The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Impact of Pain on Depression Treatment Response in Primary Care
Abstract
OBJECTIVE: Pain commonly coexists with depression, but its impact on treatment outcomes has not been well studied. Therefore, we prospectively evaluated the impact of comorbid pain on depression treatment response and health-related quality of life. METHODS: We analyzed data from the ARTIST study, a randomized controlled trial with naturalistic follow-up conducted in 37 primary care clinics. Participants were 573 clinically depressed patients randomized to one of three selective serotonin reuptake inhibitor (SSRI) antidepressants: fluoxetine, paroxetine, or sertraline. Depression as assessed by the Symptom Checklist-20 (SCL-20) was the primary outcome. Secondary outcomes included pain and health-related quality of life. RESULTS: Pain was reported by more than two thirds of depressed patients at baseline, with the severity of pain mild in 25% of patients, moderate in 30%, and severe in 14%. After 3 months of antidepressant therapy, 24% of patients had a poor depression treatment response (ie, SCL-20 >1.3). Multivariate odds ratios for poor treatment response were 1.5 (95% confidence interval, 0.8-3.2) for mild pain, 2.0 (1.1-4.0) for moderate pain, and 4.1 (1.9-8.8) for severe pain compared with those without pain. Increasing pain severity also had an adverse impact on outcomes in multiple domains of health-related quality of life. CONCLUSIONS: Pain is present in two thirds of depressed primary care patients begun on antidepressant therapy, and the severity of pain is a strong predictor of poor depression and health-related quality of life outcomes at 3 months. Better recognition, assessment, and treatment of comorbid pain may enhance outcomes of depression therapy.
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“When self-report measures of depression are used, the prevalence of depression in individuals experiencing chronic pain is as high as 86%”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Bair et al., 2004
In the citing paper
“These latter fi ndings are consistent with previous studies that older age is associated with increased pain severity (Bair et al., 2004; Demyttenaere et al., 2006).”
From Presence and predictors of pain in depression: Results from the FINDER study (2010) · cites this paper as Bair et al., 2004
Citations
Cites
SF-36 health survey: Manual and interpretation guide
Ware, J. (2003) · Medical Entomology and Zoology · Cited by 11,424
The PHQ-15: Validity of a New Measure for Evaluating the Severity of Somatic Symptoms
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200203000-00008 · Cited by 3,415
Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.272.22.1749 · Cited by 2,648
Unützer, J., Katon, W., Callahan, C. M., Williams, Jr., Hunkeler, E., Harpole, L., Hoffing, M., Della Penna, R. D., Noël, P. H., Lin, E. H. B., et al. (2002) · JAMA · doi:10.1001/jama.288.22.2836 · Cited by 2,405
Effect Sizes for Interpreting Changes in Health Status
Kazis, L. E., Anderson, J. J., & Meenan, R. F. (1989) · Medical Care · doi:10.1097/00005650-198903001-00015 · Cited by 2,401
Elkin, I. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110013002 · Cited by 2,300
Utility of a New Procedure for Diagnosing Mental Disorders in Primary Care: The PRIME-MD 1000 Study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.1994.03520220043029 · Cited by 1,873
An international study of the relation between somatic symptoms and depression
Simon, G. E., VonKorff, M., Piccinelli, M., Fullerton, C., & Ormel, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910283411801 · Cited by 1,303
An epidemiologic comparison of pain complaints
Korff, M. V., Dworkin, S. F., LeResche, L., & Kruger, A. (1988) · Pain · doi:10.1016/0304-3959(88)90066-8 · Cited by 966
A Multifaceted Intervention to Improve Treatment of Depression in Primary Care
Katon, W. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830100072009 · Cited by 835
Research works printed but not linked: 1
- Rickels, 1985, J Clin Psychiatry, 46, 38
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Depression and Pain Comorbidity: A Literature Review
Bair, M. J., Robinson, R. L., Katon, W., & Kroenke, K. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.20.2433 · Cited by 3,463
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206
Anderson, I. M., Ferrier, I. N., Baldwin, R., Cowen, P. J., Howard, L. M., Lewis, G., Matthews, K., McAllister-Williams, H., Peveler, R. C., Scott, J. L., et al. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107088441 · Cited by 909
Cleare, A., Pariante, C., Young, A., Anderson, I., Christmas, D., Cowen, P., Dickens, C., Ferrier, I., Geddes, J., Gilbody, S., et al. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115581093 · Cited by 759
Kroenke, K., Wu, J., Bair, M. J., Krebs, E. E., Damush, T. M., & Tu, W. (2011) · The Journal of Pain · doi:10.1016/j.jpain.2011.03.003 · Cited by 573
Self-citation
Metadata
- Authors
- Bair, M. J., Robinson, R. L., Eckert, G. J., Stang, P. E., Croghan, T. W., & Kroenke, K.
- Affiliations
- Regenstrief Institute (US)
- University of North Carolina at Chapel Hill (US)
- Venue
- Psychosomatic Medicine
- Published
- 2004-01
- Volume
- 66
- Issue
- 1
- Pages
- 17-22
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2080747491
- Cited by
- 371
- References
- 42
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 16 · 2023: 9 · 2022: 15 · 2021: 17 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 14 · 2016: 17 · 2015: 20 · 2014: 25 · 2013: 29 · 2012: 22
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- pain, depression, comorbidities, antidepressant response, selective serotonin reuptake inhibitors, fluoxetine, paroxetine, sertraline, health-related quality of life, pain intensity, primary care, artist study
- MeSH terms
- Adult, Antidepressive Agents, Depressive Disorder, Female, Fluoxetine, Follow-Up Studies, Humans, Male, Middle Aged, Pain, Pain Measurement, Quality of Life, Treatment Failure, Selective Serotonin Reuptake Inhibitors, Paroxetine, Sertraline
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