Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model
Abstract
Accumulating evidence demonstrates the important role of oxytocin (OT) in the modulation of social cognition and behavior. This has led many to suggest that the intranasal administration of OT may benefit psychiatric disorders characterized by social dysfunction, such as autism spectrum disorders and schizophrenia. Here, we review nasal anatomy and OT pathways to central and peripheral destinations, along with the impact of OT delivery to these destinations on social behavior and cognition. The primary goal of this review is to describe how these identified pathways may contribute to mechanisms of OT action on social cognition and behavior (that is, modulation of social information processing, anxiolytic effects, increases in approach-behaviors). We propose a two-level model involving three pathways to account for responses observed in both social cognition and behavior after intranasal OT administration and suggest avenues for future research to advance this research field.
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Taken together, those results suggest that intranasal oxytocin reaches the central nervous system and produces observable affective, behavioral, or cognitive modifications.
“Taken together, those results suggest that IN-OT reaches, directly or indirectly (41), the central nervous system and would so produces observable affective, behavioral or cognitive modifications.”
From Is there a Publication Bias in Behavioural Intranasal Oxytocin Research on Humans? Opening the File Drawer of One Laboratory (2016) · cites this paper as [41]
Cites
1 retracted
Gumley, A. I., Braehler, C., & MacBeth, A. M. (2014) · British Journal of Clinical Psychology · doi:10.1111/bjc.12041 · Cited by 34 · see citing works
Retracted(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,148 · see citing works
Heart rate variability: origins, methods, and interpretive caveats
BERNTSON, G. G., THOMAS BIGGER, J., ECKBERG, D. L., GROSSMAN, P., KAUFMANN, P. G., MALIK, M., NAGARAJA, H. N., PORGES, S. W., SAUL, J. P., STONE, P. H., et al. (1997) · Psychophysiology · doi:10.1111/j.1469-8986.1997.tb02140.x · Cited by 3,962 · see citing works
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396 · see citing works
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
Thayer, J. F., & Lane, R. D. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.004 · Cited by 2,040 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580 · see citing works
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,572 · see citing works
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · see citing works
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
(2009) · Elsevier eBooks · doi:10.1016/c2009-1-03742-3 · Cited by 1,332 · see citing works
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
Dhuria, S. V., Hanson, L. R., & Frey, W. H. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21924 · Cited by 1,239 · see citing works
Intranasal delivery of biologics to the central nervous system
Lochhead, J. J., & Thorne, R. G. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.002 · Cited by 1,214 · see citing works
(2011) · Cited by 1,181 · see citing works
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059 · see citing works
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962 · see citing works
Self-citationThorne, R. G., Pronk, G. J., Padmanabhan, V., & Frey, W. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.029 · Cited by 958 · see citing works
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954 · see citing works
Oxytocin promotes human ethnocentrism
De Dreu, C. K. W., Greer, L. L., Van Kleef, G. A., Shalvi, S., & Handgraaf, M. J. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015316108 · Cited by 838 · see citing works
Oxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798 · see citing works
Self-citationOxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · see citing works
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693 · see citing works
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689 · see citing works
Bal, E., Harden, E., Lamb, D., Van Hecke, A. V., Denver, J. W., & Porges, S. W. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0884-3 · Cited by 575 · see citing works
Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review
Djupesland, P. G. (2013) · Drug Delivery and Translational Research · doi:10.1007/s13346-012-0108-9 · Cited by 563 · see citing works
Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder
Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.123 · Cited by 549 · see citing works
Intranasal Administration of Oxytocin Increases Envy and Schadenfreude (Gloating)
Shamay-Tsoory, S. G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., & Levkovitz, Y. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.009 · Cited by 542 · see citing works
Price, J. L. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901500105 · Cited by 530 · see citing works
Cho, M. M., DeVries, A. C., Williams, J. R., & Carter, C. S. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.1071 · Cited by 529 · see citing works
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521 · see citing works
Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511 · see citing works
Distinct representations of olfactory information in different cortical centres
Sosulski, D. L., Bloom, M. L., Cutforth, T., Axel, R., & Datta, S. R. (2011) · Nature · doi:10.1038/nature09868 · Cited by 479 · see citing works
Modulating social behavior with oxytocin: How does it work? What does it mean?
