Speed of Improvement in Sleep Disturbance and Anxiety Compared With Core Mood Symptoms During Acute Treatment of Depression in Old Age
Abstract
Objectives The objective of this study was to examine the relative speed of improvement in sleep disturbance and anxiety symptoms compared with core mood symptoms in acute treatment of late-life major depression.Method The authors conducted secondary analysis of acute treatment data in 470 older patients treated in three federally funded studies. The authors compared rates of improvement in three Hamilton Rating Scale for Depression symptom clusters after stratification by study.Results Anxiety symptoms improved more slowly with antidepressant monotherapy and with combined pharmacotherapy/psychotherapy, whereas sleep symptoms improved at a similar rate as core mood symptoms.Conclusions Anxiety symptoms tend to persist in patients with late-life depression.
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The treatment literature indicates that the combination of anxiety and depression is more difficult to treat, with greater risk of relapse and poorer treatment response, than either alone.
“The treatment literature indicates that the combination of anxiety and depression is more difficult to treat, with greater risk of relapse and poorer treatment response, than either alone [25,26]”
From A longitudinal study of affective and anxiety disorders, depressive affect and diabetes distress in adults with type 2 diabetes (2008) · cites this paper as [25]
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Self-citation
- Authors
- Dombrovski, A. Y., Blakesley-Ball, R. E., Mulsant, B. H., Mazumdar, S., Houck, P. R., Szanto, K., & Reynolds, C. F.
- Affiliations
- University of Pittsburgh (US)
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Mulsant, Benoit H.
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 14
- Issue
- 6
- Pages
- 550-554
- ISSN
- 1064-7481 (ISSN-L)
- OpenAlex
- W2015213354
- Cited by
- 27
- References
- 17
- Citations by year
- 2023: 1 · 2020: 2 · 2017: 2 · 2016: 1 · 2013: 4
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01 MH37869, P30MH052247, R37 MH43832, R25MH60473, R37MH043832, P30MH071944, R25MH060473, P30-MH52247, K24MH069430, R01MH037869, K23MH070471)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- geriatric depression, sleep disorders, anxiety symptoms, antidepressant monotherapy, combined psychotherapy and pharmacotherapy, acute treatment, older adults
- MeSH terms
- Aged, Antidepressive Agents, Tricyclic, Anxiety Disorders, Combined Modality Therapy, Major Depressive Disorder, Female, Humans, Male, Nortriptyline, Surveys and Questionnaires, Severity of Illness Index, Sleep Wake Disorders, Time Factors, Cognitive Behavioral Therapy, Prevalence, Mood Disorders
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