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Cited by 346

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Perioperative Synbiotic Treatment to Prevent Postoperative Infectious Complications in Biliary Cancer Surgery: A Randomized Controlled Trial

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Sugawara, Gen, Nagino, Masato, Nishio, Hideki, Ebata, Tomoki, Takagi, Kenji, Asahara, Takashi, Nomoto, Koji, Nimura, Yuji·2006·Annals of Surgery
DOI 10.1097/01.sla.0000219039.20924.88
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Abstract

SUMMARY BACKGROUND DATA: Use of synbiotics has been reported to benefit human health, but clinical value in surgical patients remains unclear. OBJECTIVE: To investigate the effect of perioperative oral administration of synbiotics upon intestinal barrier function, immune responses, systemic inflammatory responses, microflora, and surgical outcome in patients undergoing high-risk hepatobiliary resection. METHODS: Patients with biliary cancer involving the hepatic hilus (n = 101) were randomized before hepatectomy, into a group receiving postoperative enteral feeding with synbiotics (group A); or another receiving preoperative plus postoperative synbiotics (group B). Lactulose-mannitol (L/M) ratio, serum diamine oxidase (DAO) activity, natural killer (NK) cell activity, interleukin-6 (IL-6), fecal microflora, and fecal organic acid concentrations were determined before and after hepatectomy. Postoperative infectious complications were recorded. RESULTS: Of 101 patients, 81 completed the trial. Preoperative and postoperative changes in L/M ratio and DAO activity were similar between groups. Preoperatively in group B, NK activity, and lymphocyte counts increased, while IL-6 decreased significantly (P < 0.05). Postoperative serum IL-6, white blood cell counts, and C-reactive protein in group B were significantly lower than in group A (P < 0.05). During the preoperative period, numbers of Bifidobacterium colonies cultured from and total organic acid concentrations measured in feces increased significantly in group B (P < 0.05). Postoperative concentrations of total organic acids and acetic acid in feces were significantly higher in group B than in group A (P < 0.05). Incidence of postoperative infectious complications was 30.0% (12 of 40) in group A and 12.1% (5 of 41) in group B (P < 0.05). CONCLUSIONS: Preoperative oral administration of synbiotics can enhance immune responses, attenuate systemic postoperative inflammatory responses, and improve intestinal microbial environment. These beneficial effects likely reduce postoperative infectious complications after hepatobiliary resection for biliary tract cancer.

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Research works printed but not linked: 50

