The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Keloid Pathogenesis and Treatment
Abstract
BACKGROUND: Keloid management can be difficult and frustrating, and the mechanisms underlying keloid formation are only partially understood. METHODS: Using original and current literature in this field, this comprehensive review presents the major concepts of keloid pathogenesis and the treatment options stemming from them. RESULTS: Mechanisms for keloid formation include alterations in growth factors, collagen turnover, tension alignment, and genetic and immunologic contributions. Treatment strategies for keloids include established (e.g., surgery, steroid, radiation) and experimental (e.g., interferon, 5-fluorouracil, retinoid) regimens. CONCLUSION: The scientific basis and empiric evidence supporting the use of various agents is presented. Combination therapy, using surgical excision followed by intradermal steroid or other adjuvant therapy, currently appears to be the most efficacious and safe current regimen for keloid management.
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Cites
Transforming Growth Factor β in Tissue Fibrosis
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International Clinical Recommendations on Scar Management
Mustoe, T. A., Cooter, R. D., Gold, M. H., Richard Hobbs, F. D., Ramelet, A.-A., Shakespeare, P. G., Stella, M., Téot, L., Wood, F. M., & Ziegler, U. E. (2002) · Plastic and Reconstructive Surgery · doi:10.1097/00006534-200208000-00031 · Cited by 1,080
On the Nature of Hypertrophic Scars and Keloids: A Review
Niessen, F. B., Spauwen, P. H. M., Schalkwijk, J., & Kon, M. (1999) · Plastic and Reconstructive Surgery · doi:10.1097/00006534-199910000-00031 · Cited by 816
Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages
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Morphological and immunochemical differences between keloid and hypertrophic scar.
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Cited by
Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies
Gauglitz, G. G., Korting, H. C., Pavicic, T., Ruzicka, T., & Jeschke, M. G. (2011) · Molecular Medicine · doi:10.2119/molmed.2009.00153 · Cited by 1,462
Broughton, G., Janis, J. E., & Attinger, C. E. (2006) · Plastic and Reconstructive Surgery · doi:10.1097/01.prs.0000222562.60260.f9 · Cited by 917
Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring
Wang, Y., Beekman, J., Hew, J., Jackson, S., Issler-Fisher, A. C., Parungao, R., Lajevardi, S. S., Li, Z., & Maitz, P. K. M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.09.018 · Cited by 696
miR-196a Downregulation Increases the Expression of Type I and III Collagens in Keloid Fibroblasts
Kashiyama, K., Mitsutake, N., Matsuse, M., Ogi, T., Saenko, V. A., Ujifuku, K., Utani, A., Hirano, A., & Yamashita, S. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.22 · Cited by 139
Jeong, W., Yang, C. E., Roh, T. S., Kim, J. H., Lee, J. H., & Lee, W. J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081698 · Cited by 97
Metadata
- Authors
- Al-Attar, A., Mess, S., Thomassen, J. M., Kauffman, C. L., & Davison, S. P.
- Venue
- Plastic and Reconstructive Surgery
- Published
- 2006-01
- Volume
- 117
- Issue
- 1
- Pages
- 286-300
- ISSN
- 0032-1052 (ISSN-L)
- OpenAlex
- W2036933739
- Cited by
- 553
- References
- 131
- FWCI
- 27.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Al-Attar, A., Mess, S., Thomassen, J. M., Kauffman, C. L., & Davison, S. P. (2006). Keloid Pathogenesis and Treatment. Plastic and Reconstructive Surgery. https://doi.org/10.1097/01.prs.0000195073.73580.46
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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