The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
Open accessAbstract
PURPOSE OF REVIEW: Many recent studies have revealed the key roles played by Th1/Th2 cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling in the pathogenesis of atopic dermatitis. Accordingly, current therapy has been largely directed towards ameliorating Th2-mediated inflammation and/or pruritus. We will review here emerging evidence that the inflammation in atopic dermatitis results from inherited and acquired insults to the barrier and the therapeutic implications of this new paradigm. RECENT FINDINGS: Recent molecular genetic studies have shown a strong association between mutations in FILAGGRIN and atopic dermatitis, particularly in Northern Europeans. But additional acquired stressors to the barrier are required to initiate inflammation. Sustained hapten access through a defective barrier stimulates a Th1 --> Th2 shift in immunophenotype, which in turn further aggravates the barrier. Secondary Staphylococcus aureus colonization not only amplifies inflammation but also further stresses the barrier in atopic dermatitis. SUMMARY: These results suggest a new 'outside-to-inside, back to outside' paradigm for the pathogenesis of atopic dermatitis. This new concept is providing impetus for the development of new categories of 'barrier repair' therapy.
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Cites
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
The development of allergic inflammation
Galli, S. J., Tsai, M., & Piliponsky, A. M. (2008) · Nature · doi:10.1038/nature07204 · Cited by 1,839
Filaggrin in atopic dermatitis
O'Regan, G. M., Sandilands, A., McLean, W. H. I., & Irvine, A. D. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.08.002 · Cited by 350
Seidenari, S., & Giusti, G. (1995) · Acta Dermato-Venereologica · doi:10.2340/0001555575429433 · Cited by 344
Keratinocytes store the antimicrobial peptide cathelicidin in lamellar bodies
Braff, M. H., Nardo, A. D., & Gallo, R. L. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23443.x · Cited by 213
Krien, P. M., & Kermici, M. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00083.x · Cited by 151
Cited by
The important role of stratum corneum lipids for the cutaneous barrier function
van Smeden, J., Janssens, M., Gooris, G. S., & Bouwstra, J. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.006 · Cited by 549
One remarkable molecule: filaggrin
Brown, S. J., & Irwin McLean, W. H. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.393 · Cited by 527
Janssens, M., van Smeden, J., Gooris, G. S., Bras, W., Portale, G., Caspers, P. J., Vreeken, R. J., Hankemeier, T., Kezic, S., Wolterbeek, R., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p030338 · Cited by 488
The multifunctional role of filaggrin in allergic skin disease
McAleer, M. A., & Irvine, A. D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.668 · Cited by 419
van Smeden, J., & Bouwstra, J. A. (2016) · Current Problems in Dermatology · doi:10.1159/000441540 · Cited by 366
Metadata
- Authors
- Elias, P. M., & Schmuth, M.
- Venue
- Current Opinion in Allergy & Clinical Immunology
- Published
- 2009-10
- Volume
- 9
- Issue
- 5
- Pages
- 437-446
- ISSN
- 1473-6322 (ISSN-L)
- 1528-4050
- OpenAlex
- W2047250004
- Cited by
- 246
- References
- 6
- FWCI
- 23.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Elias, P. M., & Schmuth, M. (2009). Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Current Opinion in Allergy & Clinical Immunology. https://doi.org/10.1097/aci.0b013e32832e7d36
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
