Breath Actuated Device Improves Delivery to Target Sites Beyond the Nasal Valve
Abstract
Objectives: The objective was to compare nasal deposition patterns achieved with a conventional hand actuated spray pump and a novel breath actuated bidirectional prototype device housing the same spray pump (OptiMist™, OptiNose AS, Oslo, Norway). Study Design and Methods: The bidirectional delivery device exploits the posterior connection between the nasal passages persisting when the velum automatically closes during oral exhalation. The deposition and clearance patterns achieved with the two devices were compared in nine healthy subjects by scintigraphy after administration of 99m Tc‐aerosols. Results: Compared with traditional spray pump delivery, the OptiMist device provided significantly (P < .004) larger initial and cumulative deposition (area under the deposition vs. time curve) in the upper posterior segment of the nasal passage, housing the sinus ostia and the olfactory region, and significantly lower deposition (P < .004) in the anterior segment, lined by nonciliated squamous epithelium. Furthermore, intersubject reproducibility of the initial and cumulative deposition was higher for the OptiMist™ device both in the upper posterior segment and the entire nose. Conclusions: Compared with a spray pump, the novel breath actuated bidirectional device provides significantly larger deposition in the clinically important regions beyond the nasal valve and reduced anterior deposition. These striking differences provide new opportunities for improved therapy of chronic rhinosinusitis and polyposis as well as extended use of the nose for delivery of drugs from the nose into the brain.
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The Breath Powered device was shown to enhance deposition in intranasal sites targeted for nose-to-brain transport.
“using a novel Breath Powered device shown to enhance deposition in intranasal sites targeted for nose-to-brain transport.38, 39”
Only a small fraction of liquid delivered with conventional nasal spray devices reaches the upper-posterior region of the nasal cavity.
“Only a small fraction of liquid delivered with such devices reaches the upper-posterior region of the nasal cavity,38”
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- Authors
- Djupesland, P. G., Skretting, A., Winderen, M., & Holand, T.
- Affiliations
- OptiNose (Norway) (NO)
- Corresponding author
- Djupesland, Per Gisle
- Venue
- The Laryngoscope
- Publisher
- Wiley
- Published
- 2006-03
- Volume
- 116
- Issue
- 3
- Pages
- 466-472
- ISSN
- 0023-852X (ISSN-L)
- 1531-4995
- OpenAlex
- W2081374067
- Cited by
- 146
- References
- 15
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 5 · 2013: 7 · 2012: 7
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Laryngoscope (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Keywords
- intranasal drug delivery, nasal valve, scintigraphy, chronic rhinosinusitis, nasal polyps
- MeSH terms
- Administration, Intranasal, Adult, Aerosols, Aged, Equipment Design, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nasal Cavity, Nebulizers and Vaporizers, Radionuclide Imaging, Reference Values, Respiration, Technetium Tc 99m Pentetate, Radiopharmaceuticals
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