Churchland, P. S., & Winkielman, P. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.003 · Cited by 464 · see citing works
Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4572-07.2008 · Cited by 424 · see citing works
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423 · see citing works
Moncrieff, R. W. (1967) · Medical Entomology and Zoology · Cited by 407 · see citing works
Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala
Viviani, D., Charlet, A., van den Burg, E., Robinet, C., Hurni, N., Abatis, M., Magara, F., & Stoop, R. (2011) · Science · doi:10.1126/science.1201043 · Cited by 381 · see citing works
Neuron-specific contribution of the superior colliculus to overt and covert shifts of attention
Ignashchenkova, A., Dicke, P. W., Haarmeier, T., & Thier, P. (2003) · Nature Neuroscience · doi:10.1038/nn1169 · Cited by 381 · see citing works
Graustella, A. J., & MacLeod, C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.002 · Cited by 379 · see citing works
Parasympathetic control of the heart
Levy, M. N., & Pj, M. (1984) · Unknown eBooks · Cited by 376 · see citing works
Quintana, D. S., Guastella, A. J., Outhred, T., Hickie, I. B., & Kemp, A. H. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.08.012 · Cited by 367 · see citing works
Self-citationGuastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366 · see citing works
Self-citationOxytocin–dopamine interactions mediate variations in maternal behavior in the rat
Shahrokh, D. K., Zhang, T.-Y., Diorio, J., Gratton, A., & Meaney, M. J. (2010) · Endocrinology · doi:10.1210/en.2009-1271 · Cited by 366 · see citing works
Balin, B. J., Broadwell, R. D., Salcman, M., & El‐Kalliny, M. (1986) · Journal of Comparative Neurology · doi:10.1002/cne.902510209 · Cited by 358 · see citing works
Guastella, A. J., Hickie, I. B., McGuinness, M. M., Otis, M., Woods, E. A., Disinger, H. M., Chan, H.-K., Chen, T. F., & Banati, R. B. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.019 · Cited by 357 · see citing works
Self-citationA review of safety, side-effects and subjective reactions to intranasal oxytocin in human research
MacDonald, E., Dadds, M. R., Brennan, J. L., Williams, K., Levy, F., & Cauchi, A. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.015 · Cited by 352 · see citing works
Oxytocin enhances brain function in children with autism
Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312857110 · Cited by 336 · see citing works
Declerck, C. H., Boone, C., & Kiyonari, T. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.01.006 · Cited by 331 · see citing works
Thomas, J. S., Koh, S.-B., & COOPER, G. M. (2006) · British Journal of Anaesthesia · doi:10.1093/bja/ael302 · Cited by 313 · see citing works
Djupesland, P. G., Messina, J. C., & Mahmoud, R. A. (2014) · Therapeutic Delivery · doi:10.4155/tde.14.41 · Cited by 297 · see citing works
Bethlehem, R. A. I., van Honk, J., Auyeung, B., & Baron-Cohen, S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.011 · Cited by 285 · see citing works
Immunohistochemical localization of oxytocin receptors in human brain
Boccia, M. L., Petrusz, P., Suzuki, K., Marson, L., & Pedersen, C. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.048 · Cited by 276 · see citing works
Bales, K. L., Perkeybile, A. M., Conley, O. G., Lee, M. H., Guoynes, C. D., Downing, G. M., Yun, C. R., Solomon, M., Jacob, S., & Mendoza, S. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.025 · Cited by 265 · see citing works
Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart
Gutkowska, J., Jankowski, M., Lambert, C., Mukaddam‐Daher, S., Zingg, H. H., & McCann, S. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11704 · Cited by 264 · see citing works
Danielyan, L., Schäfer, R., von Ameln-Mayerhofer, A., Bernhard, F. P., Verleysdonk, S., Buadze, M., Lourhmati, A., Klopfer, T., Schaumann, F. T., Schmid, B., et al. (2011) · Rejuvenation Research · doi:10.1089/rej.2010.1130 · Cited by 261 · see citing works
Parasympathetic Control of the Heart
Higgins, C. B., Vatner, S. F., & D, E. B. M. (1973) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06588-3 · Cited by 254 · see citing works
Grippo, A. J., Trahanas, D. M., Zimmerman, R. R., Porges, S. W., & Carter, C. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.017 · Cited by 240 · see citing works
Schaefer, M. L., Böttger, B., Silver, W. L., & Finger, T. E. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10143 · Cited by 239 · see citing works
Oxytocin causes a long-term decrease of blood pressure in female and male rats
PETERSSON, M., ALSTER, P., LUNDEBERG, T., & UVNÄS-MOBERG, K. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00261-2 · Cited by 229 · see citing works
The Role of Oxytocin in Human Affect: A Novel Hypothesis
Kemp, A. H., & Guastella, A. J. (2011) · Current Directions in Psychological Science · doi:10.1177/0963721411417547 · Cited by 228 · see citing works
Self-citationSofroniew, M. V., & Schrell, U. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90108-7 · Cited by 224 · see citing works
Groppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.023 · Cited by 218 · see citing works
The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies
Modi, M. E., & Young, L. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.010 · Cited by 218 · see citing works
Erdeniz, B., Rohe, T., Done, J., & Seidler, R. D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00116 · Cited by 215 · see citing works
Low doses of oxytocin facilitate social recognition in rats
Popik, P., Vetulani, J., & van Ree, J. M. (1992) · Psychopharmacology · doi:10.1007/bf02253591 · Cited by 212 · see citing works
Oxytocin increases autonomic cardiac control: Moderation by loneliness
Norman, G. J., Cacioppo, J. T., Morris, J. S., Malarkey, W. B., Berntson, G. G., & DeVries, A. C. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2010.11.006 · Cited by 211 · see citing works
Oxytocin revisited: Its role in cardiovascular regulation
