A prospective randomised study of the probiotic Lactobacillus plantarum 299V on indices of gut barrier function in elective surgical patients
Open accessAbstract
Background: Bacterial translocation occurs in surgical patients and may predispose to postoperative septic morbidity. Many factors are thought to influence the prevalence of bacterial translocation, one of which is the composition of the gut microflora. The aim of this prospective and randomised study was to assess the effect of the probiotic Lactobacillus plantarum 299v on the incidence of bacterial translocation, gastric colonisation, and septic complications in elective surgical patients. Methods: Patients undergoing elective major abdominal surgery were randomised to either a treatment or control group. The treatment group received an oral preparation containing Lactobacillus plantarum 299v ( Proviva ) for at least one week preoperatively and also in the postoperative period. Bacterial translocation was determined by culture of a mesenteric lymph node and serosal scraping obtained at laparotomy. Gastric colonisation was assessed by microbiological culture of nasogastric aspirates. All postoperative septic complications were recorded. Results: A total of 129 patients completed the study (probiotic group n=64). There was no significant difference between the two groups in terms of bacterial translocation (12% v 12%; p=0.82), gastric colonisation with enteric organisms (11% v 17%; p=0.42), or septic morbidity (13% v 15%; p=0.74). Conclusions: Administration of Lactobacillus plantarum 299v in elective surgical patients does not influence the rate of bacterial translocation, gastric colonisation, or incidence of postoperative septic morbidity.
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Knowledge about probiotics and CRP is limited; some strains appear to affect CRP while others do not.
“To date, not much is known about probiotics and CRP, but some strains seem to be able to influence CRP, whereas others have no effect. 37, 39, 40”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [40]
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- Authors
- McNaught, C. E., Woodcock, N. P., MacFie, J., & Mitchell, C. J.
- Affiliations
- Scarborough General Hospital (GB)
- Corresponding author
- MacFie, J
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2002-12
- Volume
- 51
- Issue
- 6
- Pages
- 827-831
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1773461
- OpenAlex
- W2156266318
- Cited by
- 156
- References
- 30
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 10 · 2014: 4 · 2013: 11 · 2012: 8
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus plantarum 299v, probiotics, bacterial translocation, intestinal barrier, postoperative sepsis, elective abdominal surgery, mesenteric lymph nodes, gut microbiota
- MeSH terms
- Adult, Aged, Bacterial Infections, C-Reactive Protein, Female, Gastric Mucosa, Humans, Intestinal Mucosa, Lactobacillus, Lymph Nodes, Male, Middle Aged, Postoperative Complications, Preoperative Care, Prospective Studies, Chi-Square Distribution, Statistics, Nonparametric, Bacterial Translocation, Probiotics
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