Bifidobacterium infantis35624 modulates host inflammatory processes beyond the gut
Open accessAbstract
Certain therapeutic microbes, including Bifidobacteria infantis (B. infantis) 35624 exert beneficial immunoregulatory effects by mimicking commensal-immune interactions; however, the value of these effects in patients with non-gastrointestinal inflammatory conditions remains unclear. In this study, we assessed the impact of oral administration of B. infantis 35624, for 6‒8 weeks on inflammatory biomarker and plasma cytokine levels in patients with ulcerative colitis (UC) (n = 22), chronic fatigue syndrome (CFS) (n = 48) and psoriasis (n = 26) in three separate randomized, double-blind, placebo-controlled interventions. Additionally, the effect of B. infantis 35624 on immunological biomarkers in healthy subjects (n = 22) was assessed. At baseline, both gastrointestinal (UC) and non-gastrointestinal (CFS and psoriasis) patients had significantly increased plasma levels of C-reactive protein (CRP) and the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) compared with healthy volunteers. B. infantis 35624 feeding resulted in reduced plasma CRP levels in all three inflammatory disorders compared with placebo. Interestingly, plasma TNF-α was reduced in CFS and psoriasis while IL-6 was reduced in UC and CFS. Furthermore, in healthy subjects, LPS-stimulated TNF-α and IL-6 secretion by peripheral blood mononuclear cells (PBMCs) was significantly reduced in the B. infantis 35624-treated groups compared with placebo following eight weeks of feeding. These results demonstrate the ability of this microbe to reduce systemic pro-inflammatory biomarkers in both gastrointestinal and non-gastrointestinal conditions. In conclusion, these data show that the immunomodulatory effects of the microbiota in humans are not limited to the mucosal immune system but extend to the systemic immune system.
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B. infantis 35624 was effective in reducing inflammatory biomarkers in patients with non-gastrointestinal inflammatory processes, such as chronic fatigue syndrome and psoriasis.
“the immune modulation effect of B. infantis 35624 was extended to systemic level since it was effective in reducing inflammatory biomarkers in patients with non-gastrointestinal inflammatory processes, such as chronic fatigue syndrome and psoriasis [144]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [144]
B. infantis 35624 was effective in reducing the proinflammatory state of patients with UC.
“The studies carried out with the strain 35624 show that it was effective in reducing the proinflammatory state of patients with IBD [142,143] , as well as with UC [144]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [144]
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BackgroundResultModulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics
Liu, Y., Wang, J., & Wu, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.634897 · Cited by 393 · see citing works
“infantis 35624 has been shown to increase the proportion of Foxp3 lymphocytes in peripheral blood in healthy volunteers and decrease levels of pro-inflammatory cytokines and C-reactive protein in psoriasis patients, chronic fatigue syndrome patients, or ulcerative colitis patients (32, 33).”
BackgroundHaahtela, T. (2019) · Allergy · doi:10.1111/all.13763 · Cited by 407 · see citing works
Prebiotics and Probiotics in Digestive Health
Quigley, E. M. M. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.09.028 · Cited by 387 · see citing works
Self-citationBifidobacterium mechanisms of immune modulation and tolerance
Gavzy, S. J., Kensiski, A., Lee, Z. L., Mongodin, E. F., Ma, B., & Bromberg, J. S. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2291164 · Cited by 375 · see citing works
Giloteaux, L., Goodrich, J. K., Walters, W. A., Levine, S. M., Ley, R. E., & Hanson, M. R. (2016) · Microbiome · doi:10.1186/s40168-016-0171-4 · Cited by 338 · see citing works
“Treatment with Bifidobacterium infantis 35624 was reported to reduce CRP levels in a cohort of ME/CFS patients [61].”