Gutkowska, J., & Jankowski, M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02235.x · Cited by 208 · see citing works
Morphology of olfactory epithelium in humans and other vertebrates
Morrison, E. E., & Costanzo, R. M. (1992) · Microscopy Research and Technique · doi:10.1002/jemt.1070230105 · Cited by 207 · see citing works
Quirin, M., Kuhl, J., & Düsing, R. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.12.005 · Cited by 204 · see citing works
Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats
Slattery, D. A., & Neumann, I. D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.038 · Cited by 195 · see citing works
Johnson, N. J., Hanson, L. R., & Frey, W. H. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100029t · Cited by 194 · see citing works
Olfactory/trigeminal interactions in nasal chemoreception
Brand, G. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.01.002 · Cited by 190 · see citing works
ELECTRON MICROSCOPIC OBSERVATIONS OF THE OLFACTORY MUCOSA AND OLFACTORY NERVE
de Lorenzo, A. J. (1957) · The Journal of Cell Biology · doi:10.1083/jcb.3.6.839 · Cited by 188 · see citing works
Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study
Cardoso, C., Ellenbogen, M. A., Orlando, M. A., Bacon, S. L., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.07.013 · Cited by 187 · see citing works
Ross, C. A., Ruggiero, D. A., JOH, T. H., Park, D. H., & Reis, D. J. (1983) · Brain Research · doi:10.1016/0006-8993(83)90862-4 · Cited by 184 · see citing works
Broadwell, R. D., & Balin, B. J. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902420410 · Cited by 180 · see citing works
Djupesland, P. G., & Skretting, A. (2012) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2011.0924 · Cited by 170 · see citing works
Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/en.138.7.2829 · Cited by 170 · see citing works
Intranasal administration of oxytocin: behavioral and clinical effects, a review
Veening, J. G., & Olivier, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.012 · Cited by 169 · see citing works
Saha, S. (2005) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2005.04210.x · Cited by 162 · see citing works
Chow, H. ‐. S., Chen, Z., & Matsuura, G. T. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js9900295 · Cited by 161 · see citing works
Kemp, A. H., Quintana, D. S., Kuhnert, R.-L., Griffiths, K., Hickie, I. B., & Guastella, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044014 · Cited by 158 · see citing works
Self-citationBaroreflex control of heart rate by oxytocin in the solitary-vagal complex
Higa, K. T., Mori, E., Viana, F. F., Morris, M., & Michelini, L. C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00806.2000 · Cited by 157 · see citing works
Anxiolytic-like effect of oxytocin in the simulated public speaking test
de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., & Crippa, J. A. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111400642 · Cited by 154 · see citing works
New therapeutic approach for brain tumors: Intranasal delivery of telomerase inhibitor GRN163
Hashizume, R., Ozawa, T., Gryaznov, S. M., Bollen, A. W., Lamborn, K. R., Frey, W. H., & Deen, D. F. (2008) · Neuro-Oncology · doi:10.1215/15228517-2007-052 · Cited by 150 · see citing works
Baker, H. A., & Spencer, R. F. (1986) · Experimental Brain Research · doi:10.1007/bf00237470 · Cited by 147 · see citing works
Breath Actuated Device Improves Delivery to Target Sites Beyond the Nasal Valve
Djupesland, P. G., Skretting, A., Winderen, M., & Holand, T. (2006) · The Laryngoscope · doi:10.1097/01.mlg.0000199741.08517.99 · Cited by 146 · see citing works
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., & Reiss, A. L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.020 · Cited by 143 · see citing works
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works
Oxytocin Modulates Neural Reactivity to Children's Faces as a Function of Social Salience
Wittfoth-Schardt, D., Gründing, J., Wittfoth, M., Lanfermann, H., Heinrichs, M., Domes, G., Buchheim, A., Gündel, H., & Waller, C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.47 · Cited by 139 · see citing works
Physicochemical and physiological considerations for efficient nose-to-brain targeting
Bahadur, S., & Pathak, K. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.636801 · Cited by 137 · see citing works
Elevated salivary levels of oxytocin persist more than 7 h after intranasal administration
van IJzendoorn, M. H., Bhandari, R., van der Veen, R., Grewen, K. M., & Bakermans-Kranenburg, M. J. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00174 · Cited by 137 · see citing works
Anton, F., & Peppel, P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90354-q · Cited by 133 · see citing works
Polymodal dose-response curve for oxytocin in the social recognition test
Benelli, A., Bertolini, A., Poggioli, R., Menozzi, B., Basaglia, R., & Arletti, R. (1995) · Neuropeptides · doi:10.1016/0143-4179(95)90029-2 · Cited by 128 · see citing works
Finger, T. E., Jeor, V. L. S., Kinnamon, J. C., & Silver, W. L. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902940212 · Cited by 127 · see citing works
Oxytocin in the Amygdala Facilitates Maternal Aggression
Ferris, C. F., FOOTE, K. B., Meltser, H., PLENBY, M. G., Smith, K. L., & Insel, T. R. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34382.x · Cited by 123 · see citing works
Åkerlund, M., Bossmar, T., Brouard, R., Kostrzewska, A., Laudanski, T., Lemancewicz, A., Gal, C. S., & Steinwall, M. (1999) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1999.tb08112.x · Cited by 123 · see citing works
Cacciotti-Saija, C., Langdon, R., Ward, P. B., Hickie, I. B., Scott, E. M., Naismith, S. L., Moore, L., Alvares, G. A., Redoblado Hodge, M. A., & Guastella, A. J. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu094 · Cited by 119 · see citing works
Self-citationDelivery of Galanin-Like Peptide to the Brain: Targeting with Intranasal Delivery and Cyclodextrins
