Cited by 151Neuroendocrine regulation and behaviorOlfactory and Sensory Function StudiesNeuropeptides and Animal Physiology

Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model

Quintana, Daniel S., Alvares, Gail A., Hickie, Ian B., Guastella, Adam J.·2015·Neuroscience & Biobehavioral Reviews

Abstract

Accumulating evidence demonstrates the important role of oxytocin (OT) in the modulation of social cognition and behavior. This has led many to suggest that the intranasal administration of OT may benefit psychiatric disorders characterized by social dysfunction, such as autism spectrum disorders and schizophrenia. Here, we review nasal anatomy and OT pathways to central and peripheral destinations, along with the impact of OT delivery to these destinations on social behavior and cognition. The primary goal of this review is to describe how these identified pathways may contribute to mechanisms of OT action on social cognition and behavior (that is, modulation of social information processing, anxiolytic effects, increases in approach-behaviors). We propose a two-level model involving three pathways to account for responses observed in both social cognition and behavior after intranasal OT administration and suggest avenues for future research to advance this research field.

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Crossref · 10.1016/j.neubiorev.2014.12.011

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Authors
Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J.
Affiliations
The University of Sydney (AU)
Corresponding author
Quintana, Daniel S.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2015-02
Volume
49
Pages
182-192
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2051491987
Cited by
149
References
143
Citations by year
2026: 7 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 19 · 2020: 12 · 2019: 12 · 2018: 25 · 2017: 27 · 2016: 17 · 2015: 11
FWCI
2.61
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Australian Research Council (LP110100513)
  • National Health and Medical Research Council (10436644, 1061922)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin, intranasal administration, delivery routes, social cognition, social behavior, nasal anatomy, social information processing, anxiolytic effects, approach behavior, autism spectrum disorder, schizophrenia, two-level model
MeSH terms
Administration, Intranasal, Animals, Cognition, Humans, Models, Biological, Nose, Oxytocin, Psychotropic Drugs, Social Behavior

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