Cardiovascular actions of berberine

Berberine sulfate: antimicrobial activity, bioassay, and mode of action

Amin, A., Subbaiah, T. V., & Abbasi, K. M. (1969) · Canadian Journal of Microbiology · doi:10.1139/m69-190 · Cited by 299 · see citing works

Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells

Fukuda, K., Hibiya, Y., Mutoh, M., Koshiji, M., Akao, S., & Fujiwara, H. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00162-7 · Cited by 270 · see citing works

Textbook of Natural Medicine

(2020) · Elsevier eBooks · doi:10.1016/c2015-0-02243-2 · Cited by 264 · see citing works

Berberine: Therapeutic Potential of an Alkaloid Found in Several Medicinal Plants

Birdsall, T. C., & Kelly, G. S. (1997) · Alternative medicine review · Cited by 258 · see citing works

Delayed afterdepolarizations in heart muscle: mechanisms and relevance.

January, C. T., & Fozzard, H. A. (1988) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00019-5 · Cited by 166 · see citing works

The control of tonic tension by membrane potential and intracellular sodium activity in the sheep cardiac Purkinje fibre.

Eisner, D. A., LEDERER, W. J., & Vaughan‐Jones, R. D. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014560 · Cited by 130 · see citing works

Cardiovascular effects of berberine in patients with severe congestive heart failure

Marin ‐ NETO, J. A., Maciel, B. C., Secches, A. L., & Gallo, L. (1988) · Clinical Cardiology · doi:10.1002/clc.4960110411 · Cited by 128 · see citing works

Vasorelaxant and antiproliferative effects of berberine

Ko, W. H., Yao, X., Lau, C., Law, W.-I., Chen, Z., Kwok, W., Ho, W. K. K., & Huang, Y. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00339-3 · Cited by 121 · see citing works

Monoamine Oxidase Inhibitors from Rhizoma of Coptis chinensis

Kong, L. D., Cheng, C. H. K., & Tan, R. X. (2001) · Planta Medica · doi:10.1055/s-2001-10874 · Cited by 110 · see citing works

Effects of ATP‐sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium

Nakaya, H., Takeda, Y., Tohse, N., et al. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12294.x · Cited by 91 · see citing works

CARDIAC ELECTROPHYSIOLOGY: A TEXTBOOK

Singer, I. (1991) · CHEST Journal · doi:10.1016/s0012-3692(16)52766-4 · Cited by 88 · see citing works

Relationship between the clinical effects of berberine on severe congestive heart failure and its concentration in plasma studied by HPLC

Zeng, X., & Zeng, X. (1999) · Biomedical Chromatography · doi:10.1002/(sici)1099-0801(199911)13:7 · Cited by 84 · see citing works

Mechanism of vasodilatory effect of berberine in rat mesenteric artery

Chiou, W., Yen, M., & Chieh-Fu, C. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90832-b · Cited by 74 · see citing works

Berberine Sulfate Inhibits Tumor-Promoting Activity of Teleocidin in Two-Stage Carcinogenesis on Mouse Skin

Nishino, H., Kitagawa, K., Fujiki, H., et al. (2009) · Oncology · doi:10.1159/000226349 · Cited by 73 · see citing works

Pharmacological studies on antidiarrheal effects of a preparation containing Berberine and Geranii Herba.

YAMAMOTO, K., TAKASE, H., Ken-ichi, A. B. E., Saito, Y., & SUZUKI, A. (1993) · Folia Pharmacologica Japonica · doi:10.1254/fpj.101.3_169 · Cited by 71 · see citing works

A biochemical study on the hypotensive effect of berberine in rats

Chun, Y. T., Yip, T. T., Lau, K. L., Kong, Y. C., & Sankawa, U. (1979) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(79)90085-5 · Cited by 59 · see citing works

On the mechanism of vasodilating action of berberine: possible role of inositol lipid signaling system.

Bova, S., Padrini, R., Goldman, W. F., Berman, D. M., & Cargnelli, G. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10978-6 · Cited by 56 · see citing works

Study of some pharmacological actions of berberine.