BackgroundEffect of probiotics on central nervous system functions in animals and humans: a systematic review
Wang, H., Lee, I.-S., Braun, C., & Enck, P. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16018 · Cited by 334 · see citing works
Bifidobacteria and Their Molecular Communication with the Immune System
Ruíz, L., Delgado, S., Ruas‐Madiedo, P., Sánchez, B., & Margollés, A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02345 · Cited by 329 · see citing works
“…psoriasis, as compared to healthy controls Six to eight weeks of probiotic administration reduced CRP, TNFα, and IL6 in UC, CFS, and psoriasis patients Groeger et al., 2013 B. infantis NLS Celiac adults Six weeks probiotic administration reduced Paneth cells numbers and expression of…”
BackgroundJakubczyk, D., Leszczyńska, K., & Górska, S. (2020) · Nutrients · doi:10.3390/nu12071973 · Cited by 314 · see citing works
Vulevic, J., Juric, A., Walton, G. E., Claus, S. P., Tzortzis, G., Toward, R. E., & Gibson, G. R. (2015) · British Journal of Nutrition · doi:10.1017/s0007114515001889 · Cited by 317 · see citing works
“They can also regulate the immune response because of their impact on T-cell regulation and subsequently the inflammatory response((39,40)).”
BackgroundPrebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence
Frei, R., Akdis, M., & O’Mahony, L. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000151 · Cited by 240 · see citing works
Self-citationEffect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial
Buigues, C., Fernández-Garrido, J., Pruimboom, L., Hoogland, A., Navarro-Martínez, R., Martínez-Martínez, M., Verdejo, Y., Mascarós, M., Peris, C., & Cauli, O. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060932 · Cited by 222 · see citing works
“The rotational of our clinical trial was based on previous in vitro studies that demonstrated the ability of prebiotics to regulate the immune response through lymphocyte regulation and subsequently the inflammatory response [16–18].”
MethodProbiotics in Inflammatory Bowel Disease
Abraham, B. P., & Quigley, E. M. M. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2017.08.003 · Cited by 217 · see citing works
Self-citationAlterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis
Olejniczak‐Staruch, I., Ciążyńska, M. A., Sobolewska-Sztychny, D., Narbutt, J., Skibińska, M., & Lesiak, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083998 · Cited by 215 · see citing works
“In studies of patients with psoriasis, the supply of these bacteria resulted in a decrease in CRP and the pro-inflammatory cytokine TNFα in the serum of patients [87].”
BackgroundImmune-to-Brain Communication Pathways in Inflammation-Associated Sickness and Depression
D’Mello, C., & Swain, M. G. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_37 · Cited by 210 · see citing works
Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential
Yong, S. J., Tong, T., Chew, J., & Lim, W. L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01361 · Cited by 217 · see citing works
Targeting the gut‐skin axis—Probiotics as new tools for skin disorder management?
Szántó, M., Dózsa, A., Antal, D., Szabó, K., Kemény, L., & Bai, P. (2019) · Experimental Dermatology · doi:10.1111/exd.14016 · Cited by 189 · see citing works
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“It was reported that Bifidobacterium infantis 35624 could exert beneficial immunoregulatory effects in the mucosal immune system [3].”
BackgroundAssociation between the gut microbiota and mineral metabolism
Skrypnik, K., & Suliburska, J. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8724 · Cited by 182 · see citing works
D'Mello, C., Ronaghan, N., Zaheer, R., Dicay, M., Le, T., MacNaughton, W. K., Surrette, M. G., & Swain, M. G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0575-15.2015 · Cited by 169 · see citing works
“…and behavior remain unclear, but have been linked to changes in gut flora (although not routinely observed), changes in gut permeability, and shifts in systemic immunity with decreased production of proinflammatory cytokines, including TNF- (O’Mahony et al., 2005; Hemarajata and Versalovic, 2013).”
BackgroundManipulation of the Microbiota for Treatment of IBS and IBD—Challenges and Controversies
Shanahan, F., & Quigley, E. M. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.050 · Cited by 172 · see citing works
“There have been a few reports of the ability of orally administered probiotics to accelerate(47) or slow(48,49) colonic transit, influence brain activation,(50) and alter circulating cytokines.(51) Other opportunities for intervention also may be available.”
BackgroundSelf-citationSchiavi, E., Gleinser, M., Molloy, E. M., Groeger, D., Frei, R., Ferstl, R., Rodríguez‐Pérez, N., Ziegler, M., Grant, R., Moriarty, T. F., et al. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.02238-16 · Cited by 173 · see citing works
“Administration of this bacterium to humans increases Foxp3+ lymphocytes in peripheral blood, enhances IL-10 secretion ex vivo , and reduces the level of circulating proinflammatory biomarkers in a wide range of patient groups (13, 14).”
