Cigarette smoking and risk of coronary heart disease incidence among middle-aged Japanese men and women: the JPHC Study Cohort I
Abstract
BACKGROUND: Few data have been available on the sex-specific magnitude of the smoking effect on the risk of coronary heart disease (CHD) in Asia. DESIGN AND METHODS: A population-based prospective cohort study of 19 782 men and 21 500 women aged 40-59 years between 1990-1992 and 2001 was conducted to examine the relationship between smoking status and the risk of CHD. RESULTS: A total of 260 incidences of CHD were confirmed among men, including 174 myocardial infarctions (MI). The numbers among women were 66 and 43, respectively. The multivariate relative risk [95% confidence interval (CI)] for current smokers versus never-smokers in men after adjustment for cardiovascular risk factors, several life style factors and public health centre was 2.85 (1.98, 4.12) for total CHD and 3.64 (2.27, 5.83) for MI. These respective risks in women were 3.07 (1.48, 6.40) and 2.90 (1.18, 7.18). Among men, a dose-dependent relationship was observed between the number of cigarettes and the risk of MI. The population-attributable risk per cent (95% CI) of CHD was 46% (34, 55) in men and 9% (0, 18) in women. Smoking cessation, however, led to a rapid decline in the CHD risk within 2 years. CONCLUSION: Smoking raises the risk of CHD significantly in both sexes of middle-aged Japanese, with large public health significance especially in men. Smoking cessation would have an immediate effect on risk reduction.
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Many epidemiological studies have reported that regardless of age and gender, the risk of recurrence of cardiovascular events decreases by approximately half after the first year of smoking cessation and continues to decrease thereafter.
“Many epidemiological studies have reported that regardless of age and gender, the risk of recurrence of cardiovascular events decreases by approximately half after the first year of smoking cessation and continue to decrease thereafter.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [784]
In the REACH Registry, the incidence rate of cardiovascular events in patients who continued to smoke was approximately 1.3-fold higher than that observed in lifelong nonsmokers.
“In the REACH Registry, a registry study on patients with ASCVD, CAD, cerebrovascular diseases, and PAD or overlapping risks factors for ASCVD, the incidence rate of cardiovascular events in patients who continued to smoke was approximately 1.3-fold higher than that observed in lifelong nonsmokers784).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [784]
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Self-citation
- Authors
- Baba, S., Iso, H., Mannami, T., Sasaki, S., Okada, K., Konishi, M., & Tsugane, S.
- Affiliations
- National Cerebral and Cardiovascular Center (JP)
- University of Tsukuba (JP)
- Kagawa University (JP)
- National Institute of Health and Nutrition, Tokyo
- Ehime University (JP)
- National Cancer Centre Japan (JP)
- Corresponding author
- Baba, Shunroku
- Venue
- European Journal of Cardiovascular Prevention & Rehabilitation
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-04
- Volume
- 13
- Issue
- 2
- Pages
- 207-213
- ISSN
- 1741-8267 (ISSN-L)
- OpenAlex
- W2006909336
- Cited by
- 79
- References
- 28
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 6 · 2012: 5
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Cardiovascular Prevention & Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- cigarette smoking, coronary artery disease, myocardial infarction, sex differences, middle-aged adults, Japanese population, smoking cessation, dose-response relationship, population attributable risk, cardiovascular risk factors
- MeSH terms
- Adult, Coronary Disease, Female, Humans, Japan, Male, Middle Aged, Smoking, Cohort Studies, Incidence, Death, Sudden, Cardiac
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