Sabir, M., & Nk, B. (1971) · PubMed · Cited by 49 · see citing works

The Antihypertensive Effect of the Berberine Derivative 6-Protoberberine in Spontaneously Hypertensive Rats

Liu, J., Chan, P., Chen, Y., Tomlinson, B., Hong, S.-F., & Cheng, J. (1999) · Pharmacology · doi:10.1159/000028331 · Cited by 46 · see citing works

Electropharmacological effects of berberine on canine cardiac Purkinje fibres and ventricular muscle and atrial muscle of the rabbit

Neto, F. R. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb12836.x · Cited by 45 · see citing works

Ionic Mechanism Responsible for Prolongation of Cardiac Action-Potential Duration by Berberine

Wang, Y.-X., & Zheng, Y. (1997) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199708000-00010 · Cited by 45 · see citing works

Relaxation of corpus cavernosum and raised intracavernous pressure by berberine in rabbit

Chiou, W., Chen, J., & Chen, C. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702249 · Cited by 43 · see citing works

Increase in action potential duration and inhibition of the delayed rectifier outward currentIKby berberine in cat ventricular myocytes

Sánchez‐Chapula, J. A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15302.x · Cited by 42 · see citing works

Effects of Berberine on Delayed Afterdepolarizations in Ventricular Muscles In Vitro and In Vivo

Wang, Y.-X., Yao, X. J., & Tan, Y.-H. (1994) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199405000-00005 · Cited by 41 · see citing works

Inotropic and Chronotropic Activity of Berberine on Isolated Guinea Pig Atria

Shaffer, J. E. (1985) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198503000-00016 · Cited by 40 · see citing works

Structural specificity of the NaK-ATPase inhibition by sanguinarine, an isoquinoline benzophenanthridine alkaloid

Cohen, H. G., Seifen, E. E., Straub, K. D., et al. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90325-8 · Cited by 37 · see citing works

Pharmacological effects of berberine on the longitudinal muscle of the guinea-pig isolated ileum.

Tsai, C., & Ochillo, R. F. (1992) · PubMed · Cited by 35 · see citing works

Inhibitory effects of berberine on ATP-sensitive K+ channels in cardiac myocytes

Wang, Y.-X., Zheng, Y., & Zhou, X.-B. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00663-2 · Cited by 33 · see citing works

Mechanical and electrophysiological effects of 8‐oxoberberine (JKL1073A) on atrial tissue

Chi, J., Chu, S., Lee, C., et al. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15431.x · Cited by 27 · see citing works

Effects of berberine of L- and T-type calcium channels in guinea pig ventricular myocytes.

Xu, S., Zhang, Y., Ren, J. Y., et al. (1997) · PubMed · Cited by 27 · see citing works

Mechanism of the Aortic Relaxation Induced by Low Concentrations of Berberine

Wong, K. (1998) · Planta Medica · doi:10.1055/s-2006-957575 · Cited by 26 · see citing works

Dicentrine, an ?-adrenoceptor antagonist with sodium and potassium channel blocking activities

Su, M., Nieh, Y.-C., Huang, H.-C., et al. (1994) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00178204 · Cited by 24 · see citing works

Evaluation of the alpha-adrenoceptor antagonistic action of berberine in isolated organs.

Ölmez, E., & Ilhan, M. (1992) · PubMed · Cited by 24 · see citing works

Beneficial effects of berberine on hemodynamics during acute ischemic left ventricular failure in dogs.

Huang, W., Yan, H., Jin, J., Yu, C., & Zhang, H. (1992) · PubMed · Cited by 23 · see citing works

Some Observations on the Cardiovascular Effects of 9-Substituted Berberines

Fukuda, H., Watanabe, K., & Kudo, Y. (1970) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.18.1299 · Cited by 21 · see citing works

PHARMACOLOGICAL INVESTIGATIONS OF BERBERINE SULPHATE

Kulkarni, S. K., Dandiya, P. C., & VARANDANI, N. L. (1972) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.22.11 · Cited by 17 · see citing works

[Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion].

Wu, J., & Liu, T. P. (1995) · PubMed · Cited by 17 · see citing works

THE ACTION OF BERBERINE ON MAMMALIAN HEARTS

JANG, C. S. (1941) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)03380-4 · Cited by 11 · see citing works

Effects of 8-oxoberberine on sodium current in rat ventricular and human atrial myocytes.

