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Cited by 371Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMusculoskeletal pain and rehabilitation

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Impact of Pain on Depression Treatment Response in Primary Care

Bair, Matthew J., Robinson, Rebecca L., Eckert, George J., Stang, Paul E., Croghan, Thomas W., Kroenke, Kurt·2004·Psychosomatic Medicine
DOI 10.1097/01.psy.0000106883.94059.c5
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Abstract

OBJECTIVE: Pain commonly coexists with depression, but its impact on treatment outcomes has not been well studied. Therefore, we prospectively evaluated the impact of comorbid pain on depression treatment response and health-related quality of life. METHODS: We analyzed data from the ARTIST study, a randomized controlled trial with naturalistic follow-up conducted in 37 primary care clinics. Participants were 573 clinically depressed patients randomized to one of three selective serotonin reuptake inhibitor (SSRI) antidepressants: fluoxetine, paroxetine, or sertraline. Depression as assessed by the Symptom Checklist-20 (SCL-20) was the primary outcome. Secondary outcomes included pain and health-related quality of life. RESULTS: Pain was reported by more than two thirds of depressed patients at baseline, with the severity of pain mild in 25% of patients, moderate in 30%, and severe in 14%. After 3 months of antidepressant therapy, 24% of patients had a poor depression treatment response (ie, SCL-20 >1.3). Multivariate odds ratios for poor treatment response were 1.5 (95% confidence interval, 0.8-3.2) for mild pain, 2.0 (1.1-4.0) for moderate pain, and 4.1 (1.9-8.8) for severe pain compared with those without pain. Increasing pain severity also had an adverse impact on outcomes in multiple domains of health-related quality of life. CONCLUSIONS: Pain is present in two thirds of depressed primary care patients begun on antidepressant therapy, and the severity of pain is a strong predictor of poor depression and health-related quality of life outcomes at 3 months. Better recognition, assessment, and treatment of comorbid pain may enhance outcomes of depression therapy.

Overview

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Crossref · 10.1097/01.psy.0000106883.94059.c5

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42 of 42 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 1

  1. Rickels, 1985, J Clin Psychiatry, 46, 38

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Metadata

Authors
Bair, M. J., Robinson, R. L., Eckert, G. J., Stang, P. E., Croghan, T. W., & Kroenke, K.
Affiliations
  • Regenstrief Institute (US)
  • University of North Carolina at Chapel Hill (US)
ORCID
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-01
Volume
66
Issue
1
Pages
17-22
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/01.psy.0000106883.94059.c5
OpenAlex
W2080747491
Cited by
371
References
42
Citations by year
2026: 5 · 2025: 5 · 2024: 16 · 2023: 9 · 2022: 15 · 2021: 17 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 14 · 2016: 17 · 2015: 20 · 2014: 25 · 2013: 29 · 2012: 22
FWCI
10.26
Type
journal article
Language
en
Open access
closed
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords
pain, depression, comorbidities, antidepressant response, selective serotonin reuptake inhibitors, fluoxetine, paroxetine, sertraline, health-related quality of life, pain intensity, primary care, artist study
MeSH terms
Adult, Antidepressive Agents, Depressive Disorder, Female, Fluoxetine, Follow-Up Studies, Humans, Male, Middle Aged, Pain, Pain Measurement, Quality of Life, Treatment Failure, Selective Serotonin Reuptake Inhibitors, Paroxetine, Sertraline

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