Nonaka, N., Farr, S. A., Kageyama, H., Shioda, S., & Banks, W. A. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.132381 · Cited by 114 · see citing works
Oxytocin in schizophrenia: a review of evidence for its therapeutic effects
MacDonald, K. S., & Feifel, D. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00634.x · Cited by 111 · see citing works
Impact of prosocial neuropeptides on human brain function
MEYERLINDENBERG, A. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00436-6 · Cited by 109 · see citing works
Viral Replication in Olfactory Receptor Neurons and Entry into the Olfactory Bulb and Braina
Reiss, C. S., Plakhov, I. V., & Komatsu, T. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10655.x · Cited by 105 · see citing works
The assessment of topical nasal drug distribution
Aggarwal, R., Cardozo, A., & Homer, J. J. (2004) · Clinical Otolaryngology · doi:10.1111/j.1365-2273.2004.00797.x · Cited by 102 · see citing works
Intravenous oxytocin bolus of 2 units is superior to 5 units during elective Caesarean section
Sartain, J. B., Barry, J. J., Howat, P., McCormack, D. I., & Bryant, M. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aen273 · Cited by 98 · see citing works
Paraventricular stimulation with glutamate elicits bradycardia and pituitary responses
Darlington, D. N., Miyamoto, M., KEIL, L. C., & Dallman, M. F. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.256.1.r112 · Cited by 94 · see citing works
Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal
Riem, M. M. E., van IJzendoorn, M. H., Tops, M., Boksem, M. A. S., Rombouts, S. A. R. B., & Bakermans-Kranenburg, M. J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.01.011 · Cited by 91 · see citing works
Nasal Delivery. The Use of Animal Models to Predict Performance in Man
Illum, L. (1996) · Journal of drug targeting · doi:10.3109/10611869609015963 · Cited by 88 · see citing works
Direct transport of VEGF from the nasal cavity to brain
Yang, J., Liu, H., Cheng, S., Wang, Z., Cheng, X., Yu, H.-X., & Liu, X. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.10.090 · Cited by 87 · see citing works
Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat
Wolburg, H., Wolburg‐Buchholz, K., Sam, H., Horvát, S., Deli, M. A., & Mack, A. F. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0410-2 · Cited by 85 · see citing works
Nose-to-Brain Transport Pathways of Wheat Germ Agglutinin Conjugated PEG-PLA Nanoparticles
Liu, Q., Shen, Y., Chen, J., Gao, X., Feng, C., Wang, L., Zhang, Q., & Jiang, X. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0641-0 · Cited by 84 · see citing works
Yu, G.-Z., Kaba, H., Okutani, F., Takahashi, S., Higuchi, T., & Seto, K. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00599-4 · Cited by 83 · see citing works
Visualization of In Vivo Olfactory Uptake and Transfer Using Fluorescein Dextran
Jansson, B., & Björk, E. (2002) · Journal of drug targeting · doi:10.1080/1061186021000001823 · Cited by 82 · see citing works
Irngartinger, M., Camuglia, V., Damm, M., Goede, J., & Frijlink, H. W. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.03.016 · Cited by 80 · see citing works
Williams, L., Schmalfuss, I. M., Sistrom, C. L., Inoue, T. K., Tanaka, R., Seoane, E., & Mancuso, A. (2003) · PubMed Central · Cited by 79 · see citing works
Rogers, R. C., & Hermann, G. E. (1986) · Peptides · doi:10.1016/0196-9781(86)90046-x · Cited by 79 · see citing works
Influence of Oxytocin on Renal Hemodynamics and Sodium Excretiona
Conrad, K. P., Gellai, M., North, W. G., & Valtin, H. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb55559.x · Cited by 79 · see citing works
Kaur, P., & Kim, K. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.07.030 · Cited by 77 · see citing works
Meddle, S., Leng, G., Selvarajah, J., Bicknell, R. J., & Russell, J. A. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00300-6 · Cited by 75 · see citing works
Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males
Alvares, G. A., Chen, N. T. M., Balleine, B. W., Hickie, I. B., & Guastella, A. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.018 · Cited by 71 · see citing works
Self-citationKang, N., Baum, M. J., & Cherry, J. A. (2010) · Chemical Senses · doi:10.1093/chemse/bjq120 · Cited by 69 · see citing works
DeSesso, J. M. (1993) · PubMed · Cited by 67 · see citing works
Usunoff, K. G., Marani, E., & Schoen, J. H. R. (1997) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-60779-0 · Cited by 64 · see citing works
Quintana, D. S., Kemp, A. H., Alvares, G. A., & Guastella, A. J. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00048 · Cited by 61 · see citing works
Self-citationDisruption of Reflexive Attention and Eye Movements in an Individual with a Collicular Lesion
Sereno, A. B., Briand, K. A., Amador, S. C., & Szapiel, S. V. (2006) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390590929298 · Cited by 60 · see citing works
The vomeronasal chemosensory system as a route of neuroinvasion by herpes simplex virus
Mori, I., Goshima, F., Ito, H., Koide, N., Yoshida, T., Yokochi, T., Kimura, Y., & Nishiyama, Y. (2005) · Virology · doi:10.1016/j.virol.2005.01.023 · Cited by 59 · see citing works
The human amygdala drives reflexive orienting towards facial features
Gamer, M., Schmitz, A. K., Tittgemeyer, M., & Schilbach, L. (2013) · Current Biology · doi:10.1016/j.cub.2013.09.008 · Cited by 59 · see citing works
Oxytocin and social cognition in affective and psychotic disorders
Pérez-Rodríguez, M. M., Mahon, K., Russo, M., Ungar, A. K., & Burdick, K. E. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.07.012 · Cited by 52 · see citing works
Cifuentes, M., Rodr�guez, S., P�rez, J., Grondona, J. M., Rodr�guez, E. M., & Fern�ndez-Llebrez, P. (1994) · Experimental Brain Research · doi:10.1007/bf00233981 · Cited by 52 · see citing works
Afferent renal inputs to paraventricular nucleus vasopressin and oxytocin neurosecretory neurons
Ciriello, J. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.6.r1745 · Cited by 49 · see citing works
