Cited by 383Hormonal and reproductive studiesTreatment of Major DepressionStress Responses and Cortisol

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Testosterone and Depression: Systematic Review and Meta-Analysis

Zarrouf, Fahd Aziz, Artz, Steven, Griffith, James, Sirbu, Cristian, Kommor, Martin·2009·Journal of Psychiatric Practice

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Abstract

BACKGROUND: Studies suggest that testosterone (TT) replacement may have an antidepressant effect in depressed patients. OBJECTIVE: The objective of this study was to explore the effect of TT administration on depression using both a systematic review of the literature and a meta-analysis. METHODOLOGY: A search was conducted of MEDLINE, the Clinical Trials Registry, and Cochrane Central for English-language publications concerning randomized, placebo-controlled trials involving use of TT therapy in depressed patients. We searched for additional trials in the individual reference lists of the articles identified in the search. A study was judged to be relevant for inclusion in this review and meta-analysis if it reported original data from a controlled trial comparing use of TT and placebo in patients diagnosed with a depressive disorder according to DSM criteria, and the treatment response was evaluated according to changes on the Hamilton Rating Scale for Depression (HAM-D). We extracted the following data from the identified studies: study source, total number of participants in the study and in each treatment group, participants' ages, number of participants with a diagnosis of hypogonadism or HIV/AIDS, study duration, type of intervention, and change in HAM-D scores in the groups receiving TT versus placebo. The meta-analysis evaluated the effect of TT replacement on response in depressed patients as measured by change in HAM-D scores in the available placebo-controlled, randomized clinical trails. RESULTS: Seven studies (N=364) were identified that included a placebo-control group in a double-blind design. Eligibility criteria were clearly reported in all trials. Meta-analysis of the data from these seven studies showed a significant positive effect of TT therapy on HAM-D response in depressed patients when compared with placebo (z=4.04, P<0.0001). Subgroup analysis also showed a significant response in the subpopulations with hypogonadism (z=3.84, P=0.0001) and HIV/AIDS (z=3.33, P=0.0009) as well as in patients treated with TT gel (z=2.32, P=0.02). CONCLUSIONS: TT may have an antidepressant effect in depressed patients, especially those with hypogonadism or HIV/AIDS and elderly subpopulations. The route by which TT is administered may play a role in treatment response.

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An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
Development and validation of a geriatric depression screening scale: a preliminary report
Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., & Leirer, V. O. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90033-4 · Cited by 15,025
The Depression Anxiety Stress Scales (DASS): Normative data and latent structure in a large non-clinical sample
Crawford, J. R., & Henry, J. D. (2003) · British Journal of Clinical Psychology · doi:10.1348/014466503321903544 · Cited by 1,756
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men
Bhasin, S., Storer, T. W., Berman, N., Callegari, C., Clevenger, B., Phillips, J., Bunnell, T. J., Tricker, R., Shirazi, A., & Casaburi, R. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350101 · Cited by 1,659
Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma
DUNN, J. F., NISULA, B. C., & RODBARD, D. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-1-58 · Cited by 1,238
Biological Actions of Androgens
MOORADIAN, A. D., MORLEY, J. E., & KORENMAN, S. G. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-1-1 · Cited by 1,080
Transdermal testosterone treatment in women with impaired sexual function after oophorectomy.
Shifren, J. L., Braunstein, G. D., Simon, J. A., Casson, P. R., Buster, J. E., Redmond, G. P., Burki, R. E., Ginsburg, E. S., Rosen, R. C., Leiblum, S. R., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009073431002 · Cited by 954
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales, A. J., Nolan, J. J., Nelson, J. C., & Yen, S. S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.7515387 · Cited by 841
Effect of Stress on the Activity of the Hypothalamic-Pituitary-Gonadal Axis: Peripheral and Central Mechanisms1
Rivier, C., & Rivest, S. (1991) · Biology of Reproduction · doi:10.1095/biolreprod45.4.523 · Cited by 799
Gonadotropin-releasing hormone: One polypeptide regulates secretion of luteinizing and follicle-stimulating hormones
Schally, A. V., Arimura, A., Kastin, A. J., Matsuo, H., Baba, Y., Redding, T. W., Nair, R. M. G., Debeljuk, L., & White, W. F. (1971) · Science · doi:10.1126/science.173.4001.1036 · Cited by 770

Show all 141 references

Research works printed but not linked: 3

Mason, 1990, Serum testosteronelevels in posttraumatic stress disorder patients, J Trauma Stress, 3, 449, 10.1002/jts.2490030313 · DOI
Schweiger, 1992, Gonadotropinsecretion in bulimia nervosa, J Clin Endocrinol Metab, 74, 1122
Orengo, 2005, Safety and efficacy oftestosterone gel 1% augmentation in depressed men withpartial response to antidepressant therapy, J eriatrPsychiatry Neurol, 18, 20

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Authors: Zarrouf, F. A., Artz, S., Griffith, J., Sirbu, C., & Kommor, M.
Affiliations: West Virginia University (US)
Corresponding author: Zarrouf, Fahd Aziz
ORCID: Sirbu, Cristian
Venue: Journal of Psychiatric Practice
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-07
Volume: 15
Issue: 4
Pages: 289-305
ISSN: 1527-4160 (ISSN-L)
1538-1145
DOI: 10.1097/01.pra.0000358315.88931.fc
OpenAlex: W2072447154
Cited by: 383
References: 141
Citations by year: 2026: 10 · 2025: 22 · 2024: 21 · 2023: 18 · 2022: 19 · 2021: 32 · 2020: 26 · 2019: 20 · 2018: 19 · 2017: 30 · 2016: 23 · 2015: 39 · 2014: 26 · 2013: 23 · 2012: 24
FWCI: 2.18
Type: journal article
Language: en
Open access: closed
Locations: Journal of Psychiatric Practice (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: testosterone replacement therapy, depression, antidepressant effects, hypogonadism, HIV/AIDS, testosterone gel, Hamilton Depression Rating Scale, elderly patients, route of administration
MeSH terms: Major Depressive Disorder, Humans, Hypogonadism, Male, Quality of Life, Registries, Sexual Behavior, Testosterone, Hormone Replacement Therapy, Diagnostic and Statistical Manual of Mental Disorders

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