Cited by 89Posttraumatic Stress Disorder ResearchStress Responses and CortisolPsychoanalysis and Psychopathology Research

Recent Progress in Understanding the Pathophysiology of Post-Traumatic Stress Disorder: Implications for Targeted Pharmacological Treatment

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Bailey, Christopher R., Cordell, Elisabeth, Sobin, Sean M., Neumeister, Alexander·2013·CNS Drugs

Abstract

Post-traumatic stress disorder (PTSD) is a common and chronic anxiety disorder that can result after exposure to a traumatic event. Though our understanding of the aetiology of PTSD is incomplete, several neurobiological systems have been implicated in the pathophysiology and vulnerability towards developing PTSD after trauma exposure. We aimed to provide a concise review of benchmark findings in important neurobiological systems related to the aetiology and maintenance of PTSD symptomology. Specifically, we discuss functional aetiologies in the noradrenergic, serotonergic, endogenous cannabinoid and opioid systems as well as the hypothalamic-pituitary adrenal (HPA) axis. This article provides a succinct framework to appreciate the current understanding of neurobiological mechanisms related to the pathophysiology of PTSD and how these findings may impact the development of future, targeted pharmacological treatments for this debilitating disorder.

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Crossref · 10.1007/s40263-013-0051-4

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  • Other neuropeptides/neurotrophic factors, such as neuropeptide Y, dynorphin, oxytocin, and brain-derived neurotrophic factor (BDNF), are also involved in the HPA axis and in the orchestration of the response to stress.

    “Other neuropeptides/neurotrophic factors, such as neuropeptide Y (95), dynorphin (96), and oxytocin as well as brain-derived neurotrophic factor (BDNF), are also involved in the HPA axis and in the orchestration of the response to stress.”

    From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [96]

    Section 6 (Opioid System; page unavailable) says the dynorphin/κ-opioid receptor system has a role in stress-induced behaviours, supporting the part of the sentence to which this paper appears to be cited. Section 5 (HPA Axis; page unavailable) discusses CRF and endocannabinoids, but does not link dynorphin to the HPA axis. Searches for neuropeptide Y, oxytocin, and BDNF did not find support for attributing those examples to this paper. (LLM, conf=0.84)

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1 of the 203 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [87]Palacios J Pazos A Hoyer D Dourish C Ahlenius S Hutson P Characterisation and mapping of 5-HT1A receptors in animals and in man Brain 5-HT1A receptors: behavioural and neurochemical pharmacology 1987 Ellis Horwood Chichester Chapter 6

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Authors
Bailey, C. R., Cordell, E., Sobin, S. M., & Neumeister, A.
Affiliations
  • Johns Hopkins University (US)
  • NYU Langone Health (US)
Corresponding author
Neumeister, Alexander
Venue
CNS Drugs
Published
2013-03
Volume
27
Issue
3
Pages
221-232
ISSN
  • 1172-7047 (ISSN-L)
  • 1179-1934
OpenAlex
W2085725087
Cited by
89
References
203
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 4 · 2021: 10 · 2020: 9 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 2
FWCI
1.17
Type
journal article
Language
en
Open access
Locations
  • CNS Drugs (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (R21MH085627, R01MH096876, R21MH081103, R21MH096105)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
post-traumatic stress disorder, pathophysiology, noradrenergic system, serotonergic system, endocannabinoid system, opioid system, hypothalamic-pituitary-adrenal axis, trauma exposure
MeSH terms
Animals, Female, Humans, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Stress Disorders, Post-Traumatic, Drug Design, Molecular Targeted Therapy

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