Self-citationChen, L., Li, J., Zhu, W., Kuang, Y., Liu, T., Zhang, W., Chen, X., & Peng, C. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.589726 · Cited by 175 · see citing works
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Lee, H. J., Hong, J. K., Kim, J.-K., Kim, D., Jang, S. W., Han, S.-W., & Yoon, I. (2021) · Nutrients · doi:10.3390/nu13082660 · Cited by 158 · see citing works
“fidobacterium [39] and Lactobacillus strains [40] can downregulate pro-inflammatory cytokine secretion.”
BackgroundKanda, N., Hoashi, T., & Saeki, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155405 · Cited by 152 · see citing works
Sokołowska, M., Frei, R., Lunjani, N., Akdiş, C. A., & O’Mahony, L. (2018) · Asthma Research and Practice · doi:10.1186/s40733-017-0037-y · Cited by 148 · see citing works
“Notably, consumption of Bifidobacterium longum 35,624 by healthy human volunteers increased Foxp3+ T regulatory cells in peripheral blood, while administration of this bacterial strain to psoriasis patients, chronic fatigue syndrome patients or ulcerative colitis patients consistently resulted in reduced levels of ser…”
BackgroundSelf-citationGut–Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis
Thye, A. Y.-K., Bah, Y.-R., Law, J. W.-F., Tan, L. T.-H., He, Y.-W., Wong, S.-H., Thurairajasingam, S., Chan, K.-G., Lee, L.-H., & Letchumanan, V. (2022) · Biomedicines · doi:10.3390/biomedicines10051037 · Cited by 156 · see citing works
Changing our microbiome: probiotics in dermatology
Yu, Y., Dunaway, S., Champer, J., Kim, J., & Alikhan, A. (2019) · British Journal of Dermatology · doi:10.1111/bjd.18088 · Cited by 144 · see citing works
Immune regulation by histamine and histamine-secreting bacteria
Barcik, W., Wawrzyniak, M., Akdiş, C. A., & O’Mahony, L. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.08.011 · Cited by 137 · see citing works
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The role of the skin and gut microbiome in psoriatic disease
Yan, D., Issa, N., Afifi, L., Jeon, C., Chang, H.-W., & Liao, W. (2017) · Current Dermatology Reports · doi:10.1007/s13671-017-0178-5 · Cited by 135 · see citing works
Role of probiotics and prebiotics in immunomodulation
Yahfoufi, N., Mallet, J., Graham, É. A., & Matar, C. (2018) · Current Opinion in Food Science · doi:10.1016/j.cofs.2018.04.006 · Cited by 135 · see citing works
Functional Role of Probiotics and Prebiotics on Skin Health and Disease
Lolou, V., & Panayiotidis, M. I. (2019) · Fermentation · doi:10.3390/fermentation5020041 · Cited by 136 · see citing works
“A year later, Groeger et al., 2013 studied the immuno-regulatory effects of B. infantis in patients with ulcerative colitis, chronic fatigue syndrome and psoriasis.”
BackgroundNutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review
Inglis, J. E., Lin, P., Kerns, S. L., Kleckner, I. R., Kleckner, A. S., Castillo, D. A., Mustian, K. M., & Peppone, L. J. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2018.1513046 · Cited by 135 · see citing works
The effects of gut microbiota on CNS function in humans
Tillisch, K. (2014) · Gut Microbes · doi:10.4161/gmic.29232 · Cited by 144 · see citing works
The gut microbiome in psoriasis and psoriatic arthritis
Myers, B., Brownstone, N., Reddy, V., Chan, S., Thibodeaux, Q., Truong, A., Bhutani, T., Chang, H.-W., & Liao, W. (2019) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2020.101494 · Cited by 127 · see citing works
Exploring the role of the microbiota member Bifidobacterium in modulating immune-linked diseases
O’Neill, I. J., Schofield, Z., & Hall, L. J. (2017) · Emerging Topics in Life Sciences · doi:10.1042/etls20170058 · Cited by 129 · see citing works
Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders
Doney, E., Cadoret, A., Dion‐Albert, L., Lebel, M., & Ménard, C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15239 · Cited by 130 · see citing works
Psoriasis and Gut Microbiome—Current State of Art
Polak, K., Bergler-Czop, B. S., Szczepanek, M., Wojciechowska, K., Frątczak, A., & Kiss, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094529 · Cited by 127 · see citing works
“[26] 2013 ulcerative colitis (22), chronic fatigue syndrome (48), psoriasis (26) 25 female and 10 male healthy volunteers at the age 18–65 with no history of abdominal surgery except for hernia repair or appendectomy, no comorbidities, no probiotic or immunosupressant therapy Caucasian (Ireland) randomized, double-bli…”
BackgroundInfluentialKawahara, T., Takahashi, T., Oishi, K., Tanaka, H., Masuda, M., Takahashi, S., Takano, M., Kawakami, T., Fukushima, K., Kanazawa, H., et al. (2015) · Microbiology and Immunology · doi:10.1111/1348-0421.12210 · Cited by 125 · see citing works
“Bifidobacterium is one of the major components of the intestinal microflora and modulates the intestinal immune system (16).”
BackgroundZhao, Q., Yu, J., Zhou, H., Zhang, C., Wang, X., Hu, J., Hu, Y., HU, Y., Zeng, F., Zeng, F., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01219-0 · Cited by 127 · see citing works
The effect of probiotics on inflammatory biomarkers: A meta-analysis of randomized clinical trials
Milajerdi, A., Mousavi, S. M., Sadeghi, A., Salari-Moghaddam, A., Parohan, M., Larijani, B., & Esmaillzadeh, A. (2020) · European Journal of Nutrition · doi:10.1007/s00394-019-01931-8 · Cited by 123 · see citing works
Buhaș, M. C., Gavrilaș, L. I., CANDREA, A. R., Cătinean, A., Mocan, A., Miere, D., & Tataru, A. D. (2022) · Nutrients · doi:10.3390/nu14142970 · Cited by 130 · see citing works
Kazemi, A., Soltani, S., Ghorabi, S., Keshtkar, A., Daneshzad, E., Nasri, F., & Mazloomi, S. M. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2019.04.004 · Cited by 131 · see citing works
Recent developments and highlights in mechanisms of allergic diseases: Microbiome
Lunjani, N., Satitsuksanoa, P., Łukasik, Z. M., Sokołowska, M., Eiwegger, T., & O’Mahony, L. (2018) · Allergy · doi:10.1111/all.13634 · Cited by 119 · see citing works
“levels, possibly due to increased numbers of Tregs, which suggests that bacteria in the gut can influence skin inflammatory activity in adults.(131,132) Taken together, supplementation with specific probiotic strains may modulate the gut bacteria in a way that influences inflam-”
BackgroundSelf-citationThe Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)
König, R. S., Albrich, W. C., Kahlert, C. R., Bahr, L. S., Löber, U., Vernazza, P., Scheibenbogen, C., & Forslund, S. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628741 · Cited by 123 · see citing works
Exploring the Links between Obesity and Psoriasis: A Comprehensive Review
Barros, G., Durán, P., Vera, I., & Bermúdez, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147499 · Cited by 120 · see citing works
Gut microbiota and obesity: Role in aetiology and potential therapeutic target
Moran, C. P., & Shanahan, F. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.07.005 · Cited by 118 · see citing works
Self-citationThe Human Microbiota and Skin Cancer
Woo, Y. R., Cho, S. H., Lee, J. D., & Kim, H. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031813 · Cited by 115 · see citing works
The challenges of primary biliary cholangitis: What is new and what needs to be done
Terziroli Beretta-Piccoli, B., Mieli-Vergani, G., Vergani, D., Vierling, J. M., Adams, D., Alpini, G., Banales, J. M., Beuers, U., Björnsson, E., Bowlus, C., et al. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102328 · Cited by 114 · see citing works
Self-citationStarter Culture Development and Innovation for Novel Fermented Foods
Gänzle, M. G., Monnin, L., Zheng, J., Zhang, L., Coton, M., Sicard, D., & Walter, J. (2023) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-072023-034207 · Cited by 121 · see citing works
Skin Health from the Inside Out
Woodby, B. L., Penta, K., Pecorelli, A., Lila, M. A., & Valacchi, G. (2020) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-032519-051722 · Cited by 112 · see citing works
Pathogenesis, multi-omics research, and clinical treatment of psoriasis
Yu, J., Zhao, Q., Wang, X., Zhou, H., Hu, J. Y., Gu, L., Hu, Y., Zeng, F., Zhao, F., Yue, C., et al. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102916 · Cited by 111 · see citing works
Li, Y., Li, Q., Yuan, R., Wang, Y., Guo, C., & Wang, L. (2024) · Theranostics · doi:10.7150/thno.92350 · Cited by 112 · see citing works
“It can regulate host’s immune responses [17], relieve allergic symptoms [18], and treat inflammatory diseases [19].”
