The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Respiratory Viral Infections in Adults With Hematologic Malignancies and Human Stem Cell Transplantation Recipients: A Retrospective Study at a Major Cancer Center
Abstract
Community respiratory viruses (CRVs) have been recognized as a potential cause of pneumonia and death among hematopoietic stem cell transplantation (HSCT) recipients and patients with hematologic malignancies. We reviewed the Microbiology Laboratory records dated from July 1, 2000, to June 30, 2002, to identify patients who had respiratory specimens positive for influenza, parainfluenza, respiratory syncytial virus, or picornavirus. We identified 343 infections among patients with underlying hematologic malignancies and HSCT. We collected data on type of disease, age, sex, type of infection, neutrophil and lymphocyte counts, therapy, and outcome. Influenza, parainfluenza, and respiratory syncytial virus accounted for most cases and were approximately equal in frequency. Most infections occurred predominantly among recipients of allogeneic transplants. Infection progressed to pneumonia in 119 patients (35%) and occurred with similar frequency for the 3 viruses. Patients at greatest risk for developing pneumonia included those with leukemia, those aged more than 65 years, and those with severe neutropenia or lymphopenia. Lack of respiratory syncytial virus-directed antiviral therapy (p = 0.025) and age (p = 0.042) were associated with development of respiratory syncytial virus pneumonia, and an absolute lymphocyte count ≤200 cells/mL (p = 0.049) was associated with development of influenza pneumonia. The overall mortality rate for CRV pneumonia was 15%. The only independent predictor of fatal outcome was an absolute lymphocyte count ≤200 cells/mL (p = 0.03) in patients with influenza pneumonia. HSCT recipients and patients with hematologic malignancies who develop upper respiratory infection due to CRVs should be considered for antiviral therapy of proven efficacy to reduce the risk of pneumonia and death. Abbreviations: CRV = community respiratory virus; HSCT = hematopoietic stem cell transplantation; RSV = respiratory syncytial virus; URI = upper respiratory infection.
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Citations
Cites
The IMpact-RSV Study Group (1998) · Pediatrics · doi:10.1542/peds.102.3.531 · Cited by 1,961
Nonbacterial Pneumonia After Allogeneic Marrow Transplantation: A Review of Ten Years' Experience
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Use of the Selective Oral Neuraminidase Inhibitor Oseltamivir to Prevent Influenza
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An Outbreak of Respiratory Syncytial Virus in a Bone Marrow Transplant Center
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Community Respiratory Virus Infections Among Hospitalized Adult Bone Marrow Transplant Recipients
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Self-citationNosocomial Respiratory Syncytial Virus Infections
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Respiratory Syncytial Virus Infection in Immunocompromised Adults
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Cited by
Muthuri, S. G., Venkatesan, S., Myles, P. R., Leonardi-Bee, J., Al Khuwaitir, T. S. A., Al Mamun, A., Anovadiya, A. P., Azziz-Baumgartner, E., Báez, C., Bassetti, M., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70041-4 · Cited by 644
Harper, S. A., Bradley, J. S., Englund, J. A., File, T. M., Gravenstein, S., Hayden, F. G., McGeer, A. J., Neuzil, K. M., Pavia, A. T., Tapper, M. L., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/598513 · Cited by 647
Nosocomial infections in patients with cancer
Kamboj, M., & Sepkowitz, K. A. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70069-5 · Cited by 318
Clonal haematopoiesis and dysregulation of the immune system
Belizaire, R., Wong, W. J., Robinette, M. L., & Ebert, B. L. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00843-3 · Cited by 161
Tramontana, A. R., George, B., Hurt, A. C., Doyle, J. S., Langan, K., Reid, A. B., Harper, J. M., Thursky, K., Worth, L. J., Dwyer, D. E., et al. (2010) · Emerging Infectious Diseases · doi:10.3201/eid1607.091691 · Cited by 127
Metadata
- Authors
- Chemaly, R. F., Ghosh, S., Bodey, G. P., Rohatgi, N., Safdar, A., Keating, M. J., Champlin, R. E., Aguilera, E. A., Tarrand, J. J., & Raad, I. I.
- Venue
- Medicine
- Published
- 2006-09
- Volume
- 85
- Issue
- 5
- Pages
- 278-287
- ISSN
- 0025-7974 (ISSN-L)
- OpenAlex
- W2034643586
- Cited by
- 329
- References
- 40
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Respiratory Viral Infections in Adults With Hematologic Malignancies and Human Stem Cell Transplantation Recipients: A Retrospective Study at a Major Cancer Center. https://app.cochat.ai/papers/10.1097/01.md.0000232560.22098.4e
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- Chemaly, R. F., Ghosh, S., Bodey, G. P., Rohatgi, N., Safdar, A., Keating, M. J., Champlin, R. E., Aguilera, E. A., Tarrand, J. J., & Raad, I. I. (2006). Respiratory Viral Infections in Adults With Hematologic Malignancies and Human Stem Cell Transplantation Recipients: A Retrospective Study at a Major Cancer Center. Medicine. https://doi.org/10.1097/01.md.0000232560.22098.4e
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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