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Cited by 63Treatment of Major DepressionMusculoskeletal pain and rehabilitationAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The Adverse Effects of Comorbid Pain on Depression Outcomes in Primary Care Patients: Results from the Artist Trial

DeVeaugh-Geiss, Angela M., West, Suzanne L., Miller, William C., Sleath, Betsy, Gaynes, Bradley N., Kroenke, Kurt·2010·Pain Medicine
DOI 10.1111/j.1526-4637.2010.00830.x
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Abstract

OBJECTIVES: To explore the effect of pain symptoms and improvements in pain on depression outcomes. METHODS: We analyzed data from A Randomized Trial Investigating SSRI Treatment (ARTIST), a randomized longitudinal effectiveness study comparing selective serotonin reuptake inhibitors (SSRIs) for the treatment of depression in primary care (n = 573). Depression outcome at month 6, defined as remission, partial response, and nonresponse using the Symptom Checklist-20, was the primary outcome. RESULTS: Compared to patients with no pain at baseline, those with severe pain were less likely to achieve remission (OR = 0.11, 95% CI 0.05-0.25) and partial response (OR = 0.24, 95% CI 0.10-0.59) vs nonresponse. Patients with moderate pain were less likely to achieve remission vs nonresponse (OR = 0.25, 95% CI 0.13-0.48). Patients with early improvement in pain were more likely to achieve remission (OR = 1.90, 95% CI 1.03-3.49). Accounting for missing data with last observation carried forward or multiple imputation yielded similar results. CONCLUSION: Pain symptoms are present in the majority of depressed primary care patients beginning antidepressant therapy. Pain symptoms are associated with worse depression outcomes, while improvement in pain is associated with significantly better depression outcomes. Attention to comorbid pain may be important in enhancing depression care.

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Authors
DeVeaugh-Geiss, A. M., West, S. L., Miller, W. C., Sleath, B., Gaynes, B. N., & Kroenke, K.
Affiliations
  • RTI International (US)
  • University of North Carolina at Chapel Hill (US)
  • Regenstrief Institute (US)
ORCID
Venue
Pain Medicine
Publisher
Oxford University Press (OUP)
Published
2010-05
Volume
11
Issue
5
Pages
732-741
ISSN
  • 1526-2375 (ISSN-L)
  • 1526-4637
DOI
10.1111/j.1526-4637.2010.00830.x
OpenAlex
W1900828123
Cited by
63
References
59
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 5 · 2014: 9 · 2013: 3 · 2012: 4
FWCI
3.29
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1 (tdm, 1949 d)
Locations
  • Pain Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Bristol-Myers Squibb
  • Eli Lilly and Company
  • Pfizer
  • GlaxoSmithKline
  • University of North Carolina at Chapel Hill
  • National Institute of Mental Health
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
comorbid pain, depression, selective serotonin reuptake inhibitors, antidepressant response, depression remission, primary care, pain improvement
MeSH terms
Depressive Disorder, Female, Humans, Interviews as Topic, Pain, Pain Measurement, Primary Health Care, Comorbidity, Randomized Controlled Trials as Topic, Treatment Outcome, Selective Serotonin Reuptake Inhibitors

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