Two new rare variants in the circadian “clock” gene may influence sleep pattern
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Both individuals with the rare CLOCK SNPs had the same pattern of sleep consisting of alternating phases of good sleep and insomnia over the course of a few days.
“both of these individuals had the same pattern of sleep which consisted of alternating phases of good sleep and insomnia over the course of a few days”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Pirovano et al., 2005
Two rare SNPs in the 3′ flanking region of the CLOCK gene (3117 G to T and 3125 A to G) were identified in two subjects with major depression and not in any healthy controls in the study.
“two rare SNPs in the same region (3117 G to T and 3125 A to G) have been identified by Pirovano et al., in two subjects with major depression, and not in any of the healthy controls in their study (Pirovano et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Pirovano et al., 2005
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- Authors
- Pirovano, A., Lorenzi, C., Serretti, A., Ploia, C., Landoni, S., Catalano, M., Smeraldi, E., & Lorenzi, C.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- Venue
- Genetics in Medicine
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 7
- Issue
- 6
- Pages
- 455-457
- ISSN
- 1098-3600 (ISSN-L)
- OpenAlex
- W2056127448
- Cited by
- 17
- References
- 19
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 2 · 2017: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Genetics in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- clock genes, rare variants, sleep patterns, suprachiasmatic nucleus, circadian rhythm, genetic polymorphism, sleep timing, genotype-phenotype correlation, genetic association studies, gene-environment interaction
- MeSH terms
- Bipolar Disorder, Circadian Rhythm, Depressive Disorder, Humans, Sleep, Sleep Wake Disorders, Trans-Activators, Case-Control Studies, 3' Untranslated Regions, Polymorphism, Single Nucleotide, CLOCK Proteins
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