The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Association of μ‐opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty
Abstract
Background: Morphine consumption after a given surgical procedure can vary considerably. Studies show that single nucleotide polymorphism involving the nucleotide position 118 at exon 1 of the μ‐opioid receptor gene (OPRM1) may play a role in mediating the effects of opioids. This study was performed to correlate the A118G polymorphism at OPRM1 with morphine consumption in patients undergoing total knee arthroplasty. Methods: Post‐operative pain was relieved by patient‐controlled analgesia (PCA). The analgesic effect was evaluated using a visual analogue scale. Side‐effects, such as sedation, nausea and vomiting, and pruritus, were recorded systematically. The genotypes were determined by sequencing polymerase chain reaction‐amplified DNA. The differences in demographics and consumed morphine from the PCA device between the different genotypes were tested using one‐way analysis of variance. The prevalence of side‐effects from morphine and sex distribution were compared using the Kruskal–Wallis test. Results: One hundred and forty‐seven patients were included in the study. Twenty‐seven patients who required rescue analgesia were excluded; these patients did not differ demographically or genetically from the 120 who completed the study. Of the latter, 74 were A118 homozygous (AA), 33 were heterozygous (AG) and 13 were G118 homozygous (GG). Group GG consumed significantly more morphine (40.4 ± 22.0 mg) than group AA (25.3 ± 15.5 mg) and group AG (25.6 ± 11.7 mg) during the first 48 h post‐operatively. The groups did not differ with respect to reported pain, age, sex, weight and adverse effects. Conclusions: G118 homozygotes have a poorer response to morphine for post‐operative pain control than A118 homozygotes or heterozygotes. The genotype may thus influence the post‐operative response to pain and cause differences in the amounts of analgesic consumed by patients after total knee arthroplasty.
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Bond, C., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., Gong, J., Schluger, J., Strong, J. A., Leal, S. M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9608 · Cited by 1,074
Klepstad, P., Rakvåg, T. T., Kaasa, S., Holthe, M., Dale, O., Borchgrevink, P. C., Baar, C., Vikan, T., Krokan, H. E., & Skorpen, F. (2004) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2004.00517.x · Cited by 381
Beyer, A., Koch, T., Schröder, H., Schulz, S., & Höllt, V. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02340.x · Cited by 258
Gender differences in drug effects: implications for anesthesiologists
Pleym, H., Spigset, O., Kharasch, E. D., & Dale, O. (2003) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.2003.00036.x · Cited by 229
Skarke, C., Darimont, J., Schmidt, H., Geisslinger, G., & Lötsch, J. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2003.5 · Cited by 226
Lötsch, J., Skarke, C., Grösch, S., Darimont, J., Schmidt, H., & Geisslinger, G. (2002) · Pharmacogenetics · doi:10.1097/00008571-200201000-00002 · Cited by 211
Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations
Tan, E.-C., Tan, C.-H., Karupathivan, U., & Yap, E. P. H. (2003) · NeuroReport · doi:10.1097/00001756-200303240-00008 · Cited by 172
Lötsch, J., Zimmermann, M., Darimont, J., Marx, C., Dudziak, R., Skarke, C., & Geißlinger, G. (2002) · Anesthesiology · doi:10.1097/00000542-200210000-00011 · Cited by 155
Opioid receptor and peptide gene polymorphisms: potential implications for addictions
LaForge, K. S., Yuferov, V. P., & Kreek, M. J. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00819-0 · Cited by 154
Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts
Szeto, C. Y.-K., Tang, N. L. S., Lee, D. T. S., & Stadlin, A. (2001) · Neuroreport · doi:10.1097/00001756-200105080-00011 · Cited by 147
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The neural bases of social pain: Evidence for shared representations with physical pain
Eisenberger, N. I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182464dd1 · Cited by 492
Sia, A. T., Lim, Y., Lim, E. C. P., Goh, R. W. C., Law, H. Y., Landau, R., Teo, Y.-Y., & Tan, E. C. (2008) · Anesthesiology · doi:10.1097/aln.0b013e318182af21 · Cited by 297
Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting
Horn, C. C., Wallisch, W. J., Homanics, G. E., & Williams, J. P. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.037 · Cited by 288
Way, B. M., Taylor, S. E., & Eisenberger, N. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812612106 · Cited by 264
Tan, E.-C., Lim, E. C., Teo, Y.-Y., Lim, Y., Law, H.-Y., & Sia, A. T. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-32 · Cited by 133
Metadata
- Authors
- Chou, W. ‐., Yang, L. ‐., Lu, H. ‐., Ko, J. ‐., Wang, C. ‐., Lin, S. ‐., Lee, T. ‐., Concejero, A., & Hsu, C. ‐.
- Venue
- Acta Anaesthesiologica Scandinavica
- Publisher
- Wiley
- Published
- 2006-07-06
- Volume
- 50
- Issue
- 7
- Pages
- 787-792
- ISSN
- 0001-5172 (ISSN-L)
- 1399-6576
- OpenAlex
- W2018655119
- Cited by
- 296
- References
- 14
- FWCI
- 20.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chou, W. ‐., Yang, L. ‐., Lu, H. ‐., Ko, J. ‐., Wang, C. ‐., Lin, S. ‐., Lee, T. ‐., Concejero, A., & Hsu, C. ‐. (2006). Association of μ‐opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty. Acta Anaesthesiologica Scandinavica. https://doi.org/10.1111/j.1399-6576.2006.01058.x
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