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Cited by 315

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial

Open access
Kitajima, Hiroyuki, Sumida, Yutaka, Tanaka, Ryuichiro, Yuki, Norikatsu, Takayama, Hiroo, Fujimura, Masanori·1997·Archives of Disease in Childhood - Fetal and Neonatal Edition

Abstract

AIM: To investigate the colonisation with Bifidobacterium breve of the bowels of very low birthweight (VLBW) infants. METHODS: The adverse effects of B breve were examined in 66 VLBW infants (preliminary study). A prospective randomised clinical study of 91 VLBW infants was also completed and these infants were followed up for three years. Precise viable bacterial counts of serial stool specimens were examined for the first eight weeks after birth in 10 infants. The colonisation rates of administered bacteria were examined using immunohistochemical staining of stool specimens with a B breve specific monoclonal antibody. RESULTS: In the preliminary study there were no side effects attributable to the bacteria. Immunohistochemical staining of stool specimens showed that the colonisation rates of the administered bacteria were 73% at 2 weeks of age, but only 12% in the control group. Early administration of B breve significantly decreased aspirated air volume from the stomach and improved weight gain. CONCLUSIONS: B breve can colonise the immature bowel very effectively and is associated with fewer abnormal abdominal signs and better weight gain in VLBW infants, probably as a result of stabilisation of their intestinal flora and accelerated feeding schedules.

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Metadata

Authors
Kitajima, H., Sumida, Y., Tanaka, R., Yuki, N., Takayama, H., & Fujimura, M.
Venue
Archives of Disease in Childhood - Fetal and Neonatal Edition
Publisher
BMJ
Published
1997-03-01
Volume
76
Issue
2
Pages
F101-F107
ISSN
  • 1359-2998 (ISSN-L)
  • 1468-2052
OpenAlex
W2114811866
Cited by
315
References
1
FWCI
5.66
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial. https://app.cochat.ai/papers/10.1136/fn.76.2.f101
The paper
Kitajima, H., Sumida, Y., Tanaka, R., Yuki, N., Takayama, H., & Fujimura, M. (1997). Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial. Archives of Disease in Childhood - Fetal and Neonatal Edition. https://doi.org/10.1136/fn.76.2.f101

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.