BackgroundAhlawat, S., Kumar, P., Mohan, H., Goyal, S., & Sharma, K. K. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1876631 · Cited by 111 · see citing works
Astó, E., Méndez, I., Audivert, S., Farrán-Codina, A., & Espadaler, J. (2019) · Nutrients · doi:10.3390/nu11020293 · Cited by 109 · see citing works
“2015 [48] 60/Inactive ≥18 UCDAI Probiotic vs. control a Bio-Three Placebo * Petersen et al. 2014 [49] 50/Active ≥18 CAI Probiotic vs. control a Mutaflor Placebo Groeger et al. 2013 [50] 22/Active ≥18 Not assessed Probiotic vs. control B. infantis 35624 b Placebo Outcomes considered in this systematic review were the e…”
Human Microbiome: Composition and Role in Inflammatory Skin Diseases
Balato, A., Cacciapuoti, S., Caprio, R. D., Marasca, C., Masarà, A., Raimondo, A., & Fabbrocini, G. (2018) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-018-0528-4 · Cited by 110 · see citing works
Probiotics: A potential immunomodulator in COVID-19 infection management
Singh, K., & Rao, A. (2021) · Nutrition Research · doi:10.1016/j.nutres.2020.12.014 · Cited by 109 · see citing works
“[54] Groeger D , O’Mahony L , Murphy EF , Bourke JF , Dinan TG , et al.”
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Metabolite and Microbiome Interplay in Cancer Immunotherapy
Johnson, C. H., Spilker, M. E., Goetz, L. H., Peterson, S. N., & Siuzdak, G. E. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0309 · Cited by 104 · see citing works
“Changes to the microbiome have been associated with various inflammatory diseases, such as atopic dermatitis (2) and psoriasis (3) as well as chronic lung diseases [chronic obstructive pulmonary disease (COPD) and cystic fibrosis], which are associated with the state of the lung microbiome (4).”
BackgroundMechanisms of microbe-immune system dialogue within the skin
Lunjani, N., Ahearn-Ford, S., Dube, F. S., Hlela, C., & O’Mahony, L. (2021) · Genes and Immunity · doi:10.1038/s41435-021-00133-9 · Cited by 106 · see citing works
“Other recent studies have shown potentially beneficial effects of oral probiotics in plaque psoriasis [87, 88], adult AD [89], hand dermatitis [90], papulopustular rosacea, seborrhoeic dermatitis [86] and dandruff [91].”
ResultSelf-citationMartami, F., Togha, M., Seifishahpar, M., Ghorbani, Z., Ansari, H., Karimi, T., & Jahromi, S. R. (2019) · Cephalalgia · doi:10.1177/0333102418820102 · Cited by 102 · see citing works
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“Administration of this bacterium to humans increases Foxp3+ lymphocytes in peripheral blood, enhances IL-10 secretion ex vivo, and reduces the level of circulating proinflammatory biomarkers in a wide range of patient groups and healthy volunteers [16, 17].”
BackgroundSelf-citationRelationship between oral and gut microbiota in elderly people
Iwauchi, M., Horigome, A., Ishikawa, K., Mikuni, A., Nakano, M., Xiao, J., Odamaki, T., & Hironaka, S. (2019) · Immunity Inflammation and Disease · doi:10.1002/iid3.266 · Cited by 96 · see citing works
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“Little has been reported on the clinical effects of probiotic treatment in patients with psoriasis, but administration of a Bifidobacterium longum strain to adults with psoriasis resulted in reduced circulating levels of C-reactive protein, tumor necrosis factor, and IL17 [55].”