Intranasal administration delivers peptoids to the rat central nervous system
Ross, T. M., Zuckermann, R. N., Reinhard, C., & Frey, W. H. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.04.097 · Cited by 44 · see citing works
Autoradiographic localization of binding sites for oxytocin and vasopressin in the rat kidney
Stoeckel, M. E., Freund‐Mercier, M. J., Palacios, J. M., Richard, P., & Porte, A. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.1130179 · Cited by 43 · see citing works
Usunoff, K. G., Marani, E., & Schoen, J. H. R. (1997) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-60779-0_1 · Cited by 43 · see citing works
Metabolism of vasopressin, oxytocin, and their analogues in the human gastrointestinal tract
Fjellestad‐Paulsen, A., Söderberg-Ahlm, C., & Lundin, S. (1995) · Peptides · doi:10.1016/0196-9781(95)00088-2 · Cited by 42 · see citing works
Jolkkonen, E., Miettinen, R., & Pitkänen, A. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1113 · Cited by 41 · see citing works
Heart Rate Variability: A Neurovisceral Integration Model
Thayer, J. F. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.01991-4 · Cited by 37 · see citing works
Petersson, M., & Uvnäs‐Moberg, K. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.091 · Cited by 35 · see citing works
Macroscopic, Microscopic, and Ultrastructural Anatomy of the Nasal Cavity, Rat
Popp, J. A., & Monteiro‐Riviere, N. A. (1985) · Monographs on pathology of laboratory animals · doi:10.1007/978-3-642-96846-4_1 · Cited by 27 · see citing works
Roldán-Valadéz, E., Martínez–Anda, J. J., & Corona-Cedillo, R. (2013) · Clinical Anatomy · doi:10.1002/ca.22311 · Cited by 13 · see citing works
One Hormonal System for Love and Envy: A Reply to Tops
Shamay‐Tsoory, S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.002 · Cited by 9 · see citing works
The Use of Oxytocin in Personality Disorders: Rationale and Current Status
Pérez-Rodríguez, M. M., Derish, N. E., & New, A. S. (2014) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-014-0026-1 · Cited by 7 · see citing works
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Valstad, M., Alvares, G. A., Egknud, M., Matziorinis, A. M., Andreassen, O. A., Westlye, L. T., & Quintana, D. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.017 · Cited by 277 · see citing works
Self-citationGuastella, A. J., & Hickie, I. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.028 · Cited by 223 · see citing works
Self-citationBrain oxytocin: how puzzle stones from animal studies translate into psychiatry
Grinevich, V., & Neumann, I. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0802-9 · Cited by 189 · see citing works
Yamasue, H., Okada, T., Munesue, T., Kuroda, M., Fujioka, T., Uno, Y., Matsumoto, K., Kuwabara, H., Mori, D., Okamoto, Y., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0097-2 · Cited by 185 · see citing works
Marsh, A. A. (2018) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-103010 · Cited by 164 · see citing works
Feldman, R., & Bakermans-Kranenburg, M. J. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2017.02.011 · Cited by 160 · see citing works
Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases
Huang, Q., Chen, Y., Zhang, W., Xia, X., Li, H., Qin, M., & Gao, H. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.054 · Cited by 151 · see citing works
Oxytocin and Pain Perception: From Animal Models to Human Research
Boll, S., de Minas, A. C. A., Raftogianni, A., Herpertz, S. C., & Grinevich, V. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.041 · Cited by 137 · see citing works
Lane, A., Luminet, O., Nave, G., & Mikolajczak, M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12384 · Cited by 134 · see citing works
van Zuiden, M., Frijling, J. L., Nawijn, L., Koch, S. B. J., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Veltman, D. J., & Olff, M. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.012 · Cited by 134 · see citing works
Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques
Freeman, S. M., Samineni, S., Allen, P. C., Stockinger, D., Bales, K. L., Hwa, G. G. C., & Roberts, J. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.014 · Cited by 128 · see citing works
Overview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121 · see citing works
Self-citationGrace, S. A., Rossell, S. L., Heinrichs, M., Kordsachia, C., & Labuschagne, I. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.031 · Cited by 120 · see citing works
Quintana, D. S., Westlye, L. T., Hope, S., Nærland, T., Elvsåshagen, T., Dørum, E., Rustan, Ø., Valstad, M., Rezvaya, L., Lishaugen, H., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.103 · Cited by 111 · see citing works
Self-citationSmith, A. S., Korgan, A. C., & Young, W. S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104324 · Cited by 107 · see citing works
Oxytocin and Autism Spectrum Disorders
Yamasue, H., & Domes, G. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_24 · Cited by 109 · see citing works
Quintana, D. S., Guastella, A. J., Westlye, L. T., & Andreassen, O. A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.166 · Cited by 107 · see citing works
Self-citationLefevre, A., Mottolese, R., Dirheimer, M., Mottolese, C., Duhamel, J.-R., & Sirigu, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-17674-7 · Cited by 105 · see citing works
The Role of Oxytocin and Vasopressin in Attachment
Carter, C. S. (2017) · Psychodynamic Psychiatry · doi:10.1521/pdps.2017.45.4.499 · Cited by 105 · see citing works
Quintana, D. S., Westlye, L. T., Rustan, Ø. G., Tesli, N., Poppy, C. L., Smevik, H., Tesli, M., Røine, M., Mahmoud, R. A., Smerud, K. T., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.93 · Cited by 103 · see citing works
Self-citationQuintana, D. S., Westlye, L. T., Alnæs, D., Rustan, Ø. G., Kaufmann, T., Smerud, K. T., Mahmoud, R. A., Djupesland, P. G., & Andreassen, O. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.010 · Cited by 102 · see citing works