Chi, J. F., Chu, S., Lee, C. S., et al. (1997) · PubMed · Cited by 10 · see citing works

Influence of berberine on the blood pressure of rabbits

Ko, S.-T., & Lim, D. Y. (1980) · Archives of Pharmacal Research · doi:10.1007/bf02884757 · Cited by 9 · see citing works

(±)-Govadine and (±)-THP, Two Tetrahydroprotoberberine Alkaloids, as Selective α1-Adrenoceptor Antagonists in Vascular Smooth Muscle Cells

Ko, F., Chang, Y., Chen, C. A., et al. (1996) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1996.tb05986.x · Cited by 9 · see citing works

Effects of (-)-stepholidine and tetrahydroberberine on high potassium-evoked contraction and calcium influx in rat artery.

Yang, S., Miao, Y., Han, Q., et al. (1993) · PubMed · Cited by 9 · see citing works

Effects of tetrahydroberberine on ischemic and reperfused myocardium in rats.

Zhou, J., XUAN, B., & Li, D. (1993) · PubMed · Cited by 7 · see citing works

[Protective effects of berberine on spontaneous ventricular fibrillation in dogs after myocardial infarction].

Xu, Z. F., Cao, H.-Y., & Li, Q. (1989) · PubMed · Cited by 7 · see citing works

[The role and mechanism of berberine on coronary arteries].

Huang, W. (1990) · PubMed · Cited by 5 · see citing works

Inhibitory effect of molecular moiety in papaverine structure on cyclic AMP-phosphodiesterase of smooth and cardiac muscles.

Kimura, M., Waki, I., & Kimura, I. (1978) · Journal of Pharmacobio-Dynamics · doi:10.1248/bpb1978.1.145 · Cited by 4 · see citing works

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1135 · Cited by 1,391 · see citing works

Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics

Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, S. T. S., Šmejkal, K., Malaník, M., et al. (2019) · Theranostics · doi:10.7150/thno.30787 · Cited by 465 · see citing works

Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats

Chen, W., Miao, Y.-Q., Fan, D.-J., Yang, S.-S., Lin, X., Meng, L.-K., & Tang, X. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9632-z · Cited by 363 · see citing works

Berberine on metabolic and cardiovascular risk factors: An analysis from preclinical evidences to clinical trials

Derosa, G., Maffioli, P., & Cicero, A. F. (2012) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2012.704014 · Cited by 171 · see citing works

Block of hERG Channels by Berberine: Mechanisms of Voltage- and State-Dependence Probed With Site-Directed Mutant Channels

Rodriguez-Menchaca, A., Ferrer-Villada, T., Lara, J., Fernandez, D., Navarro-Polanco, R. A., & Sanchez-Chapula, J. A. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000191564.52242.00 · Cited by 39 · see citing works

Quasi-Irreversible Inhibition of CYP2D6 by Berberine

Kim, H. G., Lee, H. S., Jeon, J. S., Choi, Y. J., Choi, Y. J., Yoo, S.-Y., Kim, E.-Y., Lee, K., Park, I., Na, M., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100916 · Cited by 21 · see citing works

Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review

Dumitru, C. N., Marcu, T., Dumitru, A. O., Tudor, S. S., Ferțu, I. D., Elisei, A.-M., & Goroftei, L. (2026) · Pharmaceuticals · doi:10.3390/ph19081313 · Cited by 2 · see citing works

Temperature-Dependence of Maturation of Chronotropic and Inotropic Responses to Isoproterenol

Park, M. K., Johnson, J. M., & Hayashi, S. (2017) · Developmental Pharmacology and Therapeutics · doi:10.1159/000457738

N-aralkyl substitution of 2-aminoindans. Synthesis and their inotropic and chronotropic activity in isolated guinea pig atria.

Pérez, J. A., Dominguez, J. N., Ángel, J., et al. (1997) · PubMed · Cited by 5 · see citing works

Chronotropic and Inotropic Effects of Prostaglandins E1, A1, and F2 on Isolated Mammalian Cardiac Tissue

Su, J. Y., Higgins, C. B., & Wf, F. (1973) · Experimental Biology and Medicine · doi:10.3181/00379727-143-37507 · Cited by 10 · see citing works

Chronotropic and Inotropic Effects of [Mg++]o Not Dependent Upon [Ca++]o

Woods, W. T. (1986) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5107-8_46

Studies of the positive inotropic effects of Y 909, a new pyridazinones derivative and its mechanism

Xiao, Q. (1998) · Zhongguo yaolixue tongbao