A Review of Neuroimaging Studies
Indovina, I., Passamonti, L., Mucci, V., Chiarella, G., Lacquaniti, F., & Staab, J. P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184274 · Cited by 77 · see citing works
Corticotropin releasing factor in neuroplasticity
Regev, L., & Baram, T. Z. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.10.001 · Cited by 71 · see citing works
Capsaicin Ameliorates Stress-Induced Alzheimer's Disease-Like Pathological and Cognitive Impairments in Rats
Jiang, X., Jia, L., Li, X., Cheng, X., Xie, J., Ma, Z., Xu, W., Liu, Y., Yao, Y., Du, L., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121837 · Cited by 69 · see citing works
Stress and cocaine trigger divergent and cell type-specific regulation of synaptic transmission at single spines in nucleus accumbens
Khibnik, L. A., Beaumont, M., Doyle, M., Heshmati, M., Slesinger, P. A., Nestler, E. J., & Russo, S. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.022 · Cited by 67 · see citing works
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Neural circuits regulating prosocial behaviors
Walsh, J. J., Christoffel, D. J., & Malenka, R. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01348-8 · Cited by 72 · see citing works
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Astrocyte plasticity induced by emotional stress: A new partner in psychiatric physiopathology?
Bender, C. L., Calfa, G. D., & Molina, V. A. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.005 · Cited by 69 · see citing works
Encore: Behavioural animal models of stress, depression and mood disorders
Petković, A., & Chaudhury, D. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.931964 · Cited by 70 · see citing works
Orientin improves depression‐like behavior and BDNF in chronic stressed mice
Liu, Y., Lan, N., Ren, J., Wu, Y., Wang, S., Huang, X., & Yu, Y. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400753 · Cited by 68 · see citing works
Sub-chronic variable stress induces sex-specific effects on glutamatergic synapses in the nucleus accumbens
Brancato, A., Bregman, D., Ahn, H. F., Pfau, M. L., Ménard, C., Cannizzaro, C., Russo, S. J., & Hodes, G. E. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.03.014 · Cited by 68 · see citing works
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Qi Fu Yin–a Ming Dynasty Prescription for the Treatment of Dementia
Ong, W., Wu, Y., Farooqui, T., & Farooqui, A. A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0908-0 · Cited by 67 · see citing works
Parkinson's Disease-Linked LRRK2-G2019S Mutation Alters Synaptic Plasticity and Promotes Resilience to Chronic Social Stress in Young Adulthood
Matikainen‐Ankney, B. A., Kezunovic, N., Ménard, C., Flanigan, M. E., Zhong, Y., Russo, S. J., Benson, D. L., & Huntley, G. W. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1457-18.2018 · Cited by 65 · see citing works
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Psychedelic‐inspired approaches for treating neurodegenerative disorders
Saeger, H. N., & Olson, D. E. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15544 · Cited by 65 · see citing works
TIAM1-mediated synaptic plasticity underlies comorbid depression–like and ketamine antidepressant–like actions in chronic pain
Ru, Q., Lu, Y., Saifullah, A. B., Blanco, F. A., Yao, C., Cata, J. P., Li, D., Tolias, K. F., & Li, L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158545 · Cited by 64 · see citing works
Ganoderic acid A exerted antidepressant-like action through FXR modulated NLRP3 inflammasome and synaptic activity
Bao, H., Li, H., Jia, Y., Xiao, Y., Luo, S., Zhang, D., Han, L., Dai, L., Xiao, C., Feng, L., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114561 · Cited by 63 · see citing works
Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats
Zhu, X.-L., Chen, J., Han, F., Pan, C., Zhuang, T.-T., Cai, Y., & Lu, Y.-P. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4915-7 · Cited by 63 · see citing works
Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress
Meng, D., Li, H.-Q., Deisseroth, K. A., Leutgeb, S., & Spitzer, N. C. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801598115 · Cited by 61 · see citing works
The appropriateness of the mouse model for ataxia-telangiectasia: Neurological defects but no neurodegeneration
Lavin, M. F. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.04.014 · Cited by 60 · see citing works
Stress-induced Changes in the S-palmitoylation and S-nitrosylation of Synaptic Proteins*[S]
Zaręba-Kozioł, M., Bartkowiak-Kaczmarek, A., Figiel, I., Krzystyniak, A., Wójtowicz, T., Bijata, M., & Włodarczyk, J. (2019) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra119.001581 · Cited by 58 · see citing works
Dysfunction of astrocytic connexins 30 and 43 in the medial prefrontal cortex and hippocampus mediates depressive-like behaviours
Huang, D., Li, C., Zhang, W., Qin, J., Jiang, W., & Hu, C. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111950 · Cited by 59 · see citing works
Andrographolide - A promising therapeutic agent, negatively regulates glial cell derived neurodegeneration of prefrontal cortex, hippocampus and working memory impairment
Das, S., Mishra, K. P., Ganju, L., & Singh, S. B. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.11.003 · Cited by 59 · see citing works
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Authors: Christoffel, D. J., Golden, S. A., & Russo, S. J.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Russo, Scott J.
ORCID: Christoffel, Daniel J.
Golden, Sam A.
Russo, Scott J.
Venue: Reviews in the Neurosciences
Publisher: Walter de Gruyter GmbH
Published: 2011-01-01
Volume: 22
Issue: 5
Pages: 535-49
ISSN: 0334-1763 (ISSN-L)
2191-0200
DOI: 10.1515/rns.2011.044
PMC: PMC3212803
OpenAlex: W2034154165
Cited by: 334
References: 185
Citations by year: 2026: 14 · 2025: 22 · 2024: 18 · 2023: 19 · 2022: 31 · 2021: 30 · 2020: 21 · 2019: 31 · 2018: 31 · 2017: 27 · 2016: 21 · 2015: 17 · 2014: 14 · 2013: 17 · 2012: 17
FWCI: 1.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Reviews in the Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH090264)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: stress, synaptic plasticity, structural plasticity, mesocorticolimbic system, dendritic spine morphology, mood disorders, depression, psychological stress, neuronal activity
MeSH terms: Animals, Brain, Humans, Neuronal Plasticity, Stress, Psychological, Synapses

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