  1. Isolauri, 2001, Am J Clin Nutr, 73, 444, 10.1093/ajcn/73.2.444s · DOI · Paper page
  2. Anderson, 2002, J Hum Nutr Diet, 15, 241, 10.1046/j.1365-277X.2002.00377.x · doi:10.1046/j.1365-277x.2002.00377.x
  3. Yasui, 1999, Clin Diagn Lab Immunol, 6, 186, 10.1128/CDLI.6.2.186-192.1999 · DOI
  4. Ishikawa, 1999, Immunol. Res, 20, 243, 10.1007/BF02790407 · DOI
  5. Parks, 1996, J Anat, 189, 561
  6. Welsh, 1998, Ann Surg, 227, 205, 10.1097/00000658-199802000-00009 · DOI
  7. Gouma, 1986, Am J Surg, 151, 476, 10.1016/0002-9610(86)90107-8 · doi:10.1016/0002-9610(86)90107-8
  8. Nimura, 1991, Br J Surg, 78, 727, 10.1002/bjs.1800780629 · doi:10.1002/bjs.1800780629
  9. Nagino, 1993, World J Surg, 17, 250, 10.1007/BF01658937 · DOI
  10. Nimura, 1998, J Hepatobiliary Pancreat Surg, 5, 52, 10.1007/PL00009951 · doi:10.1007/pl00009951
  11. Nagino, 2001, World J Surg, 25, 1277, 10.1007/s00268-001-0110-8 · DOI
  12. Shirabe, 1997, Hepatogastroenterology, 44, 205
  13. Zulfikaroglu, 2003, Clin Nutr, 22, 277, 10.1016/S0261-5614(02)00211-X · doi:10.1016/s0261-5614(02)00211-x
  14. Anderson, 2004, Gut, 53, 241, 10.1136/gut.2003.024620 · DOI · Paper page
  15. Shu, 2002, FEMS Immunol Med Microbiol, 34, 59
  16. Eizaguirre, 2002, J Pediatr Surg, 37, 699, 10.1053/jpsu.2002.32256 · DOI · Paper page
  17. Gill, 2001, Med Microbiol Immunol (Berl), 190, 97, 10.1007/s004300100095 · DOI · Paper page
  18. Fuller, 1991, Gut, 32, 439, 10.1136/gut.32.4.439 · DOI · Paper page
  19. Gibson, 1995, Gastroenterology, 108, 975, 10.1016/0016-5085(95)90192-2 · DOI · Paper page
  20. Collins, 1999, Am J Clin Nutr, 69, 1052, 10.1093/ajcn/69.5.1052s · DOI · Paper page
  21. Rayes, 2002, Nutrition, 18, 609, 10.1016/S0899-9007(02)00811-0 · DOI · Paper page
  22. Rayes, 2002, Transplantation, 74, 123, 10.1097/00007890-200207150-00021 · DOI · Paper page
  23. Kanazawa, 2005, Langenbecks Arch Surg, 390, 104, 10.1007/s00423-004-0536-1 · DOI · Paper page
  24. Kamiya, 2004, Ann Surg, 239, 510, 10.1097/01.sla.0000118594.23874.89 · DOI · Paper page
  25. Jansen, 1986, Clin Chim Acta, 157, 277, 10.1016/0009-8981(86)90303-7 · DOI
  26. Takagi, 1994, Clin Chim Acta, 226, 67, 10.1016/0009-8981(94)90103-1 · DOI
  27. Nagao, 1996, Immunol Invest, 25, 507, 10.3109/08820139609055739 · doi:10.3109/08820139609055739
  28. Gaines Das, 1993, J Immunol Methods, 160, 147, 10.1016/0022-1759(93)90172-4 · DOI
  29. Tanaka, 1980, Appl Environ Microbiol, 40, 866, 10.1128/AEM.40.5.866-869.1980 · DOI
  30. Petts, 1984, J Clin Microbiol, 19, 4, 10.1128/JCM.19.1.4-7.1984 · DOI
  31. Sonoike, 1986, J Food Hyg Soc Jpn, 27, 238, 10.3358/shokueishi.27.238 · doi:10.3358/shokueishi.27.238
  32. Kitajima, 1997, Arch Dis Child, 76, 101, 10.1136/fn.76.2.F101 · DOI · Paper page
  33. Kikuchi, 1992, J Sci Food Agr, 60, 139, 10.1002/jsfa.2740600202 · DOI
  34. Shigeta, 2002, Langenbecks Arch Surg, 387, 117, 10.1007/s00423-002-0301-2 · DOI
  35. Kanai, 1996, Surgery, 119, 498, 10.1016/S0039-6060(96)80257-1 · doi:10.1016/s0039-6060(96)80257-1
  36. Deitch, 1993, Curr Opin Gen Surg, &NA;, 85
  37. Nagao, 2000, Biosci Biotechnol Biochem, 64, 2706, 10.1271/bbb.64.2706 · DOI · Paper page
  38. Sheih, 2001, J Am Coll Nutr, 20, 149, 10.1080/07315724.2001.10719027 · DOI · Paper page
  39. Matsuzaki, 2000, Immunol Cell Biol, 78, 67, 10.1046/j.1440-1711.2000.00887.x · DOI · Paper page
  40. Iwata, 2000, J Vasc Surg, 31, 1003, 10.1067/mva.2000.105004 · DOI
  41. McNaught, 2005, Clin Nutr, 24, 211, 10.1016/j.clnu.2004.08.008 · DOI · Paper page
  42. Shida, 1998, Int Arch Allergy Immunol, 115, 278, 10.1159/000069458 · DOI · Paper page
  43. Kato, 1999, Int J Immunopharmacol, 21, 121, 10.1016/S0192-0561(98)00072-1 · DOI · Paper page
  44. Takagi, 2001, Carcinogenesis, 22, 599, 10.1093/carcin/22.4.599 · DOI
  45. Blackwell, 1996, Br J Anaesth, 77, 110, 10.1093/bja/77.1.110 · DOI · Paper page
  46. Sheeran, 1997, Br J Anaesth, 78, 201, 10.1093/bja/78.2.201 · DOI · Paper page
  47. Duc le, 2004, Appl Environ Microbiol, 70, 2161, 10.1128/AEM.70.4.2161-2171.2004 · DOI · Paper page
  48. Bartosch, 2005, Clin Infect Dis, 40, 28, 10.1086/426027 · DOI · Paper page
  49. Mitsuoka, 2000, Biosci Microflora, 19, 15, 10.12938/bifidus1996.19.15 · DOI
  50. Willemsen, 2003, Gut, 52, 1442, 10.1136/gut.52.10.1442 · DOI · Paper page

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Metadata

Authors
Sugawara, G., Nagino, M., Nishio, H., Ebata, T., Takagi, K., Asahara, T., Nomoto, K., & Nimura, Y.
Venue
Annals of Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-11
Volume
244
Issue
5
Pages
706-714
ISSN
0003-4932 (ISSN-L)
DOI
10.1097/01.sla.0000219039.20924.88
OpenAlex
W2110284028
Cited by
346
References
1
FWCI
21.62
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Perioperative Synbiotic Treatment to Prevent Postoperative Infectious Complications in Biliary Cancer Surgery: A Randomized Controlled Trial. https://app.cochat.ai/papers/10.1097/01.sla.0000219039.20924.88
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Sugawara, G., Nagino, M., Nishio, H., Ebata, T., Takagi, K., Asahara, T., Nomoto, K., & Nimura, Y. (2006). Perioperative Synbiotic Treatment to Prevent Postoperative Infectious Complications in Biliary Cancer Surgery: A Randomized Controlled Trial. Annals of Surgery. https://doi.org/10.1097/01.sla.0000219039.20924.88

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