BackgroundSelf-citationEmerging role of gut microbiota in autoimmune diseases
Wang, X., Yuan, W., Yang, C., Wang, Z., Zhang, J., Xu, D., Sun, X., & Sun, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1365554 · Cited by 101 · see citing works
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“[19] Groeger D, O’Mahony L, Murphy EF, et al.”
Transforming Psoriasis Care: Probiotics and Prebiotics as Novel Therapeutic Approaches
Buhaș, M. C., CANDREA, A. R., Gavrilaș, L. I., Miere, D., Tataru, A. D., Boca, A., & Cătinean, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311225 · Cited by 98 · see citing works
“showed that Bifidobacteria infantis supplementation reduced the proinflammatory status by reducing LPS-stimulated TNF-α and IL-6 levels in healthy participants [47].”
BackgroundWei, X., Xin, J., Chen, W., Wang, J., Lv, Y., Wei, Y., Li, Z., Ding, Q., Shen, Y., Xu, X., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114862 · Cited by 87 · see citing works
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“In the sera and colonic tissues of UC patients, the levels of IL1β, IL-6 and TNF-α were significantly higher than those of normal subjects, while down-regulation of them could prevent UC (Galli et al., 2011; Roberts-Thomson et al., 2011; Groeger et al., 2013).”
BackgroundThe Defect in Regulatory T Cells in Psoriasis and Therapeutic Approaches
Kanda, N., Hoashi, T., & Saeki, H. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173880 · Cited by 85 · see citing works
“Oral administration of B. infantis 35624 in patients with psoriasis reduced plasma levels of TNF-α and CRP [76].”
Neto, M. P. C., Aquino, J. D. S., da Silva, L. D. F. R., Silva, R. D. O., Guimarães, K. S. D. L., de Oliveira, Y., de Souza, E. L., Magnani, M., Vidal, H., & Alves, J. L. D. B. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.020 · Cited by 83 · see citing works
How do probiotics and prebiotics function at distant sites?
Reid, G., Abrahamsson, T., Bailey, M. T., Bindels, L. B., Bubnov, R. V., Ganguli, K. A., Martoni, C., O’Neill, C. A., Savignac, H. M., Stanton, C., et al. (2017) · Beneficial Microbes · doi:10.3920/bm2016.0222 · Cited by 83 · see citing works
Balancing reactive oxygen species generation by rebooting gut microbiota
Singh, V., Ahlawat, S., Mohan, H., Gill, S. S., & Sharma, K. K. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15504 · Cited by 83 · see citing works
“…and superoxide radical (O2 •−) Reduces the production of pro- inflammatory cytokines; epithelial cell renewal Villéger et al. (2018); Feng et al. (2015); Groeger et al. (2013) Lactobacillus Yes IBD Upregulates antioxidant factors (e.g. SOD1, SOD2, GPX2) Reduces the production of pro- inflammatory…”
BackgroundInflammatory proteins are altered in chronic fatigue syndrome—A systematic review and meta-analysis
Strawbridge, R., Sartor, M.-L., Scott, F., & Cleare, A. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.011 · Cited by 79 · see citing works
Dynamic Changes in Gut Microbiome of Ulcerative Colitis: Initial Study from Animal Model
Gu, W., Zhang, L., Tao, H., Huang, H., & Chen, J. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s358807 · Cited by 80 · see citing works
Farsi, Y., Tahvildari, A., Arbabi, M., Vazife, F., Sechi, L. A., Bonjar, A. H. S., Jamshidi, P. K., Nasiri, M. J., & Mirsaeidi, M. S. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.804644 · Cited by 78 · see citing works
“…for their immunomodulatory effects especially on Th17 and in the amelioration of inflammatory process (de Vrese et al., 2005; Wang et al., 2011; Groeger et al., 2013; Jungersen et al., 2014; King et al., 2014; Han et al., 2016; Schiavi et al., 2016; Bozkurt et al., 2019; Bozkurt and Kara,…”
BackgroundCurrent Progress and Future Perspectives on the Use of Bacillus clausii
Ghelardi, E., y Abreu, A. T. A., Marzet, C. B., Calatayud, G. Á., Perez, M. I., & Castro, A. P. M. (2022) · Microorganisms · doi:10.3390/microorganisms10061246 · Cited by 79 · see citing works
Notay, M., Foolad, N., Vaughn, A. R., & Sivamani, R. K. (2017) · American Journal of Clinical Dermatology · doi:10.1007/s40257-017-0300-2 · Cited by 74 · see citing works
“infantis 35624 is able to reduce proinflammatory biomarkers in a systemic inflammatory disorder [24]; however, future studies should incorporate clinical grading and assessments.”