Self-citationRAGE regulates oxytocin transport into the brain
Yamamoto, Y., & Higashida, H. (2020) · Communications Biology · doi:10.1038/s42003-020-0799-2 · Cited by 106 · see citing works
Oxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99 · see citing works
Evidence for Intranasal Oxytocin Delivery to the brain: Recent Advances and Future Perspectives
Quintana, D. S., Smerud, K. T., Andreassen, O. A., & Djupesland, P. G. (2018) · Therapeutic Delivery · doi:10.4155/tde-2018-0002 · Cited by 94 · see citing works
Self-citationDifferent Methods and Formulations of Drugs and Vaccines for Nasal Administration
Tai, J., Han, M. S., Lee, D., Park, I., Lee, S. H., & Kim, T. H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051073 · Cited by 93 · see citing works
Daughters, K., Manstead, A. S. R., Hubble, K., Rees, A., Thapar, A., & van Goozen, S. H. M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0145104 · Cited by 92 · see citing works
Alvares, G. A., Quintana, D. S., & Whitehouse, A. J. O. (2017) · Autism Research · doi:10.1002/aur.1692 · Cited by 91 · see citing works
Self-citationOxytocin effects in schizophrenia: Reconciling mixed findings and moving forward
Bradley, E., & Woolley, J. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.007 · Cited by 88 · see citing works
Frijling, J. L. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1302652 · Cited by 84 · see citing works
Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse
Choe, K. Y., Bethlehem, R. A. I., Safrin, M., Dong, H., Salman, E., Li, Y., Grinevich, V., Golshani, P., DeNardo, L. A., Peñagarikano, O., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.031 · Cited by 77 · see citing works
Bürkner, P., Williams, D. R., Simmons, T. C., & Woolley, J. D. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx053 · Cited by 80 · see citing works
DeMayo, M. M., Song, Y. J. C., Hickie, I. B., & Guastella, A. J. (2017) · Pediatric Drugs · doi:10.1007/s40272-017-0248-y · Cited by 71 · see citing works
Self-citationA single dose of oxytocin nasal spray improves higher-order social cognition in schizophrenia
Guastella, A. J., Ward, P. B., Hickie, I. B., Shahrestani, S., Hodge, M. A., Scott, E. M., & Langdon, R. A. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.06.005 · Cited by 66 · see citing works
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Ma, X., Zhao, W., Luo, R., Zhou, F., Geng, Y., Xu, L., Gao, Z., Zheng, X., Becker, B., & Kendrick, K. M. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.08.004 · Cited by 64 · see citing works
Oxytocin–Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice
Nasanbuyan, N., Yoshida, M., Takayanagi, Y., Inutsuka, A., Nishimori, K., Yamanaka, A., & Onaka, T. (2017) · Endocrinology · doi:10.1210/en.2017-00606 · Cited by 69 · see citing works
Jiang, Y., & Platt, M. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-25607-1 · Cited by 66 · see citing works
Endogenous Oxytocin Levels in Autism—A Meta-Analysis
Moerkerke, M., Peeters, M., de Vries, L. M., Daniëls, N., Steyaert, J. G., Alaerts, K., & Boets, B. (2021) · Brain Sciences · doi:10.3390/brainsci11111545 · Cited by 65 · see citing works
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 62 · see citing works
Improving the precision of intranasal oxytocin research
Winterton, A., Westlye, L. T., Steen, N. E., Andreassen, O. A., & Quintana, D. S. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-00996-4 · Cited by 62 · see citing works
Self-citationYamasue, H. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12364 · Cited by 58 · see citing works
The effect of oxytocin on human-directed social behaviour in dogs (Canis familiaris)
Kis, A., Ciobica, A. S., & Topál, J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.06.001 · Cited by 58 · see citing works
Frantz, M., Pellissier, L. P., Pflimlin, E., Loison, S., Gandía, J., MARSOL, C., Durroux, T., Mouillac, B., Becker, J. A. J., Merrer, J. L., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00697 · Cited by 57 · see citing works
Domes, G., Ower, N., von Dawans, B., Spengler, F. B., Dziobek, I., Bohus, M., Matthies, S., Philipsen, A., & Heinrichs, M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0658-4 · Cited by 58 · see citing works
Sniff and mimic–Intranasal oxytocin increases facial mimicry in a sample of men
Korb, S., Malsert, J., Strathearn, L., Vuilleumier, P., & Niedenthal, P. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.06.003 · Cited by 54 · see citing works
Quintana, D. S., Westlye, L. T., Smerud, K. T., Mahmoud, R. A., Andreassen, O. A., & Djupesland, P. G. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.05.004 · Cited by 52 · see citing works
Self-citationZoratto, F., Sbriccoli, M., Martinelli, A., Glennon, J. C., Macrı̀, S., & Giovanni Laviola, A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.010 · Cited by 51 · see citing works
Selective localization of oxytocin receptors and vasopressin 1a receptors in the human brainstem
Freeman, S. M., Smith, A. L., Goodman, M. M., & Bales, K. L. (2017) · Social Neuroscience · doi:10.1080/17470919.2016.1156570 · Cited by 51 · see citing works
Engel, S., Laufer, S., Miller, R., Niemeyer, H., Knaevelsrud, C., & Schumacher, S. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100775 · Cited by 50 · see citing works
Oxytocin modulates the temporal dynamics of resting EEG networks
Schiller, B., Koenig, T. W., & Heinrichs, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-49636-6 · Cited by 50 · see citing works
Quintana, D. S., & Woolley, J. D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.021 · Cited by 46 · see citing works
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Winter, J. J., Meyer, M., Berger, I., Royer, M., Bianchi, M., Kuffner, K., Peters, S., Stang, S., Langgartner, D., Hartmann, F., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01141-x · Cited by 45 · see citing works
The two fold role of oxytocin in social developmental disorders: A cause and a remedy?
