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Cited by 157Posttraumatic Stress Disorder ResearchMigration, Health and TraumaTreatment of Major Depression

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Venlafaxine Extended Release in Posttraumatic Stress Disorder: A Sertraline- and Placebo-controlled Study

Davidson, Jonathan, Rothbaum, Barbara O., Tucker, Phebe, Asnis, Gregory, Benattia, Isma, Musgnung, Jeff J.·2006·Journal of Clinical Psychopharmacology
DOI 10.1097/01.jcp.0000222514.71390.c1
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Abstract

This 12-week, double-blind, multicenter trial evaluated the efficacy of venlafaxine extended release (ER), sertraline, and placebo in adult outpatients (N = 538) with a primary diagnosis of posttraumatic stress disorder (PTSD), as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, symptoms for 6 months or more and 17-item Clinician-administered PTSD Scale (CAPS-SX17) score of 60 or more. Patients were randomly assigned to receive placebo or flexible doses of venlafaxine ER (37.5-300 mg/d) or sertraline (25-200 mg/d) for 12 weeks or less. The primary outcome was the baseline-to-end point change in total CAPS-SX17 score (last observation carried forward). Secondary measures included CAPS-SX17 symptom cluster scores for reexperiencing/intrusion, avoidance/numbing, and hyperarousal; frequency of remission (CAPS-SX17 < or =20); and changes in Davidson Trauma Scale total score and symptom cluster scores for avoidance/numbing, hyperarousal, and reexperiencing/intrusion. Mean changes in CAPS-SX17 scores were -41.8, -39.4, and -33.9 for venlafaxine ER (P < 0.05 vs. placebo), sertraline, and placebo, respectively. Mean changes for venlafaxine ER, sertraline, and placebo in CAPS-SX17 cluster scores were -13.0, -11.7, and -11.0 for reexperiencing; -17.1, -16.8, and -13.7 (P < 0.05 both active treatments vs. placebo) for avoidance/numbing; and -11.8, -10.9, and -9.2 (P < 0.05 venlafaxine vs. placebo) for hyperarousal. Week 12 remission rates were venlafaxine ER 30.2% (P < 0.05 vs. placebo), sertraline 24.3%, and placebo 19.6%. The venlafaxine ER group had significantly better Davidson Trauma Scale total and cluster scores than placebo. Mean maximum daily doses were 225-mg venlafaxine ER and 151-mg sertraline. Both treatments were generally well tolerated. Study results suggest that venlafaxine ER is effective and well tolerated in the short-term treatment of PTSD.

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Metadata

Authors
Davidson, J., Rothbaum, B. O., Tucker, P., Asnis, G., Benattia, I., & Musgnung, J. J.
Affiliations
  • Duke University (US)
  • Emory University (US)
  • OU Health (US)
  • Albert Einstein College of Medicine (US)
  • Wyeth (US)
Corresponding author
Davidson, Jonathan
ORCID
Venue
Journal of Clinical Psychopharmacology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-06
Volume
26
Issue
3
Pages
259-267
ISSN
0271-0749 (ISSN-L)
DOI
10.1097/01.jcp.0000222514.71390.c1
OpenAlex
W2066358721
Cited by
157
References
41
Citations by year
2026: 2 · 2025: 5 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 9 · 2013: 9 · 2012: 9
FWCI
13.25
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
post-traumatic stress disorder, sertraline, selective serotonin reuptake inhibitors, antidepressant efficacy, symptom remission, re-experiencing, avoidance and numbing, hyperarousal, outpatients, flexible dosing, Davidson Trauma Scale, treatment-resistant PTSD, adverse events
MeSH terms
Venlafaxine Hydrochloride, Adolescent, Adult, Cyclohexanols, Delayed-Action Preparations, Double-Blind Method, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Stress Disorders, Post-Traumatic, Antidepressive Agents, Second-Generation, Sertraline

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