Genetic dissection of psychopathological symptoms: Insomnia in mood disorders and CLOCK gene polymorphism
Abstract
We investigated the possible effect of the 3111T/C CLOCK gene polymorphism on sleep disorders in a sample of 620 patients affected by major depressive disorder (MDD) and bipolar disorder (BP). We detected a significantly higher recurrence of initial (P = 0.0001), middle (P = 0.0009), and early (P = 0.0008) insomnia in homozygotes for the C variant and a similar trend concerning decreased need of sleep in BP (P = 0.0074). Other demographic and clinical features were found not related with CLOCK polymorphisms. This preliminary observation leads to hypothesize a possible involvement of the CLOCK gene polymorphism in the sleep disregulations in MDD and BP.
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The CLOCK 3111 T to C SNP is associated with greater insomnia in bipolar patients.
“This SNP is also associated with greater insomnia and decreased need for sleep in bipolar patients, as well as greater insomnia in individuals undergoing antidepressant treatment (Serretti et al., 2003; Serretti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Serretti et al., 2003
The CLOCK 3111 T to C SNP is associated with decreased need for sleep in bipolar patients.
“This SNP is also associated with greater insomnia and decreased need for sleep in bipolar patients, as well as greater insomnia in individuals undergoing antidepressant treatment (Serretti et al., 2003; Serretti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Serretti et al., 2003
The CLOCK 3111 T to C SNP is associated with greater insomnia in individuals undergoing antidepressant treatment.
“This SNP is also associated with greater insomnia and decreased need for sleep in bipolar patients, as well as greater insomnia in individuals undergoing antidepressant treatment (Serretti et al., 2003; Serretti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Serretti et al., 2003
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- Authors
- Serretti, A., Benedetti, F., Mandelli, L., Lorenzi, C., Pirovano, A., Colombo, C., & Smeraldi, E.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- Corresponding author
- Serretti, Alessandro
- ORCID
- Venue
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2003-05-29
- Volume
- 121B
- Issue
- 1
- Pages
- 35-38
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W2023563864
- Cited by
- 264
- References
- 35
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 8 · 2020: 8 · 2019: 10 · 2018: 11 · 2017: 11 · 2016: 11 · 2015: 15 · 2014: 17 · 2013: 20 · 2012: 14
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- clock gene polymorphisms, insomnia, mood disorders, major depressive disorder, bipolar disorder, sleep disorders, genetic susceptibility, circadian rhythm genes
- MeSH terms
- Adult, Female, Gene Frequency, Genotype, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Trans-Activators, Chi-Square Distribution, Mood Disorders, CLOCK Proteins
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