Lefèvre, A., & Angela Sirigu, B. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.011 · Cited by 45 · see citing works
Seeley, S. H., Chou, Y., & O'Connor, M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.011 · Cited by 42 · see citing works
Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances
Melis, M. R., & Argiolas, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910376 · Cited by 44 · see citing works
Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects
Naja, W., & Aoun, M. P. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0819-1 · Cited by 40 · see citing works
Oxytocin regulates reunion affiliation with a pairmate following social separation in marmosets
Cavanaugh, J., Mustoe, A. C., & French, J. A. (2018) · American Journal of Primatology · doi:10.1002/ajp.22750 · Cited by 41 · see citing works
Geng, Y., Zhao, W., Zhou, F., Ma, X., Yao, S., Becker, B., & Kendrick, K. M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00572 · Cited by 40 · see citing works
Quintana, D. S., Dieset, I., Elvsåshagen, T., Westlye, L. T., & Andreassen, O. A. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.004 · Cited by 39 · see citing works
Self-citationBernaerts, S., Boets, B., Steyaert, J. G., Wenderoth, N., & Alaerts, K. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01069-w · Cited by 35 · see citing works
van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12355 · Cited by 34 · see citing works
Wang, S.-C., Lin, C.-C., Tzeng, N., Tung, C., & Liu, Y. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0514-0 · Cited by 34 · see citing works
Quintana, D. S., Westlye, L. T., Alnæs, D., Kaufmann, T., Mahmoud, R. A., Smerud, K. T., Djupesland, P. G., & Andreassen, O. A. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0241-3 · Cited by 33 · see citing works
Self-citationCui, F., Huang, X., Jing, Y., Luo, Y., Liu, J., & Gu, R. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac017 · Cited by 32 · see citing works
Impact of intranasal oxytocin on interoceptive accuracy in alcohol users: an attentional mechanism?
Betka, S., van Praag, C. G., Paloyelis, Y., Bond, R., Pfeifer, G., Sequeira, H., Duka, T., & Critchley, H. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy027 · Cited by 30 · see citing works
Yang, X., Wang, W., Wang, X. T., & Wang, Y. W. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.033 · Cited by 31 · see citing works
Lambert, B., Declerck, C. H., Boone, C., & Parizel, P. M. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.06.011 · Cited by 30 · see citing works
Morphofunctional Alterations of the Hypothalamus and Social Behavior in Autism Spectrum Disorders
Carìa, A., Ciringione, L., & de Falco, S. (2020) · Brain Sciences · doi:10.3390/brainsci10070435 · Cited by 29 · see citing works
Oxytocin and Borderline Personality Disorder
Bertsch, K., & Herpertz, S. C. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_26 · Cited by 31 · see citing works
Oxytocin Fails to Recruit Serotonergic Neurotransmission in the Autistic Brain
Lefèvre, A., Mottolese, R., Redouté, J., Costes, N., Bars, D. L., Geoffray, M., Leboyer, M., & Angela Sirigu, B. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx272 · Cited by 30 · see citing works
Modi, M. E., Majchrzak, M. J., Fonseca, K. R., Doran, A., Osgood, S., Vanase-Frawley, M., Feyfant, E., McInnes, H., Darvari, R., Buhl, D. L., et al. (2016) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.232702 · Cited by 29 · see citing works
Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders
Zhang, S., Zhang, Y., Shi, D., & Wang, Z. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01173-6 · Cited by 28 · see citing works
Divergent effects of oxytocin on eye contact in bonobos and chimpanzees
Brooks, J., Kano, F., Sato, Y., Yeow, H., Morimura, N., Nagasawa, M., Kikusui, T., & Yamamoto, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105119 · Cited by 27 · see citing works
Mitchell, I., Gillespie, S. M., & Abu-Akel, A. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.018 · Cited by 27 · see citing works
Sakamoto, T., Sugimoto, S., & Uekita, T. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112701 · Cited by 25 · see citing works
A randomized controlled trial of intranasal oxytocin in Phelan-McDermid syndrome
Fastman, J., Foss‐Feig, J. H., Frank, Y., Halpern, D. B., Harony‐Nicolas, H., Layton, C., Sandin, S., Siper, P. M., Tang, L., Trelles, M. P., et al. (2021) · Molecular Autism · doi:10.1186/s13229-021-00459-1 · Cited by 25 · see citing works
Guoynes, C. D., & Marler, C. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244033 · Cited by 28 · see citing works
Moerkerke, M., Daniëls, N., der Donck, S. V., Tibermont, L., Tang, T., Debbaut, E., Bamps, A., Prinsen, J., Steyaert, J. G., Alaerts, K., et al. (2023) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13850 · Cited by 23 · see citing works
Effects of oxytocin on serotonin 1B agonist-induced autism-like behavior in mice
Lawson, S. K., Gray, A. C., & Woehrle, N. S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.027 · Cited by 25 · see citing works
