Ethnicity and OPRM Variant Independently Predict Pain Perception and Patient-Controlled Analgesia Usage for Post-Operative Pain
Open accessAbstract
Background: Morphine consumption can vary widely between individuals even for identical surgical procedures. As mu-opioid receptor (OPRM1) is known to modulate pain perception and mediate the analgesic effects of opioid compounds in the central nervous system, we examined the influence of two OPRM polymorphisms on acute post-operative pain and morphine usage in women undergoing elective caesarean delivery. Results: Data on self-reported pain scores and amount of total morphine use according to patient-controlled analgesia were collected from 994 women from the three main ethnic groups in Singapore. We found statistically significant association of the OPRM 118A>G with self-administered morphine during the first 24-hour postoperative period both in terms of total morphine (p = 1.7 × 10 −5 ) and weight-adjusted morphine (p = 6.6 × 10 −5 ). There was also significant association of this OPRM variant and time-averaged self-rated pain scores (p = 0.024). OPRM 118G homozygotes used more morphine and reported higher pain scores than 118A carriers. Other factors which influenced pain score and morphine usage include ethnicity, age and paying class. Conclusion: Our results suggest that ethnicity and OPRM 118A>G genotype are independent and significant contributors to variation in pain perception and postoperative morphine use in patients undergoing cesarean delivery.
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Other mutations in OPRM1 are associated to heroin addiction, pain perception, but also sociality traits.
“Other mutations in this gene are associated to heroin addiction178, and pain perception179, but also sociality traits180.”
From A catalog of single nucleotide changes distinguishing modern humans from archaic hominins (2019) · cites this paper as [179]
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A catalog of single nucleotide changes distinguishing modern humans from archaic hominins
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- Authors
- Tan, E.-C., Lim, E. C., Teo, Y.-Y., Lim, Y., Law, H.-Y., & Sia, A. T.
- Affiliations
- National University of Singapore (SG)
- KK Women's and Children's Hospital (SG)
- Centre for Human Genetics (GB)
- Corresponding author
- Tan, Ene-choo
- Venue
- Molecular Pain
- Publisher
- SAGE Publications
- Published
- 2009-01-01
- Volume
- 5
- Pages
- 32-32
- ISSN
- 1744-8069 (ISSN-L)
- PMC
- PMC2709614
- OpenAlex
- W2141630515
- Cited by
- 133
- References
- 36
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 17 · 2013: 19 · 2012: 13
- FWCI
- 13.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Pain (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- mu-opioid receptor, OPRM1, postoperative pain, morphine consumption, patient-controlled analgesia, ethnicity, cesarean section, pain perception, opioid analgesia
- MeSH terms
- Adult, Ethnicity, Female, Genotype, Humans, Morphine, Pain Measurement, Postoperative Pain, Pharmacogenetics, Predictive Value of Tests, Pregnancy, Analgesia, Patient-Controlled, Receptors, Opioid, mu, Polymorphism, Single Nucleotide
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