BackgroundProbiotics: Protecting Our Health from the Gut
Varela-Trinidad, G. U., Domínguez-Díaz, C., Solórzano-Castanedo, K., Íñiguez-Gutiérrez, L., Hernández-Flores, T. D. J., & Fafutis‐Morris, M. (2022) · Microorganisms · doi:10.3390/microorganisms10071428 · Cited by 78 · see citing works
The growth potential for dairy probiotics
Reid, G. (2015) · International Dairy Journal · doi:10.1016/j.idairyj.2015.04.004 · Cited by 75 · see citing works
“This is supportedbystudies showing thatprobiotic food can enhancemucosal immunity to better eradicate the common cold virus and relieve its effect on fever, rhinorrhoea, and cough incidence (Groeger et al., 2013; Leyer, Li, Mubasher, Reifer, & Ouwehand, 2009).”
BackgroundCorrie, L., Awasthi, A., Kaur, J., Vishwas, S., Gulati, M., Kaur, I. P., Gupta, G., Kommineni, N., Dua, K., & Singh, S. K. (2023) · Pharmaceuticals · doi:10.3390/ph16020197 · Cited by 76 · see citing works
“infantis for the treatment of ulcerative colitis and psoriasis, it was found to lead to a reduction in the C reactive protein (CRP) levels [72].”
BackgroundThe role of the microbiome in psoriasis: moving from disease description to treatment selection?
Langan, E. A., Griffiths, C. E. M., Solbach, W., Knobloch, J. K. ‐., Zillikens, D., & Thaçi, D. (2017) · British Journal of Dermatology · doi:10.1111/bjd.16081 · Cited by 71 · see citing works
Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches
Štofilová, J., Kvaková, M., Kamlárová, A., Hijová, E., Bertková, I., & Guľašová, Z. (2022) · Biomedicines · doi:10.3390/biomedicines10092236 · Cited by 74 · see citing works
- Authors
- Groeger, D., O’Mahony, L., Murphy, E. F., Bourke, J. F., Dinan, T. G., Kiely, B., Shanahan, F., & Quigley, E. M. M.
- Affiliations
- Alimentary Health (Ireland) (IE)
- University of Zurich (CH)
- South Infirmary Victoria University Hospital (IE)
- University College Cork (IE)
- Corresponding author
- Quigley, Eamonn M.M.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2013-07-12
- Volume
- 4
- Issue
- 4
- Pages
- 325-339
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC3744517
- OpenAlex
- W2056812430
- Cited by
- 448
- References
- 57
- Citations by year
- 2026: 16 · 2025: 52 · 2024: 54 · 2023: 52 · 2022: 56 · 2021: 40 · 2020: 29 · 2019: 36 · 2018: 28 · 2017: 30 · 2016: 16 · 2015: 21 · 2014: 15 · 2013: 3
- FWCI
- 27.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Gut Microbes (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- probiotics, immunomodulation, ulcerative colitis, chronic fatigue syndrome, psoriasis, systemic inflammation, C-reactive protein, TNF-α, interleukin-6, peripheral blood mononuclear cells, gut microbiota
- MeSH terms
- Administration, Oral, Adolescent, Adult, Aged, Bifidobacterium, C-Reactive Protein, Colitis, Ulcerative, Double-Blind Method, Female, Humans, Immunosuppression Therapy, Male, Middle Aged, Placebos, Psoriasis, Fatigue Syndrome, Chronic, Cytokines, Treatment Outcome, Probiotics, Gastrointestinal Tract, Young Adult
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