Measuring peripheral oxytocin and vasopressin in nonhuman primates
Ziegler, T. E. (2018) · American Journal of Primatology · doi:10.1002/ajp.22871 · Cited by 24 · see citing works
Borderline Personality Disorder and Oxytocin: Review of Clinical Trials and Future Directions
Amad, A., Thomas, P., & Pérez-Rodríguez, M. M. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150619093019 · Cited by 23 · see citing works
Skinner, J. A., Garg, M. L., Dayas, C. V., Fenton, S., & Burrows, T. L. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nux078 · Cited by 22 · see citing works
Graph Theoretic Analysis Reveals Intranasal Oxytocin Induced Network Changes Over Frontal Regions
Zheng, S., Punia, D., Wu, H., & Liu, Q. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.01.018 · Cited by 20 · see citing works
Quintana, D. S. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105642 · Cited by 21 · see citing works
Self-citationShang, S., Wu, N., & Su, Y. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00396 · Cited by 21 · see citing works
Oxytocin Increases Prosocial Behavior in Groups of African Lions
Burkhart, J. C., Gupta, S., Borrego, N., Heilbronner, S. R., & Packer, C. (2021) · iScience · doi:10.1016/j.isci.2022.104049 · Cited by 19 · see citing works
Kent, P., Awadia, A., Zhao, L. L., Ensan, D., Silva, D., Cayer, C., James, J. S., Anisman, H., & Merali, Z. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.019 · Cited by 20 · see citing works
Aydın, O., Balıkçı, K., Tas, C., Ünal-Aydın, P., Taneli, F., & Esen-Danacı, A. (2019) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2018.1554698 · Cited by 14 · see citing works
Localization of oxytocin receptors in the prairie vole (Microtus ochrogaster) neocortex
Duchemin, A., Seelke, A. M. H., Simmons, T. C., Freeman, S. M., & Bales, K. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.017 · Cited by 19 · see citing works
Rung, J. M., Horta, M., Tammi, E. M., Perez, E., Ojeda, M., Lin, T., Harris, G., Somerville, J. E. T., Salmeron, D., Beltz, S. E., et al. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05862-3 · Cited by 19 · see citing works
Borie, A. M., Theofanopoulou, C., & Andari, E. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819973-2.00009-5 · Cited by 18 · see citing works
Barrera, G., Dzik, M. V., Cavalli, C. M., & Bentosela, M. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02227 · Cited by 18 · see citing works
Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories
Parmaksiz, D., & Kim, Y. (2024) · The Neuroscientist · doi:10.1177/10738584241268754 · Cited by 20 · see citing works
Simmons, T. C., Balland, J. F., Dhauna, J., Yang, S. Y., Traina, J. L., Vazquez, J., & Bales, K. L. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00145 · Cited by 16 · see citing works
Intranasal oxytocin affects the stress response to social isolation in sheep
Damián, J. P., de Soto, L., Espindola, D., Gil, J., & van Lier, E. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113282 · Cited by 16 · see citing works
Guoynes, C. D., & Marler, C. A. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113773 · Cited by 15 · see citing works
Imaging neuropeptide effects on human brain function
Lefèvre, A., Hurlemann, R., & Grinevich, V. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2899-6 · Cited by 16 · see citing works
Intranasal oxytocin modulates the salience network in aging
Liu, P., Lin, T., Feifel, D., & Ebner, N. C. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119045 · Cited by 14 · see citing works
Oxytocin Modulates Semantic Integration in Speech Comprehension
Ye, Z., Stolk, A., Toni, I., & Peter Hagoort, A. (2016) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01044 · Cited by 14 · see citing works
Quintana, D. S., Outhred, T., Westlye, L. T., Malhi, G. S., & Andreassen, O. A. (2016) · Systematic Reviews · doi:10.1186/s13643-016-0386-2 · Cited by 13 · see citing works
Self-citationCan oxytocin inhibit stress-induced hyperalgesia?
Li, Y.-X., An, H. Y., Wen, Z., Tao, Z.-Y., & Cao, D. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.101996 · Cited by 13 · see citing works
- Authors
- Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Quintana, Daniel S.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 49
- Pages
- 182-192
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2051491987
- Cited by
- 149
- References
- 143
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 19 · 2020: 12 · 2019: 12 · 2018: 25 · 2017: 27 · 2016: 17 · 2015: 11
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Australian Research Council (LP110100513)
- National Health and Medical Research Council (10436644, 1061922)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, intranasal administration, delivery routes, social cognition, social behavior, nasal anatomy, social information processing, anxiolytic effects, approach behavior, autism spectrum disorder, schizophrenia, two-level model
- MeSH terms
- Administration, Intranasal, Animals, Cognition, Humans, Models, Biological, Nose, Oxytocin, Psychotropic Drugs, Social Behavior
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